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Coumarin, 3 - chloro - 7 - hydroxy - 4 - methyl - , O - ester with O,O - diethyl phosphorothioate

RTECS #: GN6300000

CAS #: 56-72-4


UPDATE: May 2009 MW: 362.78 MF: C14H16ClO5PS


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 3 - Chloro - 7 - hydroxy - 4 - methyl - coumarin O,O - diethyl phosphorothioate
  2. 3 - Chloro - 7 - hydroxy - 4 - methyl - coumarin O - ester with O,O - diethyl phosphorothioate
  3. 3 - Chloro - 4 - methyl - 7 - coumarinyl diethyl phosphorothioate
  4. 3 - Chloro - 4 - methyl - 7 - hydroxycoumarin diethyl thiophosphoric acid ester
  5. 3 - Chloro - 4 - methylumbelliferone O - ester with O,O - diethyl phosphorothioate
  6. Agridip
  7. Asunthol
  8. Asuntol
  9. Azunthol
  10. BAY 21/199
  11. Bayer 21/199
  12. Baymix
  13. Baymix 50
  14. CO - Ral
  15. Coumafos
  16. Coumaphos
  17. Cumafos (Dutch)
  18. Diethyl 3 - chloro - 4 - methylumbelliferyl thionophosphate
  19. Diethyl thiophosphoric acid ester of 3 - chloro - 4 - methyl - 7 - hydroxycoumarin
  20. Diolice
  21. ENT 17,957
  1. Meldane
  2. Meldone
  3. Muscatox
  4. NCI - C08662
  5. Negashunt
  6. O,O - Diaethyl - O - (3 - chlor - 4 - methyl - cumarin - 7 - yl) - monothiophosphat (German)
  7. O,O - Diethyl - O - (3 - chloor - 4 - methyl - cumarin - 7 - yl) monothiofosfaat (Dutch)
  8. O,O - Diethyl O - (3 - chloro - 4 - methyl - 7 - coumarinyl) phosphorothioate
  9. O,O - Diethyl O - (3 - chloro - 4 - methylcoumarinyl - 7) thiophosphate
  10. O,O - Diethyl O - (3 - chloro - 4 - methyl - 2 - oxo - 2H - benzopyran - 7 - yl) phosphorothioate
  11. O,O - Diethyl 3 - chloro - 4 - methyl - 7 - umbelliferone thiophosphate
  12. O,O - Diethyl O - (3 - chloro - 4 - methylumbelliferyl) phosphorothioate
  13. O,O - Dietil - O - (3 - cloro - 4 - metil - cumarin - 7 - il - monotiofosfato) (Italian)
  14. O - 3 - Chloro - 4 - methyl - 7 - coumarinyl O,O - diethyl phosphorothioate
  15. Phosphorothioic acid, O,O - diethyl ester, O - ester with 3 - chloro - 7 - hydroxy - 4 - methylcoumarin
  16. Resistox
  17. Resitox
  18. Suntol
  19. Thiophosphate de O,O - diethyle et de O - (3 - chloro - 4 - methyl - 7 - coumarinyle) (French)
  20. Umbethion


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
morphological transform rat embryo 1,400 ng/plate JJATDK 1,190,1981


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 394 mg/kg (multigeneration) Reproductive: Effects on newborn: Biochemical and metabolic REPTED 12,619,1998


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lethal concentration (50 percent kill): 303 mg/m3 N/R VHTODE 24,87,1982
intraperitoneal
guinea pig
lethal dose (50 percent kill): 140 mg/kg N/R PCOC** -,282,1966
intraperitoneal
mouse
lethal dose (50 percent kill): 50 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase JAFCAU 11,91,1963
intraperitoneal
rat
lethal dose (50 percent kill): 7,500 g/kg N/R PSEBAA 129,699,1968
oral
wild bird
lethal dose (50 percent kill): 1,780 g/kg N/R ASTTA8 (680),157,1979
oral
chicken
lethal dose : >400 mg/kg Brain and Coverings: Other degenerative changes

