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Registry of Toxic Effects of Chemical Substances (RTECS)

Diphenylamine, 4-nitro-

RTECS #

JJ9600000

CAS #

836-30-6

Updated

April 2012

Molecular Weight

214.24

Molecular Formula

C12H10N2O2

Synonyms

4-Ndpa
4-Nitrodifenylamin (Czech)
4-Nitrodiphenylamine
Benzenamine, 4-nitro-N-phenyl-
p-Nitrodiphenylamine
p-Nitrophenylphenylamine

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 100 mg mildATDAEI 1,66,1990

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 10000 mg/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TOXID9 12,103,1992
oral/rat 10 gm/kg (6-15D pregnant)Reproductive: Other effects on femaleNTIS** OTS0530384
oral/rat 30 gm/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Other effects on female

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TOXID9 12,103,1992

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published lethal dose: 4 gm/kgBehavioral: Excitement

Behavioral: Muscle contraction or spasticity

Blood: Hemorrhage
TPKVAL 8,126,1966
oral/mouse lowest published lethal dose: 5000 mg/kgLiver: Other changes

Kidney, Ureter, and Bladder: Changes in blood vessels or in circulation of kidney

Blood: Hemorrhage
TPKVAL 8,126,1966
oral/rat lethal dose (50 percent kill): >7940 mg/kgATDAEI 1,66,1990
oral/rat lethal dose (50 percent kill): 7940 mg/kgPeripheral Nerve and Sensation: Sensory change involving peripheral nerve

Vascular: BP lowering not characterized in autonomic section
TOBHB* VI:275,13,1994
skin/rabbit lethal dose (50 percent kill): >7940 mg/kgBehavioral: Food intake (animal)

Behavioral: Change in motor activity (specific assay)
ATDAEI 1,66,1990
skin/rabbit lethal dose (50 percent kill): 7940 mg/kgTOBHB* VI:274 ,13,1994

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 29 mg/m3/21D- intermittentLiver: Changes in liver weight

Blood: Methemoglobinemia- Carboxhemoglobinemia

Blood: Other changes
TOBHB* VI:274 ,13,1994
oral/rat lowest published toxic dose: 22500 mg/kg/90D- continuousKidney, Ureter, and Bladder: Other changes

Blood: Methemoglobinemia- Carboxhemoglobinemia
TOBHB* VI:274 ,13,1994
oral/rat lowest published toxic dose: 3000 mg/kg/10D- intermittentBehavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TOXID9 12,103,1992
oral/rat lowest published toxic dose: 10000 mg/kg/10D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainTOXID9 12,103,1992

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWCMSHAF 53,809,2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X4095; Number of Industries 1; Total Number of Facilities 6; Number of Occupations 2; Total Number of Employees Exposed 348; Total Number of Female Employees Exposed 34

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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