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Registry of Toxic Effects of Chemical Substances (RTECS)

Cyclopropanecarboxylic acid, 3-(2,2-dichloroethenyl)-2,2-dimethyl-, cyano(3-phenoxyphenyl)methyl ester

RTECS #

GZ1250000

CAS #

52315-07-8; 69865-47-0; 86752-99-0; 86753-92-6; 88161-75-5; 97955-44-7; 137497-61-1; 139203-31-9; 142443-95-6; 146909-55-9; 186554-45-0

Updated

September 201

Molecular Weight

416.32

Molecular Formula

C22H19Cl2NO3

Synonyms

(+-)-alpha-Cyano-3-phenoxybenzyl 2,2-dimethyl-3-(2,2-dichlorovinyl)cyclopropane carboxylate
(1R,alpha-S)-cis-Cypermethrin
Agrothrin
Ambush C
Ammo (pesticide)
Antiborer 3767
Ardap
Barricade (insecticide)
Basathrin
beta-Cypermethrin
CCN 52
Chinmix
Cybil
Cymbush
Cyperkill
Cypermethrin
Cypermethrin technical
Cypermethrin-25EC
Cypermetryna (Polish)
Cypor
Ectopor
EXP 5598
Fendona
Flectron
FMC 30980
FMC 45497
FMC 45806
Hilcyperin
JF 5705F
Kordon
NRDC 149
NRDC 160
NRDC 166
Nurele
Polytrin
Ripcord
RU 27998
SF 06646
Sherpa
Supercypermethrin
Supercypermethrin forte
Supermethrin
Vucht 424
WL 43467
WL 8517
YT 305
Zeta-cypermethrin

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysissubcutaneous/mouse50 mg/kgTOLED5 41,223,1988
Cytogenetic Analysisunreported route/mouse10 mg/kgTGANAK 18,455,1984
Cytogenetic Analysisintraperitoneal/mouse50 mg/kgTOLED5 41,223,1988
Cytogenetic Analysisoral/mouse2 mg/kgMUREAV 587,120,2005
DNA adductliver/mouse0.78 mg/L/4HMUREAV 604,36,2006
DNA Damageliver/mouse0.78 mg/L/4HMUREAV 604,36,2006
DNA Damageoral/Drosophila melanogaster0.002 ppm/74H-continuousMUTAEX 19,85,2004
DNA inhibitionleukocyte/mouse13 mmol/LDCTODJ 10,291,1987
DNA inhibitionlymphocyte/human67 µmol/LDCTODJ 10,291,1987
micronucleus testintraperitoneal/mouse60 mg/kg/24H-continuousTOLED5 41,223,1988
micronucleus testoral/mouse756 mg/kg/7D-continuousMUREAV 155,135,1985
micronucleus testskin/mouse2520 mg/kg/7D-continuousMUREAV 155,135,1985
micronucleus testlymphocyte/human200 mg/LMUREAV 341,169,1995
micronucleus testoral/mouse2 mg/kgMUREAV 587,120,2005
micronucleus testlung/hamster1 mg/LCYGEDX 22(4),36,1988
mutation in microorganisms/Saccharomyes cerevisiae500 ppm (-enzymatic activation step)MUREAV 280,161,1992
sex chromosome loss and nondisjunctionoral/Drosophila melanogaster25 ppmMUTAEX 1,343,1986
sex chromosome loss and nondisjunctionparenteral/Drosophila melanogaster10 ppmMUTAEX 1,343,1986
sister chromatid exchangeintraperitoneal/mouse5 mg/kgMOCAT* 18,53,2003
sperm morphologyintraperitoneal/mouse30 mg/kg/4D-continuousTOLED5 41,223,1988

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse 30 mg/kg (1-4D male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)TOLED5 41,223,1988
oral/rat 500 mg/kg (7-16D pregnant)Reproductive: Effects on newborn: Other postnatal measures or effectsTXCYAC 125,67,1998
oral/rat 500 mg/kg (7-16D pregnant)Reproductive: Specific developmental abnormalities: Blood and lymphatic systems (including spleen and marrow)

Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial system
TXCYAC 120,231,1997
oral/rat 4.4 gm/kg (12W male)Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)

Reproductive: Other effects to embryo or fetus
AECTCV 41,522,2001
oral/rat 6.4 gm/kg (12W male)Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)

Reproductive: Other effects to embryo or fetus
AECTCV 41,522,2001
oral/rat 6361 mg/kg (84D male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
AECTCV 41,522,2001
oral/rat 25 mg/kg (multigeneration)Reproductive: Other effects on male

