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Disulfide, bis (dimethylthiocarbamoyl)

RTECS #: JO1400000

CAS #: 137-26-8


UPDATE: May 2009 MW: 240.44 MF: C6H12N2S4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. Accelerator thiuram
  2. Aceto TETD
  3. Arasan
  4. Arasan 70
  5. Arasan 75
  6. Arasan 42 - S
  7. Arasan - M
  8. Arasan - SF
  9. Arasan - SF - X
  10. Aules
  11. Bis ( (dimethylamino) carbonothioyl) disulphide
  12. Bis (dimethyl - thiocarbamoyl) - disulfid (German)
  13. Bis (dimethylthiocarbamoyl) disulfide
  14. Bis (dimethylthiocarbamoyl) disulphide
  15. Bis (dimethylthiocarbamyl) disulfide
  16. Chipco thiram 75
  17. Cyuram DS
  18. Disolfuro di tetrametiltiourame (Italian)
  19. Disulfure de tetramethylthiourame (French)
  20. Ekagom TB
  21. FMC 2070
  22. Falitiram
  23. Fermide
  24. Fernacol
  25. Fernasan
  26. Fernasan A
  27. Fernide
  28. Flo Pro T Seed Protectant
  29. Formamide, 1,1' - dithiobis (N,N - dimethylthio -
  30. Hermal
  31. Hermat TMT
  32. Heryl
  33. Hexathir
  34. Kregasan
  35. Mercuram
  36. Methyl thiram
  37. Methyl thiuramdisulfide
  38. Methyl tuads
  39. Micropearls
  40. N,N' - (Dithiodicarbonothioyl) bis (N - methylmethanamine)
  41. N,N,N',N' - Tetramethylthiuram disulfide
  42. N,N - Tetramethylthiuram disulphide
  43. Nobecutan
  44. Nomersan
  45. Normersan
  46. Panoram 75
  47. Polyram ultra
  48. Pomarsol
  49. Pomarsol forte
  50. Pomasol
  51. Puralin
  52. RCRA waste number U244
  53. Radothiram
  54. Rezifilm
  55. Royal TMTD
  56. SQ 1489
  57. Sadoplon
  58. Spotrete
  59. Spotrete - F
  60. TMTD
  61. TMTDS
  62. TUEX
  63. Tersan
  1. Tersan 75
  2. Tetramethyldiurane sulphite
  3. Tetramethylenethiuram disulphide
  4. Tetramethylthiocarbamoyldisulphide
  5. Tetramethylthioperoxydicarbonic diamide
  6. Tetramethylthioramdisulfide (Dutch)
  7. Tetramethyl - thiram disulfid (German)
  8. Tetramethylthiuram bisulfide
  9. Tetramethylthiuram bisulphide
  10. Tetramethylthiuram disulfide
  11. Tetramethylthiuram disulphide
  12. Tetramethylthiuran disulphide
  13. Tetramethyl thiurane disulfide
  14. Tetramethyl thiurane disulphide
  15. Tetramethylthiurum disulfide
  16. Tetramethylthiurum disulphide
  17. Tetrapom
  18. Tetrathiuram disulfide
  19. Tetrathiuram disulphide
  20. Thillate
  21. Thimer
  22. Thioknock
  23. Thiosan
  24. Thiotox (fungicide)
  25. Thiram
  26. Thiram (ACGIH:OSHA)
  27. Thiram 75
  28. Thiram B
  29. Thiramad
  30. Thirame (French)
  31. Thirasan
  32. Thiulix
  33. Thiurad
  34. Thiuram M
  35. Thiuram M rubber accelerator
  36. Thiuramyl
  37. Thiuram
  38. Thiuram D
  39. Thiuram disulfide, tetramethyl -
  40. Thiuramin
  41. Thylate
  42. Tigam
  43. Tirampa
  44. Tiuram (Polish)
  45. Tiuramyl
  46. Trametan
  47. Tridipam
  48. Tripomol
  49. Tuads
  50. Tulisan
  51. USAF B - 30
  52. USAF EK - 2089
  53. USAF P - 5
  54. VUAgT - I - 4
  55. Vancida TM - 95
  56. Vancide TM
  57. Vulcafor TMTD
  58. Vulkacit MTIC
  59. Vulkacit thiuram
  60. Vulkacit thiuram/C
  61. ZUPA S 80
  62. alpha,alpha' - Dithiobis (dimethylthio) formamide


