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Registry of Toxic Effects of Chemical Substances (RTECS)

1-Cyclohexene, 4-vinyl-

RTECS #

GW6650000

CAS #

100-40-3

Updated

September 201

Molecular Weight

108.20

Molecular Formula

C8H12

Synonyms

1,2,3,4-Tetrahydrostyrene
1-Vinylcyclohex-3-ene
1-Vinylcyclohexene-3
4-Ethenyl-1-cyclohexene
4-Ethenylcyclohexene
4-Vinyl-1-cyclohexene
4-Vinylcyclohexene
4-Vinylcyclohexene (ACGIH)
4-Vinylcyclohexene-1
Butadiene dimer
Cyclohexene, 4-ethenyl-
Cyclohexenylethylene
NCI-C54999

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 0.005 mL mildHPV086 -,-,2006
skin /rabbit 0.01 mL moderateHPV086 -,-,2006

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
mutation in mammalian somatic cellsother cell types/mouse60 mg/L/4H (+enzymatic activation step)HPV086 -,-,2006
specific locus testliver/mouse740 µmol/LMUREAV 608,29,2006

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse 24 gm/kg (30D prior to copulation)Reproductive: Maternal effects: Ovaries, fallopian tubesTOXID9 12,433,1992
intraperitoneal/mouse 19500 mg/kg (30D prior to copulation)Reproductive: Maternal effects: Ovaries, fallopian tubesTXAPA9 119,302,1993
oral/mouse 500 mg/kg (multigenerations)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)NTIS** PB91211250
oral/mouse 5500 mg/kg (8-18D pregnant)Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Other postnatal measures or effects
TXAPA9 215,51,2006

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 103 gm/kg/2Y- intermittentTumorigenic: Carcinogenic by RTECS criteria

Reproductive: Tumorigenic effects: Ovarian tumors
JTEHD6 21,507,1987
oral/mouse toxic dose: 103 gm/kg/2Y- intermittentTumorigenic: Neoplastic by RTECS criteria

Reproductive: Tumorigenic effects: Ovarian tumors
NTPTR* NTP-TR-303,1986
oral/mouse toxic dose: 206 gm/kg/2Y- intermittentTumorigenic: Carcinogenic by RTECS criteria

Blood: Lymphoma including Hodgkin's disease
NTPTR* NTP-TR-303,1986
oral/mouse lowest published toxic dose: 206000 mg/kg/103W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Blood: Lymphoma including Hodgkin's disease
NTIS** PB87-116182
oral/mouse lowest published toxic dose: 103000 mg/kg/103W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Reproductive: Tumorigenic effects: Ovarian tumors
NTIS** PB87-116182
oral/mouse lowest published toxic dose: 144200 mg/kg/103W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Reproductive: Tumorigenic effects: Ovarian tumors

Tumorigenic: Increased incidence of tumors in susceptible strains
HPV086 -,-,2006
oral/rat lowest published toxic dose: 103000 mg/kg/102W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Reproductive: Other reproductive system tumors
NTIS** PB87-116182
skin/mouse lowest published toxic dose: 16 gm/kg/54W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application
JNCIAM 31,41,1963

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lethal concentration (50 percent kill): 27 gm/m3IMEMDT 11,279,1976
inhalation/rat Lowest published lethal concentration: 8000 ppm/4HHPV086 -,-,2006
intraperitoneal/mouse lowest published toxic dose: 800 mg/kgReproductive: Maternal effects: Ovaries, fallopian tubes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other hydrolases

Biochemical: Metabolism (intermediary): Other
TOXID9 1,93,2001
oral/rat lethal dose (50 percent kill): 2560 mg/kgHPV086 -,-,2006
oral/rat lethal dose (50 percent kill): 3080 µL/kgAIHAAP 30,470,1969
skin/rabbit lethal dose (50 percent kill): 20 mL/kgHPV086 -,-,2006

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 1000 ppm/6H/4W- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldTOXID9 15,182,1995
inhalation/mouse lowest published toxic concentration: 1000 ppm/6H/13W- intermittentBlood: Pigmented or nucleated red blood cells

Blood: Changes in erythrocyte (RBC) count

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
FAATDF 32,1,1996
inhalation/mouse lowest published toxic concentration: 1500 ppm/6H/2W- intermittentBehavioral: Tremor

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** OTS0556756
inhalation/mouse lowest published toxic concentration: 1500 ppm/2W- intermittentBehavioral: Tremor

