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Ethane, 1 - chloro - 1,1 - difluoro -

RTECS #: KH7650000

CAS #: 75-68-3


UPDATE: February 2009 MW: 100.50 MF: C2H3ClF2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 1,1 - Difluoro - 1 - chloroethane
  2. 1 - Chloro - 1,1 - difluoroethane
  3. CFC 142b
  4. Chloroethylidene fluoride
  5. FC142b
  6. Fluorocarbon FC142b
  7. Freon 142
  8. Freon 142b
  1. Genetron 101
  2. Genetron 142b
  3. Gentron 142B
  4. Hydrochlorofluorocarbon 142b
  5. Isotron 142b
  6. Monochlorodifluoroethane
  7. alpha - Chloroethylidene fluoride


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
mutation in microorganisms Salmonella typhimurium 50 pph/24 hour (-enzymatic activation step) TXAPA9 72,15,1984


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 1,000 ppm/6 hour (3-15 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) NTIS** OTS0555347


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lethal concentration (50 percent kill): 1,758,000 mg/m3/2 hour N/R VCVGH* -,633,1990
inhalation
mouse
lethal concentration (50 percent kill): 1,758 gm/m3 N/R TPKVAL 9,27,1967
inhalation
rat
lowest published lethal concentration: 212,000 mg/m3/30 minute N/R VCVGH* -,633,1990
inhalation
rat
lethal concentration (50 percent kill): 2,050,000 mg/m3/4 hour N/R VCVGH* -,633,1990
inhalation
rat
lethal concentration (50 percent kill): 2,050.4 gm/m3 N/R TPKVAL 9,27,1967


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 10 pph/16 hour/9 day- intermittent Lung, Thorax, or Respiration: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
AIHOAX 2(3),335,1950
inhalation
rat
lowest published toxic concentration: 550 gm/m3/4 week- intermittent Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Behavioral: Alteration of classical conditioning

Endocrine: Evidence of thyroid hypofunction
TPKVAL 9,175,1967


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - HUNGARY time-weighted average 4170 mg/m3, short term exposure limit 16680 mg/m3, SEP2000
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 8380 mg/m3, 2003
Occupational Exposure Limit - RUSSIA short term exposure limit 3000 mg/m3, JUN2003
Occupational Exposure Limit - SWITZERLAND MAK- week 1000 ppm (4170 mg/m3), DEC2006


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 82201;
Number of Industries 1;
Total Number of Facilities 11;
Number of Occupations 3;
Total Number of Employees Exposed 357


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an intermediate in the production of highly specialized fluoropolymers
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

AIHOAX Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.1-2(3), 1950. For publisher information, see AEHLAU.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.

Used as an intermediate in the production of highly specialized fluoropolymers

RTECS Compound Description:
   Mutagen
   Reproductive Effector

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