Reproductive: Other effects on female
FEREAC 68,42030,2003
oral/rat 3306 mg/kg (60D male)Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)
FCTOD7 48,3153,2010
oral/rat 551 mg/kg (6-15D pregnant)Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
FCTOD7 48,3153,2010
oral/rat 551 mg/kg (6-15D pregnant)Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Respiratory system

Reproductive: Specific developmental abnormalities: Urogenital system
FCTOD7 48,3153,2010
oral/rat 3857 mg/kg (60D male/6-15D pregnant)Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
FCTOD7 48,3153,2010
oral/rat 3857 mg/kg (60D male/6-15D pregnant)Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Eye, ear

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)
FCTOD7 48,3153,2010
oral/rat 3857 mg/kg (60D male/6-15D pregnant)Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system

Reproductive: Specific developmental abnormalities: Respiratory system

Reproductive: Specific developmental abnormalities: Urogenital system
FCTOD7 48,3153,2010
oral/rat 3857 mg/kg (60D male/6-15D pregnant)Reproductive: Other developmental abnormalitiesFCTOD7 48,3153,2010
subcutaneous/rat 0.25 mg/kg (multigenerations)Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Delayed effects
HBPTO* 1,735,2001
subcutaneous/rat 1.75 mg/kg (16-22D pregnant)Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
NRTXDN 16,763,1995
unreported route/rat 400 mg/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)GISAAA 49(10),70,1984
unreported route/mammal (species unspecified) 27 mg/kg (multigenerations)Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)FEREAC 66,47983,2001

Tumorigenic Data and References

Route/OrganismDoseEffectReference
skin/mouse lowest published toxic dose: 780 mg/kg/52W- intermittentTumorigenic: Neoplastic by RTECS criteria

Skin and Appendages: Tumors
CALEDQ 182,1,2002
skin/mouse lowest published toxic dose: 960 mg/kg/32W- intermittentTumorigenic: Neoplastic by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Facilitates action of known carcinogens
CALEDQ 182,33,2002

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Hamster, ovary Inhibitor Concentration (50 percent kill): >1 mmol/L/3HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 21,1409,2007
inhalation/rat lethal concentration (50 percent kill): 2.5 gm/m3/4HFEREAC 66,47981,2001
inhalation/rat lethal concentration (50 percent kill): 7889 mg/m3/4HDEVEAA 39(236),3,1985
intraperitoneal/mouse lethal dose (50 percent kill): 25 mg/kgINJPD2 22,42,1990
intraperitoneal/mouse lowest published toxic dose: 17 mg/kgBehavioral: Change in motor activity (specific assay)

Behavioral: Alteration of classical conditioning

Gastrointestinal: Changes in structure or function of salivary glands
PHREP* 60,699,2008
intraperitoneal/mouse lethal dose (70 percent kill): 35 mg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Respiratory obstruction
VHTODE 42,303,2000
intraperitoneal/rat lowest published toxic dose: 58 mg/kgBrain and Coverings: Changes in surface EEGVHTODE 42,303,2000
intraperitoneal/rat lethal dose (50 percent kill): 404 mg/kgBehavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement
WDZAEK 3,184,1989
intraperitoneal/rat lowest published toxic dose: 300 mg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Gastrointestinal: Changes in structure or function of salivary glands
TOLED5 125,107,2001
intraperitoneal/rat lethal dose (50 percent kill): 43 mg/kgVHTODE 42,303,2000
intravenous/rat lowest published lethal dose: 6 mg/kgBehavioral: Tremor

Behavioral: Change in motor activity (specific assay)

Behavioral: Muscle contraction or spasticity
ARTODN 45,325,1980
oral/chicken lethal dose (50 percent kill): 7 gm/kgBehavioral: Tremor

Behavioral: Irritability

Gastrointestinal: Changes in structure or function of salivary glands
JJATDK 7,367,1987
oral/guinea pig lethal dose (50 percent kill): 500 mg/kgDEVEAA 34,3,1980
oral/hamster lethal dose (50 percent kill): 400 mg/kgDEVEAA 34,3,1980
oral/mammal (species unspecified) lethal dose (50 percent kill): 247 mg/kgBehavioral: AtaxiaFEREAC 66,47981,2001
oral/mouse lethal dose (50 percent kill): 24570 µg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Changes in structure or function of salivary glands
JEBIDP 11,331,1990
oral/rabbit lethal dose (50 percent kill): 1500 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Changes in structure or function of salivary glands
JEBIDP 11,331,1990
oral/rat lethal dose (50 percent kill): 57500 µg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Changes in structure or function of salivary glands
JEBIDP 11,331,1990
oral/rat lowest published toxic dose: 129 mg/kgBlood: Microcytosis with or without anemia

