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Cyclopentanone

RTECS #: GY4725000

CAS #: 120-92-3


UPDATE: August 2006 MW: 84.13 MF: C5H8O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. STANDARDS AND REGULATIONS:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. Adipic ketone
  2. Dumasin
  1. Ketocyclopentane
  2. Ketopentamethylene


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
100 mg severe FCTOD7 20,573,1982
eye
rabbit
100 mg/4S rinse severe FCTOD7 20,573,1982
skin
rabbit
500 mg/24 hour severe FCTXAV 17,271,1979
skin
rabbit
500 mg mild FCTOD7 20,563,1982


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lethal concentration (50 percent kill): 19,500 mg/m3 Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Other changes

Liver: Other changes
NTIS** OTS0572861
intraperitoneal
mouse
lethal dose (50 percent kill): 1,950 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Muscle weakness

Behavioral: Coma
COREAF 254,2245,1962
oral
mammal (species unspecified)
lethal dose (50 percent kill): 2 gm/kg N/R GTPZAB 32(10),25,1988
oral
mouse
lethal dose (50 percent kill): 1,820 mg/kg N/R VCVGK* -,453,1994
subcutaneous
frog
lowest published lethal dose: 3 gm/kg Autonomic Nervous System: Other (direct) parasympathomimetic

Behavioral: Change in motor activity (specific assay)

Skin and Appendages: Other: Sweating
AEXPBL 50,199,1903
subcutaneous
mouse
lowest published lethal dose: 2,600 mg/kg Autonomic Nervous System: Other (direct) parasympathomimetic

Behavioral: Coma

Lung, Thorax, or Respiration: Other changes
AEXPBL 50,199,1903


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mammal (species unspecified)
lowest published toxic concentration: 50 ppm/6 hour/15 week- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) VCVGK* -,453,1994


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - DENMARK time-weighted average 25 ppm (90 mg/m3), OCT 2002


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

AEXPBL Archiv fuer Experimentelle Pathologie und Pharmakologie. (Leipzig, Ger. Dem. Rep.) V.1-109, 1873-1925. For publisher information, see NSAPCC.
COREAF Comptes Rendus Hebdomadaires des Seances, Academie des Sciences. (Paris, France) V.1-261, 1835-1965. For publisher information, see CRASEV.
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

RTECS Compound Description:
   Primary Irritant

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