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Registry of Toxic Effects of Chemical Substances (RTECS)

Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, chloride

RTECS #

KH2975000

CAS #

67-48-1

Updated

December 2013

Molecular Weight

139.65

Molecular Formula

C5H14NO·Cl

Synonyms

(2-Hydroxyethyl)trimethylammonium chloride
Ammonium, (2-hydroxyethyl)trimethyl-, chloride
Biocolina
Chloride de choline (French)
Choline chlorhydrate
Choline chloride
Choline hydrochloride
Cholinium chloride
Hepacholine
Lipotril

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisovary/hamster500 µg/LENMUDM 7,1,1985
sister chromatid exchangeovary/hamster500 µg/LENMUDM 7,1,1985

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 4000 mg/kg (5-20D pregnant)Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Effects on newborn: Physical
NETEEC 31,303,2009

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intracerebral/rat lowest published toxic dose: 300 µg/kgEndocrine: HyperglycemiaEJPHAZ 438,197,2002
intracerebral/rat lowest published toxic dose: 100.5 µg/kgVascular: BP elevation not characterized in autonomic sectionCEXPB9 30,640,2003
intracerebral/rat lowest published toxic dose: 558.6 µg/kgEndocrine: Antidiuresis

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
FCLPH* 18,71,2004
intraperitoneal/mouse lethal dose (50 percent kill): 320 mg/kgPSEBAA 51,281,1942
intraperitoneal/rabbit lowest published lethal dose: 500 mg/kgEye: Corneal damage

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Other changes
JIDIAQ 42,473,1928
intraperitoneal/rat lowest published toxic dose: 120 mg/kgEndocrine: HyperglycemiaEJPHAZ 438,197,2002
intraperitoneal/rat lethal dose (50 percent kill): 450 mg/kgIJEBA6 24,91,1986
intravenous/cat lowest published lethal dose: 25 mg/kgHBAMAK 4,1289,1935
intravenous/Dog lowest published lethal dose: 5 mg/kgHBAMAK 4,1289,1935
intravenous/mouse lethal dose (50 percent kill): 53 mg/kgEye: Lacrimation

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory depression
ARZNAD 33,1016,1983
intravenous/rabbit lowest published lethal dose: 1100 µg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Cyanosis

Gastrointestinal: Changes in structure or function of salivary glands
PSEBAA 51,281,1942
oral/mouse lethal dose (50 percent kill): 3900 mg/kgEye: Lacrimation

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory depression
ARZNAD 33,1016,1983
oral/rat lethal dose (50 percent kill): 3400 mg/kgEye: Chromodacryorrhea

Behavioral: Excitement

Lung, Thorax, or Respiration: Respiratory depression
PSEBAA 58,87,1945
rectal/rabbit lowest published lethal dose: 1 gm/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Cyanosis

Gastrointestinal: Changes in structure or function of salivary glands
PSEBAA 51,281,1942
subcutaneous/mouse lowest published lethal dose: 735 mg/kgJPETAB 6,477,1914/1915
subcutaneous/rabbit lowest published lethal dose: 1 gm/kgPSEBAA 51,281,1942
unreported route/frog lowest published lethal dose: 1500 mg/kgPSEBAA 51,281,1942

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat lowest published toxic dose: 4950 mg/kg/30D- intermittentLung, Thorax, or Respiration: Changes in lung weight

Liver: Changes in liver weight

Endocrine: Changes in thymus weight
JOBSDN 10,29,1986
intraperitoneal/rat lowest published toxic dose: 6250 mg/kg/10W- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldINHEAO 23,135,1985
intraperitoneal/rat lowest published toxic dose: 3564 mg/kg/5W- intermittentLiver: Changes in liver weight

Endocrine: Changes in thymus weight

Blood: Changes in spleen
IJEBA6 24,91,1986
oral/rat lowest published toxic dose: 8379 mg/kg/3D- intermittentKidney, Ureter, and Bladder: Other changes in urine compositionJCPCBR 44,1203,2004
oral/rat lowest published toxic dose: 12.24 gm/kg/12D- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainNRTXDN 32,907,2011
oral/rat lowest published toxic dose: 331 mg/kg/14W- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainPSEBAA 58,212,1945

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWREPTED 23,297,2007
TOXICOLOGY REVIEWFEREAC 73,73648,2008
TOXICOLOGY REVIEWFEREAC 75,760,2010

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 10 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 19130; Number of Industries 10; Total Number of Facilities 2227; Number of Occupations 30; Total Number of Employees Exposed 31203; Total Number of Female Employees Exposed 8214
National Occupational Hazard Survey 1974Hazard Code 19130; Number of Industries 3; Total Number of Facilities 198; Number of Occupations 12; Total Number of Employees Exposed 2813

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: E coli polA without S9
EPA TSCA Section 8(b) CHEMICAL INVENTORY
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