Gastrointestinal: Hypermotility, diarrhea

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
VHTODE 41,290,1999
oral
duck
lethal dose (50 percent kill): 29,800 g/kg N/R DOEAAH 35,25,1979
oral
domestic animal
lethal dose (50 percent kill): 22,600 g/kg Behavioral: Ataxia

Gastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Other changes
AJVRAH 41,1857,1980
oral
guinea pig
lethal dose (50 percent kill): 58 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase HYSAAV 33(10-12),334,1968
oral
man
lowest published toxic dose: 165 mg/kg Behavioral: General anesthetic

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Changes in structure or function of exocrine pancreas
PGMJAO 57,660,1981
oral
mouse
lethal dose (50 percent kill): 28 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase HYSAAV 33(10-12),334,1968
oral
pigeon
lethal dose (50 percent kill): 5,620 g/kg N/R ASTTA8 (680),157,1979
oral
quail
lethal dose (50 percent kill): 13,300 g/kg N/R ASTTA8 (680),157,1979
oral
rat
lethal dose (50 percent kill): 13 mg/kg N/R DOEAAH 35,25,1979
oral
rabbit
lethal dose (50 percent kill): 80 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase HYSAAV 33(10-12),334,1968
skin
wild bird
lethal dose (50 percent kill): 7,500 g/kg N/R TXAPA9 26,154,1973
skin
rat
lethal dose (50 percent kill): 860 mg/kg N/R WRPCA2 9,119,1970
skin
rabbit
lethal dose (50 percent kill): 500 mg/kg N/R VHTODE 24,87,1982
unreported route
mammal (species unspecified)
lethal dose (50 percent kill): 55 mg/kg N/R 30ZDA9 -,341,1971
unreported route
rabbit
lethal dose (50 percent kill): 2,600 g/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase AJOPAA 53,512,1962


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 168 mg/kg/28 week- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase HYSAAV 33(10-12),334,1968


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.05 mg/m3 (inhalable, vapor, skin) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
AQMOAC #73-19,1973
TOXICOLOGY REVIEW
RREVAH 46,1,1973
TOXICOLOGY REVIEW
PMDCAY 10,85,1974
TOXICOLOGY REVIEW
RREVAH 63,1,1976
TOXICOLOGY REVIEW
FEREAC 72,28871,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: RED Completed RBREV* -,105,1998


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Negative: Carcinogenicity-mouse/rat
Used for control of a wide variety of livestock insects
On EPA IRIS database
NCI Carcinogenesis Bioassay (feed);no evidence:mouse,rat NCITR* NCI-TR-96,1979


REFERENCES:

CODEN
REFERENCE

30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918-
AJVRAH American Journal of Veterinary Research. (American Veterinary Medical Assoc., 930 N. Meacham Rd., Schaumburg, IL 60196) V.1- 1940-
AQMOAC Air Quality Monographs. (Washington, DC) No.69-1 - No.75-25, 1969-75(?). Discontinued.
ASTTA8 ASTM Special Technical Publication. (American Soc. for Testing Materials, 1916 Race St., Philadelphia, PA 19103) No.1- 1911-
DOEAAH Down to Earth. (Dow Chemical USA, Agricultural Products Dept., Midland, MI 48640) V.1- 1945-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA. (Springfield, VA) 1964-71. Discontinued.
JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953-
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
PCOC** Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. (Topeka, KS)
PGMJAO Postgraduate Medical Journal. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.1- 1925-
PMDCAY Progress in Medical Chemistry. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1961-
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VHTODE Veterinary and Human Toxicology. (American College of Veterinary and Comparative Toxicology, Publication Office, Comparative Toxicology, Manhattan, KS 66506) V.19- 1977-
WRPCA2 World Review of Pest Control. (London, UK) V.1-10, 1962-71. Discontinued.

Used for control of a wide variety of livestock insects

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data

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