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Registry of Toxic Effects of Chemical Substances (RTECS)

Copper (II) sulfate (1:1)

RTECS #

GL8800000

CAS #

7758-98-7

Updated

December 2013

Molecular Weight

159.60

Molecular Formula

O4S·Cu

Synonyms

BCS copper fungicide
Blue Copper
Blue stone
Blue vitriol
Copper monosulfate
Copper sulfate
Copper sulfate (1:1)
Copper(2+) sulfate
Copper(2+) sulfate (1:1)
Copper(II) sulfate
Cupric sulfate anhydrous
Cupric sulphate
Griffin super Cu
Incracide 10A
Incracide E 51
Kilcop 53
Kobasic
Phyto-bordeaux
Roman vitriol
Sulfate de cuivre (French)
Sulfuric acid, copper(2+) salt (1:1)
TNCS 53
Trinagle

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA DamageAscites tumor/rat500 µmol/LJBCHA3 261,3370,1986
DNA Damageliver/rat1 mmol/LSinJF# 26OCT1982
DNA Damageoral/mouse1.25 mg/kgFCTOD7 42,1931,2004
DNA Damagemultiple/non-mammalian species7.50 mg/L/2HMUREAV 605,78,2006
DNA inhibitionintraperitoneal/mouse20 gm/kgARGEAR 51,605,1981
micronucleus testmultiple/non-mammalian species3.75 mg/L/24HMUREAV 605,78,2006
micronucleus testoral/mouse8.5 mg/kgMUREAV 577S,1,2005
morphological transformembryo/hamster80 µmol/LCNREA8 39,193,1979
mutation in microorganisms/Escherichia coli7500 ppt/3H (-enzymatic activation step)AMNTA4 85,119,1951
mutation in microorganisms/Bacillus subtilis400 µmol/L (-enzymatic activation step)AMAHA5 21,297,1974
other mutation test systems/Bacillus subtilis400 µmol/LJOBAAY 85,1003,1963
sex chromosome loss and nondisjunctionparenteral/Drosophila melanogaster1000 ppmPNASA6 24,546,1938
sex chromosome loss and nondisjunctionunreported route/Drosophila melanogaster7100 ppmBMAOA3 7,635,1938
Unscheduled DNA Synthesisembryo/hamster200 µmol/LMUREAV 131,173,1984

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat 7500 µg/kg (3D pregnant)Reproductive: Effects on fertility: Other measures of fertilityBECTA6 25,702,1980
intratesticular/rat 3192 µg/kg (1D male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
JRPFA4 7,21,1964
intravenous/mouse 3200 µg/kg (8D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system
WRABDT 186,297,1979
intravenous/mouse 3200 µg/kg (7D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)WRABDT 186,297,1979
intravenous/hamster 2130 µg/kg (8D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Body wall
BIREBV 11,97,1974
oral/pig 140 mg/kg (1-15W preg/4W after birth)Reproductive: Effects on newborn: Biochemical and metabolicCNJNAT 71,227,1991
subcutaneous/mouse 12768 µg/kg (30D male)Reproductive: Paternal effects: Testes, epididymis, sperm ductJRPFA4 7,21,1964
subcutaneous/rat 12768 µg/kg (1D male)Reproductive: Paternal effects: Testes, epididymis, sperm ductJRPFA4 7,21,1964

Tumorigenic Data and References

Route/OrganismDoseEffectReference
parenteral/chicken lowest published toxic dose: 10 mg/kgTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Endocrine: Tumors
BEXBAN 9,519,1940

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, liver tumor Inhibitor Concentration Low: 100 µmol/L/24HIn Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.)

In Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc.

In Vitro Toxicity Studies: Other assays
FCTOD7 50,415,2012
In Vitro/Human, lung tumor Inhibitor Concentration Low: 100 µmol/L/24HIn Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.)

In Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc.

