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Registry of Toxic Effects of Chemical Substances (RTECS)

p-Cymene

RTECS #

GZ5950000

CAS #

99-87-6

Updated

September 201

Molecular Weight

134.24

Molecular Formula

C10H14

Synonyms

1-Methyl-4-isopropylbenzene
4-Isopropyl-1-methylbenzene
Benzene, 1-isopropyl-4-methyl-
Camphogen
Cumene, p-methyl-
Cymene
Cymol
Dolcymene
Paracymene
Paracymol
p-Isopropylmethylbenzene
p-Isopropyltoluene
p-Methylisopropyl benzene

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /rabbit 500 mg/24H moderateFCTXAV 12,401,1974

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
micronucleus testintraperitoneal/rat1250 mg/kgHPV121 -,-,2002
morphological transformfibroblast/mouse60000 µg/LHPV121 -,-,2002
Unscheduled DNA Synthesisliver/rat16000 µg/LHPV121 -,-,2002

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, monocyte Inhibitor Concentration Low: 1000 µg/LIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.FCTOD7 50,3079,2012
inhalation/guinea pig lowest published toxic concentration: 9700 mg/m3/5HBehavioral: Convulsions or effect on seizure thresholdHPV121 -,-,2002
inhalation/mouse Lowest published lethal concentration: 9700 mg/m3/5HBehavioral: Coma

Lung, Thorax, or Respiration: Other changes

Liver: Other changes
HPV121 -,-,2002
inhalation/mouse lethal concentration (50 percent kill): 19500 mg/m3VCVGH* -,180,1990
inhalation/mouse lethal concentration (50 percent kill): 24000 mg/m3/2HTOVEFN (1),41,2006
inhalation/rat Lowest published lethal concentration: 8000 ppm/4HHPV121 -,-,2002
inhalation/rat lowest published toxic concentration: 9700 mg/m3/5HBehavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Changes in structure or function of salivary glands
HPV121 -,-,2002
inhalation/rat lowest published toxic concentration: 500 ppm/6HBehavioral: Change in motor activity (specific assay)HPV121 -,-,2002
inhalation/rat lowest published toxic concentration: 1200 ppm/6HBehavioral: Change in motor activity (specific assay)

Nutritional and Gross Metabolic: Body temperature decrease
HPV121 -,-,2002
intraperitoneal/Dog lowest published toxic dose: 2 gm/kgGastrointestinal: Hypermotility, diarrheaVCVGH* -,180,1990
intraperitoneal/guinea pig lowest published lethal dose: 2.162 mg/kgVCVGH* -,180,1990
intraperitoneal/mouse lethal dose (50 percent kill): 1125 mg/kgVCVGH* -,180,1990
oral/human lowest published toxic dose: 42.86 mg/kgBehavioral: Headache

Gastrointestinal: Nausea or vomiting
TOVEFN (1),41,2006
oral/human lowest published toxic dose: 3 gm/kgGastrointestinal: Nausea or vomitingVCVGH* -,181,1990
oral/mouse lethal dose (50 percent kill): 1695 mg/kgVCVGH* -,180,1990
oral/rat lethal dose (50 percent kill): 4750 mg/kgEye: Chromodacryorrhea

Behavioral: Somnolence (general depressed activity)

Gastrointestinal: Hypermotility, diarrhea
FCTXAV 2,327,1964
oral/rat lethal dose (50 percent kill): 3200 mg/kgBehavioral: Tremor

Liver: Other changes

Blood: Hemorrhage
HPV121 -,-,2002
oral/rat lethal dose (50 percent kill): 4750 mg/kgBehavioral: Coma

Gastrointestinal: Hypermotility, diarrhea

Blood: Hemorrhage
HPV121 -,-,2002
oral/rat lethal dose (50 percent kill): 1400 mg/kgHPV121 -,-,2002
oral/rat lethal dose (90 percent kill): 5 mL/kgVCVGH* -,180,1990
skin/rabbit lethal dose (50 percent kill): >5000 mg/kgSkin: After topical application: Primary irritationHPV121 -,-,2002
skin/rabbit lethal dose (50 percent kill): 10545 mg/kgHPV121 -,-,2002

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 250 ppm/4W- intermittentBrain and Coverings: Other degenerative changesHPV121 -,-,2002

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-DENMARKtime-weighted average 25 ppm (135 mg/m3), MAY2011
Occupational Exposure Limit-ICELANDtime-weighted average 25 ppm (135 mg/m3), NOV2011
Occupational Exposure Limit-RUSSIAshort term exposure limit 10 mg/m3, Skin, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 25 ppm (140 mg/m3);short term exposure limit 35 ppm (190 mg/m3), JUN2005

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X8309; Number of Industries 96; Total Number of Facilities 8820; Number of Occupations 81; Total Number of Employees Exposed 176382; Total Number of Female Employees Exposed 39063

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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