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Registry of Toxic Effects of Chemical Substances (RTECS)

Crotonic acid, 2(or 4)-(1-methylheptyl)-4,6(or 2,6)-dinitrophenyl ester

RTECS #

GQ5775000

CAS #

39300-45-3; 12684-10-5

Updated

November 2008

Molecular Weight

364.44

Molecular Formula

C18H24N2O6

Synonyms

(6-(1-Methyl-heptyl)-2,3-dinitro-phenyl)-crotonat (German)
(6-(1-Methyl-heptyl)-2,4-dinitro-fenyl)-crotonaat (Dutch)
(6-(1-Metil-epitl)-2,4-dinitro-fenil)-crotonato (Italian)
2-(1-Methylheptyl)-4,6-dinitrofenylester kyseliny krotonove (Czech)
2-(1-Methylheptyl)-4,6-dinitrophenyl crotonate
2,4-Dinitro-6-(1-methylheptyl)phenyl crotonate
2,4-Dinitro-6-(1-methylheptyl)-phenylcrotonat (German)
2,4-Dinitro-6-(2-octyl)phenyl crotonate
2-Butenoic acid, 2-(or 4)-isooctyl-4,6(or 2,6)-dinitrophenyl ester (9CI)
2-Capryl-4,6-dinitrophenyl crotonate
4,6-Dinitro-2-(1-methylheptyl)phenyl crotonate
4,6-Dinitro-2-(2-capryl)phenyl crotonate
4,6-Dinitro-2-caprylphenyl crotonate
Arathane
Caprane
Capryldinitrophenyl crotonate
CR 1639
Crotonate de 2,4-dinitro 6-(1-methyl-heptyl)-phenyle (French)
Crotonic acid 2,4-dinitro-6-(1-methylheptyl)phenyl ester
Crotonic acid 2,4-dinitro-6-(2-octyl)phenyl ester
Crotothane
Dinitro(1-methylheptyl)phenyl crotonate
Dinocap
Dinokap
Dinokapu (Polish)
DPC (pesticide)
ENT 24727
Karathane
Karathane 25
Karathane FN 57
Karathane WD
Mildex
Phenol, 2-(1-methylheptyl)-4,6-dinitro-, crotonate (ester)

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
mutation in microorganisms/Salmonella typhimurium500 µg/plate (+enzymatic activation step)MUREAV 116,185,1983
mutation in microorganisms/Saccharomyes cerevisiae5 ppm (-enzymatic activation step)RSTUDV 6,161,1976

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/mouse 120 mg/kg (7-16D pregnant)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Behavioral
TCMUD8 6,33,1986
oral/mouse 250 mg/kg (7-16D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)
TCMUD8 6,33,1986
oral/mouse 50 mg/kg (7-16D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)TCMUD8 6,375,1986
oral/mouse 100 mg/kg (7-16D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Hepatobiliary system
TCMUD8 6,375,1986
oral/mouse 200 mg/kg (7-16D pregnant)Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)TCMUD8 6,375,1986
oral/hamster 400 mg/kg (8-11D pregnant)Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
TCMUD8 6,33,1986
oral/hamster 800 mg/kg (7-14D pregnant)Reproductive: Specific developmental abnormalities: Eye, earTJADAB 39,515,1989
oral/hamster 400 mg/kg (7-14D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)TJADAB 39,515,1989
oral/hamster 800 mg/kg (7-14D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death
TJADAB 39,515,1989
oral/mouse 550 mg/kg (1-21D pregnant)Reproductive: Effects on newborn: StillbirthHBPTO* 2,1230,2001
oral/mouse 264 mg/kg (1-21D pregnant)Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Other developmental abnormalities
HBPTO* 2,1230,2001
oral/mouse 300 mg/kg (6-17D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)
TERS5* -,313,2005

Tumorigenic Data and References

Route/OrganismDoseEffectReference
subcutaneous/mouse lowest published toxic dose: 10 mg/kgTumorigenic: Neoplastic by RTECS criteria

