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Registry of Toxic Effects of Chemical Substances (RTECS)

Cyclohexane, 1,2,3,4,5,6-hexachloro-

RTECS #

GV3150000

CAS #

608-73-1

Updated

December 2012

Molecular Weight

290.82

Molecular Formula

C6H6Cl6

Synonyms

1,2,3,4,5,6-Hexachlorocyclohexane
Benzene hexachloride
BHC
ENT 8,601
HCH
Hexachlorocyclohexane
Hexachlorocyclohexane technical
Latka 666 (Czech)

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
morphological transformoral/rat875 mg/kg/7W- intermittentCRNGDP 5,479,1984
mutation in microorganisms/Other microorganisms100 mg/L (-enzymatic activation step)MILEDM 5,103,1977

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 8100 mg/kg (90D male)Reproductive: Paternal effects: Testes, epididymis, sperm ductAPTOA6 52,12,1983
oral/mouse 9120 mg/kg (22W male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)BECTA6 26,508,1981
oral/mouse 5460 mg/kg (91D male)Reproductive: Paternal effects: Testes, epididymis, sperm ductBECTA6 23,431,1979

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse toxic dose: 800 mg/kg/80W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors

Blood: Tumors
JPFCD2 14,305,1979
oral/mouse toxic dose: 12600 mg/kg/30W- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
JCROD7 99,143,1981
oral/mouse toxic dose: 12960 mg/kg/26W- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
CMSHAF 1,279,1972
oral/mouse toxic dose: 21600 mg/kg/52W- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
TUMOAB 69,383,1983
oral/mouse toxic dose: 5400 mg/kg/13W- continuousTumorigenic: Neoplastic by RTECS criteria

Liver: Tumors
TUMOAB 69,383,1983
oral/mouse toxic dose: 7200 mg/kg/17W- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors
IJEBA6 19,1159,1981
oral/mouse toxic dose: 9 gm/kg/21W- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors
AEHLAU 37,156,1982
oral/mouse toxic dose: 10800 mg/kg/26W- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors
AEHLAU 37,156,1982
oral/mouse toxic dose: 7200 mg/kg/17W- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors
CMBID4 27,231,1981
oral/mouse toxic dose: 10800 mg/kg/26W- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors
CMBID4 27,231,1981
oral/mouse lowest published toxic dose: 7.2 gm/kg/120D- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors
ETPAEK 61,325,2009
oral/mouse lowest published toxic dose: 6720 mg/kg/80W- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Blood: Tumors
JPFCD2 14,305,1979
skin/mouse lowest published toxic dose: 1600 mg/kg/80W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors

Blood: Tumors
JPFCD2 14,305,1979

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/cat Lowest published lethal concentration: 25 mg/m3/6HVCVGH* -,537,1990
inhalation/man lowest published toxic concentration: 400 µg/kg/3DBehavioral: Headache

Gastrointestinal: Nausea or vomiting

Nutritional and Gross Metabolic: Body temperature increase
GISAAA 49(10),26,1984
inhalation/rat lethal concentration (50 percent kill): 690 mg/m3/4HGISAAA 56(2),80,1991
oral/cat lethal dose (50 percent kill): 300 mg/kgVCVGH* -,537,1990
oral/chicken lethal dose (50 percent kill): 597 mg/kgPeripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia
POSCAL 60,2599,1981
oral/guinea pig lowest published lethal dose: 1400 mg/kgMEMOAQ 4,25,1950
oral/mouse lethal dose (50 percent kill): 59 mg/kgPEMNDP 9,452,1991
oral/quail lethal dose (50 percent kill): 120 mg/kgPEMNDP 9,452,1991
oral/rat lethal dose (50 percent kill): 100 mg/kgATXKA8 22,115,1966
oral/rat lowest published lethal dose: 400 mg/kgVCVGH* -,537,1990
oral/wild bird lethal dose (50 percent kill): 56 mg/kgTXAPA9 21,315,1972
skin/rat lethal dose (50 percent kill): 900 mg/kg85DPAN -,-,1971/1976
subcutaneous/rabbit lethal dose (50 percent kill): 75 mg/kgXPHPAW 414,273,1955

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rabbit lowest published toxic dose: 650 mg/kg/65W- intermittentEye: Retinal changes pigmentary deposition, retinitis, other)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Nutritional and Gross Metabolic: Conditioned vitamin deficiency
JTOTDO 6,161,1987
oral/mouse lowest published toxic dose: 750 mg/kg/15D- intermittentLiver: Other changes

Kidney, Ureter, and Bladder: Other changes

Biochemical: Metabolism (intermediary): Other proteins
BECTA6 41,822,1988
oral/mouse lowest published toxic dose: 13104 mg/kg/26W- continuousLiver: Other changes

Liver: Tumors

Liver: Changes in liver weight
CMSHAF 1,279,1972
oral/mouse lowest published toxic dose: 3.6 gm/kg/60D- continuousLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases

Biochemical: Metabolism (intermediary): TCS cycle
ETPAEK 61,325,2009
oral/rat lowest published toxic dose: 350 mg/kg/2W- intermittentBrain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Biochemical: Metabolism (intermediary): Lipids including transport
TXCYAC 214,123,2005
oral/rat lowest published toxic dose: 2259 mg/kg/90D- continuousBehavioral: Tremor

Liver: Hepatitis (hepatocellular necrosis), diffuse

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JAPTO* 21,75,2001
oral/rat lowest published toxic dose: 4500 mg/kg/90D- continuousLiver: Hepatitis (hepatocellular necrosis), diffuse

Blood: Changes in cell count (unspecified)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
JAPTO* 21,75,2001
oral/rat lowest published toxic dose: 2500 mg/kg/90D- continuousLiver: Other changes

Endocrine: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
IJEBA6 19,1163,1981
skin/guinea pig lowest published toxic dose: 3 gm/kg/30D- intermittentLiver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
JTOTDO 11,3,1992
skin/rat lowest published toxic dose: 6000 mg/kg/120D- intermittentEndocrine: Androgenic

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
HETOEA 14,484,1995

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 5,47,1974
TOXICOLOGY REVIEWAABIAV 35,505,1948
TOXICOLOGY REVIEWECMAAI 14,141,1973
TOXICOLOGY REVIEWNETOX* 26,531,2005
TOXICOLOGY REVIEWCLBIAS 39,762,2006
TOXICOLOGY REVIEWENTOX* -,515,2005
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWITODC* -,327,2004
TOXICOLOGY REVIEWHTOPA* 1,501,2002

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-DENMARKtime-weighted average 0.5 mg/m3, skin, carc, MAY2011
Occupational Exposure Limit-ICELANDtime-weighted average 0.5 mg/m3, skin, NOV2011
Occupational Exposure Limit-JAPAN2B carc, MAY2012
Occupational Exposure Limit-POLANDMAC(time-weighted average) 0.05 mg/m3, MAC(short term exposure limit) 0.4 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.1 mg/m3, Skin, JUN2003

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP 10th Report on Carcinogens,2002:Reasonably anticipated to be a human carcinogen
On EPA IRIS database
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