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
100 mg/24 hour moderate 28ZPAK -,278,1972


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis oral
mouse
80 mg/kg/3 day- continuous FCTOD7 25,709,1987
dominant lethal test oral
mouse
150 mg/kg/8 week- continuous FCTOD7 35,523,1997
DNA damage human lymphocyte 100 g/L FCTOD7 36,155,1998
DNA damage oral
mouse
2,400 mg/kg/8 day- continuous FCTOD7 36,155,1998
DNA inhibition human lymphocyte 1 mg/L ARTODN 45,101,1980
DNA inhibition rat other cell types 100 g/L ARTODN 45,101,1980
DNA repair Bacillus subtilis 2 g/disc MUREAV 40,19,1976
DNA repair Salmonella typhimurium 50 g/plate MUREAV 89,1,1981
mutation in microorganisms Aspergillus nidulans 500 ng/plate (-enzymatic activation step) MUREAV 89,1,1981
mutation in microorganisms other microorganisms 1,000 ppm (-enzymatic activation step) MMAPAP 50,233,1973
mutation in microorganisms Salmonella typhimurium 50 g/plate (+enzymatic activation step) MUREAV 68,9,1979
mutation in microorganisms Salmonella typhimurium 5 g/plate (-enzymatic activation step) MUREAV 68,313,1979
micronucleus test human lymphocyte 5 mg/L FCTOD7 36,155,1998
micronucleus test intraperitoneal
mouse
100 mg/kg FCTOD7 23,373,1985
mutation in mammalian somatic cells hamster lung 5 mg/L FCTOD7 23,373,1985
morphological transform oral
rat
2,520 mg/kg/6 week CRNGDP 9,387,1988
phage inhibition capacity Escherichia coli 1 g/tube MUREAV 89,1,1981
sex chromosome loss and nondisjunction Aspergillus nidulans 20 ppm MUREAV 89,297,1981
sex chromosome loss and nondisjunction oral
Drosophila melanogaster
4 gm/L SWEHDO 9(Suppl 2),27,1983
sperm morphology intraperitoneal
mouse
100 mg/kg PMRSDJ 2,79,1981
sperm morphology oral
mouse
80 mg/kg/3 day- continuous FCTOD7 25,709,1987


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
hamster
lowest published toxic dose: 125 mg/kg (7 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system TXAPA9 15,152,1969
oral
hamster
lowest published toxic dose: 250 mg/kg (8 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) TXAPA9 15,152,1969
oral
hamster
lowest published toxic dose: 250 mg/kg (7 day pregnant) Reproductive: Specific developmental abnormalities: Body wall TXAPA9 15,152,1969
oral
hamster
lowest published toxic dose: 300 mg/kg (7 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system TXAPA9 15,152,1969
oral
mammal (species unspecified)
lowest published toxic dose: 848 mg/kg (60 day prior to copulation/1-53 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) TOXID9 4,20,1984
oral
mouse
lowest published toxic dose: 100 mg/kg (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
ATXKA8 30,251,1973
oral
mouse
lowest published toxic dose: 300 mg/kg (6-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) ATXKA8 30,251,1973
oral
mouse
lowest published toxic dose: 80 mg/kg (3 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) FCTOD7 25,709,1987
oral
rat
lowest published toxic dose: 1,200 mg/kg (7-12 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)
TXAPA9 35,83,1976
oral
rat
lowest published toxic dose: 300 mg/kg (15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Other developmental abnormalities
GISAAA 43(6),37,1978
oral
rat
lowest published toxic dose: 1,190 mg/kg (16-22 day pregnant/21 day after birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) TXAPA9 35,83,1976
oral
rat
lowest published toxic dose: 550 mg/kg (1-22 day pregnant) Reproductive: Effects on newborn: Behavioral AEEDDS 2,215,1976
oral
rat
lowest published toxic dose: 420 mg/kg (1-20 day pregnant) Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system