Blood: Tumors
NTIS** PB223-159

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lethal concentration (50 percent kill): 360 mg/m3/4HPEMNDP 9,303,1991
inhalation/rat lethal concentration (50 percent kill): 3000000 mg/m3HBPTO* 2,1229,2001
intravenous/rat lethal dose (50 percent kill): 2.5 mg/kgHBPTO* 2,1228,2001
oral/Dog lethal dose (50 percent kill): 100 mg/kgSPEADM 78-1,25,1978
oral/mouse lethal dose (50 percent kill): 49500 µg/kgBCTKAG 8,373,1975
oral/rabbit lethal dose (50 percent kill): 3 gm/kgBCTKAG 8,373,1975
oral/rat lethal dose (50 percent kill): 980 mg/kgHBPTO* 2,1229,2001
oral/rat lethal dose (50 percent kill): 766 mg/kgLiver: Other changesKHZDAN 18,379,1975
skin/rabbit lethal dose (50 percent kill): 9400 mg/kgSPEADM 78-1,25,1978

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/Dog lowest published toxic dose: 9125 mg/kg/1Y- continuousLiver: Other changes

Blood: Changes in spleen

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
AIPTAK 119,31,1959
oral/Dog lowest published toxic dose: 562.5 mg/kg/90D- continuousLiver: Hepatitis (hepatocellular necrosis), zonalHBPTO* 2,1228,2001
oral/Dog lowest published toxic dose: 1095 mg/kg/2Y- continuousEye: Retinal changes pigmentary deposition, retinitis, other)HBPTO* 2,1229,2001
oral/duck lowest published toxic dose: 123 mg/kg/7W- continuousEye: Other eye effectsAIPTAK 119,31,1959
oral/mouse lowest published toxic dose: 300 mg/kg/12D- intermittentEndocrine: Changes in spleen weight

Endocrine: Changes in thymus weight

Immunological Including Allergic: Increased immune response
TXCYAC 75,235,1992
oral/mouse lowest published toxic dose: 105 mg/kg/7D- intermittentImmunological Including Allergic: Decrease in humoral immune responseTXCYAC 75,235,1992
oral/mouse lowest published toxic dose: 175 mg/kg/7D- intermittentEndocrine: Changes in spleen weight

Endocrine: Changes in thymus weight

Immunological Including Allergic: Decrease in cellular immune response
HBPTO* 2,1230,2001
oral/mouse lowest published toxic dose: 1680 mg/kg/28D- continuousLiver: Hepatitis (hepatocellular necrosis), zonal

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HBPTO* 2,1228,2001
oral/mouse lowest published toxic dose: 9855 mg/kg/78W- continuousReproductive: Paternal effects: Testes, epididymis, sperm duct

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HBPTO* 2,1229,2001
oral/rabbit lowest published toxic dose: 2700 mg/kg/90D- continuousGastrointestinal: Other changes

Liver: Hepatitis (hepatocellular necrosis), zonal

Kidney, Ureter, and Bladder: Other changes
HBPTO* 2,1228,2001
oral/rat lowest published toxic dose: 27300 mg/kg/26W- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
AIPTAK 119,31,1959
oral/rat lowest published toxic dose: 2920 gm/kg/2Y- continuousBlood: Pigmented or nucleated red blood cells

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
BCTKAG 11,111,1978
oral/rat lowest published toxic dose: 1700 mg/kg/90D- intermittentLiver: Changes in liver weight

Endocrine: Hyperglycemia

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
BCTKAG 9,217,1976
oral/rat lowest published toxic dose: 91.25 gm/kg/2Y- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HBPTO* 2,1229,2001
oral/rat lowest published toxic dose: 91.25 gm/kg/2Y- continuousEndocrine: Other changesHBPTO* 2,1229,2001

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWMUTAEX 21,93,2006

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESSupportedRBREV* -,176,1998

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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