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Registry of Toxic Effects of Chemical Substances (RTECS)

Cyclopropanecarboxylic acid, 3-(2,2-dibromoethenyl)-2,2-dimethyl-, cyano(3-phenoxyphenyl)methyl ester, (1R-(1-alpha(S*),3-alpha))-

RTECS #

GZ1233000

CAS #

52918-63-5; 55700-96-4; 62229-77-0

Updated

December 2013

Molecular Weight

505.24

Molecular Formula

C22H19Br2NO3

Synonyms

Butox
Cislin
Crackdown
Decamethrin
Decamethrine
Decis
Dekametrin (Hungarian)
Deltagran
Deltamethrin
Deltamethrine
Deltametryna (Polish)
FMC 45498
K-Othrin
K-Othrine
NRDC 161
OMS 1988
RU 22974
RUP 987

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 100 µL/24HNTIS** OTS0545196

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysismultiple/other fish100 nL/LJFIBA9 26,13,1985
Cytogenetic Analysisintraperitoneal/rat11200 µg/kgMUREAV 311,133,1994
Cytogenetic Analysissubcutaneous/rat11200 µg/kgMUREAV 311,133,1994
Cytogenetic Analysisoral/rat11200 µg/kgMUREAV 311,133,1994
Cytogenetic Analysislymphocyte/human10 µmol/L/48HEMMUEG 48,636,2007
Cytogenetic Analysisoral/mouse6.6 mg/kgEMMUEG 48,636,2007
Cytogenetic Analysisoral/rat140 mg/kg/4W- intermittentFCTOD7 50,3421,2012
DNA Damageoral/rat140 mg/kg/4W- intermittentFCTOD7 50,3421,2012
DNA inhibitionleukocyte/mouse500 µmol/LDCTODJ 10,291,1987
DNA inhibitionlymphocyte/human110 µmol/LDCTODJ 10,291,1987
Dominant Lethal Testoral/mouse10080 µg/kg/2W-continuousMUREAV 467,119,2000
micronucleus testlymphocyte/human5 µmol/L/48HEMMUEG 48,636,2007
micronucleus testintraperitoneal/mouse325 mg/kg/24H-continuousMUREAV 346,203,1995
micronucleus testlymphocyte/human100 mg/LMUREAV 341,169,1995
micronucleus testintraperitoneal/rat5600 µg/kgMUREAV 311,133,1994
other mutation test systemsintraperitoneal/rat5600 µg/kgMUREAV 311,133,1994
other mutation test systemssubcutaneous/rat5600 µg/kgMUREAV 311,133,1994
other mutation test systemsoral/rat5600 µg/kgMUREAV 311,133,1994
sister chromatid exchangelymphocyte/human60 mg/LMUREAV 283,113,1992

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat 21 mg/kg (21D male)Reproductive: Other effects on maleTXCYAC 132,1,1999
oral/mouse 30 mg/kg (7-16D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemJEPTDQ 2(3),751,1979
oral/mouse 50 mg/kg (8-12D pregnant)Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)
TCMUD8 7,7,1987
oral/rat 0.8 mg/kg (6-15D pregnant)Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Behavioral
NETEEC 23,665,2001
oral/rat 168 mg/kg (1-21D preg/21D after birth)Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Delayed effects
RTOPDW 36,310,2002
oral/mouse 57 mg/kg (2W pre-21D after birth)Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Effects on newborn: Biochemical and metabolic
TOXID9 78,379,2004
oral/rat 450 mg/kg (30D male)Reproductive: Paternal effects: Testes, epididymis, sperm ductINJPD2 37,160,2005
oral/rat 8.5 mg/kg (5-21D pregnant)Reproductive: Specific developmental abnormalities: Hepatobiliary system

Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Behavioral
EJPHAZ 544,58,2006
oral/rat 4.25 mg/kg (5-21D pregnant)Reproductive: Effects on newborn: Biochemical and metabolicTXAPA9 214,279,2006
oral/rat 70 mg/kg (7-20D pregnant)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)JEPTDQ 2(3),751,1979
oral/rat 10 mg/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)DTTIAF 100,142,1992
oral/rat 21 mg/kg (1-21D pregnant)Reproductive: Effects on newborn: Biochemical and metabolicTOXID9 -,351,2009
oral/rat 28 mg/kg (1-7D pregnant)Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on embryo or fetus: Maternal- fetal exchange
FCTOD7 49,2541,2011
subcutaneous/mouse 10 mg/kg (13D pregnant)Reproductive: Other developmental abnormalities

