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p - Cymene

RTECS #: GZ5950000

CAS #: 99-87-6


UPDATE: May 2008 MW: 134.24 MF: C10H14


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. STANDARDS AND REGULATIONS:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. 1 - Methyl - 4 - isopropylbenzene
  2. 4 - Isopropyl - 1 - methylbenzene
  3. Benzene, 1 - isopropyl - 4 - methyl -
  4. Camphogen
  5. Cumene, p - methyl -
  6. Cymene
  7. Cymol
  1. Dolcymene
  2. Paracymene
  3. Paracymol
  4. p - Isopropylmethylbenzene
  5. p - Isopropyltoluene
  6. p - Methylisopropyl benzene


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
skin
rabbit
500 mg/24 hour moderate FCTXAV 12,401,1974


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lethal concentration (50 percent kill): 19,500 mg/m3 N/R VCVGH* -,180,1990
intraperitoneal
dog
lowest published toxic dose: 2 gm/kg Gastrointestinal: Hypermotility, diarrhea VCVGH* -,180,1990
intraperitoneal
guinea pig
lowest published lethal dose: 2.162 mg/kg N/R VCVGH* -,180,1990
intraperitoneal
mouse
lethal dose (50 percent kill): 1,125 mg/kg N/R VCVGH* -,180,1990
oral
human
lowest published toxic dose: 3 gm/kg Gastrointestinal: Nausea or vomiting VCVGH* -,181,1990
oral
mouse
lethal dose (50 percent kill): 1,695 mg/kg N/R VCVGH* -,180,1990
oral
rat
lethal dose (50 percent kill): 4,750 mg/kg Eye: Chromodacryorrhea

Behavioral: Somnolence (general depressed activity)

Gastrointestinal: Hypermotility, diarrhea
FCTXAV 2,327,1964
oral
rat
lethal dose (50 percent kill): 3,669 mg/kg N/R VCVGH* -,180,1990
oral
rat
lethal dose (90 percent kill): 5 mL/kg N/R VCVGH* -,180,1990


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - DENMARK time-weighted average 25 ppm (135 mg/m3), OCT 2002
Occupational Exposure Limit - RUSSIA short term exposure limit 10 mg/m3, Skin, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 25 ppm (140 mg/m3);
short term exposure limit 35 ppm (190 mg/m3), JUN2005


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X8309;
Number of Industries 96;
Total Number of Facilities 8,820;
Number of Occupations 81;
Total Number of Employees Exposed 176,382;
Total Number of Female Employees Exposed 39,063


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.

RTECS Compound Description:
   Human Data
   Natural Product
   Primary Irritant

Click Here for Additional Information about RTECS

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