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Dichromic acid, disodium salt

RTECS #: HX7700000

CAS #: 10588-01-9


UPDATE: May 2009 MW: 261.98 MF: Cr2O72Na


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. Bichromate de sodium (French)
  2. Bichromate of soda
  3. Disodium dichromate
  4. Natriumbichromaat (Dutch)
  5. Natriumdichromaat (Dutch)
  6. Natriumdichromat (German)
  1. Sodio (dicromato di) (Italian)
  2. Sodium bichromate
  3. Sodium dichromate (VI)
  4. Sodium dichromate
  5. Sodium (dichromate de) (French)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis hamster ovary 250 g/L TXCYAC 17,219,1980
cytogenetic analysis hamster ovary 0.1 mg/L/30 hour MUREAV 67,231,1979
cytogenetic analysis human lymphocyte 2 mol/L CARYAB 33,239,1980
DNA damage human other cell types 500 mol/L/1 hour MUTAEX 16,467,2001
DNA damage human lymphocyte 50 mol/L/1 hour MUTAEX 16,467,2001
DNA damage human lung 10 mol/L/1 hour MUTAEX 16,467,2001
DNA damage intraperitoneal
rat
20 mg/kg JBCHA3 256,3623,1981
DNA damage rat liver 300 mol/L MUREAV 189,69,1987
DNA damage rat other cell types 500 mol/L FCTOD7 31,271,1993
DNA repair Bacillus subtilis 50 mmol/L TOLED5 7,439,1981
DNA repair Escherichia coli 200 nmol/plate JTEHD6 9,287,1982
mutation in microorganisms Escherichia coli 5 g/plate (-enzymatic activation step) MUREAV 412,17,1998
mutation in microorganisms Salmonella typhimurium 35 g/plate (+enzymatic activation step) CRNGDP 9,611,1988
mutation in microorganisms Salmonella typhimurium 30 g/plate (-enzymatic activation step) PCBRD2 109,453,1982
morphological transform rat other cell types 300 nmol/L MUREAV 198,115,1988
sister chromatid exchange hamster ovary 250 g/L TXCYAC 17,219,1980


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
rat
lowest published toxic dose: 20 mg/kg (8 week male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Other effects on male

Endocrine: Androgenic
HETOEA 11,255,1992


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 252 g/m3/78 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors
TXCYAC 42,219,1986
intrapleural
rat
lowest published toxic dose: 160 mg/kg/69 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors
AEHLAU 5,445,1962


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
guinea pig
lowest published lethal dose: 335 mg/kg N/R AEHLAU 11,201,1965
intravenous
frog
lowest published lethal dose: 196 mg/kg N/R AIPTAK 62,330,1939
intravenous
mouse
lowest published lethal dose: 26,200 g/kg N/R EQSSDX 1,1,1975
intravenous
rabbit
lowest published lethal dose: 18,400 g/kg N/R EQSSDX 1,1,1975
oral
child
lowest published lethal dose: 50 mg/kg N/R YAKUD5 22,291,1980
oral
child
lowest published toxic dose: 250 mg/kg Lung, Thorax, or Respiration: Cough

Gastrointestinal: Nausea or vomiting

Skin and Appendages: Other: Sweating
AUPJB7 21,65,1985
oral
mouse
lowest published toxic dose: 19 mg/kg Brain and Coverings: Other degenerative changes

Liver: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport
TXCYAC 175,73,2002
oral
rat
lethal dose (50 percent kill): 50 mg/kg Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
GTPZAB 22(8),38,1978
oral
rat
lowest published toxic dose: 25 mg/kg Biochemical: Metabolism (intermediary): Lipids including transport TXCYAC 180,5,2002
subcutaneous
guinea pig
lowest published lethal dose: 23 mg/kg N/R HBAMAK 4,1330,1935
subcutaneous
rat
lowest published lethal dose: 80 mg/kg N/R TOXID9 4,75,1984
skin
guinea pig
lowest published lethal dose: 335 mg/kg N/R AEHLAU 11,201,1965


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 1 mg/m3/2 hour/28 week- intermittent Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Acute pulmonary edema
VCVN5* -,303,1989
intravenous
domestic animal
lowest published toxic dose: 3 mg/kg/5 day- continuous Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Proteinuria

Kidney, Ureter, and Bladder: Hematuria
COVEAZ 76,306,1986
oral
dog
lowest published toxic dose: 7,280 mg/kg/2 year- continuous Cardiac: Changes in coronary arteries GTPZAB 19(6),35,1975
oral
pig
lowest published toxic dose: 3,438 g/kg/39 week- continuous Cardiac: Other changes CUTOEX 1,221,1993
oral
rat
lowest published toxic dose: 75 mg/kg/30 day- intermittent Biochemical: Metabolism (intermediary): Lipids including transport TXCYAC 180,5,2002


