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Cyclopropanecarboxylic acid, 3 - (2 - chloro - 3,3,3 - trifluoro - 1 - propenyl) - 2,2 - dimethyl - ,cyano (3 - phenoxyphenyl) methyl ester, (1 - alpha (S*) ,3 - alpha (Z) ) - (+ - ) -

RTECS #: GZ1227780

CAS #: 91465-08-6


UPDATE: February 2009 MW: 449.88 MF: C23H19ClF3NO3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. REFERENCES:

SYNONYMS:

  1. Cyhalothrin K
  2. Icon
  3. Karate
  4. Lambda - cyhalothrin
  1. Lambda - cyhalothrin technical
  2. Lambdacyalothrin
  3. PP 321
  4. lambda - Cyhalothrin


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis intraperitoneal
rat
21.42 mg/kg/13 day MUREAV 539,91,2003
micronucleus test multiple
non-mammalian species
0.1 mg/L/36 hour MUREAV 534,93,2003
micronucleus test multiple
non-mammalian species
0.1 mg/L/90 minute MUREAV 534,93,2003
micronucleus test multiple
other fish
10 ng/L MUREAV 438,155,1999
micronucleus test intraperitoneal
rat
5.6 mg/kg/13 day MUREAV 539,91,2003


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mammal (species unspecified)
lowest published toxic dose: 5 mg/kg (multigenerations) Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
FEREAC 63,7293,1998
oral
rat
lowest published toxic dose: 5 mg/kg (multigeneration) Reproductive: Other effects on male

Reproductive: Other effects on female

Reproductive: Effects on newborn: Other neonatal measures or effects
FEREAC 68,52354,2003
oral
rat
lowest published toxic dose: 87.5 mg/kg (1-7 day pregnant) Reproductive: Maternal effects: Uterus, cervix, vagina

Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)

Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)
HETOEA 22,523,2003
oral
rat
lowest published toxic dose: 87.5 mg/kg (1-7 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Other measures of fertility
HETOEA 22,523,2003
oral
rat
lowest published toxic dose: 58.1 mg/kg (1-7 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death
HETOEA 22,523,2003
oral
rat
lowest published toxic dose: 58.1 mg/kg (1-7 day pregnant) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) HETOEA 22,523,2003


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mammal (species unspecified)
lethal concentration (50 percent kill): 60 mg/m3/4 hour N/R PEMNDP 9,203,1991
intravenous
rat
lethal dose (50 percent kill): 1,951 g/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Gastrointestinal: Changes in structure or function of salivary glands
PCBPBS 30,79,1988
oral
duck
lethal dose (50 percent kill): >3,950 mg/kg N/R FMCHA2 -,C175,1991
oral
rat
lethal dose (50 percent kill): 56 mg/kg N/R FEREAC 63,7293,1998
oral
rat
lowest published toxic dose: 8.3 mg/kg Eye: Other eye effects

Behavioral: Ataxia

Gastrointestinal: Changes in structure or function of salivary glands
HETOEA 22,523,2003
oral
rat
lowest published toxic dose: 6.3 mg/kg Gastrointestinal: Changes in structure or function of salivary glands HETOEA 22,523,2003
skin
rat
lethal dose (50 percent kill): 632 mg/kg N/R PEMNDP 9,203,1991
unreported route
rat
lethal dose (50 percent kill): 632 mg/kg N/R FEREAC 63,7293,1998


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 18.9 mg/kg/21 day- intermittent Behavioral: Ataxia

Eye: Corneal damage

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FEREAC 67,60903,2002
inhalation
rat
lowest published toxic concentration: 3.3 mg/m3/21 day- intermittent Eye: Corneal damage

Behavioral: Ataxia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FEREAC 68,52354,2003
inhalation
rat
lowest published toxic concentration: 18.9 mg/kg/21 day- intermittent Eye: Corneal damage

Kidney, Ureter, and Bladder: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FEREAC 69,18480,2004
oral
dog
lowest published toxic dose: 182.5 mg/kg/1 year- intermittent Behavioral: Ataxia FEREAC 67,60903,2002
oral
dog
lowest published toxic dose: 7 mg/kg/2 day- intermittent Behavioral: Ataxia FEREAC 68,52354,2003
oral
rat
lowest published toxic dose: 1,137.5 mg/kg/13 week- intermittent Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FEREAC 69,18480,2004
oral
rat
lowest published toxic dose: 87.5 mg/kg/7 day- intermittent Endocrine: Changes in adrenal weight

Nutritional and Gross Metabolic: Body temperature increase

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HETOEA 22,523,2003
oral
rat
lowest published toxic dose: 58.1 mg/kg/7 day- intermittent Gastrointestinal: Changes in structure or function of salivary glands

Blood: Changes in leukocyte (WBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HETOEA 22,523,2003
oral
rat
lowest published toxic dose: 44.1 mg/kg/7 day- intermittent Gastrointestinal: Changes in structure or function of salivary glands

Blood: Changes in leukocyte (WBC) count
HETOEA 22,523,2003
oral
rat
lowest published toxic dose: 24 mg/kg/6 day- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
TOXID9 -,155,2008
skin
dog
lowest published toxic dose: 1,050 mg/kg/21 day- intermittent Behavioral: Ataxia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FEREAC 68,52354,2003
skin
rat
lowest published toxic dose: 1,050 mg/kg/21 day- intermittent Behavioral: Ataxia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FEREAC 67,60903,2002
skin
rat
lowest published toxic dose: 1,050 mg/kg/21 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain FEREAC 69,18480,2004


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
TOLED5 127,29,2002
TOXICOLOGY REVIEW
MUTAEX 21,93,2006
TOXICOLOGY REVIEW
FEREAC 72,45656,2007
TOXICOLOGY REVIEW
FEREAC 72,45656,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Active registration RBREV* -,362,1998


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

N/R


REFERENCES:

CODEN
REFERENCE

FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094)
HETOEA Human & Experimental Toxicology. (Macmillan Press Ltd., Brunel Road, Houndmills, Basingstoke, Hampshire, RG21 2XS, UK) V.9- 1990-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
PCBPBS Pesticide Biochemistry and Physiology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1971-
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-

Used as an insecticide

RTECS Compound Description:
   Agricultural Chemical
   Mutagen
   Reproductive Effector

Click Here for Additional Information about RTECS

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