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Cyclopropanecarboxylic acid, 3 - (2 - chloro - 3,3,3 - trifluoro - 1 - propenyl) - 2,2 - dimethyl - ,cyano (3 - phenoxyphenyl) methyl ester

RTECS #: GZ1227770

CAS #: 68085-85-8

UPDATE: May 2009 MW: 449.88 MF: C23H19ClF3NO3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. Cyhalothrin
  2. Cyhalothrine
  3. Grenade
  4. ICI 146814
  1. ICI - PP 563
  2. Matador
  3. PP 563
  4. Saber


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 5 mg/kg (multigeneration) Reproductive: Other effects on female

Reproductive: Effects on newborn: Other neonatal measures or effects

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) 		FEREAC 67,60903,2002
oral
rat 		lowest published toxic dose: 5 mg/kg (multigenerations) Reproductive: Other effects on male

Reproductive: Other effects on female

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) 		FEREAC 69,18480,2004


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): 83 mg/m3/4 hour N/R PEMNDP 9,201,1991
intraperitoneal
rat 		lowest published toxic dose: 10 mg/kg Brain and Coverings: Other degenerative changes

Biochemical: Metabolism (intermediary): Other 		TOXID9 44,400,2005
intraperitoneal
rat 		lowest published toxic dose: 60 mg/kg Behavioral: Sleep

Behavioral: Tremor

Gastrointestinal: Hypermotility, diarrhea 		TXCYAC 243,155,2008
intraperitoneal
rat 		lowest published toxic dose: 10 mg/kg Brain and Coverings: Other degenerative changes TXCYAC 243,155,2008
oral
duck 		lethal dose (50 percent kill): >5 gm/kg N/R PEMNDP 9,201,1991
oral
guinea pig 		lethal dose (50 percent kill): >5 gm/kg N/R PEMNDP 9,201,1991
oral
rat 		lethal dose (50 percent kill): 144 mg/kg N/R PEMNDP 9,201,1991
oral
rat 		lowest published toxic dose: 20 mg/kg Biochemical: Neurotransmitters or modulators (putative): Catecholamine levels in CNS

Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum

Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites 		TOXID9 72,310,2003
oral
rabbit 		lethal dose (50 percent kill): >1 gm/kg N/R PEMNDP 9,201,1991
skin
rabbit 		lethal dose (50 percent kill): >2,500 mg/kg N/R PEMNDP 9,201,1991


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lowest published toxic dose: 48 mg/kg/6 day- intermittent Biochemical: Neurotransmitters or modulators (putative): Catecholamine levels in CNS TOXID9 72,306,2003
oral
dog 		lowest published toxic dose: 455 mg/kg/26 week- intermittent Gastrointestinal: Other changes FEREAC 67,60903,2002
oral
dog 		lowest published toxic dose: 15,000 mg/kg/21 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain FEREAC 67,60903,2002
oral
dog 		lowest published toxic dose: 455 mg/kg/26 week- continuous Gastrointestinal: Hypermotility, diarrhea FEREAC 69,18480,2004
oral
mouse 		lowest published toxic dose: 8,232 mg/kg/4 week- intermittent Liver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		FEREAC 67,60903,2002
oral
mouse 		lowest published toxic dose: 8,232 mg/kg/4 week- continuous Blood: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		FEREAC 69,18480,2004
oral
rat 		lowest published toxic dose: 48 mg/kg/6 day- intermittent Brain and Coverings: Other degenerative changes TOLED5 109(Suppl 1),58,1999
oral
rat 		lowest published toxic dose: 21 mg/kg/7 day- intermittent Behavioral: Change in motor activity (specific assay) TXAPA9 191,167,2003
oral
rat 		lowest published toxic dose: 28 mg/kg/4 day- intermittent Behavioral: Tremor

Behavioral: Change in motor activity (specific assay)

Gastrointestinal: Changes in structure or function of salivary glands 		TXAPA9 191,167,2003
oral
rat 		lowest published toxic dose: 56 mg/kg/28 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain FEREAC 67,60903,2002
oral
rat 		lowest published toxic dose: 1,137.5 mg/kg/13 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain FEREAC 69,18480,2004
oral
rat 		lowest published toxic dose: 48 mg/kg/6 day- intermittent Brain and Coverings: Recordings from specific areas of CNS

Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum

Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites 		TOXID9 66,319,2002
oral
rat 		lowest published toxic dose: 48 mg/kg/6 day- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) 		TOXID9 66,320,2002
oral
rat 		lowest published toxic dose: 24 mg/kg/6 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) TOXID9 60,275,2001
oral
rat 		lowest published toxic dose: 7 mg/kg/7 day- intermittent Immunological Including Allergic: Decrease in cellular immune response

Biochemical: Metabolism (intermediary): Other 		TXCYAC 212,98,2005
skin
rabbit 		lowest published toxic dose: 21,000 mg/kg/21 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain FEREAC 69,18480,2004


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
JTPAE7 19,1,2006
TOXICOLOGY REVIEW
HUTOX* -,541,1996


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9165;8EHQ-0892-9070
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
HUTOX*
JTPAE7 Journal of Toxicologic Pathology. (Nihon Dokusei Byori Gakkai, editor, 3-25-8 Nishi- shinbashi, Minato-ku, Tokyo 105, Japan) V.1- 1988
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-

Used as an acaricide and insecticide

RTECS Compound Description:
   Agricultural Chemical

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