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Registry of Toxic Effects of Chemical Substances (RTECS)

Diethylene glycol

RTECS #

ID5950000

CAS #

111-46-6

Updated

July 2013

Molecular Weight

106.14

Molecular Formula

C4H10O3

Synonyms

2,2'-Dihydroxyethyl ether
2,2'-Oxybisethanol
2,2'-Oxydiethanol
2,2'-Oxyethanol
3-Oxa-1,5-pentanediol
3-Oxapentane-1,5-diol
beta,beta'-Dihydroxydiethyl ether
Bis(2-hydroxyethyl) ether
Brecolane ndg
Deactivator E
DEG
Dicol
Diethylenglykol (Czech)
Diglycol
Dihydroxydiethyl ether
Dissolvant APV
Ethanol, 2,2'-oxydi-
Ethylene diglycol
TL4N

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 50 mg mildJPETAB 42,355,1931
skin /human 112 mg/3D- intermittent mild85DKA8 -,127,1977
skin /rabbit 500 mg mild34ZIAG -,731,1969

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 50 gm/kg (1-20D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemOYYAA2 27,801,1984
oral/rat 76420 mg/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)EPASR* 8EHQ-0291-1175
oral/rat 38212 mg/kg (6-15D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemEPASR* 8EHQ-0291-1175
oral/mouse 343 gm/kg (multigeneration)Reproductive: Maternal effects: Parturition

Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Effects on newborn: Sex ratio
FAATDF 14,622,1990
oral/mouse 343 gm/kg (multigeneration)Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)

Reproductive: Effects on newborn: Other postnatal measures or effects
FAATDF 14,622,1990
oral/mouse 50 gm/kg (6-15D pregnant)Reproductive: Other effects on femaleNTIS** PB91-159327
oral/mouse 16000 mg/kg (7-14D pregnant)Reproductive: Effects on newborn: Stillbirth

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
EVHPAZ 57,141,1984
oral/mouse 3.1 gm/kg (multigenerations)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)NTIS** #PB85212926/AS
oral/mouse 50 gm/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)NTIS** #PB91-159327
oral/mouse 900 gm/kg (21W prior to copulation)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)NTIS** #PB85212926/AS
oral/mouse 128.6 gm/kg (7D male/7D prior to copulation/21D pregnant)Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
NTIS** #PB85212926/AS

Tumorigenic Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 4 mg/m3/2H/30W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Blood: Lymphoma including Hodgkin's disease

Skin and Appendages: Tumors
GISAAA 33(2),36,1968
oral/mouse lowest published toxic dose: 420 mg/kg/22W- intermittentTumorigenic: Neoplastic by RTECS criteria

Blood: Tumors
VINIT* #6801-83
oral/rat toxic dose: 1752 gm/kg/2Y- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors
IMSUAI 36,55,1967
oral/rat toxic dose: 584 gm/kg/2Y- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors
FEPRA7 4,149,1945
oral/rat toxic dose: 840 mg/kg/81W- intermittentTumorigenic: Neoplastic by RTECS criteria

Blood: Tumors
VINIT* #6801-83
oral/rat lowest published toxic dose: 890 gm/kg/53W- continuousTumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors

Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli
JIHTAB 28,40,1946
subcutaneous/mouse lowest published toxic dose: 1250 mg/kg/66W- intermittentTumorigenic: Neoplastic by RTECS criteria

Blood: Tumors
VINIT* #6801-83
subcutaneous/rat lowest published toxic dose: 2500 mg/kg/82W- intermittentTumorigenic: Neoplastic by RTECS criteria

Blood: Tumors
VINIT* #6801-83

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse Lowest published lethal concentration: 130 mg/m3/2HBehavioral: General anesthetic

Behavioral: Excitement

Lung, Thorax, or Respiration: Cyanosis
GTPZAB 10(12),30,1966
intramuscular/rabbit lowest published lethal dose: 4472 mg/kgJPETAB 59,93,1937
intramuscular/rat lowest published lethal dose: 7826 mg/kgJPETAB 59,93,1937
intraperitoneal/mouse lethal dose (50 percent kill): 9719 mg/kgLung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli

Blood: Changes in spleen
FEPRA7 6,342,1947
intraperitoneal/rat lethal dose (50 percent kill): 7.7 gm/kgENTOX* -,36,2005
intravenous/rabbit lowest published lethal dose: 2236 mg/kgJPETAB 59,93,1937
intravenous/rat lethal dose (50 percent kill): 6565 mg/kgNPIRI* 1,25,1974
oral/cat lethal dose (50 percent kill): 3300 mg/kgJIHTAB 21,173,1939
oral/cat lethal dose (50 percent kill): 3400 mg/kgBrain and Coverings: Other degenerative changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,145,1984
oral/child lowest published lethal dose: 0.2 gm/kgJTCTDW 47,525,2009
oral/child lowest published toxic dose: 2400 mg/kgBehavioral: Somnolence (general depressed activity)

