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Registry of Toxic Effects of Chemical Substances (RTECS)

Distannoxane, hexabutyl-

RTECS #

JN8750000

CAS #

56-35-9

Updated

September 201

Molecular Weight

596.16

Molecular Formula

C24H54OSn2

Synonyms

Aceto TBTO
BioMet SRM
BioMet TBTO
Bis(tributyloxide) of tin
Bis(tributylstannium) oxide
Bis(tributylstannyl)oxide
Bis(tributyltin)oxide
Bis-(tri-n-butylcin)oxid (Czech)
Bis(tri-n-butyltin)oxide
Bis(tri-n-butylzinn)-oxyd (German)
BTO
Butinox
C-Sn-9
Di-tributyltin oxide
Drall
ENT 24,979
Hexabutyldistannioxan (Czech)
Hexabutyldistannoxane
Hexabutylditin
Hexabutylditin oxide
Intercide 340A
Kyslicnik tri-n-butylcinicity (Czech)
L.S. 3394
Lastanox F
Lastanox Q
Lastanox Super
Lastanox T
Mykolastanox F
OTBE (French)
Oxybis(tributyltin)
Oxyde de tributyletain
Stannane, tri-n-butyl-, oxide
Stannicide A
Stannicide O
TBTO
Tin, bis(tributyl)-, oxide
Tin, oxybis(tributyl-
Tributyl tin oxide
Tributyltin oxide
Vikol AF 25
Vikol LO 25
ZK 21995

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 50 µg/24H severe28ZPAK -,232,1972
eye /rabbit 100 µL/24H mildNTIS** OTS0571281
skin /human 0.001%/48H severeJIDEAE 12,161,1985
skin /rabbit 500 µL/24H severeNTIS** OTS0571281

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisovary/hamster5 mg/LMUREAV 188,65,1987
DNA Damageother cell types/human0.03 nmol/LMAERE* 53,243,2002
DNA Damage/Bacillus subtilis100 µg/discMUREAV 280,195,1992
DNA inhibition/Other microorganisms56200 ppbAEMIDF 45,48,1983
micronucleus testoral/mouse60 mg/kgMUREAV 188,65,1987
mutation in microorganisms/Salmonella typhimurium10 ng/tube (+enzymatic activation step)MUREAV 300,265,1993
mutation in microorganisms/Salmonella typhimurium100 µg/L (-enzymatic activation step)MUREAV 188,65,1987
other mutation test systems/Other microorganisms56200 ppbAEMIDF 45,48,1983
other mutation test systemsovary/hamster15 µg/LMUREAV 300,5,1993

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 150 mg/kg (6-20D pregnant)Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death
TXAPA9 97,113,1989
oral/rat 150 mg/kg (6-20D pregnant)Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Delayed effects
TXAPA9 97,113,1989
oral/rat 40 mg/kg (5D after birth)Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Effects on newborn: Delayed effects
TXAPA9 97,113,1989
oral/rat 150 mg/kg (6-20D pregnant)Reproductive: Effects on newborn: BehavioralTXAPA9 97,113,1989
oral/mouse 400 mg/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)TOLED5 50,257,1990
oral/mouse 50 mg/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetal deathTOLED5 50,257,1990
oral/mouse 324 mg/kg (6-17D pregnant)Reproductive: Other effects on female

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TJADAB 53,29A,1996
oral/mouse 324 mg/kg (6-17D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)
CGANE7 37,251,1997

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 37100 mg/kg/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Endocrine: Tumors

Endocrine: Thyroid tumors
FCTOD7 28,179,1990
oral/rat lowest published toxic dose: 36500 mg/kg/2Y- continuousTumorigenic: Neoplastic by RTECS criteria

Endocrine: Tumors
NTIS** OTS0571285

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Non-mammalian species, liver tumor Inhibitor Concentration (50 percent kill): 0.22 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.AQUTO* 32,143,1995
In Vitro/Non-mammalian species, liver tumor Inhibitor Concentration (50 percent kill): 0.35 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.AQUTO* 32,143,1995
inhalation/guinea pig Lowest published lethal concentration: 200 mg/m3Behavioral: Convulsions or effect on seizure threshold

Behavioral: Aggression

Lung, Thorax, or Respiration: Dyspnea
EJTXAZ 9,339,1976
intraperitoneal/mouse lethal dose (50 percent kill): 12500 µg/kgNutritional and Gross Metabolic: Body temperature decreaseRPTOAN 42,73,1979
intraperitoneal/rat lethal dose (50 percent kill): 5 mg/kgBehavioral: Coma

