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Distannoxane, hexabutyl -

RTECS #: JN8750000

CAS #: 56-35-9


UPDATE: May 2009 MW: 596.16 MF: C24H54OSn2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. Aceto TBTO
  2. BTO
  3. BioMet SRM
  4. BioMet TBTO
  5. Bis (tri - n - butyltin) oxide
  6. Bis (tri - n - butylzinn) - oxyd (German)
  7. Bis (tributyloxide) of tin
  8. Bis (tributylstannium) oxide
  9. Bis (tributylstannyl) oxide
  10. Bis (tributyltin) oxide
  11. Bis - (tri - n - butylcin) oxid (Czech)
  12. Butinox
  13. C - Sn - 9
  14. Di - tributyltin oxide
  15. Drall
  16. ENT 24,979
  17. Hexabutyldistannioxan (Czech)
  18. Hexabutyldistannoxane
  19. Hexabutylditin
  20. Hexabutylditin oxide
  21. Intercide 340A
  1. Kyslicnik tri - n - butylcinicity (Czech)
  2. L.S. 3394
  3. Lastanox F
  4. Lastanox Q
  5. Lastanox Super
  6. Lastanox T
  7. Mykolastanox F
  8. OTBE (French)
  9. Oxybis (tributyltin)
  10. Oxyde de tributyletain
  11. Stannane, tri - n - butyl - , oxide
  12. Stannicide A
  13. Stannicide O
  14. TBTO
  15. Tin, bis (tributyl) - , oxide
  16. Tin, oxybis (tributyl -
  17. Tributyl tin oxide
  18. Tributyltin oxide
  19. Vikol AF 25
  20. Vikol LO 25
  21. ZK 21995


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
50 g/24 hour severe 28ZPAK -,232,1972
eye
rabbit
100 L/24 hour mild NTIS** OTS0571281
skin
human
0.1%/48 hour severe JIDEAE 12,161,1985
skin
rabbit
500 L/24 hour severe NTIS** OTS0571281


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis hamster ovary 5 mg/L MUREAV 188,65,1987
DNA damage Bacillus subtilis 100 g/disc MUREAV 280,195,1992
DNA damage human other cell types 0.3 nmol/L MAERE* 53,243,2002
DNA inhibition other microorganisms 56,200 ppb AEMIDF 45,48,1983
mutation in microorganisms Salmonella typhimurium 10 ng/tube (+enzymatic activation step) MUREAV 300,265,1993
mutation in microorganisms Salmonella typhimurium 100 g/L (-enzymatic activation step) MUREAV 188,65,1987
micronucleus test oral
mouse
60 mg/kg MUREAV 188,65,1987
other mutation test systems hamster ovary 15 g/L MUREAV 300,5,1993
other mutation test systems other microorganisms 56,200 ppb AEMIDF 45,48,1983


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 400 mg/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TOLED5 50,257,1990
oral
mouse
lowest published toxic dose: 50 mg/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death TOLED5 50,257,1990
oral
mouse
lowest published toxic dose: 324 mg/kg (6-17 day pregnant) Reproductive: Other effects on female

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TJADAB 53,29A,1996
oral
mouse
lowest published toxic dose: 324 mg/kg (6-17 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)
CGANE7 37,251,1997
oral
rat
lowest published toxic dose: 150 mg/kg (6-20 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death
TXAPA9 97,113,1989
oral
rat
lowest published toxic dose: 150 mg/kg (6-20 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Delayed effects
TXAPA9 97,113,1989
oral
rat
lowest published toxic dose: 40 mg/kg (5 day after birth) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Effects on newborn: Delayed effects
TXAPA9 97,113,1989
oral
rat
lowest published toxic dose: 150 mg/kg (6-20 day pregnant) Reproductive: Effects on newborn: Behavioral TXAPA9 97,113,1989


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 37,100 mg/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Endocrine: Tumors

