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Registry of Toxic Effects of Chemical Substances (RTECS)

4-Cyclohexene-1,2-dicarboxylic anhydride

RTECS #

GW5775000

CAS #

85-43-8

Updated

November 2009

Molecular Weight

152.16

Molecular Formula

C8H8O3

Synonyms

1,2,3,6-Tetrahydrophthalic anhydride
1,3-Isobenzofurandione, 3a,4,7,7a-tetrahydro-
Anhydrid kyseliny tetrahydroftalove (Czech)
delta(sup 4)-Tetrahydrophthalic anhydride
Maleic anhydride adduct of butadiene
Phthalic anhydride, 1,2,3,6-tetrahydro-
Tetrahydroftalanhydrid (Czech)
Tetrahydrophthalic acid anhydride
Tetrahydrophthalic anhydride
THPA

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 20 mg/24H moderate85JCAE -,322,1986
skin /rabbit 500 mg/24H mild85JCAE -,322,1986

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/human lowest published toxic concentration: 10 mg/m3Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Other changes
TOVEFN (4),23,2000
inhalation/mouse Lethal concentration: >294 mg/m3GTPZAB 29(12),37,1985
inhalation/rat lowest published toxic concentration: 32 mg/m3Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Other changes
TOVEFN (4),23,2000
inhalation/rat Lethal concentration: >294 mg/m3GTPZAB 29(12),37,1985
intraperitoneal/mouse lowest published lethal dose: 500 mg/kgCBCCT* 7,780,1955
oral/mouse lethal dose (50 percent kill): 3300 mg/kgTOVEFN (4),23,2000
oral/rat lethal dose (50 percent kill): 3000 mg/kgTOVEFN (4),23,2000
unreported route/guinea pig lethal dose (50 percent kill): 3500 mg/kgHPV184 -,-,2001
unreported route/mouse lethal dose (50 percent kill): 3300 mg/kgHPV184 -,-,2001
unreported route/rat lethal dose (50 percent kill): 3000 mg/kgHPV184 -,-,2001

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-SWEDENSen, JUN2005

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X2931; Number of Industries 3; Total Number of Facilities 39; Number of Occupations 9; Total Number of Employees Exposed 1584; Total Number of Female Employees Exposed 547

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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