Reproductive: Effects on newborn: Behavioral
TOXID9 78,378,2004
unreported route/mouse 63 mg/kg (1-21D pregnant)Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Delayed effects
NETEEC 31,242,2009
unreported route/mouse 126 mg/kg (21D preg/21D after birth)Reproductive: Effects on newborn: BehavioralTOXID9 12,467,2008
unreported route/mouse 42 mg/kg (1D preg-21D after birth)Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Behavioral

Reproductive: Effects on newborn: Delayed effects
TOXID9 -,37,2009
unreported route/mouse 4.2 mg/kg (1D preg-21D after birth)Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Behavioral
TOXID9 44,199,2005

Tumorigenic Data and References

Route/OrganismDoseEffectReference
skin/mouse lowest published toxic dose: 384 mg/kg/32W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application
TXCYAC 163,1,2001

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mammal (species unspecified) lethal concentration (50 percent kill): 2.2 gm/m3/4HFEREAC 63,45408,1998
inhalation/rat lethal concentration (50 percent kill): 785 mg/m3/2HBehavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Changes in structure or function of salivary glands
JEPTDQ 2(3),751,1979
intracerebral/mouse lethal dose (50 percent kill): 26100 µg/kgPCBPBS 24,200,1985
intraperitoneal/mouse lethal dose (50 percent kill): 10 mg/kgEVHPAZ 21,285,1977
intraperitoneal/rat lowest published toxic dose: 60 mg/kgEye: Lacrimation

Behavioral: Excitement

Gastrointestinal: Changes in structure or function of salivary glands
TXCYAC 243,155,2008
intraperitoneal/rat lowest published toxic dose: 20 mg/kgBrain and Coverings: Other degenerative changesTXCYAC 243,155,2008
intraperitoneal/rat lowest published toxic dose: 10 mg/kgBrain and Coverings: Other degenerative changes

Biochemical: Metabolism (intermediary): Other
TOXID9 44,402,2005
intravenous/Dog lethal dose (50 percent kill): 3440 µg/kgBehavioral: Tremor

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Changes in structure or function of salivary glands
IJTEDP 6,127,1984
intravenous/rabbit lethal dose (50 percent kill): 1350 mg/kgNAYXEW 10,115,1990
intravenous/rat lowest published toxic dose: 0.05 mg/kgEndocrine: Adrenal cortex hyperplasiaTXCYAC 49,263,1988
intravenous/rat lowest published toxic dose: 0.15 mg/kgBehavioral: Alteration of classical conditioning

Biochemical: Neurotransmitters or modulators (putative): Catecholamine levels in CNS
TXCYAC 49,263,1988
intravenous/rat lowest published toxic dose: 2 mg/kgBehavioral: Tremor

Gastrointestinal: Changes in structure or function of salivary glands
TXCYAC 234,194,2007
intravenous/rat lethal dose (50 percent kill): 2526 µg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Gastrointestinal: Changes in structure or function of salivary glands
PCBPBS 30,79,1988
intravenous/rat lethal dose (50 percent kill): 2.6 mg/kgTXAPA9 216,354,2006
intravenous/rat lowest published toxic dose: 1 mg/kgGastrointestinal: Changes in structure or function of salivary glandsTOXID9 44,255,2005
oral/Dog lethal dose (50 percent kill): >300 gm/kgPEMNDP 9,232,1991
oral/duck lethal dose (50 percent kill): >4640 mg/kgPEMNDP 9,232,1991
oral/mammal (species unspecified) lethal dose (50 percent kill): 5000 mg/kgFEREAC 63,45408,1998
oral/mouse lethal dose (50 percent kill): 20 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Kidney, Ureter, and Bladder: Urine volume increased
JEBIDP 12,45,1991
oral/mouse lethal dose (50 percent kill): 33 mg/kgEMMUEG 48,636,2007
oral/mouse lowest published toxic dose: 0.7 mg/kgBrain and Coverings: Other degenerative changes

Behavioral: Change in motor activity (specific assay)
FEREAC 69,62602,2004
oral/rat lowest published toxic dose: 2 mg/kgNutritional and Gross Metabolic: Body temperature decreaseTOXID9 90,117,2006
oral/rat lowest published lethal dose: 10 mg/kgGastrointestinal: Changes in structure or function of salivary glandsTOXID9 90,117,2006
oral/rat lowest published toxic dose: 10 mg/kgGastrointestinal: Changes in structure or function of salivary glandsTOXID9 44,255,2005
oral/rat lowest published lethal dose: 10 mg/kgBehavioral: TremorTOXID9 44,255,2005
oral/rat lowest published toxic dose: 10 mg/kgBehavioral: TremorFCTOD7 41,431,2003
oral/rat lowest published toxic dose: 1 mg/kgBrain and Coverings: Other degenerative changes

