Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to page options Skip directly to site content

Registry of Toxic Effects of Chemical Substances (RTECS)

Dicyclohexylamine

RTECS #

HY4025000

CAS #

101-83-7

Updated

April 2012

Molecular Weight

181.36

Molecular Formula

C12H23N

Synonyms

DCHA
Dicha
Dicyklohexylamin (Czech)
Dodecahydrodiphenylamine
N,N-Diclohexylamine
N-Cyclohexylcyclohexanamine

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 750 µg/24H severe85JCAE -,468,1986
skin /rabbit 2 mg/24H severe85JCAE -,468,1986

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisleukocyte/human200 µg/LINHEAO 9,188,1971
DNA Damage/non-mammalian species2 mmol/LMUREAV 368,181,1996

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 40 gm/kg/52W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Tumors

Liver: Tumors
VOONAW 4,659,1958
subcutaneous/mouse lowest published toxic dose: 2404 mg/kg/48W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application
VOONAW 4,659,1958

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lethal concentration (50 percent kill): 1 gm/m3Peripheral Nerve and Sensation: Recording from peripheral motor nerveTPKVAL 8,70,1966
oral/mouse lethal dose (50 percent kill): 500 mg/kg85JCAE -,468,1986
oral/rat lethal dose (50 percent kill): 373 mg/kg85JCAE -,468,1986
subcutaneous/mouse lethal dose (50 percent kill): 135 mg/kgVOONAW 4,659,1958
subcutaneous/rabbit lowest published lethal dose: 500 mg/kgBehavioral: Convulsions or effect on seizure thresholdIECHAD 29,1247,1937

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMEMDT 22,55,1980
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 22,55,1980
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMSUDL 7,178,1987
TOXICOLOGY REVIEWMUREAV 741,32,2012

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 1 mg/m3, Skin, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code M1151; Number of Industries 2; Total Number of Facilities 40; Number of Occupations 3; Total Number of Employees Exposed 3412; Total Number of Female Employees Exposed 169
National Occupational Hazard Survey 1974Hazard Code M1151; Number of Industries 3; Total Number of Facilities 60; Number of Occupations 3; Total Number of Employees Exposed 368

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9219;8EHQ-0892-9270
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
TOP