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Registry of Toxic Effects of Chemical Substances (RTECS)

Dibenz(a,h)anthracene

RTECS #

HN2625000

CAS #

53-70-3

Updated

July 2013

Molecular Weight

278.36

Molecular Formula

C22H14

Synonyms

1,2,5,6-Dba
1,2,5,6-Dibenzanthraceen (Dutch)
1,2:5,6-Benzanthracene
1,2:5,6-Dibenz(a)anthracene
1,2:5,6-Dibenzanthracene
1,2:5,6-Dibenzoanthracene
DB(a,h)A
Dibenzo(a,h)anthracene
RCRA waste number U063

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisinhalation/Drosophila melanogaster2700 mg/LGENTAE 33,337,1948
Cytogenetic Analysisfibroblast/hamster1 mmol/LPJACAW 53,46,1977
DNA adductembryo/hamster360 nmol/LCBINA8 22,257,1978
DNA adductlung/hamster1 mg/LCBINA8 4,389,1971/1972
DNA adductoral/mouse6.3 mg/kg/9W- intermittentJJATDK 15,59,1995
DNA adductliver/rat3 µmol/L/24HMUTAEX 22,55,2007
DNA adducttestis/salmon5 µg/1H-continuousBIJOAK 110,159,1968
DNA adduct/Escherichia coli10 µmol/LMUREAV 89,95,1981
DNA adductembryo/human360 nmol/LCBINA8 22,257,1978
DNA adductintratracheal/rat25560 µg/kgMUREAV 312,165,1994
DNA adductliver/mouse6 µmol/LJJIND8 62,947,1979
DNA adductskin/mouse40 µmol/kgIJCNAW 23,201,1979
DNA adductother cell types/mouse1 mg/LCBINA8 4,389,1971/1972
DNA adductembryo/mouse510 nmol/LIJCNAW 9,349,1972
DNA Damagefibroblast/hamster5 mg/L/24HBCPCA6 20,1297,1971
DNA Damageovary/human50 µmol/LMUREAV 575,17,2005
DNA Damagefibroblast/human1 µmol/L/24HMUREAV 547,109,2004
DNA Damagefibroblast/hamster10 µmol/L/2H (-enzymatic activation step)MUREAV 650,96,2008
DNA Damagekidney/hamster5 mg/LBCPCA6 20,1297,1971
DNA Damagelymphocyte/mammal (species unspecified)2 nmol/LJMOBAK 5,521,1962
DNA Damage/Escherichia coli1207.1 µg/L/3H (+enzymatic activation step)MUREAV 515,85,2002
DNA repair/Escherichia coli25 µg/wellMUREAV 46,53,1977
gene conversion and mitotic recombination/Drosophila melanogaster2 mmol/LMUREAV 514,193,2002
micronucleus testoral/mouse6.3 mg/kg/9W- intermittentJJATDK 15,59,1995
micronucleus testskin/mouse24 mg/kg/3DMUREAV 588,58,2005
micronucleus testovary/hamster60 µmol/L/24H (-enzymatic activation step)MUREAV 751,1,2013
micronucleus testovary/hamster100 µmol/L/3H (+enzymatic activation step)MUREAV 630,1,2007
micronucleus testintratracheal/rat25500 µg/kg/16H- intermittentMUREAV 326,147,1995
micronucleus testintraperitoneal/mouse500 mg/kgMUREAV 389,3,1997
morphological transformembryo/hamster2500 µg/LCNREA8 32,1391,1972
morphological transformkidney/hamster25 µg/LTOLED5 7,143,1980
morphological transformfibroblast/mouse500 µg/LAETODY 1,133,1980
morphological transformembryo/mouse100 µg/LJNCIAM 52,1167,1974
morphological transformoral/rat200 mg/kgCNREA8 40,1157,1980
morphological transformembryo/rat100 µg/LJNCIAM 51,799,1973
morphological transformembryo/mouse0.03 mg/L/72HMUREAV 702,100,2010
mutation in mammalian somatic cellslung/hamster500 µg/LMUREAV 136,65,1984
mutation in mammalian somatic cellslymphocyte/human54 µg/LMUREAV 371,123,1996
mutation in microorganisms/Neurospora crassa500 ppm (-enzymatic activation step)ANYAA9 71,1072,1958
mutation in microorganisms/Salmonella typhimurium5 µg/plate (-enzymatic activation step)MUREAV 174,247,1986
mutation in microorganismslung/hamster56400 nmol/L (+enzymatic activation step)MUREAV 46,27,1977
mutation in microorganismslymphocyte/mouse4250 µg/L (+enzymatic activation step)MUREAV 106,101,1982
mutation in microorganisms/Salmonella typhimurium39 µg/plate/48H (+enzymatic activation step)MUTAEX 20,217,2005
mutation in microorganisms/Salmonella typhimurium9.8 µg/plate/20M (+enzymatic activation step)MUTAEX 20,217,2005
other mutation test systemslung/hamster1 mg/LCBINA8 4,389,1971/1972
other mutation test systemsother cell types/mouse1 mg/LCBINA8 4,389,1971/1972
other mutation test systemsembryo/mouse510 nmol/LIJCNAW 9,349,1972
phage inhibition capacity/Escherichia coli2 µg/wellMUREAV 260,349,1991
sex chromosome loss and nondisjunctionparenteral/Drosophila melanogaster5 mmol/LEJGCA9 4,400,1975
sex chromosome loss and nondisjunctioninhalation/Drosophila melanogaster2700 mg/LGENTAE 33,337,1948
sister chromatid exchangeintratracheal/rat51150 µg/kgMUREAV 312,165,1994
sister chromatid exchangeintraperitoneal/hamster900 mg/kg/24HMUREAV 66,65,1979
Unscheduled DNA Synthesisoral/mouse6.3 mg/kg/9W- intermittentJJATDK 15,59,1995
Unscheduled DNA Synthesisother cell types/other fish100 µmol/LCBPCEE 86,399,1987
Unscheduled DNA Synthesisfibroblast/human100 µmol/LCBPCEE 86,399,1987
Unscheduled DNA Synthesisother cell types/human10 mg/LCNREA8 38,2091,1978
Unscheduled DNA SynthesisHeLa cell/human100 nmol/LCNREA8 38,2621,1978