Biochemical: Metabolism (intermediary): Other
TOXID9 44,443,2005
oral/rat lowest published toxic dose: 30 mg/kgBrain and Coverings: Other degenerative changes

Gastrointestinal: Changes in structure or function of salivary glands
TOXID9 78,228,2004
oral/rat lowest published toxic dose: 1 mg/kgEye: Lacrimation

Behavioral: Change in motor activity (specific assay)

Gastrointestinal: Changes in structure or function of salivary glands
TOXID9 1,112,2001
oral/rat lowest published toxic dose: 2 mg/kgBehavioral: Change in motor activity (specific assay)FEREAC 69,62602,2004
oral/rat lethal dose (50 percent kill): 9360 µg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Kidney, Ureter, and Bladder: Urine volume increased
JEBIDP 12,45,1991
oral/rat lowest published toxic dose: 3 mg/kgBrain and Coverings: Other degenerative changesTOXID9 12,468,2008
oral/rat lowest published toxic dose: 10 mg/kgBehavioral: Tremor

Gastrointestinal: Changes in structure or function of salivary glands
TXCYAC 234,194,2007
oral/rat lowest published toxic dose: 3 mg/kgCardiac: Arrythmias (indlucing changes in conduction)TOXID9 90,303,2006
oral/rat lowest published toxic dose: 7.2 mg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseTOVEFN (3),15,1993
oral/rat lethal dose (50 percent kill): 150 mg/kgBehavioral: Tremor

Lung, Thorax, or Respiration: Respiratory depression

Gastrointestinal: Changes in structure or function of salivary glands
INJPD2 37,160,2005
oral/rat lowest published toxic dose: 2 mg/kgBehavioral: Food intake (animal)TOXID9 90,117,2006
oral/rat lowest published lethal dose: 10 mg/kgBehavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOXID9 90,117,2006
oral/rat lethal dose (50 percent kill): 5.1 mg/kgHBPTO* 1,881,2001
skin/mammal (species unspecified) lethal dose (50 percent kill): 2000 mg/kgFEREAC 63,45408,1998
skin/mouse lowest published toxic dose: 4 mg/kgSkin and Appendages: Tumors

Tumorigenic: Facilitates action of known carcinogens
TXCYAC 163,1,2001
skin/rabbit lethal dose (50 percent kill): 2 gm/kgDEVEAA 33,76,1979
skin/rat lethal dose (50 percent kill): >800 mg/kgJEPTDQ 2(3),751,1979
Tank with water/Carp lowest published toxic concentration: 2 µg/L/3DBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
TIVIEQ 33,279,1995
unreported route/rat lowest published lethal dose: 10 mg/kgBehavioral: Change in motor activity (specific assay)TOXID9 90,292,2006
unreported route/rat lowest published toxic dose: 10 mg/kgBehavioral: Change in motor activity (specific assay)TOXID9 90,292,2006
unreported route/rat lethal dose (50 percent kill): 150 mg/kgTOXID9 44,174,2005

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 201.6 mg/kg/21D- intermittentBehavioral: Excitement

Skin: After systemic exposure: Dermatitis, irritative

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FEREAC 69,62602,2004
inhalation/rat lowest published toxic concentration: 6 mg/m3/45D- intermittentLung, Thorax, or Respiration: Emphysema

Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
EESADV 63,318,2006
intraperitoneal/mouse lowest published toxic dose: 9 mg/kg/15D- intermittentBiochemical: Neurotransmitters or modulators (putative): Dopamine in striatumTXAPA9 211,188,2006
intraperitoneal/mouse lowest published toxic dose: 18 mg/kg/15D- intermittentBehavioral: Change in motor activity (specific assay)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes

Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum
TOXID9 78,279,2004
intraperitoneal/rat lowest published toxic dose: 3.5 mg/kg/5D- intermittentBehavioral: Change in motor activity (specific assay)

Behavioral: Change in psychophysiological tests
NETEEC 31,169,2009
intraperitoneal/rat lowest published toxic dose: 3.5 mg/kg/5D- intermittentVascular: Other changes

