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Diethylene glycol, dinitrate

RTECS #: ID6825000

CAS #: 693-21-0


UPDATE: June 2000 MW: 196.14 MF: C4H8N2O7


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. STATUS IN FEDERAL AGENCIES:
  5. REFERENCES:

SYNONYMS:

  1. Bis (hydroxyaethyl) - aether - dinitrat (German)
  2. Di (hydroxyethyl) ether dinitrate
  3. Diethylenglykoldinitrate (Czech)
  4. Diglycoldinitraat (Dutch)
  5. Diglycol (dinitrate de) (French)
  1. Diglykoldinitrat (German)
  2. Dinitrate de diethylene - glycol (French)
  3. Dinitrodiglicol (Italian)
  4. Dinitrodiglykol (Czech)
  5. Ethanol, 2,2' - oxybisdinitrate


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lethal dose (50 percent kill): 1,250 mg/kg N/R STGNBT -,91,1999
oral
guinea pig
lethal dose (50 percent kill): 650 mg/kg Brain and Coverings: Recordings from specific areas of CNS

Cardiac: EKG changes not diagnostic of above

Behavioral: Convulsions or effect on seizure threshold
STGNBT -,91,1999
oral
mouse
lethal dose (50 percent kill): 1,250 mg/kg Behavioral: Change in motor activity (specific assay)

Lung, Thorax, or Respiration: Cyanosis
JHEMA2 17,114,1973
oral
rat
lethal dose (50 percent kill): 753 mg/kg Behavioral: Tremor

Behavioral: Muscle contraction or spasticity

Behavioral: Irritability
ATDAEI 12,602,1993
oral
rabbit
lethal dose (50 percent kill): 1,060 mg/kg Brain and Coverings: Recordings from specific areas of CNS

Cardiac: Other changes

Behavioral: Convulsions or effect on seizure threshold
STGNBT -,91,1999
skin
rabbit
lethal dose : >2 gm/kg Behavioral: Tremor

Behavioral: Muscle contraction or spasticity

Behavioral: Irritability
ATDAEI 12,600,1993
unreported route
mammal (species unspecified)
lethal dose (50 percent kill): 1,250 mg/kg N/R GISAAA 39(11),13,1974


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 860 g/m3/17 week- intermittent Cardiac: EKG changes not diagnostic of above

Blood: Normocytic anemia

Blood: Luekopenia
STGNBT -,91,1999


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an agent in glue, paint and resin production
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
JHEMA2 Journal of Hygiene, Epidemiology, Microbiology, and Immunology. (Avicenum, Malostranske namesti 28, 11802 Prague 1, Czechoslovakia) V.1- 1957-
STGNBT "Spravochnik po Toksikologii i Gigienicheskim Normativam (PDK) Potentsial'no Opasnykh Khimicheskikh Veshchestv" Kushneva, V.S., and R.B. Gorshkova, eds. 46, Zhivopisnaya St., 123182, Moscow, Russia, IzdAT 1999

Used as an agent in glue, paint and resin production

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