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Registry of Toxic Effects of Chemical Substances (RTECS)

1,3-Dioxolane-4-methanol, 2,2-dimethyl-

RTECS #

JI0400000

CAS #

100-79-8

Updated

July 2011

Molecular Weight

132.18

Molecular Formula

C6H12O3

Synonyms

2,2-Dimethyl-1,3-dioxolane-4-methanol
2,2-Dimethyl-4-oxymethyl-1,3-dioxolane
2,2-Dimethyl-5-hydroxymethyl-1,3-dioxolane
4-Hydroxymethyl-2,2-dimethyl-1,3-dioxolane
Acetone glycerol
Acetone, cyclic (hydroxymethyl)ethylene acetal
Dioxolan
GIE
Glycerol dimethylketal
Glycerol, 1,2-O-isopropylidene
Glycerolacetone
Isopropylidene glycerol
Solketal

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 100 mgTXAPA9 39,129,1977

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
micronucleus testintraperitoneal/mouse1500 mg/kgTOLED5 21,349,1984

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, liver tumor Inhibitor Concentration (50 percent kill): 91 mmol/L/24HIn Vitro Toxicity Studies: Cell protein synthesisTIVIEQ 3,189,1989
intraperitoneal/rat lethal dose (50 percent kill): 3 gm/kg85KYAH 11,820,1989
intravenous/rabbit lowest published lethal dose: 8530 µg/kgCardiac: Change in rate

Vascular: BP elevation not characterized in autonomic section

Vascular: BP lowering not characterized in autonomic section
DECRDP 9,895,1983
intravenous/rat lowest published lethal dose: 3740 µg/kgCardiac: Change in rate

Vascular: BP elevation not characterized in autonomic section

Vascular: BP lowering not characterized in autonomic section
DECRDP 9,895,1983
oral/rat lethal dose (50 percent kill): 7 gm/kg85KYAH 11,820,1989

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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