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Registry of Toxic Effects of Chemical Substances (RTECS)

Cyclotetrasiloxane, octamethyl-

RTECS #

GZ4397000

CAS #

556-67-2

Updated

November 2009

Molecular Weight

296.68

Molecular Formula

C8H24O4Si4

Synonyms

Cyclic dimethylsiloxane tetramer
D4
KF 994
NUC silicone VS 7207
Octamethylcyclotetrasiloxane
Oktamethylcyklotetrasiloxan (Czech)
SF 1173
Silicone SF 1173
UC 7207
Union carbide 7207
VS 7207

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 500 mg/24H mild85JCAE -,1230,1986
skin /rabbit 500 mg/24H mild85JCAE -,1230,1986

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 500 ppm (70D male/70D pre-3W after birth)Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)TOXID9 54,370,2000
inhalation/rat 301 ppm (28D prior to copulation/19D pregnant)Reproductive: Maternal effects: OogenesisREPTED 23,192,2007
inhalation/rat 503 ppm (28D prior to copulation/19D pregnant)Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on embryo or fetus: Fetal death
REPTED 23,192,2007
inhalation/rat 698 ppm (28D prior to copulation/19D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)REPTED 23,192,2007
inhalation/rat 696 ppm (3D prior to copulation/3D pregnant)Reproductive: Maternal effects: Oogenesis

Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on embryo or fetus: Fetal death
REPTED 23,192,2007
inhalation/rat 700 ppm (1D prior to copulation)Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)REPTED 23,192,2007
inhalation/rat 700 ppm (3D prior to copulation/3D pregnant)Reproductive: Maternal effects: Ovaries, fallopian tubes

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
REPTED 23,192,2007
inhalation/rat 700 ppm (70D male/70D prior to copulation/4D after birth)Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Specific developmental abnormalities: Urogenital system
REPTED 23,202,2007
inhalation/rat 700 ppm (multigeneration)Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
REPTED 23,202,2007
inhalation/rat 700 ppm (multigeneration)Reproductive: Specific developmental abnormalities: Respiratory system

Reproductive: Effects on newborn: Behavioral
REPTED 23,202,2007
inhalation/rat 700 ppm (70D male/70D prior to copulation/1-22D pregnant)Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)REPTED 23,202,2007
inhalation/rat 70 ppm (70D male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)REPTED 23,202,2007
inhalation/rat 300 ppm (multigeneration)Reproductive: Specific developmental abnormalities: Hepatobiliary system

Reproductive: Specific developmental abnormalities: Urogenital system
REPTED 23,202,2007
inhalation/rat 500 ppm (70D male/70D prior to copulation/4D after birth)Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)REPTED 23,202,2007

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lethal concentration (50 percent kill): 36 gm/m3/4HBehavioral: Excitement

Lung, Thorax, or Respiration: Dyspnea

Skin and Appendages: Other: Hair
NTIS** OTS0557551
inhalation/rat lowest published toxic concentration: 700 ppm/6HEndocrine: Change in gonadotropinsTOXID9 44,370,2005
oral/rat lethal dose (50 percent kill): 1540 mg/kgBehavioral: TremorNTIS** OTS0538262
skin/rabbit lethal dose (50 percent kill): 794 µL/kgKidney, Ureter, and Bladder: HematuriaNTIS** OTS0538262
skin/rat lethal dose (50 percent kill): 1770 mg/kgBehavioral: Tremor

Gastrointestinal: Changes in structure or function of salivary glands

Liver: Other changes
NTIS** OTS0538262
unreported route/mouse lowest published toxic dose: 100 mg/kgEndocrine: Other changesTOXID9 60,384,2001
unreported route/mouse lowest published toxic dose: 250 mg/kgReproductive: Maternal effects: Uterus, cervix, vaginaTOXID9 60,384,2001
unreported route/mouse lowest published toxic dose: 1000 mg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductasesTOXID9 60,384,2001

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/hamster lowest published toxic concentration: 697 ppm/6H/28D- intermittentLiver: Changes in liver weightNTIS** OTS0516677
inhalation/mouse lowest published toxic concentration: 697 ppm/6H/28D- intermittentLiver: Changes in liver weightNTIS** OTS0516677
inhalation/rat lowest published toxic dose: 70 ppm/6H/4W- intermittentLiver: Other changes

Liver: Changes in liver weight

Endocrine: Changes in thyroid weight
TXAPA9 172,83,2001
inhalation/rat lowest published toxic concentration: 300 ppm/6H/13W- intermittentLiver: Changes in liver weightNTIS** OTS0530406
inhalation/rat lowest published toxic concentration: 700 ppm/6H/4W- intermittentLiver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)
NTIS** OTS0573657
inhalation/rat lowest published toxic concentration: 35 ppm/6H/91D- intermittentBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
IJTOFN 21,39,2002
inhalation/rat lowest published toxic concentration: 488 ppm/6H/91D- intermittentLung, Thorax, or Respiration: Other changes

Blood: Normocytic anemia

Related to Chronic Data: Changes in testicular weight
IJTOFN 21,39,2002
inhalation/rat lowest published toxic concentration: 488 ppm/6H/91D- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Endocrine: Changes in thymus weight
IJTOFN 21,39,2002
inhalation/rat lowest published toxic concentration: 898 ppm/6H/91D- intermittentLung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Biochemical: Metabolism (intermediary): Lipids including transport
IJTOFN 21,39,2002
inhalation/rat lowest published toxic concentration: 898 ppm/6H/91D- intermittentEndocrine: Changes in adrenal weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field

