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Registry of Toxic Effects of Chemical Substances (RTECS)

Coumarin

RTECS #

GN4200000

CAS #

91-64-5

Updated

December 2013

Molecular Weight

146.15

Molecular Formula

C9H6O2

Synonyms

1,2-Benzopyrone
2H-1-Benzopyran, 2-oxo-
2H-1-Benzopyran-2-one
2-Oxo-1,2-benzopyran
2-Propenoic acid, 3-(2-hydroxyphenyl)-delta-lactone
Benzo-alpha-pyrone
Cinnamic acid, o-hydroxy-, delta-lactone
cis-o-Coumarinic acid lactone
Coumarinic anhydride
Cumarin
Kumarin (Czech)
NCI C07103
o-Hydroxycinnamic acid lactone
o-Hydroxycinnamic lactone
o-Hydroxyzimtsaure-lacton (German)
Rattex
Tonka bean camphor

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /human 5%/2DCODEDG 61,217,2009
skin /man 5%CODEDG 60,347,2009

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisovary/hamster1600 mg/LEMMUEG 10(Suppl 10),1,1987
DNA Damagelymphocyte/mammal (species unspecified)20 mmol/LPNASA6 48,686,1962
morphological transformfibroblast/mouse1 mg/L/21D (-enzymatic activation step)EMMUEG 37,231,2001
mutation in microorganisms/Salmonella typhimurium50 mg/L/2H (+enzymatic activation step)MUREAV 578,210,2005
mutation in microorganisms/Salmonella typhimurium1 mg/plate (-enzymatic activation step)ENMUDM 5(Suppl 1),3,1983
other mutation test systems/Escherichia coli62500 ng/tube (-enzymatic activation step)MUREAV 445,81,1999
sister chromatid exchangeovary/hamster100 mg/LEMMUEG 10(Suppl 10),1,1987

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/mouse 3600 mg/kg (6-17D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)ARZNAD 17,97,1967

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 144 gm/kg/2Y- intermittentTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Bronchogenic carcinoma
NTPTR* NTP-TR-422,1993
oral/mouse lowest published toxic dose: 25750 mg/kg/103W- intermittentTumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Gastrointestinal: Tumors
NTIS** PB94-215761
oral/mouse lowest published toxic dose: 103000 mg/kg/103W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
NTIS** PB94-215761
oral/rat toxic dose: 200 gm/kg/2Y- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors
TXCYAC 1,93,1973
oral/rat lowest published toxic dose: 12875 mg/kg/103W- intermittentTumorigenic: Neoplastic by RTECS criteria

Liver: Hepatitis (hepatocellular necrosis), diffuse

Kidney, Ureter, and Bladder: Kidney tumors
NTIS** PB94-215761
oral/rat lowest published toxic dose: 18025 mg/kg/2Y- intermittentTumorigenic: Neoplastic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors
NTPTR* NTP-TR-422,1993

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Hamster, lung fibroblast Inhibitor Concentration (50 percent kill): >3 mmol/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 6,21,1992
In Vitro/Rat, liver Inhibitor Concentration (50 percent kill): 102 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 6,21,1992
In Vitro/Rat, lung Inhibitor Concentration (50 percent kill): 5.68 mmol/L/24HIn Vitro Toxicity Studies: Cell countingTIVIEQ 18,79,2004
intraduodenal/rat lowest published toxic dose: 100 mg/kgGastrointestinal: Alteration in gastric secretionPYTOEY 12,72,2005
intraperitoneal/mouse lethal dose (50 percent kill): 220 mg/kgBehavioral: Analgesia

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
ARZNAD 15,897,1965
intravenous/rat lowest published toxic dose: 400 mg/kgLiver: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
BCPCA6 67,2141,2004
oral/guinea pig lethal dose (50 percent kill): 202 mg/kgBehavioral: Somnolence (general depressed activity)

Liver: Other changes
FCTXAV 2,327,1964
oral/man lowest published toxic dose: 87 mg/kg/17W- intermittentLiver: Liver function tests impairedHUTODJ 8,501,1989
oral/mouse lethal dose (50 percent kill): 196 mg/kgYKKZAJ 83,1124,1963
oral/mouse lowest published toxic dose: 100 mg/kgBehavioral: Somnolence (general depressed activity)FCTOD7 837,39,2001
oral/mouse lowest published toxic dose: 200 mg/kgLung, Thorax, or Respiration: Other changes

Liver: Hepatitis (hepatocellular necrosis), zonal
TOXID9 60,210,2001
oral/mouse lowest published toxic dose: 200 mg/kgLung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Other proteins
FCTOD7 48,1612,2010
oral/mouse lowest published lethal dose: 200 mg/kgBehavioral: Somnolence (general depressed activity)FCTOD7 39,837,2001
oral/rat lowest published toxic dose: 50 mg/kgLiver: Other changesTXAPA9 247,211,2010
oral/rat lethal dose (50 percent kill): 293 mg/kgFCTXAV 12,385,1974
oral/woman lowest published toxic dose: 30 mg/kg/30D- intermittentLiver: Liver function tests impairedHUTODJ 8,501,1989
subcutaneous/mouse lethal dose (50 percent kill): 242 mg/kgYKKZAJ 83,1124,1963

