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Registry of Toxic Effects of Chemical Substances (RTECS)

Decyl alcohol

RTECS #

HE4375000

CAS #

112-30-1

Updated

August 2009

Molecular Weight

158.32

Molecular Formula

C10H22O

Synonyms

1-Decanol
Agent 504
Alcohol C-10
Antak
C 10 alcohol
Capric alcohol
Caprinic alcohol
Decanol
Dytol S-91
Epal 10
Lorol 22
n-Decanol
n-Decyl alcohol
Nonylcarbinol
Primary decyl alcohol
Royaltac
Royaltac M-2
Royaltac-85
Sipol L10
T 148

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 83 mg severeAIHAAP 34,493,1973
eye /rabbit 500 mg/24H mild85JCAE -,202,1986
eye /rabbit 0.1 mL moderateHPV112 -,-,2008
skin /human 50%/24H mildHPV112 -,-,2008
skin /human 75 mg/3D- intermittent severe85DKA8 -,127,1977
skin /rabbit 2600 mg/24H moderateAIHAAP 34,493,1973
skin /rabbit 20 mg/24H moderate85JCAE -,202,1986
skin /rabbit 0.5 gm/4H moderateHPV112 -,-,2008
skin /rabbit 12 mL/6D severeHPV112 -,-,2008

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 35295 mg/kg (1-15D pregnant)Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)

Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)
ONGZAC 22(1),71,1991
oral/rat 35295 mg/kg (1-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on newborn: Biochemical and metabolic
ONGZAC 22(1),71,1991

Tumorigenic Data and References

Route/OrganismDoseEffectReference
skin/mouse lowest published toxic dose: 12 gm/kg/25W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application
TXAPA9 9,70,1966

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mammal (species unspecified) lethal concentration (50 percent kill): 3 gm/m3GISAAA 51(5),61,1986
inhalation/mouse lowest published toxic concentration: 0.9 gm/m3/2HTPKVAL 5,51,1963
inhalation/mouse lethal concentration (50 percent kill): 4000 mg/m3/2HHPV112 -,-,2008
inhalation/rat lethal concentration (50 percent kill): >71000 mg/m3/1HBehavioral: Ataxia

Lung, Thorax, or Respiration: Other changes

Gastrointestinal: Changes in structure or function of salivary glands
HPV112 -,-,2008
intraperitoneal/mouse lethal dose (50 percent kill): 800 mg/kg38MKAJ 2C,4631,1982
intraperitoneal/rat lethal dose (50 percent kill): 800 mg/kg38MKAJ 2C,4631,1982
ocular/rabbit lowest published toxic dose: 100 pphEye: Conjunctiva irritationTPKVAL 5,51,1963
oral/mouse lethal dose (50 percent kill): 25000 mg/kgBrain and Coverings: Changes in circulation

Vascular: Regional or general arteriolar or venous dilation
HPV112 -,-,2008
oral/mouse lethal dose (50 percent kill): 6500 mg/kgFMCHA2 -,C267,1991
oral/mouse lethal dose (50 percent kill): 34.8 gm/kgBrain and Coverings: Changes in circulation

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia
TPKVAL 5,51,1963
oral/mouse lowest published lethal dose: 25000 mg/kgTPKVAL 5,51,1963
oral/rat lethal dose (50 percent kill): 4720 mg/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea
AIHAAP 34,493,1973
oral/rat lethal dose (50 percent kill): 19500 mg/kgLung, Thorax, or Respiration: Acute pulmonary edema

Gastrointestinal: Ulceration or bleeding from stomach

Liver: Other changes
HPV112 -,-,2008
oral/rat lethal dose (50 percent kill): >5000 mg/kgHPV112 -,-,2008
skin/rabbit lethal dose (50 percent kill): 2 gm/kgGastrointestinal: Ulceration or bleeding from stomach

Skin: After topical application: Primary irritation
HPV112 -,-,2008
skin/rabbit lethal dose (50 percent kill): 3560 mg/kgFCTXAV 11,95,1973

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rabbit lowest published toxic concentration: 200 mg/m3/2H/30D- intermittentEye: Conjunctiva irritation

Eye: Other eye effects

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
NTIS** PB234-882
inhalation/rabbit lowest published toxic concentration: 200 mg/m3/2H/30D- intermittentEye: Optic nerve neuropathy

Eye: Corneal damage

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
VCVGK* -,118,1994
inhalation/rat lowest published toxic concentration: 180 mg/m3/4H/137D- intermittentBrain and Coverings: Other degenerative changes

Liver: Multiple effects

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,118,1994
inhalation/rat lowest published toxic concentration: 58 mg/m3/26W- intermittentEye: Other eye effectsVCVGK* -,118,1994
inhalation/rat lowest published toxic concentration: 0.27 gm/m3/137D- intermittentBrain and Coverings: Changes in circulation

Lung, Thorax, or Respiration: Emphysema

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
TPKVAL 5,51,1963

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESSupportedRBREV* -,291,1998
Occupational Exposure Limit-RUSSIAshort term exposure limit 10 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 83553; Number of Industries 116; Total Number of Facilities 6909; Number of Occupations 84; Total Number of Employees Exposed 241397; Total Number of Female Employees Exposed 62584
National Occupational Hazard Survey 1974Hazard Code 83553; Number of Industries 11; Total Number of Facilities 219; Number of Occupations 26; Total Number of Employees Exposed 5355

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9257
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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