Reproductive: Effects on newborn: Biochemical and metabolic
GISAAA 51(6),23,1986
oral
rat
lowest published toxic dose: 1,800 mg/kg (1 year male) Reproductive: Paternal effects: Testes, epididymis, sperm duct IJEBA6 36,390,1998
oral
rat
lowest published toxic dose: 125 mg/kg (6-10 day pregnant) Reproductive: Maternal effects: Parturition

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
TOXID9 44,229,2005
parenteral
rat
lowest published toxic dose: 400 mg/kg (4-11 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death
BEXBAN 93,107,1982
parenteral
rat
lowest published toxic dose: 800 mg/kg (2 day male/2 day prior to copulation) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death
BEXBAN 93,107,1982
subcutaneous
mouse
lowest published toxic dose: 90 mg/kg (6-14 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord)
NTIS** PB223-160
subcutaneous
mouse
lowest published toxic dose: 1,035 mg/kg (6-14 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) NTIS** PB223-160
unreported route
rat
lowest published toxic dose: 50 mg/kg (1 day prior to copulation) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death
HBPTO* 1,738,2001


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 108 mg/kg/1 year- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors
RPZHAW 31,67,1980
subcutaneous
mouse
lowest published toxic dose: 46 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Blood: Tumors
NTIS** PB223-159
skin
mouse
lowest published toxic dose: 100 mg/kg Nutritional and Gross Metabolic: Conditioned vitamin deficiency

Skin and Appendages: Tumors
FCTOD7 34,283,1996
skin
mouse
toxic dose : 15,300 mg/kg/51 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Skin and Appendages: Tumors
FCTOD7 34,283,1996


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
human
lowest published toxic concentration: 30 g/m3/5 year- intermittent Eye: Conjunctiva irritation

Cardiac: Other changes

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi
VRDEA5 (10),136,1971
inhalation
rat
lethal concentration (50 percent kill): 500 mg/m3/4 hour N/R 85JCAE -,1027,1986
intraperitoneal
mouse
lethal dose (50 percent kill): 70 mg/kg N/R NIIRDN 6,566,1982
intraperitoneal
rat
lethal dose (50 percent kill): 138 mg/kg Behavioral: Change in motor activity (specific assay)

Nutritional and Gross Metabolic: Body temperature decrease
JNPHAG 9,35,1978
intraperitoneal
rat
lowest published toxic dose: 24 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) TOXID9 66,126,2002
intraperitoneal
rat
lowest published toxic dose: 120 mg/kg Liver: Hepatitis (hepatocellular necrosis), zonal

Liver: Liver function tests impaired
TOXID9 66,126,2002
oral
wild bird
lethal dose (50 percent kill): 300 mg/kg N/R AECTCV 12,355,1983
oral
cat
lowest published lethal dose: 230 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Behavioral: Analgesia
JPETAB 17,349,1921
oral
mouse
lethal dose (50 percent kill): 1,250 mg/kg Behavioral: Somnolence (general depressed activity)