Endocrine: Thyroid tumors
FCTOD7 28,179,1990
oral
rat
lowest published toxic dose: 36,500 mg/kg/2 year- continuous Tumorigenic: Neoplastic by RTECS criteria

Endocrine: Tumors
NTIS** OTS0571285


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
guinea pig
lowest published lethal concentration: 200 mg/m3 Behavioral: Convulsions or effect on seizure threshold

Behavioral: Aggression

Lung, Thorax, or Respiration: Dyspnea
EJTXAZ 9,339,1976
intraperitoneal
mouse
lethal dose (50 percent kill): 12,500 g/kg Nutritional and Gross Metabolic: Body temperature decrease RPTOAN 42,73,1979
intraperitoneal
rat
lethal dose (50 percent kill): 5 mg/kg Behavioral: Coma

Gastrointestinal: Alteration in gastric secretion

Nutritional and Gross Metabolic: Other changes
NTIS** OTS0571270
intravenous
mouse
lethal dose (50 percent kill): 6 mg/kg Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Lung, Thorax, or Respiration: Other changes
EJTXAZ 9,31,1976
oral
mouse
lethal dose (50 percent kill): 55 mg/kg N/R GISAAA 41(5),10,1976
oral
rat
lethal dose (50 percent kill): 87 mg/kg N/R 85JCAE -,1255,1986
oral
rabbit
lowest published lethal dose: 50 mg/kg N/R SAIGBL 15,3,1973
skin
mouse
lethal dose (50 percent kill): 163 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Change in motor activity (specific assay)

Kidney, Ureter, and Bladder: Other changes
SRTCAC 36(1-4),10,1989
skin
rat
lethal dose (50 percent kill): >300 mg/kg Behavioral: Somnolence (general depressed activity)

Skin: After systemic exposure: Dermatitis, other
NTIS** OTS0571915
skin
rabbit
lethal dose (50 percent kill): 900 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Acute pulmonary edema

Gastrointestinal: Hypermotility, diarrhea
EJTXAZ 9,31,1976


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 2,800 g/m3/4 hour/32 day- intermittent Behavioral: Food intake (animal)

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** OTS0571293
oral
monkey
lowest published toxic dose: 21,120 g/kg/22 week- intermittent Blood: Changes in leukocyte (WBC) count FCTOD7 30,715,1992
oral
mouse
lowest published toxic dose: 1,860 mg/kg/4 day- continuous Endocrine: Changes in spleen weight

Blood: Changes in leukocyte (WBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
PCBPBS 6,270,1976
oral
mouse
lowest published toxic dose: 1,008 mg/kg/4 week- intermittent Immunological Including Allergic: Decrease in cellular immune response

Immunological Including Allergic: Increase in humoral response

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXCYAC 211,107,2005
oral
mouse
lowest published toxic dose: 108 mg/kg/3 day- continuous Endocrine: Changes in spleen weight

Blood: Changes in spleen

Immunological Including Allergic: Decreased immune response
TXAPA9 226,46,2008
oral
rat
lowest published toxic dose: 3,360 mg/kg/6 week- continuous Endocrine: Changes in thymus weight

Blood: Changes in spleen

Immunological Including Allergic: Decreased immune response
TXAPA9 148,126,1998
oral
rat
lowest published toxic dose: 390 mg/kg/26 week- intermittent Endocrine: Other changes

Endocrine: Changes in pituitary weight

Endocrine: Changes in thymus weight
APJAAG 30,955,1980
oral
rat
lowest published toxic dose: 462 mg/kg/22 week- continuous Endocrine: Changes in thymus weight

Immunological Including Allergic: Decreased immune response
TXAPA9 105,144,1990
oral
rat
lowest published toxic dose: 1,400 mg/kg/28 day- continuous Endocrine: Other changes