Related to Chronic Data: Changes in ovarian weight
IJTOFN 21,39,2002
inhalation/rat lowest published toxic concentration: 700 ppm/104W- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Other changes

Kidney, Ureter, and Bladder: Changes in kidney weight
TOXID9 44,307,2005
inhalation/rat lowest published toxic concentration: 700 ppm/104W- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TOXID9 44,307,2005
inhalation/rat lowest published toxic concentration: 700 ppm/52W- intermittentLiver: Other changesTOXID9 44,307,2005
inhalation/rat lowest published toxic concentration: 30 ppm/26W- intermittentLiver: Changes in liver weightTOXID9 44,307,2005
inhalation/rat lowest published toxic concentration: 150 ppm/104W- intermittentKidney, Ureter, and Bladder: Other changes

Kidney, Ureter, and Bladder: Changes in kidney weight
TOXID9 44,307,2005
inhalation/rat lowest published toxic concentration: 700 ppm/52W- intermittentKidney, Ureter, and Bladder: Other changes

Kidney, Ureter, and Bladder: Changes in kidney weight
TOXID9 44,307,2005
inhalation/rat lowest published toxic concentration: 700 ppm/104W- intermittentReproductive: Maternal effects: Uterus, cervix, vagina

Reproductive: Tumorigenic effects: Uterine tumors

Related to Chronic Data: Changes in uterine weight
TOXID9 44,307,2005
inhalation/rat lowest published toxic concentration: 700 ppm/52W- intermittentOlfaction: Other olfaction effects

Skin: After topical application: Primary irritation
TOXID9 44,307,2005
inhalation/rat lowest published toxic concentration: 700 ppm/13W- intermittentBlood: Changes in other cell count (unspecified)TOXID9 44,307,2005
inhalation/rat lowest published toxic concentration: 150 ppm/52W- intermittentLiver: Changes in liver weightTOXID9 44,307,2005
inhalation/rat lowest published toxic concentration: 700 ppm/3D- intermittentEndocrine: Estrogenic

Related to Chronic Data: Changes in uterine weight
TOXID9 44,357,2005
inhalation/rat lowest published toxic concentration: 700 ppm/6H/3D- intermittentEndocrine: Change in LH

Reproductive: Maternal effects: Oogenesis
TOXID9 66,343,2002
inhalation/rat lowest published toxic concentration: 700 ppm/35D- intermittentEndocrine: Estrogenic

Reproductive: Maternal effects: Oogenesis

Reproductive: Maternal effects: Ovaries, fallopian tubes
TOXID9 90,394,2006
inhalation/rat lowest published toxic concentration: 700 ppm/16H/3D- intermittentEndocrine: Estrogenic

Reproductive: Maternal effects: Uterus, cervix, vagina

Related to Chronic Data: Changes in uterine weight
TOSCF2 96,145,2007
inhalation/rat lowest published toxic dose: 698 ppm/6H/47D- intermittentEndocrine: Changes in adrenal weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
REPTED 23,192,2007
inhalation/rat lowest published toxic dose: 696 ppm/6H/6D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainREPTED 23,192,2007
inhalation/rat lowest published toxic dose: 700 ppm/6H/3D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainREPTED 23,202,2007
inhalation/rat lowest published toxic dose: 500 ppm/6H/16W- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldREPTED 23,202,2007
inhalation/rat lowest published toxic dose: 700 ppm/6H/84D- intermittentBehavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
REPTED 23,202,2007
inhalation/rat lowest published toxic dose: 700 ppm/6H/1W- intermittentKidney, Ureter, and Bladder: Changes in kidney weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
REPTED 23,202,2007
inhalation/rat lowest published toxic dose: 300 ppm/6H/70D- intermittentLiver: Changes in liver weightREPTED 23,202,2007
inhalation/rat lowest published toxic dose: 700 ppm/6H/70D- intermittentEndocrine: Changes in pituitary weightREPTED 23,202,2007
inhalation/rat lowest published toxic dose: 500 ppm/6H/96D- intermittentLiver: Changes in liver weightREPTED 23,202,2007
inhalation/rat lowest published toxic dose: 700 ppm/6H/96D- intermittentLung, Thorax, or Respiration: Other changesREPTED 23,202,2007
inhalation/rat lowest published toxic dose: 696 ppm/6D- intermittentRelated to Chronic Data: Changes in ovarian weightREPTED 23,192,2007
oral/mouse lowest published toxic dose: 750 mg/kg/3D- intermittentEndocrine: Estrogenic

Related to Chronic Data: Changes in uterine weight
TXAPA9 192,254,2003
oral/rat lowest published toxic dose: 4200 mg/kg/14D- intermittentLiver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
TOXID9 72,111,2003

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWFCTOD7 47,1287,2009

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X3232; Number of Industries 8; Total Number of Facilities 128; Number of Occupations 12; Total Number of Employees Exposed 3383; Total Number of Female Employees Exposed 1689

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1996: Volatile organic compound, 2549
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