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1 - Cyclohexene, 4 - vinyl -

RTECS #: GW6650000

CAS #: 100-40-3


UPDATE: February 2009 MW: 108.20 MF: C8H12


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 1,2,3,4 - Tetrahydrostyrene
  2. 1 - Vinylcyclohex - 3 - ene
  3. 1 - Vinylcyclohexene - 3
  4. 4 - Ethenyl - 1 - cyclohexene
  5. 4 - Ethenylcyclohexene
  6. 4 - Vinyl - 1 - cyclohexene
  7. 4 - Vinylcyclohexene
  1. 4 - Vinylcyclohexene (ACGIH)
  2. 4 - Vinylcyclohexene - 1
  3. Butadiene dimer
  4. Cyclohexene, 4 - ethenyl -
  5. Cyclohexenylethylene
  6. NCI - C54999


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
specific locus test mouse liver 740 Ámol/L MUREAV 608,29,2006


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lowest published toxic dose: 24 gm/kg (30 day prior to copulation) Reproductive: Maternal effects: Ovaries, fallopian tubes TOXID9 12,433,1992
intraperitoneal
mouse
lowest published toxic dose: 19,500 mg/kg (30 day prior to copulation) Reproductive: Maternal effects: Ovaries, fallopian tubes TXAPA9 119,302,1993
oral
mouse
lowest published toxic dose: 500 mg/kg (multigenerations) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) NTIS** PB91211250
oral
mouse
lowest published toxic dose: 5,500 mg/kg (8-18 day pregnant) Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Other postnatal measures or effects
TXAPA9 215,51,2006


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 103 gm/kg/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Reproductive: Tumorigenic effects: Ovarian tumors
JTEHD6 21,507,1987
oral
mouse
toxic dose : 103 gm/kg/2 year- intermittent Tumorigenic: Neoplastic by RTECS criteria

Reproductive: Tumorigenic effects: Ovarian tumors
NTPTR* NTP-TR-303,1986
oral
mouse
toxic dose : 206 gm/kg/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Blood: Lymphoma including Hodgkin's disease
NTPTR* NTP-TR-303,1986
oral
mouse
lowest published toxic dose: 206,000 mg/kg/103 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Blood: Lymphoma including Hodgkin's disease
NTIS** PB87-116182
oral
mouse
lowest published toxic dose: 103,000 mg/kg/103 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Reproductive: Tumorigenic effects: Ovarian tumors
NTIS** PB87-116182
oral
rat
lowest published toxic dose: 103,000 mg/kg/102 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Reproductive: Other reproductive system tumors
NTIS** PB87-116182
skin
mouse
lowest published toxic dose: 16 gm/kg/54 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application
JNCIAM 31,41,1963


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lethal concentration (50 percent kill): 27 gm/m3 N/R IMEMDT 11,279,1976
inhalation
rat
lowest published lethal concentration: 8,000 ppm/4 hour N/R AIHAAP 30,470,1969
intraperitoneal
mouse
lowest published toxic dose: 800 mg/kg Reproductive: Maternal effects: Ovaries, fallopian tubes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other hydrolases

Biochemical: Metabolism (intermediary): Other
TOXID9 1,93,2001
oral
rat
lethal dose (50 percent kill): 3,080 ÁL/kg N/R AIHAAP 30,470,1969
skin
rabbit
lethal dose (50 percent kill): 20 mL/kg N/R AIHAAP 30,470,1969


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic concentration: 1,000 ppm/6 hour/4 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field TOXID9 15,182,1995
inhalation
mouse
lowest published toxic concentration: 1,000 ppm/6 hour/13 week- intermittent Blood: Pigmented or nucleated red blood cells

Blood: Changes in erythrocyte (RBC) count

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
FAATDF 32,1,1996
inhalation
mouse
lowest published toxic concentration: 1,500 ppm/6 hour/2 week- intermittent Behavioral: Tremor

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** OTS0556756
inhalation
rat
lowest published toxic concentration: 1,500 ppm/6 hour/13 week- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FAATDF 32,1,1996
inhalation
rat
lowest published toxic concentration: 1,500 ppm/6 hour/2 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** OTS0556756
intraperitoneal
mouse
lowest published toxic dose: 19,500 mg/kg/30 day- intermittent Reproductive: Maternal effects: Oogenesis TXAPA9 119,302,1993
intraperitoneal
mouse
lowest published toxic dose: 24,000 mg/kg/30 day- intermittent Reproductive: Maternal effects: Oogenesis

Reproductive: Maternal effects: Menstrual cycle changes or disorders
BIREBV 42,67,1990
intraperitoneal
mouse
lowest published toxic dose: 3,000 mg/kg/30 day- intermittent Reproductive: Maternal effects: Ovaries, fallopian tubes REPTED 5,379,1991
intraperitoneal
mouse
lowest published toxic dose: 12 gm/kg/15 day- intermittent Reproductive: Maternal effects: Ovaries, fallopian tubes TXAPA9 221,215,2007
oral
mouse
lowest published toxic dose: 17,500 mg/kg/14 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field JTEHD6 21,493,1987
oral
mouse
lowest published toxic dose: 78 gm/kg/13 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field JTEHD6 21,493,1987
oral
mouse
lowest published toxic dose: 63,000 mg/kg/18 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTIS** PB91211250
oral
mouse
lowest published toxic dose: 5,500 mg/kg/11 day- intermittent Reproductive: Maternal effects: Ovaries, fallopian tubes TXAPA9 215,51,2006
oral
rat
lowest published toxic dose: 17,500 mg/kg/14 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-303,1986
oral
rat
lowest published toxic dose: 52 gm/kg/13 week- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JTEHD6 21,493,1987
unreported route
mouse
lowest published toxic dose: 12,000 mg/kg/15 day- intermittent Reproductive: Maternal effects: Ovaries, fallopian tubes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other hydrolases
TOXID9 66,372,2002


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.1 ppm DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed animal carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 39,181,1986
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 60,347,1994
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 39,181,1986
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 60,347,1994
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMEMDT 60,347,1994
TOXICOLOGY REVIEW
MUREAV 543,201,2003
TOXICOLOGY REVIEW
MUREAV 584,1,2005
TOXICOLOGY REVIEW
MUREAV 654,114,2008
TOXICOLOGY REVIEW
MUREAV 654,114,2008


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - BELGIUM time-weighted average 0.1 ppm (0.45 mg/m3), Skin, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.1 ppm (0.4 mg/m3), OCT 2002
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.4 mg/m3, 2003
Occupational Exposure Limit - POLAND MAC(time-weighted average) 10 mg/m3, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 ppm, Skin, DEC2006


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an intermediate for the production of VINYLCYCLOHEXENE DIOXIDE
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0293-8735
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (gavage);clear evidence:mouse
NCI Carcinogenesis Studies (gavage);inadequate study:rat


REFERENCES:

CODEN
REFERENCE

AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W. Clark St., Champaign, IL 61820) V.1- 1969-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8.
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used as an intermediate for the production of VINYLCYCLOHEXENE DIOXIDE

NIOSH PROFILE (ALKENES, CYCLIC), SRC, 4/78

RTECS Compound Description:
   Tumorigen
   Reproductive Effector

Click Here for Additional Information about RTECS

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