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Ethanaminium, 2 - hydroxy - N,N,N - trimethyl - , chloride

RTECS #: KH2975000

CAS #: 67-48-1


UPDATE: November 2008 MW: 139.65 MF: C5H14NOCl


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. (2 - Hydroxyethyl) trimethylammonium chloride
  2. Ammonium, (2 - hydroxyethyl) trimethyl - , chloride
  3. Biocolina
  4. Chloride de choline (French)
  5. Choline chlorhydrate
  1. Choline chloride
  2. Choline hydrochloride
  3. Cholinium chloride
  4. Hepacholine
  5. Lipotril


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis hamster ovary 500 g/L ENMUDM 7,1,1985
sister chromatid exchange hamster ovary 500 g/L ENMUDM 7,1,1985


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intracerebral
rat
lowest published toxic dose: 300 g/kg Endocrine: Hyperglycemia EJPHAZ 438,197,2002
intracerebral
rat
lowest published toxic dose: 100.5 g/kg Vascular: BP elevation not characterized in autonomic section CEXPB9 30,640,2003
intracerebral
rat
lowest published toxic dose: 558.6 g/kg Endocrine: Antidiuresis

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
FCLPH* 18,71,2004
intraperitoneal
mouse
lethal dose (50 percent kill): 320 mg/kg N/R PSEBAA 51,281,1942
intraperitoneal
rat
lethal dose (50 percent kill): 450 mg/kg N/R IJEBA6 24,91,1986
intraperitoneal
rat
lowest published toxic dose: 120 mg/kg Endocrine: Hyperglycemia EJPHAZ 438,197,2002
intraperitoneal
rabbit
lowest published lethal dose: 500 mg/kg Eye: Corneal damage

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Other changes
JIDIAQ 42,473,1928
intravenous
cat
lowest published lethal dose: 25 mg/kg N/R HBAMAK 4,1289,1935
intravenous
dog
lowest published lethal dose: 5 mg/kg N/R HBAMAK 4,1289,1935
intravenous
mouse
lethal dose (50 percent kill): 53 mg/kg Eye: Lacrimation

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory depression
ARZNAD 33,1016,1983
intravenous
rabbit
lowest published lethal dose: 1,100 g/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Cyanosis

Gastrointestinal: Changes in structure or function of salivary glands
PSEBAA 51,281,1942
oral
mouse
lethal dose (50 percent kill): 3,900 mg/kg Eye: Lacrimation

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory depression
ARZNAD 33,1016,1983
oral
rat
lethal dose (50 percent kill): 3,400 mg/kg Eye: Chromodacryorrhea

Behavioral: Excitement

Lung, Thorax, or Respiration: Respiratory depression
PSEBAA 58,87,1945
rectal
rabbit
lowest published lethal dose: 1 gm/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Cyanosis

Gastrointestinal: Changes in structure or function of salivary glands
PSEBAA 51,281,1942
subcutaneous
mouse
lowest published lethal dose: 735 mg/kg N/R JPETAB 6,477,1914/1915
subcutaneous
rabbit
lowest published lethal dose: 1 gm/kg N/R PSEBAA 51,281,1942
unreported route
frog
lowest published lethal dose: 1,500 mg/kg N/R PSEBAA 51,281,1942


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
rat
lowest published toxic dose: 4,950 mg/kg/30 day- intermittent Lung, Thorax, or Respiration: Changes in lung weight

Liver: Changes in liver weight

Endocrine: Changes in thymus weight
JOBSDN 10,29,1986
intraperitoneal
rat
lowest published toxic dose: 6,250 mg/kg/10 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field INHEAO 23,135,1985
intraperitoneal
rat
lowest published toxic dose: 3,564 mg/kg/5 week- intermittent Liver: Changes in liver weight

Endocrine: Changes in thymus weight

Blood: Changes in spleen
IJEBA6 24,91,1986
oral
rat
lowest published toxic dose: 331 mg/kg/14 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain PSEBAA 58,212,1945
oral
rat
lowest published toxic dose: 8,379 mg/kg/3 day- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition JCPCBR 44,1203,2004


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
REPTED 23,297,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - RUSSIA short term exposure limit 10 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 19130;
Number of Industries 3;
Total Number of Facilities 198;
Number of Occupations 12;
Total Number of Employees Exposed 2,813
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 19130;
Number of Industries 10;
Total Number of Facilities 2,227;
Number of Occupations 30;
Total Number of Employees Exposed 31,203;
Total Number of Female Employees Exposed 8,214


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Inconclusive: E coli polA without S9
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE

ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
CEXPB9 Clinical and Experimental Pharmacology and Physiology. (Blackwell Scientific Publications, (Australia) Pty Ltd., 107 Barry St., Carlton, Vic. 3053, Australia) V.1- 1974-
EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
FCLPH* Fundamental & Clinical Pharmacology (Oxford : Blackwell Science) 2001-
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.)
IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
INHEAO Industrial Health. (National Institute of Industrial Health, 6-21-1 Nagao, Tama-ku, Kawasaki, 213 Japan) V.1- 1963-
JCPCBR Journal of Clinical Pharmacology. (Hall Assoc., PO Box 482, Stamford, CT 06904) V.13- 1973-
JIDIAQ Journal of Infectious Diseases. (Univ. of Chicago Press, Journals Div., POB 37005, Chicago, IL 60637) V.1- 1904-
JOBSDN Journal of Biosciences. (Indian Academy of Sciences, POB 8005, Bangalore 560080, India) V.1- 1979-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-

Used as a lipotropic agent

RTECS Compound Description:
   Mutagen

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