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Registry of Toxic Effects of Chemical Substances (RTECS)

Cyclopentanone

RTECS #

GY4725000

CAS #

120-92-3

Updated

April 2012

Molecular Weight

84.13

Molecular Formula

C5H8O

Synonyms

Adipic ketone
Dumasin
Ketocyclopentane
Ketopentamethylene

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 100 mg severeFCTOD7 20,573,1982
eye /rabbit 100 mg/4S rinse severeFCTOD7 20,573,1982
skin /rabbit 500 mg/24HFCTXAV 17,271,1979
skin /rabbit 500 mg mildFCTOD7 20,563,1982

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lethal concentration (50 percent kill): 19500 mg/m3Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Other changes

Liver: Other changes
NTIS** OTS0572861
intraperitoneal/mouse lethal dose (50 percent kill): 1950 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Muscle weakness

Behavioral: Coma
COREAF 254,2245,1962
oral/mammal (species unspecified) lethal dose (50 percent kill): 2 gm/kgGTPZAB 32(10),25,1988
oral/mouse lethal dose (50 percent kill): 1820 mg/kgVCVGK* -,453,1994
subcutaneous/frog lowest published lethal dose: 3 gm/kgAutonomic Nervous System: Other (direct) parasympathomimetic

Behavioral: Change in motor activity (specific assay)

Skin and Appendages: Other: Sweating
AEXPBL 50,199,1903
subcutaneous/mouse lowest published lethal dose: 2600 mg/kgAutonomic Nervous System: Other (direct) parasympathomimetic

Behavioral: Coma

Lung, Thorax, or Respiration: Other changes
AEXPBL 50,199,1903

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mammal (species unspecified) lowest published toxic concentration: 50 ppm/6H/15W- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)VCVGK* -,453,1994

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-AUSTRIAMAK-TMW 25 ppm (90 mg/m3);KZW 50 ppm (180 mg/m3), 2007
Occupational Exposure Limit-DENMARKtime-weighted average 25 ppm (90 mg/m3), MAY2011
Occupational Exposure Limit-ICELANDtime-weighted average 25 ppm (90 mg/m3), NOV2011

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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