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/Dog lowest published toxic dose: 1900 mg/kg/19D- intermittentLiver: Jaundice, other or unclassified

Blood: Hemorrhage

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JPETAB 118,348,1956
oral/hamster lowest published toxic dose: 109 gm/kg/13W- continuousLiver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FAATDF 34,105,1996
oral/hamster lowest published toxic dose: 7728 mg/kg/12W- continuousLiver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FCTOD7 40,809,2002
oral/hamster lowest published toxic dose: 74382 mg/kg/42W- continuousLiver: Changes in liver weightFCTOD7 40,809,2002
oral/hamster lowest published toxic dose: 21252 mg/kg/12W- continuousBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferasesFCTOD7 40,809,2002
oral/mouse lowest published toxic dose: 1800 mg/kg/9D- intermittentLung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
TOXID9 60,210,2001
oral/mouse lowest published toxic dose: 300 mg/kg/3D- intermittentLiver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
TXAPA9 232,337,2008
oral/mouse lowest published toxic dose: 1800 mg/kg/11D- intermittentLung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Other proteins
FCTOD7 48,1612,2010
oral/mouse lowest published toxic dose: 1800 mg/kg/11D- intermittentBehavioral: Tolerance

Lung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Peptidases
FCTOD7 48,1612,2010
oral/mouse lowest published toxic dose: 1800 mg/kg/11D- intermittentLung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Peptidases
FCTOD7 48,1612,2010
oral/mouse lowest published toxic dose: 3600 mg/kg/16D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNTPTR* NTP-TR-422,1993
oral/mouse lowest published toxic dose: 9750 mg/kg/13W- intermittentLiver: Changes in liver weight

Blood: Normocytic anemia
NTPTR* NTP-TR-422,1993
oral/pig lowest published toxic dose: 4305 mg/kg/3W- continuousGastrointestinal: Other changes

Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
TOXIA6 50,339,2007
oral/rat lowest published toxic dose: 25 mg/kg/4D- intermittentBiochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammationBPBLEO 31,1343,2008
oral/rat lowest published toxic dose: 150 mg/kg/15D- intermittentLiver: Other changes

Endocrine: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
CEXPB9 34,1217,2007
oral/rat lowest published toxic dose: 150 mg/kg/15D- intermittentLiver: Other changes

Endocrine: Evidence of thyroid hypofunction

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
CEXPB9 34,1217,2007
oral/rat lowest published toxic dose: 9492 mg/kg/12W- continuousLiver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
FCTOD7 40,809,2002
oral/rat lowest published toxic dose: 25032 mg/kg/12W- continuousLiver: Other changesFCTOD7 40,809,2002
oral/rat lowest published toxic dose: 1400 mg/kg/7D- intermittentLiver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
FCTXAV 3,457,1965
oral/rat lowest published toxic dose: 4800 mg/kg/16D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNTPTR* NTP-TR-422,1993
oral/rat lowest published toxic dose: 9750 mg/kg/13W- intermittentLiver: Hepatitis (hepatocellular necrosis), zonal

Blood: Changes in erythrocyte (RBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
NTPTR* NTP-TR-422,1993
oral/rat lowest published toxic dose: 88 gm/kg/42W- continuousLiver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
HETOEA 9,323,1990
oral/rat lowest published toxic dose: 27300 mg/kg/39W- continuousLiver: Hepatitis (hepatocellular necrosis), diffuse

Liver: Liver function tests impaired

Blood: Changes in platelet count
NTIS** OTS0555582
oral/rat lowest published toxic dose: 35 mg/kg/5W- continuousLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
FCTOD7 50,135,2012

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMEMDT 77,564,2000
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 77,564,2000
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 77,564,2000
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMEMDT 77,564,2000
TOXICOLOGY REVIEWPMDCAY 10,85,1974
TOXICOLOGY REVIEWMUREAV 47,161,1978
TOXICOLOGY REVIEWFCTXAV 17,277,1979
TOXICOLOGY REVIEWMUREAV 543,201,2003
TOXICOLOGY REVIEWMUREAV 567,347,2004
TOXICOLOGY REVIEWEMMUEG 39,69,2002
TOXICOLOGY REVIEWFCTOD7 44,462,2006
TOXICOLOGY REVIEWENTOX* -,674,2005
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWTOPADD 33,63,2005
TOXICOLOGY REVIEWMUREAV 654,114,2008
TOXICOLOGY REVIEWMUTAEX 23,271,2008
TOXICOLOGY REVIEWMUREAV 705,184,2010
TOXICOLOGY REVIEWMUREAV 721,27,2011

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 20340; Number of Industries 113; Total Number of Facilities 16304; Number of Occupations 99; Total Number of Employees Exposed 239705; Total Number of Female Employees Exposed 110313
National Occupational Hazard Survey 1974Hazard Code 20340; Number of Industries 14; Total Number of Facilities 379; Number of Occupations 39; Total Number of Employees Exposed 31272

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (gavage);clear evidence:mouse
NCI Carcinogenesis Studies (gavage);equivocal evidence:rat
NTP Carcinogenesis studies (gavage);some evidence:rat NTPTR* NTP-TR-422,1993
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