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Registry of Toxic Effects of Chemical Substances (RTECS)

Dichromic acid, disodium salt

RTECS #

HX7700000

CAS #

10588-01-9

Updated

December 2013

Molecular Weight

261.98

Molecular Formula

Cr2O7·2Na

Synonyms

Bichromate de sodium (French)
Bichromate of soda
Disodium dichromate
Natriumbichromaat (Dutch)
Natriumdichromaat (Dutch)
Natriumdichromat (German)
Sodio (dicromato di) (Italian)
Sodium bichromate
Sodium dichromate
Sodium dichromate(VI)
Sodium(dichromate de) (French)

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislymphocyte/human2 µmol/LCARYAB 33,239,1980
Cytogenetic Analysisovary/hamster0.1 mg/L/30HMUREAV 67,231,1979
Cytogenetic Analysisovary/hamster250 µg/LTXCYAC 17,219,1980
DNA Damageother cell types/human500 µmol/L/1HMUTAEX 16,467,2001
DNA Damagelymphocyte/human50 µmol/L/1HMUTAEX 16,467,2001
DNA Damagelung/human10 µmol/L/1HMUTAEX 16,467,2001
DNA Damagemultiple/other fish42.85 mg/L/96H- intermittentMUREAV 698,43,2010
DNA Damageintraperitoneal/rat20 mg/kgJBCHA3 256,3623,1981
DNA Damageliver/rat300 µmol/LMUREAV 189,69,1987
DNA Damageother cell types/rat500 µmol/LFCTOD7 31,271,1993
DNA repair/Escherichia coli200 nmol/plateJTEHD6 9,287,1982
DNA repair/Bacillus subtilis50 mmol/LTOLED5 7,439,1981
morphological transformother cell types/rat300 nmol/LMUREAV 198,115,1988
mutation in microorganisms/Salmonella typhimurium35 µg/plate (+enzymatic activation step)CRNGDP 9,611,1988
mutation in microorganisms/Salmonella typhimurium30 µg/plate (-enzymatic activation step)PCBRD2 109,453,1982
mutation in microorganisms/Escherichia coli5 µg/plate (-enzymatic activation step)MUREAV 412,17,1998
sister chromatid exchangeovary/hamster250 µg/LTXCYAC 17,219,1980

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat 20 mg/kg (8W male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Other effects on male

Endocrine: Androgenic
HETOEA 11,255,1992

Tumorigenic Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 252 µg/m3/78W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors
TXCYAC 42,219,1986
intrapleural/rat lowest published toxic dose: 160 mg/kg/69W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors
AEHLAU 5,445,1962

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/mraInhibitor Concentration Low: 5 µmol/L/48HIn Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc.

In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.

In Vitro Toxicity Studies: Apoptosis in vitro
TXAPA9 245,226,2010
In Vitro/mraInhibitor Concentration Low: 10 µmol/L/1HIn Vitro Toxicity Studies: Other assaysTXAPA9 245,226,2010
In Vitro/mraInhibitor Concentration Low: 1 µmol/L/3HIn Vitro Toxicity Studies: Other assaysTXAPA9 245,226,2010
intraperitoneal/guinea pig lowest published lethal dose: 335 mg/kgAEHLAU 11,201,1965
intravenous/frog lowest published lethal dose: 196 mg/kgAIPTAK 62,330,1939
intravenous/mouse lowest published lethal dose: 26200 µg/kgEQSSDX 1,1,1975
intravenous/rabbit lowest published lethal dose: 18400 µg/kgEQSSDX 1,1,1975
oral/child lowest published lethal dose: 50 mg/kgYAKUD5 22,291,1980
oral/child lowest published toxic dose: 250 mg/kgLung, Thorax, or Respiration: Cough

Gastrointestinal: Nausea or vomiting

Skin and Appendages: Other: Sweating
AUPJB7 21,65,1985
oral/mouse lowest published toxic dose: 19 mg/kgBrain and Coverings: Other degenerative changes