Skin and Appendages: Other: Hair
GTPZAB 6(7),28,1962
oral
rat
lethal dose (50 percent kill): 560 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase TXAPA9 11,546,1967
oral
rabbit
lethal dose (50 percent kill): 210 mg/kg N/R KOKABN 26,358,1977
subcutaneous
mouse
lethal dose (50 percent kill): 1,109 mg/kg N/R NNGADV 15,507,1990
subcutaneous
rat
lethal dose (50 percent kill): 646 mg/kg N/R NNGADV 15,507,1990
skin
rat
lowest published lethal dose: 5 gm/kg Behavioral: Somnolence (general depressed activity) ATDAEI 15(Suppl 1),S76,1996
skin
rabbit
lowest published lethal dose: 1 gm/kg N/R 85GMAT -,110,1982
unreported route
chicken
lethal dose (50 percent kill): 840 mg/kg N/R VETNAL 54(2),70,1978
unreported route
domestic animal
lethal dose (50 percent kill): 225 mg/kg N/R VETNAL 54(2),70,1978
unreported route
mammal (species unspecified)
lethal dose (50 percent kill): 400 mg/kg N/R GISAAA 45(5),29,1980
unreported route
mouse
lethal dose (50 percent kill): 1,150 mg/kg N/R KOKABN 26,358,1977
unreported route
rat
lethal dose (50 percent kill): 740 mg/kg N/R KOKABN 26,358,1977
unreported route
rat
lowest published toxic dose: 50 mg/kg Endocrine: Evidence of thyroid hypofunction HBPTO* 1,738,2001
unreported route
rabbit
lethal dose (50 percent kill): 210 mg/kg N/R VETNAL 54(2),70,1978


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 91 mg/m3/26 week- intermittent Cardiac: Other changes TPKVAL 15,3,1979
oral
dog
lowest published toxic dose: 29,120 mg/kg/2 year- intermittent Eye: Retinal changes pigmentary deposition, retinitis, other)

Blood: Changes in erythrocyte (RBC) count

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JTSCDR 5,269,1980
oral
dog
lowest published toxic dose: 1,120 mg/kg/4 week- intermittent Eye: Retinal changes pigmentary deposition, retinitis, other)

Gastrointestinal: Nausea or vomiting

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NNGADV 15,507,1990
oral
mouse
lowest published toxic dose: 1,560 g/kg/3 day- intermittent Vascular: Other changes BJCAAI 86,779,2002
oral
mouse
lowest published toxic dose: 12,000 g/kg/4 week- intermittent Vascular: Other changes

Tumorigenic: Tumor types after systemic administration not seen spontaneously
BJCAAI 86,779,2002
oral
mouse
lowest published toxic dose: 4,680 g/kg/3 week- intermittent Liver: Other changes

Tumorigenic: Tumor types after systemic administration not seen spontaneously
BJCAAI 86,779,2002
oral
pig
lowest published toxic dose: 1,820 g/kg/1 year- continuous Cardiac: Arrythmias (indlucing changes in conduction)

Cardiac: Other changes
CUTOEX 1,221,1993
oral
rat
lowest published toxic dose: 450 mg/kg/90 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
INHEAO 31,59,1993
oral
rat
lowest published toxic dose: 406 mg/kg/14 day- intermittent Liver: Other changes

Blood: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport
BCTKAG 17,69,1984
oral
rat
lowest published toxic dose: 350 mg/kg/7 day- continuous Brain and Coverings: Other degenerative changes

Kidney, Ureter, and Bladder: Other changes

Nutritional and Gross Metabolic: Changes in: Other metals
ARTODN 48,29,1981
oral
rat
lowest published toxic dose: 10,920 mg/kg/2 year- continuous Behavioral: Food intake (animal)

Musculoskeletal: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JTSCDR 5,269,1980
oral
rat
lowest published toxic dose: 1,680 mg/kg/4 week- continuous Blood: Changes in erythrocyte (RBC) count