Gastrointestinal: Alteration in gastric secretion

Nutritional and Gross Metabolic: Other changes
NTIS** OTS0571270
intravenous/mouse lethal dose (50 percent kill): 6 mg/kgPeripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Lung, Thorax, or Respiration: Other changes
EJTXAZ 9,31,1976
oral/mouse lethal dose (50 percent kill): 55 mg/kgGISAAA 41(5),10,1976
oral/rabbit lowest published lethal dose: 50 mg/kgSAIGBL 15,3,1973
oral/rat lethal dose (50 percent kill): 87 mg/kg85JCAE -,1255,1986
skin/mouse lethal dose (50 percent kill): 163 mg/kgBehavioral: Altered sleep time (including change in righting reflex)

Behavioral: Change in motor activity (specific assay)

Kidney, Ureter, and Bladder: Other changes
SRTCAC 36(1-4),10,1989
skin/rabbit lethal dose (50 percent kill): 900 mg/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Acute pulmonary edema

Gastrointestinal: Hypermotility, diarrhea
EJTXAZ 9,31,1976
skin/rat lethal dose (50 percent kill): >300 mg/kgBehavioral: Somnolence (general depressed activity)

Skin: After systemic exposure: Dermatitis, other
NTIS** OTS0571915
Tank with water/Killifish lethal concentration (50 percent kill): 0.121 µmol/L/48HAQUTO* 32,143,1995

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 2800 µg/m3/4H/32D- intermittentBehavioral: Food intake (animal)

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** OTS0571293
oral/monkey lowest published toxic dose: 21120 µg/kg/22W- intermittentBlood: Changes in leukocyte (WBC) countFCTOD7 30,715,1992
oral/mouse lowest published toxic dose: 1860 mg/kg/4D- continuousEndocrine: Changes in spleen weight

Blood: Changes in leukocyte (WBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
PCBPBS 6,270,1976
oral/mouse lowest published toxic dose: 1008 mg/kg/4W- intermittentImmunological Including Allergic: Decrease in cellular immune response

Immunological Including Allergic: Increase in humoral response

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXCYAC 211,107,2005
oral/mouse lowest published toxic dose: 108 mg/kg/3D- continuousEndocrine: Changes in spleen weight

Blood: Changes in spleen

Immunological Including Allergic: Decreased immune response
TXAPA9 226,46,2008
oral/rat lowest published toxic dose: 3920 mg/kg/49D- continuousImmunological Including Allergic: Decreased immune responseTXCYAC 239,68,2007
oral/rat lowest published toxic dose: 3360 mg/kg/6W- continuousEndocrine: Changes in thymus weight

Blood: Changes in spleen

Immunological Including Allergic: Decreased immune response
TXAPA9 148,126,1998
oral/rat lowest published toxic dose: 390 mg/kg/26W- intermittentEndocrine: Other changes

Endocrine: Changes in pituitary weight

Endocrine: Changes in thymus weight
APJAAG 30,955,1980
oral/rat lowest published toxic dose: 462 mg/kg/22W- continuousEndocrine: Changes in thymus weight

Immunological Including Allergic: Decreased immune response
TXAPA9 105,144,1990
oral/rat lowest published toxic dose: 1400 mg/kg/28D- continuousEndocrine: Other changes

Endocrine: Changes in spleen weight
JTEHD6 32,307,1991
oral/rat lowest published toxic dose: 1700 mg/kg/34D- continuousImmunological Including Allergic: Decreased immune responseJTEHD6 32,307,1991
oral/rat lowest published toxic dose: 2240 mg/kg/4W- continuousEndocrine: Changes in thymus weight

Blood: Changes in spleen

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
TXAPA9 75,363,1984
oral/rat lowest published toxic dose: 8960 mg/kg/4W- continuousBrain and Coverings: Changes in brain weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXAPA9 75,363,1984
oral/rat lowest published toxic dose: 140 mg/kg/4W- continuousBlood: EosinophiliaTXAPA9 75,363,1984
oral/rat lowest published toxic dose: 2240 mg/kg/4W- continuousBlood: Luekopenia

Blood: Changes in spleen
TXAPA9 75,363,1984
oral/rat lowest published toxic dose: 140 mg/kg/4W- continuousLiver: Changes in liver weight

Blood: Other changes
TXAPA9 75,363,1984
oral/rat lowest published toxic dose: 8.4 mg/kg/4W- continuousBlood: Changes in spleenTXAPA9 75,363,1984
oral/rat lowest published toxic dose: 33.6 mg/kg/4W- continuousSkin and Appendages: Other: Hair

