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Registry of Toxic Effects of Chemical Substances (RTECS)

Diphenylamine, N-nitroso-

RTECS #

JJ9800000

CAS #

86-30-6

Updated

July 2012

Molecular Weight

198.24

Molecular Formula

C12H10N2O

Synonyms

Benzenamine, N-nitroso-N-phenyl- (9CI)
Curetard A
Delac J
Difenylnitrosamin (Czech)
Diphenyl N-nitrosoamine
Diphenylnitrosamin (German)
Diphenylnitrosamine
N,N-Diphenylnitrosamine
Naugard TJB
NCI-C02880
Nitrosodiphenylamine
Nitrous diphenylamide
N-Nitrosodifenylamin (Czech)
N-Nitrosodiphenylamine
N-Nitroso-N-phenylaniline
N-Nitroso-N-phenylbenzenamine
Redax
Retarder J
Vulcalent A
Vulcatard
Vulcatard A
Vulkalent A (Czech)
Vultrol

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 500 mg/24H mild85JCAE -,509,1986

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislung/hamster62500 µg/LMUREAV 241,175,1990
Cytogenetic Analysisfibroblast/hamster30 mg/L/48HMUREAV 48,337,1977
DNA Damageovary/hamster0.8 mmol/L/4H (+enzymatic activation step)MUREAV 741,109,2012
DNA Damage/Bacillus subtilis2 mg/discPMRSDJ 1,175,1981
DNA Damagefibroblast/human3 mmol/LENMUDM 7,267,1985
DNA Damageliver/rat300 µmol/LCNREA8 42,2592,1982
DNA repair/Escherichia coli36800 µmol/LMUREAV 272,145,1992
DNA repair/Saccharomyes cerevisiae100 mg/LPMRSDJ 1,502,1981
host-mediated assayEscherichia coli/mouse3 gm/kgMUREAV 272,161,1992
morphological transformembryo/hamster6300 µg/LCRNGDP 2,679,1981
morphological transformkidney/hamster97 mg/LPMRSDJ 1,626,1981
morphological transformembryo/hamster6300 µg/LNCIMAV 58,243,1981
morphological transformembryo/rat1500 µg/LJJIND8 67,1303,1981
morphological transformembryo/mouse25 mg/LEMMUEG 12,21,1988
mutation in microorganismslymphocyte/mouse100 mg/L/4H (+enzymatic activation step)MUREAV 59,61,1979
mutation in microorganisms/Salmonella typhimurium2500 mg/L/72H (+/-enzymatic activation step)MUREAV 558,181,2004
mutation in microorganisms/Saccharomyes cerevisiae89 mg/L (-enzymatic activation step)PMRSDJ 1,414,1981
mutation in microorganisms/Salmonella typhimurium1000 µg/plate (+enzymatic activation step)PMRSDJ 1,249,1981
mutation in microorganisms/Salmonella typhimurium50 µg/plate (-enzymatic activation step)CANCAR 49,1970,1982
sex chromosome loss and nondisjunction/Saccharomyes cerevisiae500 mg/LPMRSDJ 1,468,1981
sister chromatid exchangefibroblast/hamster100 µmol/LJNCIAM 58,1635,1977
specific locus testoral/Drosophila melanogaster10 µmol/vialMUREAV 252,119,1991
Unscheduled DNA Synthesisliver/rat500 µmol/LCNREA8 42,3010,1982

Tumorigenic Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat toxic dose: 7700 mg/kg/77W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors

Endocrine: Tumors
IMEMDT 27,213,1982
oral/mouse toxic dose: 1750 gm/kg/2Y- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors
IMEMDT 27,213,1982
oral/rat toxic dose: 146 gm/kg/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors
EESADV 3,29,1979
oral/rat lowest published toxic dose: 140 gm/kg/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors
NCITR* NCI-TR-164,1979
oral/rat toxic dose: 170 gm/kg/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors
NCITR* NCI-TR-164,1979
oral/rat toxic dose: 2800 gm/kg/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors

Skin and Appendages: Tumors
IMEMDT 27,213,1982
skin/mouse toxic dose: 800 mg/kg/20W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors
IMEMDT 27,213,1982
skin/mouse lowest published toxic dose: 800 mg/kg/20W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Bronchogenic carcinoma

Tumorigenic: Increased incidence of tumors in susceptible strains
EJCAAH 16,695,1980

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): 1 gm/kgPMRSDJ 1,682,1981
oral/mouse lethal dose (50 percent kill): 1860 mg/kgLung, Thorax, or Respiration: CyanosisGISAAA 45(1),18,1980
oral/rat lethal dose (50 percent kill): 1825 mg/kgLung, Thorax, or Respiration: CyanosisGISAAA 45(1),18,1980
skin/rabbit lethal dose (50 percent kill): >7940 mg/kgBehavioral: Food intake (animal)

Behavioral: Change in motor activity (specific assay)
ATDAEI 1,64,1990
unreported route/rat lethal dose (50 percent kill): 3 gm/kgGMCRDC 17,107,1975

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rabbit lowest published toxic dose: 2440 mg/kg/17W- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainGTPZAB 10(4),60,1966

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMEMDT 27,213,1982
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 27,213,1982
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMSUDL 7,56,1987
TOXICOLOGY REVIEWMUREAV 567,347,2004
TOXICOLOGY REVIEWENTOX* -,249,2005
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWMUREAV 636,178,2007
TOXICOLOGY REVIEWMUREAV 721,27,2011

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 82865; Number of Industries 1; Total Number of Facilities 137; Number of Occupations 1; Total Number of Employees Exposed 1093
National Occupational Hazard Survey 1974Hazard Code 82865; Number of Industries 3; Total Number of Facilities 102; Number of Occupations 19; Total Number of Employees Exposed 3163

Status in Federal Agencies

OrganizationReference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/93/182509/AS)
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Inconclusive: E coli polA without S9; In vitro SCE-nonhuman
EPA GENETOX PROGRAM 1988, Inconclusive: L5178Y cells in vitro-TK test; Mammalian micronucleus
EPA GENETOX PROGRAM 1988, Negative: Cell transform.-BALB/c-3T3; Host-mediated assay
EPA GENETOX PROGRAM 1988, Negative: E coli polA with S9; Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative: In vitro UDS in rat liver; V79 cell culture-gene mutation
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Negative: Sperm morphology-mouse; In vitro UDS-human fibroblast
EPA GENETOX PROGRAM 1988, Positive/limited: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Positive: SHE-clonal assay; Cell transform.-RLV F344 rat embryo
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (feed);clear evidence:ratNCITR* NCI-TR-164,1979
NCI Carcinogenesis Bioassay (feed);no evidence:mouseNCITR* NCI-TR-164,1979
On EPA IRIS database
OSHA ANALYTICAL METHOD #23
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