Skin and Appendages: Other: Hair

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NNGADV 15,507,1990
oral
rat
lowest published toxic dose: 125 mg/kg/5 day- intermittent Endocrine: Change in LH TOXID9 44,229,2005
oral
rat
lowest published toxic dose: 387.5 mg/kg/31 day- intermittent Endocrine: Other changes TOXID9 44,352,2005
oral
rat
lowest published toxic dose: 1,550 mg/kg/31 day- intermittent Endocrine: Change in LH TOXID9 44,352,2005
oral
rat
lowest published toxic dose: 3,200 mg/kg/4 day- intermittent Liver: Changes in liver weight TOXID9 66,339,2002
oral
rat
lowest published toxic dose: 1,000 mg/kg/4 day- intermittent Endocrine: Evidence of thyroid hypofunction TOXID9 66,339,2002
oral
rabbit
lowest published toxic dose: 1,520 mg/kg/15 week- intermittent Vascular: BP lowering not characterized in autonomic section

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
GTPZAB 6(7),28,1962


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 1 mg/m3 DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 12,225,1976
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 12,225,1976
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 53,403,1991
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 53,403,1991
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 53,403,1991
TOXICOLOGY REVIEW
CNDQA8 10(3),43,1975
TOXICOLOGY REVIEW
MUREAV 567,347,2004
TOXICOLOGY REVIEW
MUTAEX 21,93,2006
TOXICOLOGY REVIEW
ENTOX* -,86,2005
TOXICOLOGY REVIEW
ENTOX* -,179,2005
TOXICOLOGY REVIEW
MUREAV 584,1,2005
TOXICOLOGY REVIEW
MUTAEX 21,93,2006
TOXICOLOGY REVIEW
HUTOX* -,561,1996


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,154,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 5 mg/m3 DTLVS* 3,257,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 5 mg/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 5 mg/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 5 mg/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 5 mg/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 1 mg/m3, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 1 mg/m3, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 1 mg/m3, OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 5 mg/m3, short term exposure limit 10 mg/m3, Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 5 mg/m3, FEB2006
Occupational Exposure Limit - GERMANY MAK 5 mg/m3 (inhalable, skin, sen), 2005
Occupational Exposure Limit - KOREA time-weighted average 5 mg/m3, 2006
Occupational Exposure Limit - MEXICO time-weighted average 1 mg/m3, 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 5 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 1 mg/m3, JAN2002
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 5 mg/m3, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.5 mg/m3, MAC(short term exposure limit) 2 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 0.5 mg/m3, short term exposure limit 1.5 mg/m3, Skin, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 1 mg/m3;
short term exposure limit 2 mg/m3, Sen, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 1 mg/m3,KZG- week 2 mg/m3, DEC2006
Occupational Exposure Limit - THAILAND time-weighted average 5 mg/m3, JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 5 mg/m3, JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO THIRAM-air 10 hour time-weighted average 5 mg/m3 NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 71900;
Number of Industries 14;
Total Number of Facilities 1,502;
Number of Occupations 37;
Total Number of Employees Exposed 17,330
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 71900;
Number of Industries 23;
Total Number of Facilities 2,234;
Number of Occupations 48;
Total Number of Employees Exposed 47,798;
Total Number of Female Employees Exposed 9,520


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Positive: Mammalian micronucleus; B subtilis rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as volcanizing agent for rubber, a seed disinfectant, a lubricating oil additive
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Thiram, 5005


REFERENCES:

CODEN
REFERENCE

28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku," Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia, 1972
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973-
AEEDDS Adverse Effects of Environmental Chemicals and Psychotropic Drugs. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1973-
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990-
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Used as volcanizing agent for rubber, a seed disinfectant, a lubricating oil additive

NIOSH PROFILE (RUBBER MANUFACTURING, SYNTHETIC), SRI, 2/77

NIOSH PROFILE (RUBBER MANUFACTURING, SYNTHETIC), FIRL, 4/78

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Drug
   Mutagen
   Reproductive Effector
   Human Data
   Hormone
   Primary Irritant

ALT CAS #: 12680-07-8
ALT CAS #: 12680-62-5
ALT CAS #: 39456-80-9
ALT CAS #: 66173-72-6
ALT CAS #: 93196-73-7
Click Here for Additional Information about RTECS

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