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Cyclohexane, 1,2,3,4,5,6 - hexachloro - , alpha - isomer

RTECS #: GV3500000

CAS #: 319-84-6


UPDATE: February 2009 MW: 290.82 MF: C6H6Cl6


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 1 - alpha,2 - alpha,3 - beta,4 - alpha,5 - beta,6 - beta - Hexachlorocyclohexane
  2. Benzene hexachloride - alpha - isomer
  3. Cyclohexane, 1,2,3,4,5,6 - hexachloro - , alpha -
  4. Cyclohexane, alpha - 1,2,3,4,5,6 - hexachloro -
  5. ENT 9,232
  6. Hexachlorcyclohexan (German)
  7. alpha - 1,2,3,4,5,6 - Hexachlorocyclohexane
  8. alpha - BHC
  1. alpha - Benzenehexachloride
  2. alpha - HCH
  3. alpha - Hexachloran
  4. alpha - Hexachlorane
  5. alpha - Hexachlorcyclohexane
  6. alpha - Hexachlorocyclohexane
  7. alpha - Isomer of benzene hexachloride
  8. alpha - Lindane


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis oral
rat
756 mg/kg/3 week JNCIAM 54,1245,1975
unscheduled DNA synthesis oral
rat
100 Ámol/kg CRNGDP 8,1433,1987
unscheduled DNA synthesis rat liver 10 Ámol/L CNREA8 42,3010,1982
morphological transform oral
rat
2,520 mg/kg/6 week CRNGDP 9,387,1988


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 5 gm/kg/24 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
JNCIAM 51,1637,1973
oral
mouse
toxic dose : 10 gm/kg/24 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NAIZAM 25,635,1974
oral
mouse
toxic dose : 12,960 mg/kg/26 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
CMSHAF 1,279,1972
oral
mouse
toxic dose : 8,820 mg/kg/21 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors
JJIND8 71,1307,1983
oral
mouse
toxic dose : 5,040 mg/kg/24 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors
SAIGBL 17,54,1975
oral
mouse
toxic dose : 10,080 mg/kg/24 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NAIZAM 24,1,1973
oral
rat
lowest published toxic dose: 20 gm/kg/48 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Liver: Tumors
JNCIAM 54,801,1975
oral
rat
toxic dose : 11,040 mg/kg/86 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors
CNREA8 41,4140,1981
oral
rat
toxic dose : 13,020 mg/kg/92 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors
CNREA8 41,4140,1981
oral
rat
lowest published toxic dose: 5.040 mg/kg/6 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Liver: Tumors

Tumorigenic: Facilitates action of known carcinogens
CALEDQ 163,179,2001


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
human
lowest published lethal dose: 14 gm/kg N/R 85GYAV -,54,1971
oral
mouse
lethal dose (50 percent kill): 78 mg/kg N/R OSDIAF 15,553,1966
oral
rat
lethal dose (50 percent kill): 177 mg/kg N/R FATOAO 39,455,1976
oral
rat
lowest published toxic dose: 20 mg/kg Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
JTSCDR 32,261,2007


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 13,104 mg/kg/26 week- continuous Liver: Other changes

Liver: Tumors

Liver: Changes in liver weight
CMSHAF 1,279,1972
oral
mouse
lowest published toxic dose: 6,048 mg/kg/12 week- continuous Liver: Other changes

Liver: Tumors

Liver: Changes in liver weight
CMSHAF 1,153,1972
oral
rat
lowest published toxic dose: 18 mg/kg/15 day- continuous Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
TOLED5 56,137,1991
oral
rat
lowest published toxic dose: 36 mg/kg/30 day- continuous Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
TOLED5 56,137,1991
oral
rat
lowest published toxic dose: 8,736 mg/kg/26 week- continuous Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JPETAB 100,59,1950
oral
rat
lowest published toxic dose: 30.2 gm/kg/72 week- continuous Liver: Tumors ENVRAL 19,460,1979
oral
rat
lowest published toxic dose: 6 mg/kg/3 day- intermittent Liver: Changes in liver weight JTSCDR 32,261,2007
oral
rat
lowest published toxic dose: 140 mg/kg/7 day- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
JTSCDR 32,261,2007
oral
rat
lowest published toxic dose: 60 mg/kg/3 day- intermittent Liver: Other changes

Liver: Changes in liver weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
JTSCDR 32,261,2007


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 20,195,1979
TOXICOLOGY REVIEW
MUREAV 567,109,2004
TOXICOLOGY REVIEW
REPTED 19,209,2004
TOXICOLOGY REVIEW
CLBIAS 39,762,2006
TOXICOLOGY REVIEW
ENTOX* -,515,2005
TOXICOLOGY REVIEW
MUREAV 584,1,2005
TOXICOLOGY REVIEW
JTPAE7 19,111,2006


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - FINLAND time-weighted average 0.5 mg/m3, Skin, Carcinogen, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 0.05 mg/m3, Skin, JUN2003
Occupational Exposure Limit - SWITZERLAND MAK- week 0.5 mg/m3, Skin, DEC2006


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

ATSDR TOXICOLOGY PROFILE (NTIS** PB/90/171406/AS)
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-reversion
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an agricultural chemical, pesticide, pharmaceutical and veterinary drug
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen


REFERENCES:

CODEN
REFERENCE

85GYAV "Pflanzenschutz-und Schaedlingsbekaempfungsmittel: Abriss einer Toxikologie und Therapie von Vergiftungen," 2nd ed., Klimmer, O.R., Hattingen, Fed. Rep. Ger., Hundt-Verlag, 1971
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975-
CLBIAS Clinical Biochemistry (Ottawa). (Laureen Dodge, Bus. Off., Ottawa, Ont., Canada) V.1- 1967-
CMSHAF Chemosphere. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1972-
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967-
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ.
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8.
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JTPAE7 Journal of Toxicologic Pathology. (Nihon Dokusei Byori Gakkai, editor, 3-25-8 Nishi- shinbashi, Minato-ku, Tokyo 105, Japan) V.1- 1988
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NAIZAM Nara Igaku Zasshi. Journal of the Nara Medical Association. (Nara Igakkai, c/o Narakenritsu Ika Daigaku, Shijo-cho, Kashihara, Nara-ken, Japan) V.1- 1950-
OSDIAF Osaka Shiritsu Daigaku Igaku Zasshi. Journal of the Osaka City Medical Center. (Osaka, Japan) V.4-23, 1955-74. For publisher information, see OIGZDE.
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
SAIGBL Sangyo Igaku. Japanese Journal of Industrial Health. (Nippon Sangyo Eisei Igakkai, Kosu Eisei Bldg., 1-29-8, Shinjuku, Shinjuku-ku, Tokyo 160, Japan) V.1- 1959-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-

Used as an agricultural chemical, pesticide, pharmaceutical and veterinary drug

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Human Data

Click Here for Additional Information about RTECS

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