Liver: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport
TXCYAC 175,73,2002
oral/rat lowest published toxic dose: 25 mg/kgBiochemical: Metabolism (intermediary): Lipids including transportTXCYAC 180,5,2002
oral/rat lethal dose (50 percent kill): 50 mg/kgLiver: Other changes

Kidney, Ureter, and Bladder: Other changes
GTPZAB 22(8),38,1978
skin/guinea pig lowest published lethal dose: 335 mg/kgAEHLAU 11,201,1965
subcutaneous/guinea pig lowest published lethal dose: 23 mg/kgHBAMAK 4,1330,1935
subcutaneous/rat lowest published lethal dose: 80 mg/kgTOXID9 4,75,1984

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 1 mg/m3/2H/28W- intermittentLung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Acute pulmonary edema
VCVN5* -,303,1989
intravenous/domestic animal lowest published toxic dose: 3 mg/kg/5D- continuousKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Proteinuria

Kidney, Ureter, and Bladder: Hematuria
COVEAZ 76,306,1986
oral/Dog lowest published toxic dose: 7280 mg/kg/2Y- continuousCardiac: Changes in coronary arteriesGTPZAB 19(6),35,1975
oral/pig lowest published toxic dose: 3438 µg/kg/39W- continuousCardiac: Other changesCUTOEX 1,221,1993
oral/rat lowest published toxic dose: 75 mg/kg/30D- intermittentBiochemical: Metabolism (intermediary): Lipids including transportTXCYAC 180,5,2002
oral/rat lowest published toxic dose: 0.11 mg/kg/22D- continuousBlood: Microcytosis with or without anemiaTOXID9 -,168,2009

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Human Sufficient EvidenceIMEMDT 49,49,1990
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 23,205,1980
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMEMDT 49,49,1990
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 2,100,1973
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 23,205,1980
International Agency for Research on Cancer (IARC)Cancer Review:Group 1IMEMDT 49,49,1990
TOXICOLOGY REVIEWFCTXAV 9,105,1971
TOXICOLOGY REVIEW85DHAX Cr,22,1974
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWMUREAV 533,36,2003
TOXICOLOGY REVIEWMUREAV 533,227,2003
TOXICOLOGY REVIEWMUREAV 659,202,2008
TOXICOLOGY REVIEWHBTME* ,487,2007
TOXICOLOGY REVIEWMUREAV 669,8,2009
TOXICOLOGY REVIEWMUTAEX 26,231,2011

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESSupportedRBREV* -,101,1998
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 0.5 mg(Cr)/m3DTLVS* 3,35,1971
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.05 mg(Cr)/m3, JUL2008
Occupational Exposure Limit-FINLANDtime-weighted average 0.05 mg(CrO4)/m3, NOV2011
Occupational Exposure Limit-FRANCEVME 0.05 mg(Cr)/m3, FEB2006
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.01 mg(Cr)/m3, Skin, Carcinogen, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 0.005 mg(Cr)/m3;short term exposure limit 0.015 mg(Cr)/m3, Carcinogen, Sen, JUN2005
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 0.05 mg(Cr)/m3, carc, sen, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)ceiling concentration 0.1 mg(CrO3)/m3CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)ceiling concentration 0.1 mg(CrO3)/m3CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)ceiling concentration 0.1 mg(CrO3)/m3CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)ceiling concentration 0.1 mg(CrO3)/m3CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CHROMIUM(VI)-air10H Carcinogen time-weighted average 0.001 mg(Cr)/m3NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code M0073; Number of Industries 118; Total Number of Facilities 11523; Number of Occupations 82; Total Number of Employees Exposed 136313; Total Number of Female Employees Exposed 24542
National Occupational Hazard Survey 1974Hazard Code M0073; Number of Industries 85; Total Number of Facilities 7838; Number of Occupations 64; Total Number of Employees Exposed 44269

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP 11th Report on Carcinogens,2004:Known to be human carcinogen
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