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Decyl alcohol

RTECS #: HE4375000

CAS #: 112-30-1


UPDATE: February 2008 MW: 158.32 MF: C10H22O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 1 - Decanol
  2. Agent 504
  3. Alcohol C - 10
  4. Antak
  5. C 10 alcohol
  6. Capric alcohol
  7. Caprinic alcohol
  8. Decanol
  9. Dytol S - 91
  10. Epal 10
  1. Lorol 22
  2. Nonylcarbinol
  3. Primary decyl alcohol
  4. Royaltac
  5. Royaltac - 85
  6. Royaltac M - 2
  7. Sipol L10
  8. T 148
  9. n - Decanol
  10. n - Decyl alcohol


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
83 mg severe AIHAAP 34,493,1973
eye
rabbit
500 mg/24 hour mild 85JCAE -,202,1986
skin
human
75 mg/3 day- intermittent severe 85DKA8 -,127,1977
skin
rabbit
2,600 mg/24 hour moderate AIHAAP 34,493,1973
skin
rabbit
20 mg/24 hour moderate 85JCAE -,202,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 35,295 mg/kg (1-15 day pregnant) Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)

Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)
ONGZAC 22(1),71,1991
oral
rat
lowest published toxic dose: 35,295 mg/kg (1-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on newborn: Biochemical and metabolic
ONGZAC 22(1),71,1991


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
skin
mouse
lowest published toxic dose: 12 gm/kg/25 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application
TXAPA9 9,70,1966


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mammal (species unspecified)
lethal concentration (50 percent kill): 3 gm/m3 N/R GISAAA 51(5),61,1986
inhalation
mouse
lethal concentration (50 percent kill): 4 gm/m3/2 hour N/R 85GMAT -,42,1982
inhalation
mouse
lowest published toxic concentration: 0.9 gm/m3/2 hour N/R TPKVAL 5,51,1963
intraperitoneal
mouse
lethal dose (50 percent kill): 800 mg/kg N/R 38MKAJ 2C,4631,1982
intraperitoneal
rat
lethal dose (50 percent kill): 800 mg/kg N/R 38MKAJ 2C,4631,1982
ocular
rabbit
lowest published toxic dose: 100 pph Eye: Conjunctiva irritation TPKVAL 5,51,1963
oral
mouse
lethal dose (50 percent kill): 6,500 mg/kg N/R FMCHA2 -,C267,1991
oral
mouse
lethal dose (50 percent kill): 34.8 gm/kg Brain and Coverings: Changes in circulation

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia
TPKVAL 5,51,1963
oral
mouse
lowest published lethal dose: 25,000 mg/kg N/R TPKVAL 5,51,1963
oral
rat
lethal dose (50 percent kill): 4,720 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea
AIHAAP 34,493,1973
skin
mouse
lowest published toxic dose: 100 pph/3 hour Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression

Skin: After topical application: Primary irritation
TPKVAL 5,51,1963
skin
rabbit
lethal dose (50 percent kill): 3,560 mg/kg N/R FCTXAV 11,95,1973
skin
rabbit
lowest published toxic dose: 100 pph Skin: After topical application: Primary irritation TPKVAL 5,51,1963


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 180 mg/m3/4 hour/137 day- intermittent Brain and Coverings: Other degenerative changes

Liver: Multiple effects

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,118,1994
inhalation
rat
lowest published toxic concentration: 58 mg/m3/26 week- intermittent Eye: Other eye effects VCVGK* -,118,1994
inhalation
rat
lowest published toxic concentration: 0.27 gm/m3/137 day- intermittent Brain and Coverings: Changes in circulation

Lung, Thorax, or Respiration: Emphysema

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
TPKVAL 5,51,1963
inhalation
rabbit
lowest published toxic concentration: 200 mg/m3/2 hour/30 day- intermittent Eye: Conjunctiva irritation

Eye: Other eye effects

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
NTIS** PB234-882
inhalation
rabbit
lowest published toxic concentration: 200 mg/m3/2 hour/30 day- intermittent Eye: Optic nerve neuropathy

Eye: Corneal damage

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
VCVGK* -,118,1994


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,291,1998
Occupational Exposure Limit - RUSSIA short term exposure limit 10 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83553;
Number of Industries 11;
Total Number of Facilities 219;
Number of Occupations 26;
Total Number of Employees Exposed 5,355
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83553;
Number of Industries 116;
Total Number of Facilities 6,909;
Number of Occupations 84;
Total Number of Employees Exposed 241,397;
Total Number of Female Employees Exposed 62,584


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as tobacco sucker control agent, DECYL CHLORIDE intermediate, defoamer, food additive
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9257
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985.
85DKA8 "Cutaneous Toxicity, Proceedings of the 3rd Conference, 1976," Drill, V.A., and P. Lazar, eds., New York, Academic Press, Inc. 1977
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094)
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
ONGZAC Ontogenez (Moscow). For English translation, see SJDBA9. (V/O Mezhdunarodnaya Kniga, 113095, Moscow, USSR) V.1- 1970-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used as tobacco sucker control agent, DECYL CHLORIDE intermediate, defoamer, food additive

NIOSH PROFILE (ALCOHOLS), SRI, 2/77

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Reproductive Effector
   Human Data
   Natural Product
   Primary Irritant

Click Here for Additional Information about RTECS

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