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Crotonic acid, 2 (or 4) - (1 - methylheptyl) - 4,6 (or 2,6) - dinitrophenyl ester

RTECS #: GQ5775000

CAS #: 39300-45-3


UPDATE: November 2008 MW: 364.44 MF: C18H24N2O6


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. (6 - (1 - Methyl - heptyl) - 2,4 - dinitro - fenyl) - crotonaat (Dutch)
  2. (6 - (1 - Methyl - heptyl) - 2,3 - dinitro - phenyl) - crotonat (German)
  3. (6 - (1 - Metil - epitl) - 2,4 - dinitro - fenil) - crotonato (Italian)
  4. 2,4 - Dinitro - 6 - (1 - methylheptyl) - phenylcrotonat (German)
  5. 2,4 - Dinitro - 6 - (1 - methylheptyl) phenyl crotonate
  6. 2,4 - Dinitro - 6 - (2 - octyl) phenyl crotonate
  7. 2 - (1 - Methylheptyl) - 4,6 - dinitrofenylester kyseliny krotonove (Czech)
  8. 2 - (1 - Methylheptyl) - 4,6 - dinitrophenyl crotonate
  9. 2 - Butenoic acid, 2 - (or 4) - isooctyl - 4,6 (or 2,6) - dinitrophenyl ester (9CI)
  10. 2 - Capryl - 4,6 - dinitrophenyl crotonate
  11. 4,6 - Dinitro - 2 - caprylphenyl crotonate
  12. 4,6 - Dinitro - 2 - (2 - capryl) phenyl crotonate
  13. 4,6 - Dinitro - 2 - (1 - methylheptyl) phenyl crotonate
  14. Arathane
  15. CR 1639
  16. Caprane
  17. Capryldinitrophenyl crotonate
  1. Crotonate de 2,4 - dinitro 6 - (1 - methyl - heptyl) - phenyle (French)
  2. Crotonic acid 2,4 - dinitro - 6 - (1 - methylheptyl) phenyl ester
  3. Crotonic acid 2,4 - dinitro - 6 - (2 - octyl) phenyl ester
  4. Crotothane
  5. DPC (pesticide)
  6. Dinitro (1 - methylheptyl) phenyl crotonate
  7. Dinocap
  8. Dinokap
  9. Dinokapu (Polish)
  10. ENT 24727
  11. Karathane
  12. Karathane 25
  13. Karathane FN 57
  14. Karathane WD
  15. Mildex
  16. Phenol, 2 - (1 - methylheptyl) - 4,6 - dinitro - , crotonate (ester)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
mutation in microorganisms Salmonella typhimurium 500 g/plate (+enzymatic activation step) MUREAV 116,185,1983
mutation in microorganisms Saccharomyes cerevisiae 5 ppm (-enzymatic activation step) RSTUDV 6,161,1976


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
hamster
lowest published toxic dose: 400 mg/kg (8-11 day pregnant) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
TCMUD8 6,33,1986
oral
hamster
lowest published toxic dose: 800 mg/kg (7-14 day pregnant) Reproductive: Specific developmental abnormalities: Eye, ear TJADAB 39,515,1989
oral
hamster
lowest published toxic dose: 400 mg/kg (7-14 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TJADAB 39,515,1989
oral
hamster
lowest published toxic dose: 800 mg/kg (7-14 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death
TJADAB 39,515,1989
oral
mouse
lowest published toxic dose: 120 mg/kg (7-16 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Behavioral
TCMUD8 6,33,1986
oral
mouse
lowest published toxic dose: 250 mg/kg (7-16 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)
TCMUD8 6,33,1986
oral
mouse
lowest published toxic dose: 50 mg/kg (7-16 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TCMUD8 6,375,1986
oral
mouse
lowest published toxic dose: 100 mg/kg (7-16 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Hepatobiliary system
TCMUD8 6,375,1986
oral
mouse
lowest published toxic dose: 200 mg/kg (7-16 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) TCMUD8 6,375,1986
oral
mouse
lowest published toxic dose: 550 mg/kg (1-21 day pregnant) Reproductive: Effects on newborn: Stillbirth HBPTO* 2,1230,2001
oral
mouse
lowest published toxic dose: 264 mg/kg (1-21 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Other developmental abnormalities
HBPTO* 2,1230,2001
oral
mouse
lowest published toxic dose: 300 mg/kg (6-17 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)
TERS5* -,313,2005


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
subcutaneous
mouse
lowest published toxic dose: 10 mg/kg Tumorigenic: Neoplastic by RTECS criteria

