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Registry of Toxic Effects of Chemical Substances (RTECS)

Cyclopropanecarboxylic acid, 3-(2-chloro-3,3,3-trifluoro-1-propenyl)-2,2-dimethyl-,cyano(3-phenoxyphenyl)methyl ester, (1-alpha(S*),3-alpha(Z))- (+-)-

RTECS #

GZ1227780

CAS #

91465-08-6

Updated

April 2013

Molecular Weight

449.88

Molecular Formula

C23H19ClF3NO3

Synonyms

Cyhalothrin K
Icon
Karate
Lambdacyalothrin
lambda-Cyhalothrin
Lambda-cyhalothrin
Lambda-cyhalothrin technical
PP 321

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisintraperitoneal/rat21.42 mg/kg/13DMUREAV 539,91,2003
micronucleus testintraperitoneal/rat5.6 mg/kg/13DMUREAV 539,91,2003
micronucleus testoral/rat5.6 mg/kg/13D- intermittentMUTAEX 20,125,2006
micronucleus testmultiple/other fish0.1 ng/LMUREAV 726,104,2011
micronucleus testmultiple/non-mammalian species0.00001 mg/L/36HMUREAV 534,93,2003
micronucleus testmultiple/non-mammalian species0.00001 mg/L/90MMUREAV 534,93,2003

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/mammal (species unspecified) 5 mg/kg (multigenerations)Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
FEREAC 63,7293,1998
oral/rat 5 mg/kg (multigeneration)Reproductive: Other effects on male

Reproductive: Other effects on female

Reproductive: Effects on newborn: Other neonatal measures or effects
FEREAC 68,52354,2003
oral/rat 87.5 mg/kg (1-7D pregnant)Reproductive: Maternal effects: Uterus, cervix, vagina

Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)

Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)
HETOEA 22,523,2003
oral/rat 87.5 mg/kg (1-7D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Other measures of fertility
HETOEA 22,523,2003
oral/rat 58.1 mg/kg (1-7D pregnant)Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death
HETOEA 22,523,2003
oral/rat 58.1 mg/kg (1-7D pregnant)Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)HETOEA 22,523,2003

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mammal (species unspecified) lethal concentration (50 percent kill): 60 mg/m3/4HPEMNDP 9,203,1991
intravenous/rat lethal dose (50 percent kill): 1951 µg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Gastrointestinal: Changes in structure or function of salivary glands
PCBPBS 30,79,1988
oral/duck lethal dose (50 percent kill): >3950 mg/kgFMCHA2 -,C175,1991
oral/rat lethal dose (50 percent kill): 56 mg/kgFEREAC 63,7293,1998
oral/rat lowest published toxic dose: 8.3 mg/kgEye: Other eye effects

Behavioral: Ataxia

Gastrointestinal: Changes in structure or function of salivary glands
HETOEA 22,523,2003
oral/rat lowest published toxic dose: 6.3 mg/kgGastrointestinal: Changes in structure or function of salivary glandsHETOEA 22,523,2003
skin/rat lethal dose (50 percent kill): 632 mg/kgPEMNDP 9,203,1991
unreported route/rat lethal dose (50 percent kill): 632 mg/kgFEREAC 63,7293,1998

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 18.9 mg/kg/21D- intermittentBehavioral: Ataxia

Eye: Corneal damage

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FEREAC 67,60903,2002
inhalation/rat lowest published toxic concentration: 18.9 mg/kg/21D- intermittentEye: Corneal damage

Kidney, Ureter, and Bladder: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FEREAC 69,18480,2004
inhalation/rat lowest published toxic concentration: 3.3 mg/m3/21D- intermittentEye: Corneal damage

Behavioral: Ataxia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FEREAC 68,52354,2003
oral/Dog lowest published toxic dose: 182.5 mg/kg/1Y- intermittentBehavioral: AtaxiaFEREAC 67,60903,2002
oral/Dog lowest published toxic dose: 7 mg/kg/2D- intermittentBehavioral: AtaxiaFEREAC 68,52354,2003
oral/rabbit lowest published toxic dose: 1120 mg/kg/16W- intermittentEndocrine: Androgenic

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Related to Chronic Data: Changes in testicular weight
FCTOD7 48,1152,2010
oral/rat lowest published toxic dose: 1137.5 mg/kg/13W- intermittentBehavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FEREAC 69,18480,2004
oral/rat lowest published toxic dose: 87.5 mg/kg/7D- intermittentEndocrine: Changes in adrenal weight

Nutritional and Gross Metabolic: Body temperature increase

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HETOEA 22,523,2003
oral/rat lowest published toxic dose: 58.1 mg/kg/7D- intermittentGastrointestinal: Changes in structure or function of salivary glands

Blood: Changes in leukocyte (WBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HETOEA 22,523,2003
oral/rat lowest published toxic dose: 44.1 mg/kg/7D- intermittentGastrointestinal: Changes in structure or function of salivary glands

Blood: Changes in leukocyte (WBC) count
HETOEA 22,523,2003
oral/rat lowest published toxic dose: 24 mg/kg/6D- intermittentLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
TOXID9 -,155,2008
oral/rat lowest published toxic dose: 1134 mg/kg/3W- continuousLiver: Hepatitis (hepatocellular necrosis), zonal

Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
ETPAEK 61,189,2009
skin/Dog lowest published toxic dose: 1050 mg/kg/21D- intermittentBehavioral: Ataxia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FEREAC 68,52354,2003
skin/rat lowest published toxic dose: 1050 mg/kg/21D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainFEREAC 69,18480,2004
skin/rat lowest published toxic dose: 1050 mg/kg/21D- intermittentBehavioral: Ataxia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FEREAC 67,60903,2002

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWTOLED5 127,29,2002
TOXICOLOGY REVIEWMUTAEX 21,93,2006
TOXICOLOGY REVIEWFEREAC 72,45656,2007
TOXICOLOGY REVIEWMUTAEX 26,223,2011
TOXICOLOGY REVIEWMUTAEX 21,343,2006

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESActive registrationRBREV* -,362,1998
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