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Registry of Toxic Effects of Chemical Substances (RTECS)

Ethane, 2-chloro-1,1,1-trifluoro-

RTECS #

KH8008500

CAS #

75-88-7

Updated

February 2008

Molecular Weight

118.49

Molecular Formula

C2H2ClF3

Synonyms

1,1,1-Trifluoro-2-chloroethane
1,1,1-Trifluoroethyl chloride
1-Chloro-2,2,2-trifluoroethane
2,2,2-Trifluorochloroethane
2-Chloro-1,1,1-trifluoroethane
CFC 133a
FC 133a
Freon 133a
Genetron 133a
R 133a

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 78 gm/kg/1Y- intermittentTumorigenic: Carcinogenic by RTECS criteria

Reproductive: Tumorigenic effects: Testicular tumors

Reproductive: Tumorigenic effects: Uterine tumors
TXAPA9 72,15,1984

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/guinea pig Lowest published lethal concentration: 33000 ppm/5HLung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Acute pulmonary edema
NTIS** OTS0530594
inhalation/mouse lethal concentration (50 percent kill): 15 pph/1HBehavioral: General anesthetic

Behavioral: Convulsions or effect on seizure threshold
BJANAD 37,716,1965

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/Dog lowest published toxic concentration: 10 pph/1H/25D- intermittentBehavioral: General anesthetic

Liver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Interstitial nephritis
NTIS** OTS0528422

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMEMDT 41,253,1986
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMEMDT 71,1355,1999
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 41,253,1986
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 71,1355,1999
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMEMDT 71,1355,1999
TOXICOLOGY REVIEWMUREAV 584,1,2005

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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