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Disulfide, dimethyl

RTECS #: JO1927500

CAS #: 624-92-0


UPDATE: May 2008 MW: 94.20 MF: C2H6S2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Dimethyldisulfide


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
100 L/24 hour N/R NTIS** OTS0572030


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lethal concentration (50 percent kill): 12,300 g/m3/2 hour N/R GTPZAB 16(6),46,1972
inhalation
rat
lethal concentration (50 percent kill): 15,850 g/m3/4 hour N/R GTPZAB 16(6),46,1972
inhalation
rat
lethal concentration (50 percent kill): 805 ppm/4 hour N/R ENTOX* -,75,2005
oral
rat
lethal dose (50 percent kill): 190 mg/kg N/R ENTOX* -,75,2005
skin
rabbit
lethal dose (50 percent kill): >2 gm/kg N/R ENTOX* -,75,2005
unreported route
mammal (species unspecified)
lethal dose (50 percent kill): 138 mg/kg N/R GTPZAB 16(6),46,1972


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 250 ppm/6 hour/13 day- intermittent Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
BJIMAG 27,1,1970
skin
rabbit
lowest published toxic dose: 2,126 mg/kg/4 week- intermittent Skin: After systemic exposure: Dermatitis, other NTIS** OTS0000696-1
skin
rabbit
lowest published toxic dose: 13,819 mg/kg/16 day- intermittent Cardiac: Other changes

Skin: After systemic exposure: Dermatitis, other

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** OTS0000696-1


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.5 ppm (skin) DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
ENTOX* -,75,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - SWEDEN time-weighted average 1 ppm, JUN2005


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X5408;
Number of Industries 3;
Total Number of Facilities 14;
Number of Occupations 21;
Total Number of Employees Exposed 3,492;
Total Number of Female Employees Exposed 272


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

BJIMAG British Journal of Industrial Medicine. (British Medical Journal, Box 560B, Kennebunkport, ME 04046) V.1- 1944-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.

RTECS Compound Description:
   Primary Irritant

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