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Registry of Toxic Effects of Chemical Substances (RTECS)

Disulfide, dimethyl

RTECS #

JO1927500

CAS #

624-92-0

Updated

September 201

Molecular Weight

94.20

Molecular Formula

C2H6S2

Synonyms

Dimethyldisulfide

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 100 µL/24HNTIS** OTS0572030
eye /rabbit 0.1 mLHPV428 -,-,2008

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 15 ppm (6-15D pregnant)Reproductive: Other effects on femaleHPV209 -,-,2005
inhalation/rat 50 ppm (6-15D pregnant)Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
HPV428 -,-,2008

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lethal concentration (50 percent kill): 12300 µg/m3/2HGTPZAB 16(6),46,1972
inhalation/rat lethal concentration (50 percent kill): 805 ppm/4HHPV428 -,,2008
inhalation/rat lethal concentration (50 percent kill): 15850 µg/m3/4HGTPZAB 16(6),46,1972
oral/rat lowest published lethal dose: 290 mg/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Ulceration or bleeding from stomach
HPV209 -,-,2005
oral/rat lowest published lethal dose: 290 mg/kgBehavioral: Coma

Gastrointestinal: Ulceration or bleeding from stomach
HPV428 -,,2008
oral/rat lethal dose (50 percent kill): 190 mg/kgHPV428 -,,2008
skin/rabbit lethal dose (50 percent kill): >2000 mg/kgHPV428 -,,2008
skin/rabbit Lethal dose: >2000 mg/kgHPV209 -,-,2005
unreported route/mammal (species unspecified) lethal dose (50 percent kill): 138 mg/kgGTPZAB 16(6),46,1972

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 50 ppm/90D- intermittentOlfaction: Other olfaction effectsHPV209 -,-,2005
inhalation/rat lowest published toxic concentration: 50 ppm/90D- intermittentOlfaction: Other olfaction effects

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
HPV428 -,-,2008
inhalation/rat lowest published toxic concentration: 250 ppm/6H/13D- intermittentBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
BJIMAG 27,1,1970
skin/rabbit lowest published toxic dose: 2126 mg/kg/4W- intermittentSkin: After systemic exposure: Dermatitis, otherNTIS** OTS0000696-1
skin/rabbit lowest published toxic dose: 13819 mg/kg/16D- intermittentCardiac: Other changes

Skin: After systemic exposure: Dermatitis, other

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** OTS0000696-1
skin/rabbit lowest published toxic dose: 2976.4 mg/kg/28D- intermittentBehavioral: Somnolence (general depressed activity)

Skin: After topical application: Primary irritation

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV428 -,-,2008
skin/rabbit lowest published toxic dose: 1488.2 mg/kg/14D- intermittentBehavioral: Somnolence (general depressed activity)

Skin: After topical application: Primary irritation
HPV428 -,-,2008

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.5 ppm (skin)DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWENTOX* -,75,2005

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-SWEDENtime-weighted average 1 ppm, JUN2005

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X5408; Number of Industries 3; Total Number of Facilities 14; Number of Occupations 21; Total Number of Employees Exposed 3492; Total Number of Female Employees Exposed 272

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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