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Registry of Toxic Effects of Chemical Substances (RTECS)

Ethane, 1-chloro-1,1-difluoro-

RTECS #

KH7650000

CAS #

75-68-3

Updated

July 2013

Molecular Weight

100.50

Molecular Formula

C2H3ClF2

Synonyms

1,1-Difluoro-1-chloroethane
1-Chloro-1,1-difluoroethane
alpha-Chloroethylidene fluoride
CFC 142b
Chloroethylidene fluoride
FC142b
Fluorocarbon FC142b
Freon 142
Freon 142b
Genetron 101
Genetron 142b
Gentron 142B
Hydrochlorofluorocarbon 142b
Isotron 142b
Monochlorodifluoroethane

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
mutation in microorganisms/Salmonella typhimurium50 pph/24H (-enzymatic activation step)TXAPA9 72,15,1984

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 1000 ppm/6H (3-15D pregnant)Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)NTIS** OTS0555347

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lethal concentration (50 percent kill): 1758000 mg/m3/2HVCVGH* -,633,1990
inhalation/mouse lethal concentration (50 percent kill): 1758 gm/m3TPKVAL 9,27,1967
inhalation/rat lethal concentration (50 percent kill): 2050.4 gm/m3TPKVAL 9,27,1967
inhalation/rat Lowest published lethal concentration: 212000 mg/m3/30MVCVGH* -,633,1990
inhalation/rat lethal concentration (50 percent kill): 2050000 mg/m3/4HVCVGH* -,633,1990

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 10 pph/16H/9D- intermittentLung, Thorax, or Respiration: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
AIHOAX 2(3),335,1950
inhalation/rat lowest published toxic concentration: 550 gm/m3/4W- intermittentPeripheral Nerve and Sensation: Recording from peripheral motor nerve

Behavioral: Alteration of classical conditioning

Endocrine: Evidence of thyroid hypofunction
TPKVAL 9,175,1967

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWFCTOD7 47,1287,2009

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-AUSTRIAMAK-TMW 1000 ppm (4170 mg/m3);KZW 2000 ppm (8340 mg/m3), 2007
Occupational Exposure Limit-DENMARKtime-weighted average 1000 ppm (4110 mg/m3), MAY2011
Occupational Exposure Limit-GERMANYMAK 1000 ppm (4200 mg/m3), 2011
Occupational Exposure Limit-HUNGARYtime-weighted average 4170 mg/m3, short term exposure limit 16680 mg/m3, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 1000 ppm (4110 mg/m3), NOV2011
Occupational Exposure Limit-PERUtime-weighted average 1000 ppm (4200 mg/m3), JUL2005
Occupational Exposure Limit-RUSSIAshort term exposure limit 3000 mg/m3, JUN2003
Occupational Exposure Limit-SWITZERLANDMAK-week 1000 ppm (4170 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 8380 mg/m3, 2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Hazard Survey 1974Hazard Code 82201; Number of Industries 1; Total Number of Facilities 11; Number of Occupations 3; Total Number of Employees Exposed 357

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database
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