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Cyclotetrasiloxane, octamethyl -

RTECS #: GZ4397000

CAS #: 556-67-2


UPDATE: February 2009 MW: 296.68 MF: C8H24O4Si4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Cyclic dimethylsiloxane tetramer
  2. D4
  3. KF 994
  4. NUC silicone VS 7207
  5. Octamethylcyclotetrasiloxane
  6. Oktamethylcyklotetrasiloxan (Czech)
  1. SF 1173
  2. Silicone SF 1173
  3. UC 7207
  4. Union carbide 7207
  5. VS 7207


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
500 mg/24 hour mild 85JCAE -,1230,1986
skin
rabbit
500 mg/24 hour mild 85JCAE -,1230,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 500 ppm (70 day male/70 day prior to copulation-3 week after birth) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) TOXID9 54,370,2000
inhalation
rat
lowest published toxic concentration: 301 ppm (28 day prior to copulation/19 day pregnant) Reproductive: Maternal effects: Oogenesis REPTED 23,192,2007
inhalation
rat
lowest published toxic concentration: 503 ppm (28 day prior to copulation/19 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on embryo or fetus: Fetal death
REPTED 23,192,2007
inhalation
rat
lowest published toxic concentration: 698 ppm (28 day prior to copulation/19 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) REPTED 23,192,2007
inhalation
rat
lowest published toxic concentration: 696 ppm (3 day prior to copulation/3 day pregnant) Reproductive: Maternal effects: Oogenesis

Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on embryo or fetus: Fetal death
REPTED 23,192,2007
inhalation
rat
lowest published toxic concentration: 700 ppm (1 day prior to copulation) Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated) REPTED 23,192,2007
inhalation
rat
lowest published toxic concentration: 700 ppm (3 day prior to copulation/3 day pregnant) Reproductive: Maternal effects: Ovaries, fallopian tubes

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
REPTED 23,192,2007
inhalation
rat
lowest published toxic concentration: 700 ppm (70 day male/70 day prior to copulation/4 day after birth) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Specific developmental abnormalities: Urogenital system
REPTED 23,202,2007
inhalation
rat
lowest published toxic concentration: 700 ppm (multigeneration) Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
REPTED 23,202,2007
inhalation
rat
lowest published toxic concentration: 700 ppm (multigeneration) Reproductive: Specific developmental abnormalities: Respiratory system

Reproductive: Effects on newborn: Behavioral
REPTED 23,202,2007
inhalation
rat
lowest published toxic concentration: 700 ppm (70 day male/70 day prior to copulation/1-22 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) REPTED 23,202,2007
inhalation
rat
lowest published toxic concentration: 70 ppm (70 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) REPTED 23,202,2007
inhalation
rat
lowest published toxic concentration: 300 ppm (multigeneration) Reproductive: Specific developmental abnormalities: Hepatobiliary system

Reproductive: Specific developmental abnormalities: Urogenital system
REPTED 23,202,2007
inhalation
rat
lowest published toxic concentration: 500 ppm (70 day male/70 day prior to copulation/4 day after birth) Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) REPTED 23,202,2007


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lethal concentration (50 percent kill): 36 gm/m3/4 hour Behavioral: Excitement

Lung, Thorax, or Respiration: Dyspnea

Skin and Appendages: Other: Hair
NTIS** OTS0557551
inhalation
rat
lowest published toxic concentration: 700 ppm/6 hour Endocrine: Change in gonadotropins TOXID9 44,370,2005
oral
rat
lethal dose (50 percent kill): 1,540 mg/kg Behavioral: Tremor NTIS** OTS0538262
skin
rat
lethal dose (50 percent kill): 1,770 mg/kg Behavioral: Tremor

Gastrointestinal: Changes in structure or function of salivary glands

Liver: Other changes
NTIS** OTS0538262
skin
rabbit
lethal dose (50 percent kill): 794 ÁL/kg Kidney, Ureter, and Bladder: Hematuria NTIS** OTS0538262
unreported route
mouse
lowest published toxic dose: 100 mg/kg Endocrine: Other changes TOXID9 60,384,2001
unreported route
mouse
lowest published toxic dose: 250 mg/kg Reproductive: Maternal effects: Uterus, cervix, vagina TOXID9 60,384,2001
unreported route
mouse
lowest published toxic dose: 1,000 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases TOXID9 60,384,2001


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
hamster
lowest published toxic concentration: 697 ppm/6 hour/28 day- intermittent Liver: Changes in liver weight NTIS** OTS0516677
inhalation
mouse
lowest published toxic concentration: 697 ppm/6 hour/28 day- intermittent Liver: Changes in liver weight NTIS** OTS0516677
inhalation
rat
lowest published toxic concentration: 300 ppm/6 hour/13 week- intermittent Liver: Changes in liver weight NTIS** OTS0530406
inhalation
rat
lowest published toxic concentration: 700 ppm/6 hour/4 week- intermittent Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)
NTIS** OTS0573657
inhalation
rat
lowest published toxic dose: 70 ppm/6 hour/4 week- intermittent Liver: Other changes

Liver: Changes in liver weight

Endocrine: Changes in thyroid weight
TXAPA9 172,83,2001
inhalation
rat
lowest published toxic concentration: 35 ppm/6 hour/91 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
IJTOFN 21,39,2002
inhalation
rat
lowest published toxic concentration: 488 ppm/6 hour/91 day- intermittent Lung, Thorax, or Respiration: Other changes