Endocrine: Changes in spleen weight
JTEHD6 32,307,1991
oral
rat
lowest published toxic dose: 1,700 mg/kg/34 day- continuous Immunological Including Allergic: Decreased immune response JTEHD6 32,307,1991
oral
rat
lowest published toxic dose: 2,240 mg/kg/4 week- continuous Endocrine: Changes in thymus weight

Blood: Changes in spleen

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
TXAPA9 75,363,1984
oral
rat
lowest published toxic dose: 8,960 mg/kg/4 week- continuous Brain and Coverings: Changes in brain weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXAPA9 75,363,1984
oral
rat
lowest published toxic dose: 140 mg/kg/4 week- continuous Blood: Eosinophilia TXAPA9 75,363,1984
oral
rat
lowest published toxic dose: 2,240 mg/kg/4 week- continuous Blood: Luekopenia

Blood: Changes in spleen
TXAPA9 75,363,1984
oral
rat
lowest published toxic dose: 140 mg/kg/4 week- continuous Liver: Changes in liver weight

Blood: Other changes
TXAPA9 75,363,1984
oral
rat
lowest published toxic dose: 8.4 mg/kg/4 week- continuous Blood: Changes in spleen TXAPA9 75,363,1984
oral
rat
lowest published toxic dose: 33.6 mg/kg/4 week- continuous Skin and Appendages: Other: Hair

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
TXAPA9 75,363,1984
oral
rat
lowest published toxic dose: 134.4 mg/kg/4 week- continuous Behavioral: Somnolence (general depressed activity)

Blood: Changes in cell count (unspecified)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXAPA9 75,363,1984
oral
rat
lowest published toxic dose: 537.6 mg/kg/4 week- continuous Behavioral: Muscle weakness

Behavioral: Ataxia

Liver: Hepatitis (hepatocellular necrosis), diffuse
TXAPA9 75,363,1984
oral
rat
lowest published toxic dose: 7 mg/kg/4 week- continuous Liver: Changes in liver weight

Blood: Changes in spleen
TXAPA9 75,363,1984
oral
rat
lowest published toxic dose: 28 mg/kg/4 week- continuous Skin and Appendages: Other: Hair TXAPA9 75,363,1984
oral
rat
lowest published toxic dose: 112 mg/kg/4 week- continuous Behavioral: Somnolence (general depressed activity)

Endocrine: Changes in thymus weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
TXAPA9 75,363,1984
oral
rat
lowest published toxic dose: 448 mg/kg/4 week- continuous Behavioral: Ataxia

Blood: Changes in cell count (unspecified)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXAPA9 75,363,1984
oral
rat
lowest published toxic dose: 252 mg/kg/6 week- continuous Endocrine: Other changes TXAPA9 75,363,1984
oral
rat
lowest published toxic dose: 1,008 mg/kg/6 week- continuous Endocrine: Evidence of thyroid hypofunction

Endocrine: Change in LH
TXAPA9 75,363,1984
oral
rat
lowest published toxic dose: 3,920 mg/kg/49 day- continuous Immunological Including Allergic: Decreased immune response TXCYAC 239,68,2007