Blood: Tumors
NTIS** PB223-159


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lethal concentration (50 percent kill): 360 mg/m3/4 hour N/R PEMNDP 9,303,1991
inhalation
rat
lethal concentration (50 percent kill): 3,000,000 mg/m3 N/R HBPTO* 2,1229,2001
intravenous
rat
lethal dose (50 percent kill): 2.5 mg/kg N/R HBPTO* 2,1228,2001
oral
dog
lethal dose (50 percent kill): 100 mg/kg N/R SPEADM 78-1,25,1978
oral
mouse
lethal dose (50 percent kill): 49,500 g/kg N/R BCTKAG 8,373,1975
oral
rat
lethal dose (50 percent kill): 766 mg/kg Liver: Other changes KHZDAN 18,379,1975
oral
rat
lethal dose (50 percent kill): 980 mg/kg N/R HBPTO* 2,1229,2001
oral
rabbit
lethal dose (50 percent kill): 3 gm/kg N/R BCTKAG 8,373,1975
skin
rabbit
lethal dose (50 percent kill): 9,400 mg/kg N/R SPEADM 78-1,25,1978


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
duck
lowest published toxic dose: 123 mg/kg/7 week- continuous Eye: Other eye effects AIPTAK 119,31,1959
oral
dog
lowest published toxic dose: 9,125 mg/kg/1 year- continuous Liver: Other changes

Blood: Changes in spleen

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
AIPTAK 119,31,1959
oral
dog
lowest published toxic dose: 562.5 mg/kg/90 day- continuous Liver: Hepatitis (hepatocellular necrosis), zonal HBPTO* 2,1228,2001
oral
dog
lowest published toxic dose: 1,095 mg/kg/2 year- continuous Eye: Retinal changes pigmentary deposition, retinitis, other) HBPTO* 2,1229,2001
oral
mouse
lowest published toxic dose: 300 mg/kg/12 day- intermittent Endocrine: Changes in spleen weight

Endocrine: Changes in thymus weight

Immunological Including Allergic: Increased immune response
TXCYAC 75,235,1992
oral
mouse
lowest published toxic dose: 105 mg/kg/7 day- intermittent Immunological Including Allergic: Decrease in humoral immune response TXCYAC 75,235,1992
oral
mouse
lowest published toxic dose: 1,680 mg/kg/28 day- continuous Liver: Hepatitis (hepatocellular necrosis), zonal

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HBPTO* 2,1228,2001
oral
mouse
lowest published toxic dose: 9,855 mg/kg/78 week- continuous Reproductive: Paternal effects: Testes, epididymis, sperm duct

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HBPTO* 2,1229,2001
oral
mouse
lowest published toxic dose: 175 mg/kg/7 day- intermittent Endocrine: Changes in spleen weight

Endocrine: Changes in thymus weight

Immunological Including Allergic: Decrease in cellular immune response
HBPTO* 2,1230,2001
oral
rat
lowest published toxic dose: 27,300 mg/kg/26 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
AIPTAK 119,31,1959
oral
rat
lowest published toxic dose: 2,920 gm/kg/2 year- continuous Blood: Pigmented or nucleated red blood cells

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
BCTKAG 11,111,1978
oral
rat
lowest published toxic dose: 1,700 mg/kg/90 day- intermittent Liver: Changes in liver weight

Endocrine: Hyperglycemia

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
BCTKAG 9,217,1976
oral
rat
lowest published toxic dose: 91.25 gm/kg/2 year- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HBPTO* 2,1229,2001
oral
rat
lowest published toxic dose: 91.25 gm/kg/2 year- continuous Endocrine: Other changes HBPTO* 2,1229,2001
oral
rabbit
lowest published toxic dose: 2,700 mg/kg/90 day- continuous Gastrointestinal: Other changes

Liver: Hepatitis (hepatocellular necrosis), zonal

Kidney, Ureter, and Bladder: Other changes
HBPTO* 2,1228,2001


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
MUTAEX 21,93,2006


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,176,1998


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
BCTKAG Bromatologia i Chemia Toksykologiczna. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.4- 1971-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
KHZDAN Khigiena i Zdraveopazvane. Hygiene and Sanitation. (Hemus, Blvd. Russki 6, Sofia, Bulgaria) V.9- 1966-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
RSTUDV Rivista di Scienza e Technologia degli Alimenti e di Nutrizione Umana. Review of Science and Technology of Food and Human Nutrition. (Bologna, Italy) V.5-6, 1975-76. Discontinued.
SPEADM Special Publication of the Entomological Society of America. (4603 Calvert Rd., College Park, MD 20740)
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980-
TERS5*
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-

Used for control of powdery mildew diseases and certain species of mites

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector

ALT CAS #: 12684-10-5
Click Here for Additional Information about RTECS

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