Liver: Other changes

Nutritional and Gross Metabolic: Changes in: Metabolic acidosis
JOPDAB 109,731,1986
oral/Dog lethal dose (50 percent kill): 9 gm/kgJPETAB 67,101,1939
oral/Dog lethal dose (50 percent kill): 9900 mg/kgBrain and Coverings: Other degenerative changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,145,1984
oral/guinea pig lethal dose (50 percent kill): 7800 mg/kgBehavioral: General anesthetic

Behavioral: Muscle weakness

Liver: Other changes
FEPRA7 4,142,1945
oral/guinea pig lethal dose (50 percent kill): 8000 mg/kgBrain and Coverings: Other degenerative changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,145,1984
oral/human lowest published lethal dose: 0.75 mg/kgBrain and Coverings: Other degenerative changes

Behavioral: Tetany

Lung, Thorax, or Respiration: Dyspnea
VCVGK* -,145,1984
oral/human lowest published lethal dose: 0.23 gm/kgJTCTDW 47,525,2009
oral/man lowest published toxic dose: 1.7 gm/kgBrain and Coverings: Other degenerative changes

Peripheral Nerve and Sensation: Structural change in nerve or sheath

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
JEMME* 35,401,2008
oral/mouse lethal dose (50 percent kill): 2300 mg/kgBrain and Coverings: Other degenerative changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,145,1984
oral/mouse lethal dose (50 percent kill): 23700 mg/kgBehavioral: General anesthetic

Behavioral: Muscle weakness

Liver: Other changes
FEPRA7 4,142,1945
oral/rabbit lethal dose (50 percent kill): 4400 mg/kgBehavioral: Coma

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Body temperature decrease
JIHTAB 21,173,1939
oral/rabbit lethal dose (50 percent kill): 26.9 gm/kgENTOX* -,36,2005
oral/rat lowest published toxic dose: 16000 mg/kgKidney, Ureter, and Bladder: Renal function tests depressed

Nutritional and Gross Metabolic: Changes in: Metabolic acidosis
JTCTDW 42,713,2004
oral/rat lethal dose (50 percent kill): 12000 mg/kgBrain and Coverings: Other degenerative changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,145,1984
oral/rat lethal dose (66 percent kill): 15 mL/kgBrain and Coverings: Other degenerative changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,145,1984
oral/rat lethal dose (50 percent kill): 12565 mg/kgNPIRI* 1,25,1974
skin/rabbit lethal dose (50 percent kill): 11890 mg/kgNPIRI* 1,25,1974
subcutaneous/mouse lowest published lethal dose: 5 gm/kgJPETAB 42,355,1931
subcutaneous/mouse lowest published lethal dose: 5000 mg/kgBrain and Coverings: Other degenerative changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,145,1984
subcutaneous/rat lethal dose (50 percent kill): 18800 mg/kg38MKAJ 2C,3836,1982
unreported route/guinea pig lethal dose (50 percent kill): 14 gm/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Excitement

Gastrointestinal: Nausea or vomiting
GISAAA 33(3),16,1968
unreported route/mammal (species unspecified) lowest published toxic dose: 6 mL/kgLiver: Other changes

Kidney, Ureter, and Bladder: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
VCVGK* -,145,1984
unreported route/mouse lethal dose (50 percent kill): 13300 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Excitement

Gastrointestinal: Nausea or vomiting
GISAAA 33(3),16,1968
unreported route/rabbit lethal dose (50 percent kill): 2688 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Excitement

Gastrointestinal: Nausea or vomiting
GISAAA 33(3),16,1968
unreported route/rat lethal dose (50 percent kill): 15650 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Excitement

Gastrointestinal: Nausea or vomiting
GISAAA 33(3),16,1968
unreported route/rat lowest published toxic dose: 2000 mg/kgNutritional and Gross Metabolic: Changes in: Metabolic acidosisTOXID9 -,103,2009
unreported route/rat lowest published toxic dose: 10000 mg/kgKidney, Ureter, and Bladder: Other changes in urine composition

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
TOXID9 -,103,2009
unreported route/rat lowest published toxic dose: 10 gm/kgLiver: Liver function tests impaired

