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Registry of Toxic Effects of Chemical Substances (RTECS)

Copper(II) sulfate, pentahydrate (1:1:5)

RTECS #

GL8900000

CAS #

7758-99-8

Updated

July 2013

Molecular Weight

249.70

Molecular Formula

O4S·Cu·5H2O

Synonyms

Blue copper AS
Copper sulphate pentahydrate
Copper(2+) sulfate pentahydrate
Copper(II) sulfate pentahydrate
Cupric sulfate pentahydrate
Kupfersulfat-pentahydrat (German)
Kupfervitriol (German)
Salzburg vitriol
Sulfuric acid copper(2+) salt (1:1), pentahydrate (8CI,9CI)
Sulfuric acid, copper(2+) salt, pentahydrate
Vencedor

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic AnalysisAscites tumor/rat300 mg/kgGANNA2 54,155,1963
Cytogenetic Analysisintraperitoneal/mouse1100 µg/kgMUREAV 243,1,1990
Cytogenetic Analysisoral/chicken10 mg/kgMUREAV 367,57,1996
Cytogenetic Analysisintraperitoneal/chicken7500 µg/kgMUREAV 367,57,1996
Cytogenetic Analysismultiple/other fish0.407 mg/L/24HMUREAV 678,7,2009
DNA Damageoral/Drosophila melanogaster50 µmol/L/24H- intermittentMUREAV 726,222,2011
DNA inhibitionlymphocyte/human76 µmol/LIAAAAM 79,83,1986
micronucleus testintraperitoneal/mouse5 mg/kgCYTOAN 52,801,1987
micronucleus testintraperitoneal/chicken7500 µg/kgMUREAV 367,57,1996
micronucleus testoral/chicken10 mg/kgMUREAV 367,57,1996
sperm morphologyintraperitoneal/mouse5 mg/kg/5D- intermittentCYTOAN 52,801,1987
Unscheduled DNA Synthesisliver/rat31 µmol/LCBTOE2 5,15,1989

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Chicken, neurons Inhibitor Concentration (50 percent kill): 60 µmol/L/21HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 7,653,1993
In Vitro/Chicken, neurons Inhibitor Concentration (10 percent kill): 16 µmol/L/21HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 7,653,1993
In Vitro/Chicken, neurons Inhibitor Concentration (50 percent kill): 21 µmol/L/20HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 7,653,1993
In Vitro/Chicken, neurons Inhibitor Concentration (10 percent kill): 2 µmol/L/20HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 7,653,1993
intraperitoneal/mammal (species unspecified) lethal dose (50 percent kill): 7500 µg/kgBehavioral: Somnolence (general depressed activity)

Gastrointestinal: Changes in structure or function of salivary glands

Gastrointestinal: Nausea or vomiting
JANSAG 55,337,1982
intraperitoneal/mouse lethal dose (50 percent kill): 20 mg/kgTOVEFN (6),10,2006
intraperitoneal/rat lethal dose (50 percent kill): 18700 µg/kgGISAAA 53(4),78,1988
intratracheal/rat lowest published toxic dose: 249.7 µg/kgLung, Thorax, or Respiration: Other changes

Blood: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TXAPA9 241,71,2009
multiple/non-mammalian species lowest published lethal dose: 1 gm/m3/24HVascular: Effect on gills and gill functions

Liver: Hepatitis (hepatocellular necrosis), diffuse

Liver: Fatty liver degeneration
ETPAEK 61,113,2009
multiple/non-mammalian species lowest published toxic dose: 0.1 gm/m3/24HVascular: Effect on gills and gill functions

Liver: Fatty liver degeneration

Liver: Other changes
ETPAEK 61,113,2009
multiple/non-mammalian species lowest published toxic dose: 0.01 gm/m3/24HVascular: Effect on gills and gill functions

Liver: Other changes
ETPAEK 61,113,2009
oral/chicken lethal dose (50 percent kill): 693 mg/kgVCVN1* -,67,1998
oral/Dog lowest published lethal dose: 60 mg/kgHBAMAK 4,1289,1935
oral/Dog lowest published toxic dose: 20 mg/kgGastrointestinal: Nausea or vomitingJPETAB 292,1002,2000
oral/domestic animal lowest published lethal dose: 5 mg/kgBehavioral: Somnolence (general depressed activity)

Gastrointestinal: Hypermotility, diarrhea

Blood: Hemorrhage
JCVPAR 82,47,1972
oral/duck lowest published lethal dose: 600 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Coma

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
AUVJA2 16,147,1940
oral/human lowest published toxic dose: 272 mg/kgLiver: Other changes

Kidney, Ureter, and Bladder: Other changes

Blood: Other hemolysis with or without anemia
IPRAA8 18,807,1965
oral/human lowest published lethal dose: 1088 mg/kgBehavioral: Coma

Liver: Other changes

Blood: Other hemolysis with or without anemia
IPRAA8 18,807,1965
oral/mammal (species unspecified) lowest published toxic dose: 100 mg/kgGastrointestinal: Nausea or vomitingEJPHAZ 453,299,2002
oral/man lowest published toxic dose: 429 mg/kgBehavioral: Sleep

Vascular: BP lowering not characterized in autonomic section

Nutritional and Gross Metabolic: Body temperature decrease
YAKUD5 41,193,1999
oral/mouse lethal dose (50 percent kill): 43 mg/kgVCVN1* -,67,1998
oral/pigeon lowest published lethal dose: 1 gm/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Coma

