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1,2 - Ethanediamine

RTECS #: KH8575000

CAS #: 107-15-3


UPDATE: May 2009 MW: 60.12 MF: C2H8N2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. 1,2 - Diaminoaethan (German)
  2. 1,2 - Diamino - ethaan (Dutch)
  3. 1,2 - Diaminoethane (OSHA)
  4. 1,2 - Diamino - ethano (Italian)
  5. 1,2 - Ethylenediamine
  6. Aethaldiamin (German)
  7. Aethylenediamin (German)
  1. Dimethylenediamine
  2. Ethyleendiamine (Dutch)
  3. Ethylendiamine
  4. Ethylenediamine
  5. Ethylene - diamine (French)
  6. Ethylenediamine (ACGIH:OSHA)
  7. NCI - C60402


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
750 g severe AJOPAA 29,1363,1946
eye
rabbit
750 g/24 hour severe 85JCAE -,440,1986
skin
rabbit
450 mg open irritation test moderate UCDS** 12/15/1971
skin
rabbit
10 mg/24 hour open irritation test severe AMIHBC 4,119,1951


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
mutation in microorganisms Salmonella typhimurium 33 g/plate (+enzymatic activation step) ENMUDM 5(Suppl 1),3,1983


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 3,200 mg/kg (6-13 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) TCMUD8 7,29,1987


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
human
lowest published toxic concentration: 200 ppm Peripheral Nerve and Sensation: Paresthesia AMIHBC 9,223,1954
inhalation
mouse
lethal concentration (50 percent kill): 300 mg/m3 N/R 85GMAT -,66,1982
inhalation
rat
lowest published lethal concentration: 4,000 ppm/8 hour N/R AMIHBC 4,119,1951
intraperitoneal
mouse
lethal dose (50 percent kill): 200 mg/kg N/R CHTPBA 4,136,1969
intraperitoneal
rat
lethal dose (50 percent kill): 76 mg/kg N/R TXAPA9 21,454,1972
intravenous
dog
lowest published lethal dose: 100 mg/kg N/R HBAMAK 4,1295,1935
oral
guinea pig
lethal dose (50 percent kill): 470 mg/kg Behavioral: Somnolence (general depressed activity)

Gastrointestinal: Other changes

Kidney, Ureter, and Bladder: Other changes
JIHTAB 23,259,1941
oral
mouse
lethal dose (50 percent kill): 1 gm/kg Behavioral: Ataxia MTPEEI (1),38,1997
oral
rat
lethal dose (50 percent kill): 1,200 mg/kg Behavioral: Ataxia MTPEEI (1),38,1997
subcutaneous
rat
lethal dose (50 percent kill): 300 mg/kg N/R 85GMAT -,66,1982
subcutaneous
rabbit
lowest published lethal dose: 500 mg/kg N/R HBAMAK 4,1295,1935
skin
human
lowest published toxic concentration: 1 pph Skin: After topical application: Dermatitis, allergic AJCDE* 13,125,2002
skin
rabbit
lethal dose (50 percent kill): 730 L/kg N/R AMIHBC 4,119,1951


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic dose: 700 g/m3/17 week- intermittent Brain and Coverings: Other degenerative changes

Blood: Changes in spleen

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
VMDKAM 38(2),1932
inhalation
rat
lowest published toxic concentration: 225 ppm/7 hour/30 day- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
AMIHBC 9,223,1954
oral
rat
lowest published toxic dose: 3,500 mg/kg/7 day- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0571059
oral
rat
lowest published toxic dose: 39 gm/kg/13 week- intermittent Eye: Other eye effects

Blood: Hemorrhage

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0536438
oral
rat
lowest published toxic dose: 540 mg/kg/6 week- intermittent Lung, Thorax, or Respiration: Changes in lung weight

Liver: Liver function tests impaired

Kidney, Ureter, and Bladder: Other changes in urine composition
MTPEEI (1),38,1997
oral
rabbit
lowest published toxic dose: 1,400 mg/kg/14 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTIS** #PB93-190056
skin
human
lowest published toxic concentration: 1 pph/48 hour- continuous Skin: After topical application: Dermatitis, allergic AJCDE* 13,59,2002


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 10 ppm (skin) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
JJOMDZ 15,808,1973
TOXICOLOGY REVIEW
CHHSA* 9,6,2002
TOXICOLOGY REVIEW
HUTOX* -,649,1996


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,308,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 10 ppm (25 mg/m3) DTLVS* 3,109,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 10 ppm (25 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 10 ppm (25 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 10 ppm (25 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 10 ppm (25 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 10 ppm (25 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 10 ppm (25 mg/m3), Skin, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 10 ppm (25 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 10 ppm (25 mg/m3), short term exposure limit 20 ppm (50 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 10 ppm (25 mg/m3), VLE 15 ppm (35 mg/m3), FEB2006
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 10 ppm (25 mg/m3), skin, sen, APR2007
Occupational Exposure Limit - KOREA time-weighted average 10 ppm (25 mg/m3), 2006
Occupational Exposure Limit - MEXICO time-weighted average 10 ppm (25 mg/m3);
short term exposure limit 3 mg/m3, 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 18 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 10 ppm (25 mg/m3), skin, sen, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 10 ppm (25 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 10 ppm (25 mg/m3), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 2 mg/m3, MAC(short term exposure limit) 6 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 2 mg/m3, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 10 ppm (25 mg/m3);
short term exposure limit 15 ppm (35 mg/m3), Sen, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 10 ppm (25 mg/m3),KZG- week 20 ppm (50 mg/m3), DEC2006
Occupational Exposure Limit - TURKEY time-weighted average 10 ppm (25 mg/m3), JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ETHYLENEDIAMINE-air 10 hour time-weighted average 10 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 32220;
Number of Industries 33;
Total Number of Facilities 2,126;
Number of Occupations 35;
Total Number of Employees Exposed 15,918
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 32220;
Number of Industries 77;
Total Number of Facilities 6,260;
Number of Occupations 85;
Total Number of Employees Exposed 113,007;
Total Number of Female Employees Exposed 29,888


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Negative: CHO gene mutation
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an intermediate or as a urine acidifier
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Ethylenediamine, 2540
OSHA ANALYTICAL METHOD #ID-60


REFERENCES:

CODEN
REFERENCE

85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AJCDE* American Journal of Contact Dermatitis: Official Journal of the American Contact Dermatitis Society (Philadelphia, PA : W.B. Saunders, Harcourt Brace Jovanovich) V.1-14 1990-2003.
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918-
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CHHSA* Chemical Health & Safety (Orlando, FL : Published by Elsevier Inc. for the ACS Division of Chemical Health and Safety) V.1- 1994-
CHTPBA Chimica Therapeutica. (Paris, France) V.1-8, 1965-73. For publisher information, see EJMCA5.
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.)
HUTOX*
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
JJOMDZ JOM, Journal of Occupational Medicine. (American Occupational Medicine Assoc., 150 N. Wacker Dr., Chicago, IL 60606) V.10- 1968-
MTPEEI Meditsina Truda i Promyshlennaya Ekologiya. Industrial Medicine and Ecology. (Mezhdunarodnaya Kniga, ul.B. Yakimanka, 39 117049 Moscow, Russia) No.1- 1993-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
VMDKAM Voprosy Meditsinskoi Khimii. Problems of Medical Chemistry. (V/O Me zhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1955-

Used as an intermediate or as a urine acidifier

NIOSH PROFILE (AMINES, POLY), SRI, 2/77

RTECS Compound Description:
   Mutagen
   Reproductive Effector
   Human Data
   Hormone
   Primary Irritant

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