Blood: Changes in erythrocyte (RBC) count

Blood: Changes in leukocyte (WBC) count
BECTA6 70,839,2003
oral/rat lowest published lethal dose: 643 mg/kgBECTA6 70,839,2003
oral/rat lowest published toxic dose: 83 mg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseTOVEFN (3),15,1993
oral/rat lowest published toxic dose: 10.7 mg/kgBrain and Coverings: Other degenerative changesTOXID9 12,468,2008
oral/rat lethal dose (50 percent kill): 86.0 mg/kgFEREAC 66,47981,2001
oral/rat lowest published lethal dose: 55.7 mg/kgBlood: Normocytic anemia

Blood: Luekopenia
FEREAC 66,47981,2001
skin/mammal (species unspecified) lethal dose (50 percent kill): 2355 mg/kgGISAAA 56(4),83,1991
skin/rabbit lethal dose (50 percent kill): >2400 mg/kgPEMNDP 9,208,1991
skin/rabbit lethal dose (50 percent kill): 2460 mg/kgEye: Lacrimation

Behavioral: Tremor
FEREAC 66,47981,2001
skin/rat lethal dose (50 percent kill): >1600 mg/kg85JFAN A110,1984
unreported route/chicken lethal dose (50 percent kill): 2 gm/kgDEVEAA 34,3,1980
unreported route/domestic bird lethal dose (50 percent kill): 3 gm/kgDEVEAA 34,3,1980
unreported route/rat lethal dose (50 percent kill): 400 mg/kgGISAAA 49(10),70,1984
unreported route/rat lowest published toxic dose: 50 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FEREAC 66,47984,2001
unreported route/rat lowest published toxic dose: 26.3 mg/kgBehavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FEREAC 66,47985,2001

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 300 µg/m3/24H/13W- continuousBlood: Other changes

Immunological Including Allergic: Decreased immune response

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
GISAAA 55(2),20,1990
intraperitoneal/mouse lowest published toxic dose: 130 mg/kg/26D- intermittentImmunological Including Allergic: Hypersensitivity delayed (multiple organ involvement)HBPTO* 1,777,2001
intraperitoneal/rat lowest published toxic dose: 2100 mg/kg /7D- intermittentLiver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOLED5 125,107,2001
intraperitoneal/rat lowest published toxic dose: 900 mg/kg /3D- intermittentBehavioral: Muscle weakness

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TOLED5 125,107,2001
intraperitoneal/rat lowest published toxic dose: 1500 mg/kg/5D- intermittentLiver: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport
TOLED5 125,107,2001
oral/chicken lowest published toxic dose: 69993 µg/kg/21D- intermittentEndocrine: Hypoglycemia

Blood: Change in clotting factors

Blood: Other changes
JJATDK 7,367,1987
oral/mouse lowest published toxic dose: 169680 mg/kg/101W- continuousLung, Thorax, or Respiration: TumorsHBPTO* 1,814,2001
oral/quail lowest published toxic dose: 1157 mg/kg/7D- continuousGastrointestinal: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)
BECTA6 31,479,1983
oral/rabbit lowest published toxic dose: 6300 mg/kg/6W- intermittentImmunological Including Allergic: Decrease in cellular immune response

Immunological Including Allergic: Decrease in humoral immune response
ATSUDG 8,305,1985
oral/rabbit lowest published toxic dose: 1008 mg/kg/12W- intermittentEndocrine: Hyperglycemia

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Lipids including transport
TXCYAC 189,223,2003
oral/rat lowest published toxic dose: 1500 mg/kg/60D- intermittentLiver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Biochemical: Metabolism (intermediary): Lipids including transport
TXCYAC 191,233,2003
oral/rat lowest published toxic dose: 42.98 mg/kg/7D- intermittentBlood: Microcytosis with or without anemia

Blood: Changes in erythrocyte (RBC) count
BECTA6 70,839,2003
oral/rat lowest published toxic dose: 85.96 mg/kg/14D- intermittentBlood: Microcytosis with or without anemia

Blood: Changes in erythrocyte (RBC) count

Blood: Changes in leukocyte (WBC) count
BECTA6 70,839,2003
oral/rat lowest published toxic dose: 20000 mg/kg/40D- continuousGastrointestinal: Hypermotility, diarrhea

