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Registry of Toxic Effects of Chemical Substances (RTECS)

1,2-Ethanediamine, N-(2-aminoethyl)-N'-(2-((2-aminoethyl)amino)ethyl)-

RTECS #

KH8585000

CAS #

112-57-2

Updated

October 1997

Molecular Weight

189.36

Molecular Formula

C8H23N5

Synonyms

1,4,7,10,13-Pentaazatridecane
DEH 26
Tetraethylpentylamine
Tetren

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 5 mg moderateUCDS** 3/20/1973
eye /rabbit 100 mg/24H moderate85JCAE -,446,1986
skin /rabbit 495 mg open irritation test severeUCDS** 3/20/1973
skin /rabbit 5 mg/24H severe85JCAE -,446,1986

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
mutation in microorganisms/Salmonella typhimurium333 µg/plate (+/-enzymatic activation step)ENMUDM 8(Suppl 7),1,1986
sister chromatid exchangeovary/hamster250 µg/LMUREAV 320,31,1994
Unscheduled DNA Synthesisliver/rat10 µg/LMUREAV 320,31,1994

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat lethal dose (50 percent kill): 205 mg/kgICHAA3 91,L51,1984
intravenous/mouse lethal dose (50 percent kill): 320 mg/kgCSLNX* NX#03522
oral/rat lethal dose (50 percent kill): 3990 mg/kgUCDS** 3/20/1973
skin/rabbit lethal dose (50 percent kill): 660 µL/kgJIHTAB 31,60,1949

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 84383; Number of Industries 45; Total Number of Facilities 1513; Number of Occupations 49; Total Number of Employees Exposed 50358; Total Number of Female Employees Exposed 8280
National Occupational Hazard Survey 1974Hazard Code 84383; Number of Industries 25; Total Number of Facilities 798; Number of Occupations 25; Total Number of Employees Exposed 17539

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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