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Decane

RTECS #: HD6550000

CAS #: 124-18-5


UPDATE: May 2008 MW: 142.32 MF: C10H22


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. UN 2247
  1. n - Decane


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
skin
pig
1,200 ÁL/4 day- intermittent mild TOPADD 33,258,2005


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
skin
mouse
lowest published toxic dose: 25 gm/kg/52 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application
TXAPA9 9,70,1966


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lethal concentration (50 percent kill): 72,300 mg/m3/2 hour Behavioral: Antipsychotic GTPZAB 26(8),53,1982
inhalation
mouse
lethal concentration (16 percent kill): 42,000 mg/m3/2 hour N/R VCVGH* -,40,1990
inhalation
mouse
lethal concentration (50 percent kill): 72,300 mg/m3/2 hour N/R VCVGH* -,40,1990
inhalation
mouse
lethal concentration (84 percent kill): 90,000 mg/m3/2 hour N/R VCVGH* -,40,1990
inhalation
rat
lethal concentration (50 percent kill): >1,369 ppm/8 hour N/R PHTOEH 62,259,1988
inhalation
rat
lethal concentration (50 percent kill): 72,300 mg/m3/2 hour N/R ENTOX* -,727,2005
intravenous
mouse
lowest published lethal dose: 912 mg/kg Behavioral: Altered sleep time (including change in righting reflex) APTOA6 37,56,1975


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 500 mg/m3/30 day- continuous Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases
VCVGH* -,40,1990
inhalation
rat
lowest published toxic concentration: 800 ppm/4 week- intermittent Reproductive: Paternal effects: Testes, epididymis, sperm duct TOXID9 60,325,2001


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
TOLED5 127,111,2002
TOXICOLOGY REVIEW
ENTOX* -,727,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - SWEDEN time-weighted average 350 mg/m3;
short term exposure limit 500 mg/m3, JUN2005


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: A1315;
Number of Industries 3;
Total Number of Facilities 666;
Number of Occupations 3;
Total Number of Employees Exposed 716
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: A1315;
Number of Industries 3;
Total Number of Facilities 80;
Number of Occupations 4;
Total Number of Employees Exposed 1,667;
Total Number of Female Employees Exposed 43


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1996: Volatile organic compound, 2549


REFERENCES:

CODEN
REFERENCE

APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
PHTOEH Pharmacology and Toxicology (Copenhagen). (Munksgaard International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) V.60- 1987-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia, Warner-Lambert Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 1978-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.

RTECS Compound Description:
   Tumorigen
   Primary Irritant

Click Here for Additional Information about RTECS

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