Liver: Changes in liver weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
TOXIA6 53,33,2009
oral/rat lowest published toxic dose: 10000 mg/kg/20D- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainTOXIA6 53,33,2009
oral/rat lowest published toxic dose: 5000 mg/kg/10D- continuousLiver: Other changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Changes in kidney weight
TOXIA6 53,33,2009
oral/rat lowest published toxic dose: 56 mg/kg/8W- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainTOXID9 -,245,2009
oral/rat lowest published toxic dose: 21 mg/kg/3W- intermittentEndocrine: Other changesTOXID9 -,245,2009
oral/rat lowest published toxic dose: 336 mg/kg/8W- intermittentEndocrine: Evidence of thyroid hypofunctionTOXID9 -,245,2009
oral/rat lowest published toxic dose: 350 mg/kg/7D- continuousReproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands

Related to Chronic Data: Changes in prostate weight
REPTED 25,491,2008
oral/rat lowest published toxic dose: 1.55 gm/kg/4W- intermittentImmunological Including Allergic: Decrease in cellular immune response

Immunological Including Allergic: Decrease in humoral immune response
TXCYAC 172,59,2002
oral/rat lowest published toxic dose: 750 mg/kg/60D- intermittentBlood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases

Biochemical: Metabolism (intermediary): Lipids including transport
TXCYAC 175,91,2002
oral/rat lowest published toxic dose: 1512 mg/kg/28D- continuousBehavioral: Convulsions or effect on seizure threshold

Behavioral: Change in motor activity (specific assay)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0539722
oral/rat lowest published toxic dose: 2275 mg/kg/13W- intermittentImmunological Including Allergic: Decrease in cellular immune response

Immunological Including Allergic: Decrease in humoral immune response
ATSUDG 8,305,1985
oral/rat lowest published toxic dose: 1050 mg/kg/7D- intermittentPeripheral Nerve and Sensation: Recording from peripheral motor nerve

Behavioral: Muscle weakness

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
ARTODN 53,297,1983
oral/rat lowest published toxic dose: 1500 mg/kg/30D- intermittentKidney, Ureter, and Bladder: Urine volume increased

Kidney, Ureter, and Bladder: Proteinuria
BCTKAG 21,146,1988
skin/domestic animal lowest published toxic dose: 1248 mg/kg/30D- intermittentImmunological Including Allergic: Hypersensitivity delayed (multiple organ involvement)HBPTO* 1,777,2001
skin/domestic animal lowest published toxic dose: 0.1 pph/16D- continuousLiver: Other changes

Blood: Change in clotting factors

Blood: Changes in erythrocyte (RBC) count
ETPAEK 61,151,2009
skin/domestic animal lowest published toxic dose: 0.4 pph/16D- continuousCardiac: Other changes

Lung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
ETPAEK 61,151,2009
skin/domestic animal lowest published toxic dose: 0.8 pph/16D- continuousLiver: Hepatitis (hepatocellular necrosis), diffuse

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Hemorrhage
ETPAEK 61,151,2009
skin/domestic animal lowest published toxic dose: 0.1 pph/16D- continuousReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
ETPAEK 61,339,2009
skin/guinea pig lowest published toxic dose: 0.59 gm/kg/21D- intermittentSkin: After topical application: Cutaneous sensitization (experimental)JAPTO* 21,257,2001
skin/mouse lowest published toxic dose: 125 mg/kg/5D- intermittentImmunological Including Allergic: Increase in humoral response

Tumorigenic: Cells (cultured) transformed
JAPTO* 21,257,2001

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWJTCTDW 38,103,2000
TOXICOLOGY REVIEWTOLED5 142,207,2003
TOXICOLOGY REVIEWMUTAEX 21,93,2006
TOXICOLOGY REVIEWENTOX* -,714,2005
TOXICOLOGY REVIEWFEREAC 72,53455,2007
TOXICOLOGY REVIEWFEREAC 73,1517,2008
TOXICOLOGY REVIEWJTPAE7 19,1,2006
TOXICOLOGY REVIEWITODC* -,327,2004
TOXICOLOGY REVIEWHUTOX* -,541,1996
TOXICOLOGY REVIEWNETEEC 30,55,2008
TOXICOLOGY REVIEWMUREAV 675,1,2009
TOXICOLOGY REVIEWMUREAV 721,27,2011
TOXICOLOGY REVIEWMUREAV 743-744,151,2013

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.5 mg/m3, JUN2003

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast; S cerevisiae-homozygosis
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9085;8EHQ-0892-9309
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9157;8EHQ-0892-9069
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9310
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database
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