Diisopropylamine
RTECS #
IM4025000
CAS #
Updated
September 2013
Molecular Weight
101.22
Molecular Formula
C6H15N
Synonyms
2-Propanamine, N-(1-methylethyl)- (9CI)
Diisopropylamine (ACGIH:OSHA)
N-(1-Methylethyl)-2-propanamine
Diisopropylamine (ACGIH:OSHA)
N-(1-Methylethyl)-2-propanamine
Mutation Data and Reference
| System Test | Route/Organism/Tissue | Dose | Reference |
|---|---|---|---|
| mutation in microorganisms | /Salmonella typhimurium | 1 µg/plate (+/-enzymatic activation step) | NUCADQ 3,129,1982 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/cat | Lowest published lethal concentration: 2207 ppm/72M | Behavioral: Coma Lung, Thorax, or Respiration: Cough Gastrointestinal: Changes in structure or function of salivary glands | JIHTAB 31,142,1949 |
| inhalation/guinea pig | Lowest published lethal concentration: 2207 ppm/82M | Behavioral: Coma Lung, Thorax, or Respiration: Cough Gastrointestinal: Changes in structure or function of salivary glands | JIHTAB 31,142,1949 |
| inhalation/mammal (species unspecified) | lethal concentration (50 percent kill): 4200 mg/m3 | TPKVAL 14,80,1975 | |
| inhalation/mammal (species unspecified) | lowest published toxic concentration: 2.4 gm/m3 | Eye: Conjunctiva irritation | TPKVAL 7,56,1965 |
| inhalation/mouse | lethal concentration (50 percent kill): 4200 mg/m3/2H | 85GMAT -,54,1982 | |
| inhalation/rabbit | Lowest published lethal concentration: 2207 ppm/2.5H | Behavioral: Coma Lung, Thorax, or Respiration: Cough Gastrointestinal: Changes in structure or function of salivary glands | JIHTAB 31,142,1949 |
| inhalation/rat | lethal concentration (50 percent kill): 4800 mg/m3/2H | 85GMAT -,54,1982 | |
| oral/guinea pig | lethal dose (50 percent kill): 2800 mg/kg | GISAAA 45(3),79,1980 | |
| oral/mouse | lethal dose (50 percent kill): 2120 mg/kg | GISAAA 45(3),79,1980 | |
| oral/rabbit | lethal dose (50 percent kill): 4700 mg/kg | GISAAA 45(3),79,1980 | |
| oral/rat | lethal dose (50 percent kill): 770 mg/kg | UCDS** 12/15/1971 | |
| skin/rabbit | lethal dose (50 percent kill): >10 gm/kg | UCDS** 12,15,1971 | |
| subcutaneous/guinea pig | lowest published lethal dose: 1400 mg/kg | JIHTAB 31,142,1949 | |
| unreported route/mammal (species unspecified) | lethal dose (50 percent kill): 600 mg/kg | TPKVAL 14,80,1975 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/guinea pig | lowest published toxic concentration: 597 ppm/7H/9D- intermittent | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | JIHTAB 31,142,1949 |
| inhalation/mouse | lowest published toxic concentration: 48300 ppb/6H/14D- intermittent | Olfaction: Other olfaction effects | JJATDK 15,207,1995 |
| inhalation/pig | lowest published toxic concentration: 3.2 gm/m3/2D- intermittent | Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Kidney, Ureter, and Bladder: Other changes Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | TPKVAL 7,56,1965 |
| inhalation/rabbit | lowest published toxic concentration: 261 ppm/7H/54D- intermittent | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | JIHTAB 31,142,1949 |
| inhalation/rabbit | lowest published toxic concentration: 597 ppm/7H/9D- intermittent | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | JIHTAB 31,142,1949 |
| inhalation/rabbit | lowest published toxic concentration: 3.2 gm/m3/2D- intermittent | Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Kidney, Ureter, and Bladder: Other changes Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | TPKVAL 7,56,1965 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 5 ppm (skin) | DTLVS* TLV/BEI,2013 |
| TOXICOLOGY REVIEW | CHHSA* 9,6,2002 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 5 ppm (20 mg/m3) (skin) | DTLVS* 3,87,1971 |
| Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
| Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
| Occupational Exposure Limit-AUSTRALIA | time-weighted average 5 ppm (21 mg/m3), JUL2008 | |
| Occupational Exposure Limit-AUSTRIA | MAK-TMW 5 ppm (20 mg/m3);KZW 10 ppm (40 mg/m3), skin, 2007 | |
| Occupational Exposure Limit-BELGIUM | time-weighted average 5 ppm (21 mg/m3), Skin, MAR2002 | |
| Occupational Exposure Limit-DENMARK | time-weighted average 5 ppm (20 mg/m3), skin, MAY2011 | |
| Occupational Exposure Limit-FINLAND | short term exposure limit 5 ppm (21 mg/m3), skin, NOV2011 | |
| Occupational Exposure Limit-FRANCE | VME 5 ppm (20 mg/m3), Skin, FEB2006 | |
| Occupational Exposure Limit-ICELAND | time-weighted average 5 ppm (20 mg/m3), skin, NOV2011 | |
| Occupational Exposure Limit-KOREA | time-weighted average 5 ppm (20 mg/m3), skin, 2006 | |
| Occupational Exposure Limit-MEXICO | time-weighted average 5 ppm (20 mg/m3) (skin), 2004 | |
| Occupational Exposure Limit-NEW ZEALAND | time-weighted average 5 ppm (21 mg/m3), skin, JAN2002 | |
| Occupational Exposure Limit-NORWAY | time-weighted average 5 ppm (20 mg/m3), JAN1999 | |
| Occupational Exposure Limit-PERU | time-weighted average 5 ppm (21 mg/m3), JUL2005 | |
| Occupational Exposure Limit-RUSSIA | short term exposure limit 5 mg/m3, Skin, JUN2003 | |
| Occupational Exposure Limit-SWEDEN | time-weighted average 5 ppm (20 mg/m3);short term exposure limit 10 ppm (40 mg/m3), Skin, JUN2005 | |
| Occupational Exposure Limit-SWITZERLAND | MAK-week 5 ppm (20 mg/m3), skin, JAN2011 | |
| Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 20 mg/m3, Skin, 2003 | |
| Occupational Exposure Limit-THE PHILIPPINES | time-weighted average 5 ppm (20 mg/m3), Skin, JAN1993 | |
| Occupational Exposure Limit-UNITED KINGDOM | time-weighted average 5 ppm (21 mg/m3), OCT2007 | |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 5 ppm (20 mg/m3) (skin) | CFRGBR 29,1926.55,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 5 ppm (20 mg/m3) (skin) | CFRGBR 41,50-204.50,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 5 ppm (20 mg/m3) (skin) | CFRGBR 29,1910.1000,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 5 ppm (20 mg/m3) (skin) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DIISOPROPYLAMINE-air | 10H time-weighted average 5 ppm (Sk) | NIOSH* DHHS #92-100,1992 |
| National Occupational Exposure Survey 1983 | Hazard Code 25850; Number of Industries 3; Total Number of Facilities 30; Number of Occupations 7; Total Number of Employees Exposed 4577; Total Number of Female Employees Exposed 745 | |
| National Occupational Hazard Survey 1974 | Hazard Code 25850; Number of Industries 91; Total Number of Facilities 6803; Number of Occupations 99; Total Number of Employees Exposed 91123 |
Status in Federal Agencies
| Organization | Reference |
|---|---|
| EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
| EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 |
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health