Tumorigenic Data and References

Route/OrganismDoseEffectReference
implant/mouse lowest published toxic dose: 80 mg/kgTumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors
BJCAAI 11,212,1957
implant/mouse toxic dose: 14 mg/kgTumorigenic: Neoplastic by RTECS criteria

Tumorigenic: Tumors at site of application
AJPAA4 16,287,1940
implant/mouse toxic dose: 200 mg/kgTumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Bronchogenic carcinoma

Tumorigenic: Tumors at site of application
AJCAA7 36,201,1939
implant/mouse toxic dose: 100 mg/kgTumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors

Tumorigenic: Tumors at site of application
BMBUAQ 14,147,1958
intramuscular/pigeon lowest published toxic dose: 6 mg/kgTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Tumorigenic: Tumors at site of application
JNCIAM 32,905,1964
intrarenal/frog lowest published toxic dose: 12 mg/kgTumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Kidney, Ureter, and Bladder: Kidney tumors
CNREA8 24,1969,1964
intratracheal/rat lowest published toxic dose: 100 mg/kgTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
GISAAA 31(7),12,1966
intravenous/guinea pig lowest published toxic dose: 30 mg/kgTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Tumorigenic: Tumors at site of application
JNCIAM 13,705,1952
intravenous/mouse lowest published toxic dose: 40 mg/kgTumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors
PHRPA6 54,1158,1939
multiple/mouse lowest published toxic dose: 40 mg/kg/12D- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Tumorigenic: Tumors at site of application
PHRPA6 52,637,1937
oral/mouse lowest published toxic dose: 4160 mg/kg/26W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
JPBAA7 49,21,1939
oral/mouse toxic dose: 4520 mg/kg/36W- continuousTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Gastrointestinal: Tumors
JNCIAM 1,17,1940
skin/mouse toxic dose: 400 mg/kg/40W- intermittentTumorigenic: Neoplastic by RTECS criteria

Skin and Appendages: Tumors
CNREA8 22,78,1962
skin/mouse toxic dose: 6 µg/kgTumorigenic: Neoplastic by RTECS criteria

Skin and Appendages: Tumors
CNREA8 20,1179,1960
skin/mouse lowest published toxic dose: 1200 mg/kg/50W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application
14JTAF -,275,1965
subcutaneous/guinea pig lowest published toxic dose: 250 mg/kg/24D- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Tumorigenic: Tumors at site of application
AKBNAE 51,112,1938
subcutaneous/mouse lowest published toxic dose: 445 µg/kgTumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application
CRNGDP 11,1721,1990
subcutaneous/mouse toxic dose: 6 mg/kgTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application
IJCNAW 32,765,1983
subcutaneous/mouse toxic dose: 78 µg/kgTumorigenic: Neoplastic by RTECS criteria