Reproductive: Specific developmental abnormalities: Central nervous system
HBPTO* 2,1298,2001
intraperitoneal/rat lowest published toxic dose: 240 mg/kg/6D- intermittentBiochemical: Neurotransmitters or modulators (putative): Catecholamine levels in CNSTOXID9 72,306,2003
intraperitoneal/rat lowest published toxic dose: 35 mg/kg/7D- intermittentLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
JEPOEC 14,45,1995
oral/mammal (species unspecified) lowest published toxic dose: 504 mg/kg/84D- intermittentImmunological Including Allergic: Decrease in cellular immune response

Immunological Including Allergic: Decrease in humoral immune response
HBPTO* 1,777,2001
oral/mammal (species unspecified) lowest published toxic dose: 210 mg/kg/14D- intermittentImmunological Including Allergic: Decrease in cellular immune response

Immunological Including Allergic: Decrease in humoral immune response
HBPTO* 1,777,2001
oral/mouse lowest published toxic dose: 39 mg/kg/13W- intermittentCardiac: Changes in heart weight

Liver: Changes in liver weight

Endocrine: Changes in spleen weight
JEBIDP 12,45,1991
oral/mouse lowest published toxic dose: 210 mg/kg/2W- intermittentBlood: Other changes

Immunological Including Allergic: Decrease in cellular immune response

Immunological Including Allergic: Decrease in humoral immune response
ENVRAL 59,467,1992
oral/mouse lowest published toxic dose: 9 mg/kg/15D- intermittentBrain and Coverings: Other degenerative changes

Biochemical: Metabolism (intermediary): Other proteins
TOXID9 12,467,2008
oral/quail lowest published toxic dose: 1228 mg/kg/7D- continuousGastrointestinal: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
BECTA6 31,479,1983
oral/rat lowest published toxic dose: 12500 µg/kg/10D- intermittentBehavioral: Food intake (animal)

Liver: Other changes
WDZAEK 8,189,1994
oral/rat lowest published toxic dose: 105 mg/kg/15D- intermittentBrain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JTEHD6 48,515,1996
oral/rat lowest published toxic dose: 450 mg/kg/30D- intermittentKidney, Ureter, and Bladder: Urine volume increased

Kidney, Ureter, and Bladder: Proteinuria
BCTKAG 21,146,1988
oral/rat lowest published toxic dose: 140 mg/kg/7D- intermittentPeripheral Nerve and Sensation: Recording from peripheral motor nerve

Behavioral: Muscle weakness

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
ARTODN 53,297,1983
oral/rat lowest published toxic dose: 450 mg/kg/30D- intermittentEndocrine: Hyperglycemia

Blood: Hemorrhage

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
INJPD2 37,160,2005
oral/rat : 38.4 mg/kg/30D- intermittentBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases

Biochemical: Metabolism (intermediary): Lipids including transport
TOXID9 227,240,2006
oral/rat lowest published toxic dose: 140 mg/kg/4W- intermittentEndocrine: Change in LH

Endocrine: Other changes

Reproductive: Paternal effects: Testes, epididymis, sperm duct
FCTOD7 50,3421,2012
skin/rat lowest published toxic dose: 0.78 mg/kg/60D- intermittentEndocrine: Other changes

Related to Chronic Data: Changes in ovarian weight
FCLPH* 23(Suppl 1),68,2009

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 53,251,1991
International Agency for Research on Cancer (IARC)Cancer Review:Human No Available DataIMEMDT 53,251,1991
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMEMDT 53,251,1991
TOXICOLOGY REVIEWMUREAV 557,109,2004
TOXICOLOGY REVIEWTOLED5 127,29,2002
TOXICOLOGY REVIEWTOLED5 134,3,2002
TOXICOLOGY REVIEWTOLED5 142,207,2003
TOXICOLOGY REVIEWMUTAEX 21,93,2006
TOXICOLOGY REVIEWENTOX* -,736,2005
TOXICOLOGY REVIEWTOXIA6 49,452,2007
TOXICOLOGY REVIEWHUTOX* -,541,1996
TOXICOLOGY REVIEWNETEEC 30,55,2008
TOXICOLOGY REVIEWMUREAV 681,93,2009
TOXICOLOGY REVIEWTPHSDY 29,322,2008
TOXICOLOGY REVIEWREPTED 26,13,2008
TOXICOLOGY REVIEWMUTAEX 26,19,2011
TOXICOLOGY REVIEWMUTAEX 26,19,2011
TOXICOLOGY REVIEWMUTAEX 21,343,2006
TOXICOLOGY REVIEWMUREAV 721,27,2011
TOXICOLOGY REVIEWNRTXDN 32,383,2011

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESActive registrationRBREV* -,363,1998

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database
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