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV086 -,-,2006
inhalation/mouse lowest published toxic concentration: 1000 ppm/13W- intermittentRelated to Chronic Data: Changes in ovarian weightHPV086 -,-,2006
inhalation/rat lowest published toxic concentration: 1500 ppm/2W- intermittentBehavioral: Tremor

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HPV086 -,-,2006
inhalation/rat lowest published toxic concentration: 1000 ppm/13W- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Other changes

Kidney, Ureter, and Bladder: Changes in kidney weight
HPV086 -,-,2006
inhalation/rat lowest published toxic concentration: 1500 ppm/6H/13W- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FAATDF 32,1,1996
inhalation/rat lowest published toxic concentration: 1500 ppm/6H/2W- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** OTS0556756
intraperitoneal/mouse lowest published toxic dose: 12 gm/kg/15D- intermittentReproductive: Maternal effects: Ovaries, fallopian tubesTXAPA9 221,215,2007
intraperitoneal/mouse lowest published toxic dose: 19500 mg/kg/30D- intermittentReproductive: Maternal effects: OogenesisTXAPA9 119,302,1993
intraperitoneal/mouse lowest published toxic dose: 24000 mg/kg/30D- intermittentReproductive: Maternal effects: Oogenesis

Reproductive: Maternal effects: Menstrual cycle changes or disorders
BIREBV 42,67,1990
intraperitoneal/mouse lowest published toxic dose: 3000 mg/kg/30D- intermittentReproductive: Maternal effects: Ovaries, fallopian tubesREPTED 5,379,1991
oral/mouse lowest published toxic dose: 63000 mg/kg/18W- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainNTIS** PB91211250
oral/mouse lowest published toxic dose: 5500 mg/kg/11D- intermittentReproductive: Maternal effects: Ovaries, fallopian tubesTXAPA9 215,51,2006
oral/mouse lowest published toxic dose: 17500 mg/kg/14D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldJTEHD6 21,493,1987
oral/mouse lowest published toxic dose: 78 gm/kg/13W- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldJTEHD6 21,493,1987
oral/mouse lowest published toxic dose: 17500 mg/kg/2W- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldHPV086 -,-,2006
oral/rat lowest published toxic dose: 17500 mg/kg/2W- intermittentBehavioral: Tremor

Gastrointestinal: Hypermotility, diarrhea

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV086 -,-,2006
oral/rat lowest published toxic dose: 36400 mg/kg/13W- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldHPV086 -,-,2006
oral/rat lowest published toxic dose: 72800 mg/kg/13W- intermittentGastrointestinal: Gastritis

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV086 -,-,2006
oral/rat lowest published toxic dose: 103000 mg/kg/103W- intermittentGastrointestinal: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV086 -,-,2006
oral/rat lowest published toxic dose: 17500 mg/kg/14D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNTPTR* NTP-TR-303,1986
oral/rat lowest published toxic dose: 52 gm/kg/13W- intermittentKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JTEHD6 21,493,1987
unreported route/mouse lowest published toxic dose: 12000 mg/kg/15D- intermittentReproductive: Maternal effects: Ovaries, fallopian tubes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other hydrolases
TOXID9 66,372,2002

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.1 ppmDTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Confirmed animal carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMEMDT 39,181,1986
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 60,347,1994
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 39,181,1986
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 60,347,1994
International Agency for Research on Cancer (IARC)Cancer Review:Group 2BIMEMDT 60,347,1994
TOXICOLOGY REVIEWMUREAV 543,201,2003
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWMUREAV 654,114,2008
TOXICOLOGY REVIEWMUREAV 721,27,2011
TOXICOLOGY REVIEWREPTED 33,269,2012

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-BELGIUMtime-weighted average 0.1 ppm (0.45 mg/m3), Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.1 ppm (0.4 mg/m3), carc, MAY2011
Occupational Exposure Limit-ICELANDtime-weighted average 0.1 ppm (0.4 mg/m3), NOV2011
Occupational Exposure Limit-JAPAN2B carc, MAY2012
Occupational Exposure Limit-PERUtime-weighted average 0,1 ppm (0,44 mg/m3), JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 10 mg/m3, JAN1999
Occupational Exposure Limit-SWITZERLANDMAK-week 0.1 ppm, carc 3, skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.4 mg/m3, 2003

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0293-8735
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (gavage);clear evidence:mouse
NCI Carcinogenesis Studies (gavage);inadequate study:rat
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