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
TXAPA9 75,363,1984
oral/rat lowest published toxic dose: 134.4 mg/kg/4W- continuousBehavioral: Somnolence (general depressed activity)

Blood: Changes in cell count (unspecified)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXAPA9 75,363,1984
oral/rat lowest published toxic dose: 537.6 mg/kg/4W- continuousBehavioral: Muscle weakness

Behavioral: Ataxia

Liver: Hepatitis (hepatocellular necrosis), diffuse
TXAPA9 75,363,1984
oral/rat lowest published toxic dose: 7 mg/kg/4W- continuousLiver: Changes in liver weight

Blood: Changes in spleen
TXAPA9 75,363,1984
oral/rat lowest published toxic dose: 28 mg/kg/4W- continuousSkin and Appendages: Other: HairTXAPA9 75,363,1984
oral/rat lowest published toxic dose: 112 mg/kg/4W- continuousBehavioral: Somnolence (general depressed activity)

Endocrine: Changes in thymus weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
TXAPA9 75,363,1984
oral/rat lowest published toxic dose: 448 mg/kg/4W- continuousBehavioral: Ataxia

Blood: Changes in cell count (unspecified)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXAPA9 75,363,1984
oral/rat lowest published toxic dose: 252 mg/kg/6W- continuousEndocrine: Other changesTXAPA9 75,363,1984
oral/rat lowest published toxic dose: 1008 mg/kg/6W- continuousEndocrine: Evidence of thyroid hypofunction

Endocrine: Change in LH
TXAPA9 75,363,1984

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.1 mg(Sn)/m3DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-short term exposure limit 0.2 mg(Sn)/m3 (skin)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWTOLED5 127,135,2002
TOXICOLOGY REVIEWEQSFAP 4,80,1975
TOXICOLOGY REVIEWMUREAV 613,76,2006
TOXICOLOGY REVIEWENTOX* -,312,2005
TOXICOLOGY REVIEWJTPAE7 17,69,2004
TOXICOLOGY REVIEWREPTED 26,1,2008
TOXICOLOGY REVIEWJTPAE7 17,137,2004
TOXICOLOGY REVIEWITODC* -,355,2004
TOXICOLOGY REVIEWHUTOX* -,561,1996
TOXICOLOGY REVIEWHTOPA* 1,501,2002
TOXICOLOGY REVIEWREPTED 38,1,2013

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESSupportedRBREV* -,207,1998
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 0.1 mg(Sn)/m3DTLVS* 3,258,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.1 mg(Sn)/m3, short term exposure limit 0.2 mg(Sn)/m3, JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 0.1 mg(Sn)/m3, short term exposure limit 0.2 mg(Sn)/m3, Skin, MAR2002
Occupational Exposure Limit-FRANCEVME 0.1 mg(Sn)/m3, VLE 0.2 mg(Sn)/m3, FEB2006
Occupational Exposure Limit-HUNGARYtime-weighted average 0.1 mg(Sn)/m3, short term exposure limit 0.4 mg(Sn)/m3, Skin, SEP2000
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.1 mg(Sn)/m3, short term exposure limit 0.2 mg(Sn)/m3, skin, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.1 mg(Sn)/m3, JAN1999
Occupational Exposure Limit-SWEDENtime-weighted average 0.1 mg(Sn)/m3;short term exposure limit 0.2 mg(Sn)/m3, Skin, JUN2005
Occupational Exposure Limit-SWITZERLANDceiling concentration 0.004 ppm (0.02 mg(Sn)/m3), skin, JAN2011
Occupational Exposure Limit-THAILANDtime-weighted average 0.1 mg(Sn)/m3, JAN1993
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.05 mg/m3, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 0.1 mg(Sn)/m3, JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 0.1 mg(Sn)/m3;short term exposure limit 0.2 mg(Sn)/m3, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 0.1 mg(Sn)/m3CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 0.1 mg(Sn)/m3CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 0.1 mg(Sn)/m3CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 0.1 mg(Sn)/m3CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ORGANOTIN COMPOUND-air10H time-weighted average 0.1 mg(Sn)/m3NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 84318; Number of Industries 45; Total Number of Facilities 2686; Number of Occupations 31; Total Number of Employees Exposed 36413; Total Number of Female Employees Exposed 7903
National Occupational Hazard Survey 1974Hazard Code 84318; Number of Industries 25; Total Number of Facilities 1217; Number of Occupations 24; Total Number of Employees Exposed 7773

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database
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