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Registry of Toxic Effects of Chemical Substances (RTECS)

Crotonic acid

RTECS #

GQ2800000

CAS #

3724-65-0

Updated

July 2011

Molecular Weight

86.10

Molecular Formula

C4H6O2

Synonyms

2-Butenoic acid (9CI)
3-Methylacrylic acid
Acrylic acid, 3-methyl-
alpha-Butenoic acid
alpha-Crotonic acid
beta-Methylacrylic acid
Kyselina krotonova (Czech)

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /rabbit 10 mg/24H open irritation testJIHTAB 26,269,1944

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, liver tumor Inhibitor Concentration (50 percent kill): 49 mmol/L/24HIn Vitro Toxicity Studies: Cell protein synthesisTIVIEQ 3,189,1989
intraperitoneal/mouse lethal dose (50 percent kill): 25 mg/kg38MKAJ 2C,4953,1982
oral/mouse lethal dose (50 percent kill): 4800 mg/kgTumorigenic: Active as anti-cancer agentBIJOAK 34,1196,1940
oral/rat lethal dose (50 percent kill): 1 gm/kgJIHTAB 26,269,1944
skin/guinea pig lethal dose (50 percent kill): 200 mg/kg38MKAJ 2C,4953,1982
skin/rabbit lethal dose (50 percent kill): 600 mg/kg85JCAE -,309,1986
subcutaneous/mouse lethal dose (50 percent kill): 3590 mg/kgJPPMAB 21,85,1969

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 84287; Number of Industries 6; Total Number of Facilities 303; Number of Occupations 7; Total Number of Employees Exposed 5343; Total Number of Female Employees Exposed 209
National Occupational Hazard Survey 1974Hazard Code 84287; Number of Industries 7; Total Number of Facilities 234; Number of Occupations 9; Total Number of Employees Exposed 2460

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
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