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Registry of Toxic Effects of Chemical Substances (RTECS)

Cyclohexane, 1,2,3,4,5,6-hexachloro-, beta-isomer

RTECS #

GV4375000

CAS #

319-85-7

Updated

December 2013

Molecular Weight

290.82

Molecular Formula

C6H6Cl6

Synonyms

1-alpha,2-beta,3-alpha,4-beta,5-alpha,6-beta-Hexachlorocyclohexane
beta-1,2,3,4,5,6-Hexachlorocyclohexane
beta-BHC
beta-HCH
beta-Hexachlorobenzene
beta-Hexachlorocyclohexane
Beta-Hexachlorocyclohexane
beta-Lindane
Cyclohexane, 1,2,3,4,5,6-hexachloro-, beta-
Cyclohexane, 1,2,3,4,5,6-hexachloro-, trans-
Cyclohexane, beta-1,2,3,4,5,6-hexachloro-
ENT 9,233
trans-alpha-Benzenehexachloride

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 672 mg/kg (2W male)Reproductive: Paternal effects: Testes, epididymis, sperm ductBECTA6 41,531,1988
subcutaneous/mouse 100 mg/kg (7D prior to copulation)Reproductive: Maternal effects: Uterus, cervix, vaginaEVHPAZ 108,973,2000

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 18 gm/kg/2Y- continuousTumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors
FCTXAV 11,433,1973

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/jrdInhibitor Concentration Low: 10 µmol/L/5MBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: PhosphokinaseTXAPA9 245,160,2010
In Vitro/jrdInhibitor Concentration Low: 10 µmol/L/24HIn Vitro Toxicity Studies: Other assaysTXAPA9 245,160,2010
intraperitoneal/mouse lowest published toxic dose: 5000 µg/kgLiver: Other changes

Endocrine: Estrogenic

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
TXAPA9 201,137,2004
oral/mouse lowest published lethal dose: 1500 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea
PHTXA6 22,273,1959
oral/rat lethal dose (50 percent kill): 6 gm/kgALLVAR 43,-,1955

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/monkey lowest published toxic dose: 2250 mg/kg/90D- intermittentLiver: Fatty liver degeneration

Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
NYKZAU 70,85P,1974
oral/mouse lowest published toxic dose: 13104 mg/kg/26W- continuousLiver: Other changes

Liver: Tumors

Liver: Changes in liver weight
CMSHAF 1,279,1972
oral/mouse lowest published toxic dose: 6048 mg/kg/12W- continuousLiver: Other changes

Liver: Changes in liver weight
CMSHAF 1,153,1972
oral/mouse lowest published toxic dose: 1080 mg/kg/30D- continuousBlood: Changes in spleenHBPTO* 1,771,2001
oral/mouse lowest published toxic dose: 9 gm/kg/30D- continuousEndocrine: Changes in spleen weight

Blood: Changes in other cell count (unspecified)

Immunological Including Allergic: Decrease in cellular immune response
FAATDF 11,293,1988
oral/rat lowest published toxic dose: 9 mg/kg/3D- intermittentRelated to Chronic Data: Changes in uterine weightTXAPA9 218,280,2007
oral/rat lowest published toxic dose: 672 mg/kg/2W- continuousLiver: Other changes

Liver: Changes in liver weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
BECTA6 41,531,1988
oral/rat lowest published toxic dose: 22750 mg/kg/13W- continuousLiver: Changes in liver weight

Blood: Changes in leukocyte (WBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
FAATDF 6,697,1986
oral/rat lowest published toxic dose: 8736 mg/kg/26W- continuousLiver: Other changes

Liver: Changes in liver weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JPETAB 100,59,1950
oral/rat lowest published toxic dose: 1989 mg/kg/30D- continuousPeripheral Nerve and Sensation: Recording from peripheral motor nerveBECTA6 27,704,1981
subcutaneous/mouse lowest published toxic dose: 100 mg/kg/1W- continuousEndocrine: Estrogenic

Reproductive: Maternal effects: Uterus, cervix, vagina
EVHPAZ 108,973,2000

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMEMDT 20,195,1979
TOXICOLOGY REVIEWREPTED 19,209,2004
TOXICOLOGY REVIEWNRTXDN 27,579,2006
TOXICOLOGY REVIEWCLBIAS 39,762,2006
TOXICOLOGY REVIEWENTOX* -,515,2005
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWJTEHD6 7,1,2004
TOXICOLOGY REVIEWJTPAE7 19,111,2006

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-DENMARKtime-weighted average 0.5 mg/m3, skin, carc, MAY2011
Occupational Exposure Limit-GERMANYMAK 0.5 mg/m3, inhal, 2011
Occupational Exposure Limit-ICELANDtime-weighted average 0.5 mg/m3, skin, NOV2011
Occupational Exposure Limit-SWITZERLANDMAK-week 0.5 mg/m3, inhal, skin, JAN2011

Status in Federal Agencies

OrganizationReference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/99/166662)
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen
On EPA IRIS database
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