Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to page options Skip directly to site content

Registry of Toxic Effects of Chemical Substances (RTECS)

Coumarin, 3-chloro-7-hydroxy-4-methyl-, O-ester with O,O-diethyl phosphorothioate

RTECS #

GN6300000

CAS #

56-72-4

Updated

September 201

Molecular Weight

362.78

Molecular Formula

C14H16ClO5PS

Synonyms

3-Chloro-4-methyl-7-coumarinyl diethyl phosphorothioate
3-Chloro-4-methyl-7-hydroxycoumarin diethyl thiophosphoric acid ester
3-Chloro-4-methylumbelliferone O-ester with O,O-diethyl phosphorothioate
3-Chloro-7-hydroxy-4-methyl-coumarin O,O-diethyl phosphorothioate
3-Chloro-7-hydroxy-4-methyl-coumarin O-ester with O,O-diethyl phosphorothioate
Agridip
Asunthol
Asuntol
Azunthol
BAY 21/199
Bayer 21/199
Baymix
Baymix 50
CO-Ral
Coumafos
Coumaphos
Cumafos (Dutch)
Diethyl 3-chloro-4-methylumbelliferyl thionophosphate
Diethyl thiophosphoric acid ester of 3-chloro-4-methyl-7-hydroxycoumarin
Diolice
ENT 17,957
Meldane
Meldone
Muscatox
NCI-C08662
Negashunt
O,O-Diaethyl-O-(3-chlor-4-methyl-cumarin-7-yl)-monothiophosphat (German)
O,O-Diethyl 3-chloro-4-methyl-7-umbelliferone thiophosphate
O,O-Diethyl O-(3-chloro-4-methyl-2-oxo-2H-benzopyran-7-yl)phosphorothioate
O,O-Diethyl O-(3-chloro-4-methyl-7-coumarinyl)phosphorothioate
O,O-Diethyl O-(3-chloro-4-methylcoumarinyl-7) thiophosphate
O,O-Diethyl O-(3-chloro-4-methylumbelliferyl)phosphorothioate
O,O-Diethyl-O-(3-chloor-4-methyl-cumarin-7-yl)monothiofosfaat (Dutch)
O,O-Dietil-O-(3-cloro-4-metil-cumarin-7-il-monotiofosfato) (Italian)
O-3-Chloro-4-methyl-7-coumarinyl O,O-diethyl phosphorothioate
Phosphorothioic acid, O,O-diethyl ester, O-ester with 3-chloro-7-hydroxy-4-methylcoumarin
Resistox
Resitox
Suntol
Thiophosphate de O,O-diethyle et de O-(3-chloro-4-methyl-7-coumarinyle) (French)
Umbethion

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
morphological transformembryo/rat1400 ng/plateJJATDK 1,190,1981

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 394 mg/kg (multigeneration)Reproductive: Effects on newborn: Biochemical and metabolicREPTED 12,619,1998

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lethal concentration (50 percent kill): 303 mg/m3VHTODE 24,87,1982
intraperitoneal/guinea pig lethal dose (50 percent kill): 140 mg/kgPCOC** -,282,1966
intraperitoneal/mouse lethal dose (50 percent kill): 50 mg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseJAFCAU 11,91,1963
intraperitoneal/rat lethal dose (50 percent kill): 7500 µg/kgPSEBAA 129,699,1968
oral/chicken Lethal dose: >400 mg/kgBrain and Coverings: Other degenerative changes

Gastrointestinal: Hypermotility, diarrhea

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
VHTODE 41,290,1999
oral/domestic animal lethal dose (50 percent kill): 22600 µg/kgBehavioral: Ataxia

Gastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Other changes
AJVRAH 41,1857,1980
oral/duck lethal dose (50 percent kill): 29800 µg/kgDOEAAH 35,25,1979
oral/guinea pig lethal dose (50 percent kill): 58 mg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseHYSAAV 33(10-12),334,1968
oral/man lowest published toxic dose: 165 mg/kgBehavioral: General anesthetic

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Changes in structure or function of exocrine pancreas
PGMJAO 57,660,1981
oral/mouse lethal dose (50 percent kill): 28 mg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseHYSAAV 33(10-12),334,1968
oral/pigeon lethal dose (50 percent kill): 5620 µg/kgASTTA8 (680),157,1979
oral/quail lethal dose (50 percent kill): 13300 µg/kgASTTA8 (680),157,1979
oral/rabbit lethal dose (50 percent kill): 80 mg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseHYSAAV 33(10-12),334,1968
oral/rat lethal dose (50 percent kill): 13 mg/kgDOEAAH 35,25,1979
oral/wild bird lethal dose (50 percent kill): 1780 µg/kgASTTA8 (680),157,1979
skin/rabbit lethal dose (50 percent kill): 500 mg/kgVHTODE 24,87,1982
skin/rat lethal dose (50 percent kill): 860 mg/kgWRPCA2 9,119,1970
skin/wild bird lethal dose (50 percent kill): 7500 µg/kgTXAPA9 26,154,1973
unreported route/mammal (species unspecified) lethal dose (50 percent kill): 55 mg/kg30ZDA9 -,341,1971
unreported route/rabbit lethal dose (50 percent kill): 2600 µg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseAJOPAA 53,512,1962

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 168 mg/kg/28W- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseHYSAAV 33(10-12),334,1968

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.05 mg/m3 (inhal, vapor, skin)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWAQMOAC #73-19,1973
TOXICOLOGY REVIEWRREVAH 46,1,1973
TOXICOLOGY REVIEWPMDCAY 10,85,1974
TOXICOLOGY REVIEWRREVAH 63,1,1976
TOXICOLOGY REVIEWFEREAC 72,28871,2007

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESRED CompletedRBREV* -,105,1998

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Negative: Carcinogenicity-mouse/rat
NCI Carcinogenesis Bioassay (feed);no evidence:mouse,ratNCITR* NCI-TR-96,1979
On EPA IRIS database
TOP