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Registry of Toxic Effects of Chemical Substances (RTECS)

o-Cresol, 4-chloro-

RTECS #

GO7120000

CAS #

1570-64-5

Updated

February 2004

Molecular Weight

142.59

Molecular Formula

C7H7ClO

Synonyms

4-Chloro-2-methylphenol
4-Chloro-o-cresol

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
mutation in microorganisms/Salmonella typhimurium100 µg/plate (+enzymatic activation step)TECSDY 14,143,1987

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat lethal dose (50 percent kill): 794 mg/kgVCVGK* -,254,1994
intravenous/mouse lethal dose (50 percent kill): 56 mg/kgVCVGK* -,254,1994
oral/mouse lethal dose (50 percent kill): 1320 mg/kgPHARAT 30,147,1975

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 14000 mg/kg/4W- intermittentLiver: Other changes

Kidney, Ureter, and Bladder: Other changes

Gastrointestinal: Other changes
VCVGK* -,254,1994
oral/rat lowest published toxic dose: 2800 mg/kg/4W- intermittentGastrointestinal: GastritisVCVGK* -,254,1994
oral/rat lowest published toxic dose: 3500 mg/kg/2W- intermittentLiver: Other changes

Kidney, Ureter, and Bladder: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVGK* -,254,1994

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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