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
AUVJA2 16,147,1940
oral/rat lethal dose (50 percent kill): 300 mg/kgVCVN1* -,67,1998
oral/wild bird lowest published lethal dose: 300 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Coma

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
AUVJA2 16,147,1940
skin/rat lethal dose (50 percent kill): >2 gm/kgNNGADV 18,S161,1993
subcutaneous/guinea pig lowest published lethal dose: 62 mg/kgAutonomic Nervous System: Other (direct) parasympathomimetic

Behavioral: Coma

Gastrointestinal: Hypermotility, diarrhea
BMJOAE 2,217,1913
Tank with water/other fish lowest published toxic concentration: 200 µg/L/6DNutritional and Gross Metabolic: Changes in: Na

Nutritional and Gross Metabolic: Changes in: Cl

Nutritional and Gross Metabolic: Changes in: K
TIVIEQ 32,271,1995
Tank with water/Other invertebrate lethal concentration (50 percent kill): 26 µg/L/24HTIVIEQ 32,271,1995
unreported route/man lowest published lethal dose: 221 mg/kg85DCAI 2,73,1970

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intravenous/mammal (species unspecified) lowest published toxic dose: 190 mg/kg/95D- intermittentBehavioral: Food intake (animal)

Behavioral: Muscle weakness

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JCVPAR 108,191,1993
multiple/non-mammalian species lowest published toxic dose: 0.4 gm/m3/24H/2D- continuousRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldETPAEK 61,113,2009
multiple/non-mammalian species lowest published toxic dose: 0.33 gm/m3/24H/3D- continuousRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldETPAEK 61,113,2009
multiple/non-mammalian species lowest published toxic dose: 0.32 gm/m3/24H/4D- continuousRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldETPAEK 61,113,2009
multiple/non-mammalian species lowest published toxic dose: 0.1 gm/m3/24H/4D- continuousVascular: Effect on gills and gill functions

Liver: Hepatitis (hepatocellular necrosis), diffuse

Liver: Fatty liver degeneration
ETPAEK 61,113,2009
oral/mammal (species unspecified) lowest published toxic dose: 1 gm/kg/5D- intermittentBehavioral: Food intake (animal)

Gastrointestinal: Hypermotility, diarrhea

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JCVPAR 108,191,1993
oral/mouse lowest published toxic dose: 3390 mg/kg/2W- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTPTR* NIH-93-3352
oral/mouse lowest published toxic dose: 67 gm/kg/13W- continuousLiver: Changes in liver weightNTPTR* NIH-93-3352
oral/rat lowest published toxic dose: 1427 mg/kg/1Y- intermittentLiver: Other changes

Blood: Other changes

Nutritional and Gross Metabolic: Changes in: Fe
KHZDAN 30(3),34,1987
oral/rat lowest published toxic dose: 2625 mg/kg/2W- continuousBehavioral: Fluid intake

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTPTR* NIH-93-3352
oral/rat lowest published toxic dose: 24 gm/kg/13W- continuousGastrointestinal: Other changes

Blood: Pigmented or nucleated red blood cells

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
NTPTR* NIH-93-3352
oral/rat lowest published toxic dose: 10 gm/kg/5D/4W- intermittentLiver: Liver function tests impairedVHTODE 42,261,2000
oral/rat lowest published toxic dose: 5 gm/kg/5D/2W- intermittentLiver: Other changes

Blood: Other changes
VHTODE 42,261,2000
subcutaneous/turkey lowest published toxic dose: 100 mg/kg/14W- intermittentGastrointestinal: Hypermotility, diarrhea

Liver: Other changes

Blood: Other changes
PSEBAA 128,627,1968

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWFEREAC 71,46106,2006
TOXICOLOGY REVIEWFEREAC 74,22478,2009

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESSupportedRBREV* -,105,1998
Occupational Exposure Limit-ARAB Republic of Egypttime-weighted average 0.1 mg(Cu)/m3 (fume), JAN1993
Occupational Exposure Limit-FINLANDtime-weighted average 1 mg(Cu)/m3, NOV2011
Occupational Exposure Limit-GERMANYMAK 0.1 mg(Cu)/m3, inhal, 2011
Occupational Exposure Limit-HUNGARYtime-weighted average 1 mg(Cu)/m3, short term exposure limit 4 mg(Cu)/m3, SEP2000
Occupational Exposure Limit-INDIAtime-weighted average 0.2 mg(Cu)/m3 (fume), JAN1993
Occupational Exposure Limit-POLANDMAC(time-weighted average) 0.1 mg(Cu)/m3 (fume), JAN1993
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.5 ppm (1 mg(Cu)/m3) (dust), JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 1 mg(Cu)/m3;time-weighted average 0.2 mg(Cu)/m3 (resp. dust), JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.1 mg(Cu)/m3, KZG-week 0.2 mg(Cu)/m3, inhal, JAN2011
Occupational Exposure Limit-THAILANDtime-weighted average 1 mg(Cu)/m3, JAN1993
Occupational Exposure Limit-THAILANDtime-weighted average 0.1 mg(Cu)/m3 (fume), JAN1993
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 1.0 mg(Cu)/m3 (fume), JAN1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X5421; Number of Industries 13; Total Number of Facilities 979; Number of Occupations 21; Total Number of Employees Exposed 10821; Total Number of Female Employees Exposed 3606

Status in Federal Agencies

OrganizationReference
NTP Toxicity studies, RPT# TOX-29, October 2000
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