Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to page options Skip directly to site content

Registry of Toxic Effects of Chemical Substances (RTECS)

Dibutylamine

RTECS #

HR7780000

CAS #

111-92-2

Updated

April 2012

Molecular Weight

129.28

Molecular Formula

C8H19N

Synonyms

1-Butanamine, N-butyl-
Dibutilamina (Romanian)
N-Butyl-1-butanamine
n-Dibutylamine

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /rabbit 500 mg open irritation test moderateUCDS** 3/25/1970

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisfibroblast/hamster200 mg/L/48HMUREAV 48,337,1977
DNA repair/Bacillus subtilis5 gm/LMUREAV 42,19,1977

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat Lowest published lethal concentration: 500 ppm/4HAMIHBC 10,61,1954
inhalation/rat lowest published toxic concentration: 450 mg/m3/6HBehavioral: Convulsions or effect on seizure thresholdINHTE5 15,701,2003
intraperitoneal/mouse lethal dose (50 percent kill): 200 mg/kgUSXXAM #3816470
intraperitoneal/rat lethal dose (50 percent kill): 110 mg/kgTSCAT* OTS0515594
oral/guinea pig lethal dose (50 percent kill): 230 mg/kgGISAAA 40(11),21,1975
oral/mouse lethal dose (50 percent kill): 290 mg/kgGISAAA 40(11),21,1975
oral/rat lethal dose (50 percent kill): 189 mg/kgRCBUAU 36,667,1985
skin/rabbit lethal dose (50 percent kill): 770 mg/kgNTIS** OTS0535430
subcutaneous/rat lethal dose (50 percent kill): 494 mg/kgTSCAT* OTS0515594

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 450 mg/m3/28D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainINHTE5 15,701,2003
inhalation/rat lowest published toxic concentration: 450 mg/m3/28D- intermittentLung, Thorax, or Respiration: Changes in lung weightINHTE5 15,701,2003
inhalation/rat lowest published toxic concentration: 150 mg/m3/91D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainINHTE5 15,701,2003
inhalation/rat lowest published toxic concentration: 450 mg/m3/3D- intermittentOlfaction: Ulcerated nasal septum

Lung, Thorax, or Respiration: Other changes

Blood: Hemorrhage
INHTE5 15,701,2003
inhalation/rat lowest published toxic concentration: 50 mg/m3/91D- intermittentOlfaction: Other olfaction effectsINHTE5 15,701,2003

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWCHREAY 9,389,1931

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-AUSTRIAMAK-TMW 5 ppm (29 mg/m3);KZW 5 ppm (29 mg/m3), skin, 2007
Occupational Exposure Limit-FINLANDshort term exposure limit 5 ppm (27 mg/m3), skin, NOV2011

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 84285; Number of Industries 12; Total Number of Facilities 711; Number of Occupations 17; Total Number of Employees Exposed 15196; Total Number of Female Employees Exposed 3349
National Occupational Hazard Survey 1974Hazard Code 84285; Number of Industries 8; Total Number of Facilities 200; Number of Occupations 6; Total Number of Employees Exposed 977

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Positive/dose response: In vitro cytogenetics-nonhuman
EPA GENETOX PROGRAM 1988, Positive: In vitro SCE-nonhuman
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
TOP