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Registry of Toxic Effects of Chemical Substances (RTECS)

Cyclohexane, 1,2,3,4,5,6-hexachloro-, alpha-isomer

RTECS #

GV3500000

CAS #

319-84-6

Updated

April 2013

Molecular Weight

290.82

Molecular Formula

C6H6Cl6

Synonyms

1-alpha,2-alpha,3-beta,4-alpha,5-beta,6-beta-Hexachlorocyclohexane
alpha-1,2,3,4,5,6-Hexachlorocyclohexane
alpha-Benzenehexachloride
alpha-BHC
alpha-HCH
alpha-Hexachloran
alpha-Hexachlorane
alpha-Hexachlorcyclohexane
alpha-Hexachlorocyclohexane
alpha-Isomer of benzene hexachloride
alpha-Lindane
Benzene hexachloride-alpha-isomer
Cyclohexane, 1,2,3,4,5,6-hexachloro-, alpha-
Cyclohexane, alpha-1,2,3,4,5,6-hexachloro-
ENT 9,232
Hexachlorcyclohexan (German)

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisoral/rat756 mg/kg/3WJNCIAM 54,1245,1975
morphological transformoral/rat2520 mg/kg/6WCRNGDP 9,387,1988
Unscheduled DNA Synthesisoral/rat100 µmol/kgCRNGDP 8,1433,1987
Unscheduled DNA Synthesisliver/rat10 µmol/LCNREA8 42,3010,1982

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 5 gm/kg/24W- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
JNCIAM 51,1637,1973
oral/mouse toxic dose: 10 gm/kg/24W- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NAIZAM 25,635,1974
oral/mouse toxic dose: 12960 mg/kg/26W- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
CMSHAF 1,279,1972
oral/mouse toxic dose: 8820 mg/kg/21W- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors
JJIND8 71,1307,1983
oral/mouse toxic dose: 5040 mg/kg/24W- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors
SAIGBL 17,54,1975
oral/mouse toxic dose: 10080 mg/kg/24W- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NAIZAM 24,1,1973
oral/rat lowest published toxic dose: 5.040 mg/kg/6W- continuousTumorigenic: Neoplastic by RTECS criteria

Liver: Tumors

Tumorigenic: Facilitates action of known carcinogens
CALEDQ 163,179,2001
oral/rat toxic dose: 11040 mg/kg/86W- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors
CNREA8 41,4140,1981
oral/rat toxic dose: 13020 mg/kg/92W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors
CNREA8 41,4140,1981
oral/rat lowest published toxic dose: 20 gm/kg/48W- continuousTumorigenic: Neoplastic by RTECS criteria

Liver: Tumors
JNCIAM 54,801,1975

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
oral/human lowest published lethal dose: 14 gm/kg85GYAV -,54,1971
oral/mouse lethal dose (50 percent kill): 78 mg/kgOSDIAF 15,553,1966
oral/rat lowest published toxic dose: 20 mg/kgLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
JTSCDR 32,261,2007
oral/rat lethal dose (50 percent kill): 177 mg/kgFATOAO 39,455,1976

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 13104 mg/kg/26W- continuousLiver: Other changes

Liver: Tumors

Liver: Changes in liver weight
CMSHAF 1,279,1972
oral/mouse lowest published toxic dose: 6048 mg/kg/12W- continuousLiver: Other changes

Liver: Tumors

Liver: Changes in liver weight
CMSHAF 1,153,1972
oral/rat lowest published toxic dose: 30.2 gm/kg/72W- continuousLiver: TumorsENVRAL 19,460,1979
oral/rat lowest published toxic dose: 6 mg/kg/3D- intermittentLiver: Changes in liver weightJTSCDR 32,261,2007
oral/rat lowest published toxic dose: 140 mg/kg/7D- intermittentLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
JTSCDR 32,261,2007
oral/rat lowest published toxic dose: 60 mg/kg/3D- intermittentLiver: Other changes

Liver: Changes in liver weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
JTSCDR 32,261,2007
oral/rat lowest published toxic dose: 18 mg/kg/15D- continuousBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
TOLED5 56,137,1991
oral/rat lowest published toxic dose: 36 mg/kg/30D- continuousBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
TOLED5 56,137,1991
oral/rat lowest published toxic dose: 8736 mg/kg/26W- continuousLiver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JPETAB 100,59,1950

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 20,195,1979
TOXICOLOGY REVIEWMUREAV 567,109,2004
TOXICOLOGY REVIEWREPTED 19,209,2004
TOXICOLOGY REVIEWCLBIAS 39,762,2006
TOXICOLOGY REVIEWENTOX* -,515,2005
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWJTPAE7 19,111,2006
TOXICOLOGY REVIEWMUREAV 682,94,2009

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-DENMARKtime-weighted average 0.5 mg/m3, skin, carc, MAY2011
Occupational Exposure Limit-GERMANYMAK 0.5 mg/m3, inhal, 2011
Occupational Exposure Limit-ICELANDtime-weighted average 0.5 mg/m3, skin, NOV2011
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.05 mg/m3, Skin, JUN2003

Status in Federal Agencies

OrganizationReference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/90/171406/AS)
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-reversion
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen
On EPA IRIS database
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