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

International Agency for Research on Cancer (IARC) Cancer Review Human Sufficient Evidence IMEMDT 49,49,1990
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 23,205,1980
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 49,49,1990
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 2,100,1973
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 23,205,1980
International Agency for Research on Cancer (IARC) Cancer Review Group 1 IMEMDT 49,49,1990
TOXICOLOGY REVIEW
FCTXAV 9,105,1971
TOXICOLOGY REVIEW
85DHAX Cr,22,1974
TOXICOLOGY REVIEW
MUREAV 584,1,2005
TOXICOLOGY REVIEW
MUREAV 533,36,2003
TOXICOLOGY REVIEW
MUREAV 533,227,2003
TOXICOLOGY REVIEW
MUREAV 533,227,2003
TOXICOLOGY REVIEW
MUREAV 659,202,2008
TOXICOLOGY REVIEW
MUREAV 659,202,2008
TOXICOLOGY REVIEW
HBTME* ,487,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,101,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.5 mg(Cr)/m3 DTLVS* 3,35,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) ceiling concentration 0.1 mg(CrO3)/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) ceiling concentration 0.1 mg(CrO3)/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) ceiling concentration 0.1 mg(CrO3)/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) ceiling concentration 0.1 mg(CrO3)/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.05 mg(Cr)/m3, JUL2008
Occupational Exposure Limit - AUSTRIA TRK 0.05 mg(Cr)/m3, JAN 2006
Occupational Exposure Limit - AUSTRIA TRK 0.1 mg(Cr)/m3 (production), JAN 2006
Occupational Exposure Limit - AUSTRIA TRK 0.1 mg(Cr)/m3 (welding fumes), JAN 2006
Occupational Exposure Limit - DENMARK time-weighted average 0.005 mg(Cr)/m3, OCT 2002
Occupational Exposure Limit - FRANCE VME 0.05 mg(Cr)/m3, FEB2006
Occupational Exposure Limit - RUSSIA short term exposure limit 0.01 mg(Cr)/m3, Skin, Carcinogen, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 0.005 mg(Cr)/m3;
short term exposure limit 0.015 mg(Cr)/m3, Carcinogen, Sen, JUN2005


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CHROMIUM(VI)-air Carcinogen;
10 hour time-weighted average 0.001 mg(Cr)/m3
NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M0073;
Number of Industries 85;
Total Number of Facilities 7,838;
Number of Occupations 64;
Total Number of Employees Exposed 44,269
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M0073;
Number of Industries 118;
Total Number of Facilities 11,523;
Number of Occupations 82;
Total Number of Employees Exposed 136,313;
Total Number of Female Employees Exposed 24,542


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in manufacture of CHROMIC ACID and pigments, leather tanning, and corrosion control
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP 11th Report on Carcinogens,2004:Known to be human carcinogen


REFERENCES:

CODEN
REFERENCE

85DHAX "Medical and Biologic Effects of Environmental Pollutants Series," Washington, DC, National Academy of Sciences, 1972-77
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960-
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
AUPJB7 Australian Paediatric Journal. (Royal Childrens Hospital, Parkville, Vic., Australia) V.1- 1965-
CARYAB Caryologia. (Via G. LaPira 4, 50121 Florence, Italy) V.1- 1948-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
COVEAZ Cornell Veterinarian. (Cornell Univ. New York State College of Veterinary Medicine, Ithaca, NY 14853) V.1- 1911-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
CUTOEX Current Toxicology. (Nova Science Publishers, Inc., 6080 Jericho Turnpike, Suite 207, Commack, NY 11725) V.1 1993-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EQSSDX Environmental Quality and Safety, Supplement. (Stuttgart, Fed. Rep. Ger.) V.1-5, 1975-76. Discontinued.
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.)
HBTME*
HETOEA Human & Experimental Toxicology. (Macmillan Press Ltd., Brunel Road, Houndmills, Basingstoke, Hampshire, RG21 2XS, UK) V.9- 1990-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JBCHA3 Journal of Biological Chemistry. (428 E. Preston St., Baltimore, MD 21202) V.1- 1905-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
PCBRD2 Progress in Clinical and Biological Research. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1975-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
VCVN5* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov V-VII groopp" (Hazardous substances. Inornanic substances containing V-VII group elements), Bandman A.L. et al., Chimia, 1989.
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959-

Used in manufacture of CHROMIC ACID and pigments, leather tanning, and corrosion control

NIOSH PROFILE (INORGANIC CHROMIUM COMPOUNDS), SRC, 2/82

FDA-over the counter drug

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data

Click Here for Additional Information about RTECS

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