Tumorigenic: Tumors at site of application
JNCIAM 3,503,1943
subcutaneous/mouse toxic dose: 400 mg/kg/10W- intermittentTumorigenic: Neoplastic by RTECS criteria

Tumorigenic: Tumors at site of application
IJCNAW 2,500,1967
subcutaneous/rat toxic dose: 135 mg/kg/9W- intermittentTumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Tumorigenic: Tumors at site of application
PSEBAA 68,330,1948

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, liver tumor Inhibitor Concentration Low: 1 µmol/L/14HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TXCYAC 279,36,2011
intratracheal/mouse lowest published toxic dose: 3 mg/kgLung, Thorax, or Respiration: Other changes

Immunological Including Allergic: Decreased immune response

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TOXID9 12,439,2008
intravenous/mouse lowest published lethal dose: 10 mg/kgJNCIAM 1,225,1940
oral/mouse lowest published toxic dose: 8351 µg/kgImmunological Including Allergic: Decrease in humoral immune response

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
TOXID9 44,182,2005

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 58.5 mg/kg/7D- intermittentEndocrine: Changes in spleen weight

Endocrine: Changes in thymus weight

Blood: Changes in spleen
TOXID9 44,182,2005
oral/mouse lowest published toxic dose: 58.5 mg/kg/7D- intermittentImmunological Including Allergic: Decrease in cellular immune responseTOXID9 44,182,2005
subcutaneous/mouse lowest published toxic dose: 14000 µg/kg/28D- intermittentImmunological Including Allergic: Decrease in humoral immune responseTOXID9 44,182,2005
subcutaneous/mouse lowest published toxic dose: 1120 mg/kg/28D- intermittentImmunological Including Allergic: Hypersensitivity delayed (multiple organ involvement)TOXID9 44,182,2005
subcutaneous/mouse lowest published toxic dose: 140000 µg/kg/28D- intermittentImmunological Including Allergic: Decrease in cellular immune responseTOXID9 44,182,2005
unreported route/mouse lowest published toxic dose: 180 mg/kg/12D- intermittentImmunological Including Allergic: Uncharacterized (multiple organ involvement)TOXID9 48,13,1999

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 3,178,1973
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 32,299,1983
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 32,299,1983
International Agency for Research on Cancer (IARC)Cancer Review:Group 2AIMSUDL 7,56,1987
TOXICOLOGY REVIEWMUREAV 544,397,2003
TOXICOLOGY REVIEWMUREAV 540,89,2003
TOXICOLOGY REVIEWMUREAV 558,155,2004
TOXICOLOGY REVIEWMUREAV 558,7,2004
TOXICOLOGY REVIEWTOLED5 140-141,353,2003
TOXICOLOGY REVIEWMUREAV 567,227,2004
TOXICOLOGY REVIEWMUREAV 567,109,2004
TOXICOLOGY REVIEWMUREAV 567,401,2004
TOXICOLOGY REVIEWMUREAV 567,151,2004
TOXICOLOGY REVIEWMUREAV 567,347,2004
TOXICOLOGY REVIEWMUREAV 613,103,2006
TOXICOLOGY REVIEWFCTOD7 44,1699,2006
TOXICOLOGY REVIEWMUREAV 627,10,2007
TOXICOLOGY REVIEWENTOX* -,790,2005
TOXICOLOGY REVIEWMUREAV 547,1,2004
TOXICOLOGY REVIEWMUREAV 705,184,2010
TOXICOLOGY REVIEWMUTAEX 26,223,2011
TOXICOLOGY REVIEWMUREAV 727,1,2011

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-NORWAYtime-weighted average 0.04 mg/m3, JAN1999
Occupational Exposure Limit-POLANDtime-weighted average 0.004 mg/m3, JAN1999

Status in Federal Agencies

OrganizationReference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/95/264370)
EPA GENETOX PROGRAM 1988, Inconclusive: Cell transform.-mouse prostate; In vivo SCE-nonhuman
EPA GENETOX PROGRAM 1988, Inconclusive: In vitro UDS-human fibroblast
EPA GENETOX PROGRAM 1988, Positive/dose response: SHE-clonal assay
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat; Cell transform.-SA7/F344 rat
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-BALB/c-3T3; SHE-focus assay
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-C3H/10T1/2; Cell transform.-mouse embryo
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-RLV F344 rat embryo
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-SA7/SHE; N crassa-forward mutation
EPA GENETOX PROGRAM 1988, Positive: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Positive: V79 cell culture-gene mutation
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Polynuclear aromatic hydrocarbons by HPLC, 5506; by GC, 5515
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen
On EPA IRIS database
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