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Diphenylamine, 4 - nitro -

RTECS #: JJ9600000

CAS #: 836-30-6


UPDATE: February 2008 MW: 214.24 MF: C12H10N2O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 4 - Ndpa
  2. 4 - Nitrodifenylamin (Czech)
  3. 4 - Nitrodiphenylamine
  1. Benzenamine, 4 - nitro - N - phenyl -
  2. p - Nitrodiphenylamine
  3. p - Nitrophenylphenylamine


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
100 mg mild ATDAEI 1,66,1990


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 10,000 mg/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TOXID9 12,103,1992
oral
rat
lowest published toxic dose: 10 gm/kg (6-15 day pregnant) Reproductive: Other effects on female NTIS** OTS0530384
oral
rat
lowest published toxic dose: 30 gm/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Other effects on female

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TOXID9 12,103,1992


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published lethal dose: 4 gm/kg Behavioral: Excitement

Behavioral: Muscle contraction or spasticity

Blood: Hemorrhage
TPKVAL 8,126,1966
oral
mouse
lethal dose : 5,000 mg/kg Liver: Other changes

Kidney, Ureter, and Bladder: Changes in blood vessels or in circulation of kidney

Blood: Hemorrhage
TPKVAL 8,126,1966
oral
rat
lethal dose (50 percent kill): >7,940 mg/kg N/R ATDAEI 1,66,1990
oral
rat
lethal dose (50 percent kill): 7,940 mg/kg Peripheral Nerve and Sensation: Sensory change involving peripheral nerve

Vascular: BP lowering not characterized in autonomic section
TOBHB* VI:275,13,1994
skin
rabbit
lethal dose (50 percent kill): >7,940 mg/kg Behavioral: Food intake (animal)

Behavioral: Change in motor activity (specific assay)
ATDAEI 1,66,1990
skin
rabbit
lethal dose (50 percent kill): 7,940 mg/kg N/R TOBHB* VI:274 ,13,1994


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 29 mg/m3/21 day- intermittent Liver: Changes in liver weight

Blood: Methemoglobinemia- Carboxhemoglobinemia

Blood: Other changes
TOBHB* VI:274 ,13,1994
oral
rat
lowest published toxic dose: 10,000 mg/kg/10 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain TOXID9 12,103,1992
oral
rat
lowest published toxic dose: 22,500 mg/kg/90 day- continuous Kidney, Ureter, and Bladder: Other changes

Blood: Methemoglobinemia- Carboxhemoglobinemia
TOBHB* VI:274 ,13,1994
oral
rat
lowest published toxic dose: 3,000 mg/kg/10 day- intermittent Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TOXID9 12,103,1992


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
CMSHAF 53,809,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X4095;
Number of Industries 1;
Total Number of Facilities 6;
Number of Occupations 2;
Total Number of Employees Exposed 348;
Total Number of Female Employees Exposed 34


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990-
CMSHAF Chemosphere. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1972-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TOBHB* TA:Toxikologische Bewertung. Heidelberg, Berufsgenossenschaft der chemischen Industrie
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-

RTECS Compound Description:
   Reproductive Effector
   Primary Irritant

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