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Registry of Toxic Effects of Chemical Substances (RTECS)

Cyclopropanecarboxylic acid, 3-(2-chloro-3,3,3-trifluoro-1-propenyl)-2,2-dimethyl-,cyano(3-phenoxyphenyl)methyl ester

RTECS #

GZ1227770

CAS #

68085-85-8

Updated

May 2009

Molecular Weight

449.88

Molecular Formula

C23H19ClF3NO3

Synonyms

Cyhalothrin
Cyhalothrine
Grenade
ICI 146814
ICI-PP 563
Matador
PP 563
Saber

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 5 mg/kg (multigeneration)Reproductive: Other effects on female

Reproductive: Effects on newborn: Other neonatal measures or effects

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
FEREAC 67,60903,2002
oral/rat 5 mg/kg (multigenerations)Reproductive: Other effects on male

Reproductive: Other effects on female

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
FEREAC 69,18480,2004

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lethal concentration (50 percent kill): 83 mg/m3/4HPEMNDP 9,201,1991
intraperitoneal/rat lowest published toxic dose: 10 mg/kgBrain and Coverings: Other degenerative changes

Biochemical: Metabolism (intermediary): Other
TOXID9 44,400,2005
intraperitoneal/rat lowest published toxic dose: 60 mg/kgBehavioral: Sleep

Behavioral: Tremor

Gastrointestinal: Hypermotility, diarrhea
TXCYAC 243,155,2008
intraperitoneal/rat lowest published toxic dose: 10 mg/kgBrain and Coverings: Other degenerative changesTXCYAC 243,155,2008
oral/duck lethal dose (50 percent kill): >5 gm/kgPEMNDP 9,201,1991
oral/guinea pig lethal dose (50 percent kill): >5 gm/kgPEMNDP 9,201,1991
oral/rabbit lethal dose (50 percent kill): >1 gm/kgPEMNDP 9,201,1991
oral/rat lethal dose (50 percent kill): 144 mg/kgPEMNDP 9,201,1991
oral/rat lowest published toxic dose: 20 mg/kgBiochemical: Neurotransmitters or modulators (putative): Catecholamine levels in CNS

Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum

Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites
TOXID9 72,310,2003
skin/rabbit lethal dose (50 percent kill): >2500 mg/kgPEMNDP 9,201,1991

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat lowest published toxic dose: 48 mg/kg/6D- intermittentBiochemical: Neurotransmitters or modulators (putative): Catecholamine levels in CNSTOXID9 72,306,2003
oral/Dog lowest published toxic dose: 455 mg/kg/26W- intermittentGastrointestinal: Other changesFEREAC 67,60903,2002
oral/Dog lowest published toxic dose: 15000 mg/kg/21D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainFEREAC 67,60903,2002
oral/Dog lowest published toxic dose: 455 mg/kg/26W- continuousGastrointestinal: Hypermotility, diarrheaFEREAC 69,18480,2004
oral/mouse lowest published toxic dose: 8232 mg/kg/4W- continuousBlood: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
FEREAC 69,18480,2004
oral/mouse lowest published toxic dose: 8232 mg/kg/4W- intermittentLiver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
FEREAC 67,60903,2002
oral/rat lowest published toxic dose: 48 mg/kg/6D- intermittentBrain and Coverings: Other degenerative changesTOLED5 109(Suppl 1),58,1999
oral/rat lowest published toxic dose: 21 mg/kg/7D- intermittentBehavioral: Change in motor activity (specific assay)TXAPA9 191,167,2003
oral/rat lowest published toxic dose: 28 mg/kg/4D- intermittentBehavioral: Tremor

Behavioral: Change in motor activity (specific assay)

Gastrointestinal: Changes in structure or function of salivary glands
TXAPA9 191,167,2003
oral/rat lowest published toxic dose: 56 mg/kg/28D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainFEREAC 67,60903,2002
oral/rat lowest published toxic dose: 48 mg/kg/6D- intermittentBrain and Coverings: Recordings from specific areas of CNS

Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum

Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites
TOXID9 66,319,2002
oral/rat lowest published toxic dose: 48 mg/kg/6D- intermittentLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
TOXID9 66,320,2002
oral/rat lowest published toxic dose: 24 mg/kg/6D- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)TOXID9 60,275,2001
oral/rat lowest published toxic dose: 7 mg/kg/7D- intermittentImmunological Including Allergic: Decrease in cellular immune response

Biochemical: Metabolism (intermediary): Other
TXCYAC 212,98,2005
oral/rat lowest published toxic dose: 1137.5 mg/kg/13W- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainFEREAC 69,18480,2004
skin/rabbit lowest published toxic dose: 21000 mg/kg/21D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainFEREAC 69,18480,2004

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWJTPAE7 19,1,2006
TOXICOLOGY REVIEWHUTOX* -,541,1996

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9165;8EHQ-0892-9070
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database
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