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Cyclopropanecarboxylic acid, 2,2 - dimethyl - 3 - (2 - methyl - 1 - propenyl) - , 2 - methyl - 4 - oxo - 3 - (2 - propenyl) - 2 - cyclopenten - 1 - yl ester

RTECS #: GZ1925000

CAS #: 584-79-2


UPDATE: May 2009 MW: 302.45 MF: C19H26O3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. (+) - Allelrethonyl (+) - cis,trans - chrysanthemate
  2. 3 - Allyl - 2 - methyl - 4 - oxo - 2 - cyclopenten - 1 - yl chrysanthemate
  3. 3 - Allyl - 4 - keto - 2 - methylcyclopentenyl chrysanthemummonocarboxylate
  4. Allethrin I
  5. Allethrin coil
  6. Allyl cinerin I
  7. Allylrethronyl dl - cis - trans - chrysanthemate
  8. Binamin forte
  9. Bioallethrin
  10. Bioaltrina (Portuguese)
  11. Chrysanthemummonocarboxylic acid, 3 - allyl - 2 - methyl - 4 - oxo - 2 - cyclopenten - 1 - yl ester (6CI)
  12. Depallethrin
  13. ENT 17,510
  14. Exthrin
  1. FDA 1446
  2. FMC 249
  3. NIA 249
  4. Necarboxylic acid
  5. OMS 468
  6. Pallethrine
  7. Pynamin - forte
  8. Pyresyn
  9. Wasp Stopper CF
  10. d,l - 2 - Allyl - 4 - hydroxy - 3 - methyl - 2 - cyclopenten - 1 - one - d,l - chrysanthemum monocarboxylate
  11. d - Allethrin
  12. d - trans Allethrin
  13. dl - 3 - Allyl - 2 - methyl - 4 - oxocyclopent - 2 - enyl dl - cis trans chrysanthemate


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis hamster lung 1,900 g/L MUREAV 66,277,1979
mutation in microorganisms Salmonella typhimurium 500 g/plate (-enzymatic activation step) MUREAV 116,185,1983


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intracerebral
mouse
lowest published lethal dose: 4 mg/kg N/R TXAPA9 66,290,1982
inhalation
mouse
lethal concentration (50 percent kill): >2 gm/m3 N/R YKYUA6 37,187,1986
inhalation
rat
lowest published lethal concentration: 13,800 mg/m3/4 hour Behavioral: Tremor

Behavioral: Excitement
AMIHBC 2,420,1950
intraperitoneal
mouse
lethal dose (50 percent kill): 38 mg/kg N/R JAFCAU 31,250,1983
intraperitoneal
rat
lowest published toxic dose: 10 mg/kg Brain and Coverings: Other degenerative changes

Biochemical: Metabolism (intermediary): Other
TOXID9 44,402,2005
intraperitoneal
rat
lowest published toxic dose: 60 mg/kg Behavioral: Tremor

Gastrointestinal: Hypermotility, diarrhea
TXCYAC 243,155,2008
intraperitoneal
rat
lowest published toxic dose: 10 mg/kg Brain and Coverings: Other degenerative changes TXCYAC 243,155,2008
intraperitoneal
rabbit
lethal dose (50 percent kill): 11,200 mg/kg N/R WRPCA2 3,28,1964
intravenous
rat
lowest published lethal dose: 4 mg/kg Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Aggression
PCBPBS 2,308,1972
oral
mouse
lethal dose (50 percent kill): 370 mg/kg N/R ABCHA6 28,914,1965
oral
mouse
lowest published toxic dose: 0.7 mg/kg Behavioral: Alteration of classical conditioning TOXID9 44,199,2005
oral
quail
lethal dose (50 percent kill): 2,030 mg/kg N/R PEMNDP 9,19,1991
oral
rat
lethal dose (50 percent kill): 685 mg/kg N/R FMCHA2 -,C255,1991
oral
rabbit
lethal dose (50 percent kill): 4,290 mg/kg N/R SPEADM 78-1,7,1978
skin
mouse
lethal dose (50 percent kill): 1,200 mg/kg N/R ABCHA6 27,684,1963
skin
rat
lethal dose (50 percent kill): 2,500 mg/kg N/R YKYUA6 37,187,1986
skin
rabbit
lethal dose (50 percent kill): 11,332 mg/kg Behavioral: Tremor

Behavioral: Excitement
AMIHBC 2,420,1950
unreported route
rat
lethal dose (50 percent kill): 680 mg/kg N/R 30ZDA9 -,131,1971


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 3.6 pph/90 day- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Reproductive: Paternal effects: Testes, epididymis, sperm duct
JTSCDR 31,1,2006
inhalation
rat
lowest published toxic concentration: 3.6 pph/90 day- intermittent Behavioral: Somnolence (general depressed activity)

Liver: Changes in liver weight

Endocrine: Changes in thyroid weight
JTSCDR 31,1,2006
oral
rat
lowest published toxic dose: 21 gm/kg/12 week- intermittent Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Metabolism (intermediary): Other proteins
BOCKAF 35,103,1970
unreported route
mouse
lowest published toxic dose: 5.04 mg/kg/7 day- intermittent Brain and Coverings: Other degenerative changes HBPTO* 1,880,2001


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
JTCTDW 38,103,2000
TOXICOLOGY REVIEW
TOXIA6 49,452,2007
TOXICOLOGY REVIEW
HUTOX* -,541,1996
TOXICOLOGY REVIEW
NETEEC 30,55,2008


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Occupational Exposure Limit - RUSSIA short term exposure limit 1 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X2264;
Number of Industries 2;
Total Number of Facilities 202;
Number of Occupations 2;
Total Number of Employees Exposed 1,366


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast; S cerevisiae-homozygosis
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE

30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971
ABCHA6 Agricultural and Biological Chemistry. (Maruzen Co. Ltd., POB 5050, Tokyo International, Tokyo 100-31, Japan) V.25- 1961-
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
BOCKAF Bochu Kagaku. Scientific Pest Control. (Kyoto, Japan) V.1-42, 1937-77. Discontinued.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094)
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
HUTOX*
JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953-
JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.19- 1982-
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987-
PCBPBS Pesticide Biochemistry and Physiology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1971-
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968-
SPEADM Special Publication of the Entomological Society of America. (4603 Calvert Rd., College Park, MD 20740)
TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
WRPCA2 World Review of Pest Control. (London, UK) V.1-10, 1962-71. Discontinued.
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950-

Used as an insecticide

RTECS Compound Description:
   Agricultural Chemical
   Mutagen

ALT CAS #: 137-98-4
ALT CAS #: 8018-12-0
ALT CAS #: 18877-88-8
ALT CAS #: 71119-51-2
ALT CAS #: 71211-88-6
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