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Diisopropylamine

RTECS #: IM4025000

CAS #: 108-18-9


UPDATE: May 2009 MW: 101.22 MF: C6H15N


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 2 - Propanamine, N - (1 - methylethyl) - (9CI)
  2. Diisopropylamine (ACGIH:OSHA)
  1. N - (1 - Methylethyl) - 2 - propanamine


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
mutation in microorganisms Salmonella typhimurium 1 g/plate (+/-enzymatic activation step) NUCADQ 3,129,1982


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
cat
lowest published lethal concentration: 2,207 ppm/72 minute Behavioral: Coma

Lung, Thorax, or Respiration: Cough

Gastrointestinal: Changes in structure or function of salivary glands
JIHTAB 31,142,1949
inhalation
guinea pig
lowest published lethal concentration: 2,207 ppm/82 minute Behavioral: Coma

Lung, Thorax, or Respiration: Cough

Gastrointestinal: Changes in structure or function of salivary glands
JIHTAB 31,142,1949
inhalation
mammal (species unspecified)
lethal concentration (50 percent kill): 4,200 mg/m3 N/R TPKVAL 14,80,1975
inhalation
mammal (species unspecified)
lowest published toxic concentration: 2.4 gm/m3 Eye: Conjunctiva irritation TPKVAL 7,56,1965
inhalation
mouse
lethal concentration (50 percent kill): 4,200 mg/m3/2 hour N/R 85GMAT -,54,1982
inhalation
rat
lethal concentration (50 percent kill): 4,800 mg/m3/2 hour N/R 85GMAT -,54,1982
inhalation
rabbit
lowest published lethal concentration: 2,207 ppm/2.5 hour Behavioral: Coma

Lung, Thorax, or Respiration: Cough

Gastrointestinal: Changes in structure or function of salivary glands
JIHTAB 31,142,1949
oral
guinea pig
lethal dose (50 percent kill): 2,800 mg/kg N/R GISAAA 45(3),79,1980
oral
mouse
lethal dose (50 percent kill): 2,120 mg/kg N/R GISAAA 45(3),79,1980
oral
rat
lethal dose (50 percent kill): 770 mg/kg N/R UCDS** 12/15/1971
oral
rabbit
lethal dose (50 percent kill): 4,700 mg/kg N/R GISAAA 45(3),79,1980
subcutaneous
guinea pig
lowest published lethal dose: 1,400 mg/kg N/R JIHTAB 31,142,1949
skin
rabbit
lethal dose (50 percent kill): >10 gm/kg N/R UCDS** 12,15,1971
unreported route
mammal (species unspecified)
lethal dose (50 percent kill): 600 mg/kg N/R TPKVAL 14,80,1975


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
guinea pig
lowest published toxic concentration: 597 ppm/7 hour/9 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field JIHTAB 31,142,1949
inhalation
mouse
lowest published toxic concentration: 48,300 ppb/6 hour/14 day- intermittent Olfaction: Other olfaction effects JJATDK 15,207,1995
inhalation
pig
lowest published toxic concentration: 3.2 gm/m3/2 day- intermittent Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Kidney, Ureter, and Bladder: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TPKVAL 7,56,1965
inhalation
rabbit
lowest published toxic concentration: 261 ppm/7 hour/54 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field JIHTAB 31,142,1949
inhalation
rabbit
lowest published toxic concentration: 597 ppm/7 hour/9 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field JIHTAB 31,142,1949
inhalation
rabbit
lowest published toxic concentration: 3.2 gm/m3/2 day- intermittent Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Kidney, Ureter, and Bladder: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TPKVAL 7,56,1965


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 5 ppm (skin) DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
CHHSA* 9,6,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 5 ppm (20 mg/m3) (skin) DTLVS* 3,87,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 5 ppm (20 mg/m3) (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 5 ppm (20 mg/m3) (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 5 ppm (20 mg/m3) (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 5 ppm (20 mg/m3) (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 5 ppm (21 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 5 ppm (21 mg/m3), Skin, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 5 ppm (20 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND short term exposure limit 5 ppm (20 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 5 ppm (20 mg/m3), Skin, FEB2006
Occupational Exposure Limit - KOREA time-weighted average 5 ppm (20 mg/m3), skin, 2006
Occupational Exposure Limit - MEXICO time-weighted average 5 ppm (20 mg/m3) (skin), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 20 mg/m3, Skin, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 5 ppm (21 mg/m3), skin, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 5 ppm (20 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 5 ppm (20 mg/m3), Skin, JAN1993
Occupational Exposure Limit - RUSSIA short term exposure limit 5 mg/m3, Skin, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 5 ppm (20 mg/m3);
short term exposure limit 10 ppm (40 mg/m3), Skin, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 5 ppm (20 mg/m3), Skin, DEC2006
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 5 ppm (21 mg/m3), 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 5 ppm (skin)
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 5 ppm (skin)


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DIISOPROPYLAMINE-air 10 hour time-weighted average 5 ppm (Sk) NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 25850;
Number of Industries 91;
Total Number of Facilities 6,803;
Number of Occupations 99;
Total Number of Employees Exposed 91,123
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 25850;
Number of Industries 3;
Total Number of Facilities 30;
Number of Occupations 7;
Total Number of Employees Exposed 4,577;
Total Number of Female Employees Exposed 745


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in the preparation of vapor-phase inhibitors and rubber accelerators
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CHHSA* Chemical Health & Safety (Orlando, FL : Published by Elsevier Inc. for the ACS Division of Chemical Health and Safety) V.1- 1994-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NUCADQ Nutrition and Cancer. (Franklin Institute Press, POB 2266, Phildelphia, PA 19103) V.1- 1978-
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)

Used in the preparation of vapor-phase inhibitors and rubber accelerators

RTECS Compound Description:
   Mutagen

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