CDC logo, Safer Healthier People  CDC HomeCDC SearchCDC Health Topics A-Z
NIOSH - National Institute for Occupational Safety and Health

Search NIOSH  |  NIOSH Home  |  NIOSH Topics  |  Site Index  |  Databases and Information Resources  |  NIOSH Products  |  Contact Us






Dibutylamine

RTECS #: HR7780000

CAS #: 111-92-2


UPDATE: May 2008 MW: 129.28 MF: C8H19N


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 1 - Butanamine, N - butyl -
  2. Dibutilamina (Romanian)
  1. N - Butyl - 1 - butanamine
  2. n - Dibutylamine


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
skin
rabbit
500 mg open irritation test moderate UCDS** 3/25/1970


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis hamster fibroblast 200 mg/L/48 hour MUREAV 48,337,1977
DNA repair Bacillus subtilis 5 gm/L MUREAV 42,19,1977


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published lethal concentration: 500 ppm/4 hour N/R AMIHBC 10,61,1954
inhalation
rat
lowest published toxic concentration: 450 mg/m3/6 hour Behavioral: Convulsions or effect on seizure threshold INHTE5 15,701,2003
intraperitoneal
mouse
lethal dose (50 percent kill): 200 mg/kg N/R USXXAM #3816470
intraperitoneal
rat
lethal dose (50 percent kill): 110 mg/kg N/R TSCAT* OTS0515594
oral
guinea pig
lethal dose (50 percent kill): 230 mg/kg N/R GISAAA 40(11),21,1975
oral
mouse
lethal dose (50 percent kill): 290 mg/kg N/R GISAAA 40(11),21,1975
oral
rat
lethal dose (50 percent kill): 189 mg/kg N/R RCBUAU 36,667,1985
subcutaneous
rat
lethal dose (50 percent kill): 494 mg/kg N/R TSCAT* OTS0515594
skin
rabbit
lethal dose (50 percent kill): 770 mg/kg N/R NTIS** OTS0535430


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 450 mg/m3/28 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain INHTE5 15,701,2003
inhalation
rat
lowest published toxic concentration: 450 mg/m3/28 day- intermittent Lung, Thorax, or Respiration: Changes in lung weight INHTE5 15,701,2003
inhalation
rat
lowest published toxic concentration: 150 mg/m3/91 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain INHTE5 15,701,2003
inhalation
rat
lowest published toxic concentration: 450 mg/m3/3 day- intermittent Olfaction: Ulcerated nasal septum

Lung, Thorax, or Respiration: Other changes

Blood: Hemorrhage
INHTE5 15,701,2003
inhalation
rat
lowest published toxic concentration: 50 mg/m3/91 day- intermittent Olfaction: Other olfaction effects INHTE5 15,701,2003


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
CHREAY 9,389,1931


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - AUSTRIA MAK 29 mg/m3 (5 ppm), JAN 2006
Occupational Exposure Limit - DENMARK time-weighted average 5 ppm (tentative), OCT 2002


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84285;
Number of Industries 8;
Total Number of Facilities 200;
Number of Occupations 6;
Total Number of Employees Exposed 977
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84285;
Number of Industries 12;
Total Number of Facilities 711;
Number of Occupations 17;
Total Number of Employees Exposed 15,196;
Total Number of Female Employees Exposed 3,349


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Positive: In vitro SCE-nonhuman
EPA GENETOX PROGRAM 1988, Positive/dose response: In vitro cytogenetics-nonhuman
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an industrial chemical
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
CHREAY Chemical Reviews. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1924-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
INHTE5 Inhalation Toxicology. (Published by Taylor & Francis Health, 11 New Fetter Lane, London EC4P 4EE) V.1- 1989-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
RCBUAU Revista de Chimie (Bucharest). (Rompresfilatelia, POB 12-201, Bucharest, Romania) V.1- 1950-
TSCAT* Office of Toxic Substances Report. (U.S. Environmental Protection Agency, Office of Toxic Substances, 401 M St., SW, Washington, DC 20460)
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231)

Used as an industrial chemical

NIOSH PROFILE (AMINES, SECONDARY ALIPHATIC), SRI, 2/77

RTECS Compound Description:
   Drug
   Mutagen
   Primary Irritant

Click Here for Additional Information about RTECS

NIOSH Home |  NIOSH Search  |  Site Index  |  Topic List |  Contact Us