Blood: Normocytic anemia

Related to Chronic Data: Changes in testicular weight
IJTOFN 21,39,2002
inhalation
rat
lowest published toxic concentration: 488 ppm/6 hour/91 day- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Endocrine: Changes in thymus weight
IJTOFN 21,39,2002
inhalation
rat
lowest published toxic concentration: 898 ppm/6 hour/91 day- intermittent Lung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Biochemical: Metabolism (intermediary): Lipids including transport
IJTOFN 21,39,2002
inhalation
rat
lowest published toxic concentration: 898 ppm/6 hour/91 day- intermittent Endocrine: Changes in adrenal weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field

Related to Chronic Data: Changes in ovarian weight
IJTOFN 21,39,2002
inhalation
rat
lowest published toxic concentration: 700 ppm/104 week- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Other changes

Kidney, Ureter, and Bladder: Changes in kidney weight
TOXID9 44,307,2005
inhalation
rat
lowest published toxic concentration: 700 ppm/104 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TOXID9 44,307,2005
inhalation
rat
lowest published toxic concentration: 700 ppm/52 week- intermittent Liver: Other changes TOXID9 44,307,2005
inhalation
rat
lowest published toxic concentration: 30 ppm/26 week- intermittent Liver: Changes in liver weight TOXID9 44,307,2005
inhalation
rat
lowest published toxic concentration: 150 ppm/104 week- intermittent Kidney, Ureter, and Bladder: Other changes

Kidney, Ureter, and Bladder: Changes in kidney weight
TOXID9 44,307,2005
inhalation
rat
lowest published toxic concentration: 700 ppm/52 week- intermittent Kidney, Ureter, and Bladder: Other changes

Kidney, Ureter, and Bladder: Changes in kidney weight
TOXID9 44,307,2005
inhalation
rat
lowest published toxic concentration: 700 ppm/104 week- intermittent Reproductive: Maternal effects: Uterus, cervix, vagina

Reproductive: Tumorigenic effects: Uterine tumors

Related to Chronic Data: Changes in uterine weight
TOXID9 44,307,2005
inhalation
rat
lowest published toxic concentration: 700 ppm/52 week- intermittent Olfaction: Other olfaction effects

Skin: After topical application: Primary irritation
TOXID9 44,307,2005
inhalation
rat
lowest published toxic concentration: 700 ppm/13 week- intermittent Blood: Changes in other cell count (unspecified) TOXID9 44,307,2005
inhalation
rat
lowest published toxic concentration: 150 ppm/52 week- intermittent Liver: Changes in liver weight TOXID9 44,307,2005
inhalation
rat
lowest published toxic concentration: 700 ppm/3 day- intermittent Endocrine: Estrogenic

Related to Chronic Data: Changes in uterine weight
TOXID9 44,357,2005
inhalation
rat
lowest published toxic concentration: 700 ppm/6 hour/3 day- intermittent Endocrine: Change in LH

Reproductive: Maternal effects: Oogenesis
TOXID9 66,343,2002
inhalation
rat
lowest published toxic concentration: 700 ppm/35 day- intermittent Endocrine: Estrogenic

Reproductive: Maternal effects: Oogenesis

Reproductive: Maternal effects: Ovaries, fallopian tubes
TOXID9 90,394,2006
inhalation
rat
lowest published toxic concentration: 700 ppm/16 hour/3 day- intermittent Endocrine: Estrogenic

Reproductive: Maternal effects: Uterus, cervix, vagina

Related to Chronic Data: Changes in uterine weight
TOSCF2 96,145,2007
inhalation
rat
lowest published toxic dose: 698 ppm/6 hour/47 day- intermittent Endocrine: Changes in adrenal weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
REPTED 23,192,2007
inhalation
rat
lowest published toxic dose: 696 ppm/6 hour/6 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain REPTED 23,192,2007
inhalation
rat
lowest published toxic dose: 700 ppm/6 hour/3 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain REPTED 23,202,2007
inhalation
rat
lowest published toxic dose: 500 ppm/6 hour/16 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field REPTED 23,202,2007
inhalation
rat
lowest published toxic dose: 700 ppm/6 hour/84 day- intermittent Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
REPTED 23,202,2007
inhalation
rat
lowest published toxic dose: 700 ppm/6 hour/1 week- intermittent Kidney, Ureter, and Bladder: Changes in kidney weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
REPTED 23,202,2007
inhalation
rat
lowest published toxic dose: 300 ppm/6 hour/70 day- intermittent Liver: Changes in liver weight REPTED 23,202,2007
inhalation
rat
lowest published toxic dose: 700 ppm/6 hour/70 day- intermittent Endocrine: Changes in pituitary weight REPTED 23,202,2007
inhalation
rat
lowest published toxic dose: 500 ppm/6 hour/96 day- intermittent Liver: Changes in liver weight REPTED 23,202,2007
inhalation
rat
lowest published toxic dose: 700 ppm/6 hour/96 day- intermittent Lung, Thorax, or Respiration: Other changes REPTED 23,202,2007
inhalation
rat
lowest published toxic dose: 696 ppm/6 day- intermittent Related to Chronic Data: Changes in ovarian weight REPTED 23,192,2007
oral
mouse
lowest published toxic dose: 750 mg/kg/3 day- intermittent Endocrine: Estrogenic

Related to Chronic Data: Changes in uterine weight
TXAPA9 192,254,2003
oral
rat
lowest published toxic dose: 4,200 mg/kg/14 day- intermittent Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
TOXID9 72,111,2003


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X3232;
Number of Industries 8;
Total Number of Facilities 128;
Number of Occupations 12;
Total Number of Employees Exposed 3,383;
Total Number of Female Employees Exposed 1,689


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1996: Volatile organic compound, 2549


REFERENCES:

CODEN
REFERENCE

85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
IJTOFN International Journal of Toxicology. (Taylor & Francis, 47 Runway Rd., Suite g, Levittown, PA 19057) V.16- 1997-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

RTECS Compound Description:
   Reproductive Effector
   Primary Irritant

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