Kidney, Ureter, and Bladder: Renal function tests depressed

Nutritional and Gross Metabolic: Changes in: Metabolic acidosis
CTOXAO 47,722,2009

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 35 mg/m3/11W- intermittentCardiac: Other changes

Liver: Fatty liver degeneration

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
GTPZAB 10(12),30,1966
inhalation/mouse lowest published toxic concentration: 35 mg/m3/75D- intermittentBrain and Coverings: Changes in circulation

Liver: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVGK* -,145,1994
inhalation/rat lowest published toxic concentration: 35 mg/m3/75D- intermittentBrain and Coverings: Changes in circulation

Liver: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVGK* -,145,1994
inhalation/rat lowest published toxic concentration: 20 mg/m3/2H/26W- intermittentVascular: BP lowering not characterized in autonomic section

Lung, Thorax, or Respiration: Emphysema

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
GTPZAB 10(12),30,1966
inhalation/rat lowest published toxic concentration: 20 mg/m3/4H/30D- intermittentBehavioral: Somnolence (general depressed activity)

Brain and Coverings: Other degenerative changes
VCVGK* -,145,1994
multiple/non-mammalian species lowest published toxic dose: 45000 gm/m3/4D- continuousRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldREPTED 22,263,2006
oral/Dog lowest published toxic dose: 105 gm/kg/18D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldFCTOD7 24,261,1986
oral/mouse lowest published toxic dose: 16000 mg/kg/8D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldEVHPAZ 57,141,1984
oral/mouse lowest published toxic dose: 20000 mg/kg/4D- intermittentBehavioral: Fluid intakeNTIS** #PB91-159327
oral/mouse lowest published toxic dose: 70000 mg/kg/7D- intermittentBehavioral: Food intake (animal)NTIS** #PB91-159327
oral/mouse lowest published toxic dose: 50000 mg/kg/5D- intermittentKidney, Ureter, and Bladder: Other changesNTIS** #PB91-159327
oral/mouse lowest published toxic dose: 50000 mg/kg/10D- intermittentKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Changes in kidney weight
NTIS** #PB91-159327
oral/mouse lowest published toxic dose: 100000 mg/kg/10D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNTIS** #PB91-159327
oral/mouse lowest published toxic dose: 900375 mg/kg/21W- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainNTIS** #PB85212926/AS
oral/rat lowest published toxic dose: 50000 mg/kg/10D- intermittentKidney, Ureter, and Bladder: Changes in kidney weightTOXID9 12,103,1992
oral/rat lowest published toxic dose: 297 gm/kg/99D- continuousKidney, Ureter, and Bladder: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
FCTOD7 24,261,1986
oral/rat lowest published toxic dose: 18375 mg/kg/7W- continuousRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldJAMAAP 109,1517,1937
skin/rabbit lowest published toxic dose: 17300 µL/kg/30D- intermittentLiver: Other changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JIHTAB 29,325,1947

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWAJMEAZ 38,409,1965
TOXICOLOGY REVIEWADCSAJ 13,271,1970
TOXICOLOGY REVIEWFAATDF 13,747,1989
TOXICOLOGY REVIEWNEJMAG 342,186,2000
TOXICOLOGY REVIEWENTOX* -,36,2005
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWREPTED 25,192,2008
TOXICOLOGY REVIEWHUTOX* -,623,1996

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-AUSTRALIAtime-weighted average 23 ppm (100 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 10 ppm (44 mg/m3);KZW 40 ppm (176 mg/m3), 2007
Occupational Exposure Limit-DENMARKtime-weighted average 2.5 ppm (11 mg/m3), MAY2011
Occupational Exposure Limit-GERMANYMAK 10 ppm (44 mg/m3), 2011
Occupational Exposure Limit-ICELANDtime-weighted average 2.5 ppm (11 mg/m3), NOV2011
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 23 ppm (101 mg/m3), JAN2002
Occupational Exposure Limit-POLANDMAC(time-weighted average) 10 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAshort term exposure limit 10 mg/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 10 ppm (45 mg/m3);short term exposure limit 20 ppm (90 mg/m3), Skin, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 10 ppm (44 mg/m3), KZG-week 40 ppm (176 mg/m3), JAN2011
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 23 ppm (101 mg/m3), OCT2007

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 25544; Number of Industries 292; Total Number of Facilities 55518; Number of Occupations 178; Total Number of Employees Exposed 890145; Total Number of Female Employees Exposed 261558
National Occupational Hazard Survey 1974Hazard Code 25544; Number of Industries 222; Total Number of Facilities 27975; Number of Occupations 129; Total Number of Employees Exposed 273598

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1996: Glycols, 5523
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