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.1 mg(Sn)/m3 (skin) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
TOLED5 127,135,2002
TOXICOLOGY REVIEW
EQSFAP 4,80,1975
TOXICOLOGY REVIEW
MUREAV 613,76,2006
TOXICOLOGY REVIEW
ENTOX* -,312,2005
TOXICOLOGY REVIEW
JTPAE7 17,69,2004
TOXICOLOGY REVIEW
REPTED 26,1,2008
TOXICOLOGY REVIEW
JTPAE7 17,137,2004
TOXICOLOGY REVIEW
ITODC* -,355,2004
TOXICOLOGY REVIEW
HUTOX* -,561,1996
TOXICOLOGY REVIEW
HTOPA* 1,501,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,207,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.1 mg(Sn)/m3 DTLVS* 3,258,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.1 mg(Sn)/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.1 mg(Sn)/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.1 mg(Sn)/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.1 mg(Sn)/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.1 mg(Sn)/m3, short term exposure limit 0.2 mg(Sn)/m3, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.1 mg(Sn)/m3, short term exposure limit 0.2 mg(Sn)/m3, Skin, MAR2002
Occupational Exposure Limit - FINLAND time-weighted average 0.1 mg(Sn)/m3, short term exposure limit 0.3 mg(Sn)/m3, Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 0.1 mg(Sn)/m3, VLE 0.2 mg(Sn)/m3, FEB2006
Occupational Exposure Limit - HUNGARY time-weighted average 0.1 mg(Sn)/m3, short term exposure limit 0.4 mg(Sn)/m3, Skin, SEP2000
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.05 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.1 mg(Sn)/m3, short term exposure limit 0.2 mg(Sn)/m3, skin, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 0.1 mg(Sn)/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.1 mg(Sn)/m3, JAN1993
Occupational Exposure Limit - SWEDEN time-weighted average 0.1 mg(Sn)/m3;
short term exposure limit 0.2 mg(Sn)/m3, Skin, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 0.0021 ppm (0.05 mg/m3),KZG- week 0.0021 ppm (0.05mg/m3), DEC2006
Occupational Exposure Limit - THAILAND time-weighted average 0.1 mg(Sn)/m3, JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ORGANOTIN COMPOUND-air 10 hour time-weighted average 0.1 mg(Sn)/m3 NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84318;
Number of Industries 25;
Total Number of Facilities 1,217;
Number of Occupations 24;
Total Number of Employees Exposed 7,773
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84318;
Number of Industries 45;
Total Number of Facilities 2,686;
Number of Occupations 31;
Total Number of Employees Exposed 36,413;
Total Number of Female Employees Exposed 7,903


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a biocide in paint and wood preservatives
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku," Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia, 1972
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AEMIDF Applied and Environmental Microbiology. (American Soc. for Microbiology, 1913 I St., NW, Washington, DC 20006) V.31- 1976-
APJAAG Acta Pathologica Japonica. (Japan Publications Trading Co., Ltd., POB 5030, Tokyo International, Tokyo 101-31, Japan) V.1- 1951-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CGANE7 Congenital Anomalies. (Nippon Senten Ijo Gakkai, 377-2 Ono-higashi, Osakasayama, Osaka-Fu 589 Japan) V.27- 1987-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EJTXAZ European Journal of Toxicology and Environmental Hygiene. (Paris, France) V.7-9, 1974-76. For publisher information, see TOERD9.
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
EQSFAP Environmental Quality and Safety. (Stuttgart, Fed. Rep. Ger.) V.1-5, 1972-76. Discontinued.
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HTOPA*
HUTOX*
ITODC*
JIDEAE Journal of Investigative Dermatology. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1938-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
JTPAE7 Journal of Toxicologic Pathology. (Nihon Dokusei Byori Gakkai, editor, 3-25-8 Nishi- shinbashi, Minato-ku, Tokyo 105, Japan) V.1- 1988
MAERE* Marine Environmental Research. (Kidlington, Oxford : Elsevier) V. 1- 1978-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PCBPBS Pesticide Biochemistry and Physiology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1971-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967-
SAIGBL Sangyo Igaku. Japanese Journal of Industrial Health. (Nippon Sangyo Eisei Igakkai, Kosu Eisei Bldg., 1-29-8, Shinjuku, Shinjuku-ku, Tokyo 160, Japan) V.1- 1959-
SRTCAC Science Reports of the Research Institutes, Tohoku University, Series C: Medicine. (Tohoku University, Research Institute for Tuberculosis and Cancer, 4-1 Seiryo-machi, Sendai, Japan) V.1- 1949-
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-

Used as a biocide in paint and wood preservatives

NIOSH PROFILE (ORGANIC OXIDES OR EPOXY COMPOUNDS), SRI, 2/77

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Organometallic
   Mutagen
   Reproductive Effector
   Human Data
   Hormone
   Primary Irritant

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