In Vitro Toxicity Studies: Other assays
FCTOD7 50,415,2012
In Vitro/Human, melanoma Inhibitor Concentration (50 percent kill): 70.8 mg/L/48HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.FCTOD7 50,2084,2012
In Vitro/Non-mammalian species, fibroblast Inhibitor Concentration (50 percent kill): 1.09 mmol/L/24HIn Vitro Toxicity Studies: Cell countingTIVIEQ 7,537,1993
In Vitro/Rat, lung Inhibitor Concentration (10 percent kill): 0.07 gm/L/24HIn Vitro Toxicity Studies: Cell membrane integrity (prelabeled cells): release of radioactive isotopes ([51Cr], [3H]-thymidine, [3H]-proline, [35S]- or [75Se]-methionine, 5-[125I]-2-deoxy-uridine) or fluorescent dyes (bis-carboxyethyl-carboxyfluorescein (BCECF) or calcein-AM)TIVIEQ 7,111,1993
In Vitro/Rat, lung Inhibitor Concentration (50 percent kill): 0.15 gm/L/24HIn Vitro Toxicity Studies: Cell membrane integrity (prelabeled cells): release of radioactive isotopes ([51Cr], [3H]-thymidine, [3H]-proline, [35S]- or [75Se]-methionine, 5-[125I]-2-deoxy-uridine) or fluorescent dyes (bis-carboxyethyl-carboxyfluorescein (BCECF) or calcein-AM)TIVIEQ 7,111,1993
In Vitro/Rat, lung Inhibitor Concentration (75 percent kill): 0.24 gm/L/24HIn Vitro Toxicity Studies: Cell membrane integrity (prelabeled cells): release of radioactive isotopes ([51Cr], [3H]-thymidine, [3H]-proline, [35S]- or [75Se]-methionine, 5-[125I]-2-deoxy-uridine) or fluorescent dyes (bis-carboxyethyl-carboxyfluorescein (BCECF) or calcein-AM)TIVIEQ 7,111,1993
intraperitoneal/mouse lethal dose (50 percent kill): 7182 µg/kgCOREAF 256,1043,1963
intraperitoneal/rat lethal dose (50 percent kill): 20 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold
INJPD2 23,153,1991
intratracheal/rat lowest published toxic dose: 100 µg/kgLung, Thorax, or Respiration: SputumHBTME* -,529,2007
intravenous/frog lowest published lethal dose: 25 mg/kgHBTXAC 1,76,1955
intravenous/guinea pig lowest published lethal dose: 2 mg/kgEQSSDX 1,1,1975
intravenous/mouse lethal dose (50 percent kill): 23300 µg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold
INJPD2 23,153,1991
intravenous/rabbit lethal dose (50 percent kill): 10 mg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Food intake (animal)

Gastrointestinal: Hypermotility, diarrhea
JIHTAB 31,301,1949
intravenous/rat lethal dose (50 percent kill): 48900 µg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold
INJPD2 23,153,1991
intravenous/rat lowest published toxic dose: 12 mg/kgEndocrine: Change in LHENEXAM 4,37,1970
oral/chicken lowest published toxic dose: 50 mg/kgGastrointestinal: Nausea or vomitingPYTOEY 9,146,2002
oral/child lowest published toxic dose: 150 mg/kgKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Other hemolysis with or without anemia
AJDCAI 131,149,1977
oral/Dog lowest published toxic dose: 37.5 mg/kgGastrointestinal: Nausea or vomitingFATOAO 47,55,1984
oral/human lethal dose (50 percent kill): 50 mg/kgUSXXAM #6770674
oral/human lowest published toxic dose: 0.029 mg/kgKidney, Ureter, and Bladder: Other changes in urine compositionHBTME* -,529,2007
oral/human lowest published lethal dose: 50 mg/kgBehavioral: Somnolence (general depressed activity)

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Hemorrhage
JAMAAP 235,801,1976
oral/human lowest published toxic dose: 11 mg/kgGastrointestinal: Gastritis

Gastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Nausea or vomiting
LANCAO 2,700,1960
oral/man lowest published lethal dose: 857 mg/kgGastrointestinal: Nausea or vomitingATXKA8 17,20,1958
oral/mouse lethal dose (50 percent kill): 369 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold
INJPD2 23,153,1991
oral/mouse lethal dose (50 percent kill): 87 mg/kgHBPTO* 2,1361,2001
oral/rat lethal dose (50 percent kill): 300 mg/kgUSXXAM #6770674
oral/rat lethal dose (50 percent kill): 960 mg/kgBehavioral: Muscle contraction or spasticity

Vascular: Shock

Gastrointestinal: Nausea or vomiting
HBPTO* 2,1361,2001
oral/woman lowest published toxic dose: 2100 µg/kg/5W- intermittentGastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Nausea or vomiting

Gastrointestinal: Other changes
TOXID9 54,73,2000
oral/woman lowest published lethal dose: 47320 µL/kgGastrointestinal: Hypermotility, diarrhea

Liver: Hepatitis (hepatocellular necrosis), diffuse

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
NPRNAY 15,74,1975
oral/woman lowest published toxic dose: 24 µg/kgGastrointestinal: Nausea or vomitingTOXID9 66,102,2002
oral/woman lowest published toxic dose: 0.024 mg/kgReproductive: Maternal effects: Ovaries, fallopian tubes

Reproductive: Maternal effects: Menstrual cycle changes or disorders
TOXID9 60,436,2001
oral/woman lowest published lethal dose: 50 mg/kgKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)JTCTDW 39,161,2001
subcutaneous/mouse lowest published lethal dose: 500 µg/kgTJIZAF 48,313,1978
subcutaneous/rat lethal dose (50 percent kill): 43 mg/kgPESTD5 16,252,1975
Tank with water/Catfish Lowest published lethal concentration: 354 µmol/L/7DTIVIEQ 37,327,1997
unreported route/rat lethal dose (50 percent kill): 520 mg/kgGTPZAB 26(6),21,1982

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat lowest published toxic dose: 791 mg/kg/18W- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainTXAPA9 18,562,1971
multiple/non-mammalian species lowest published toxic dose: 0.002 gm/m3/30D- continuousLiver: Other changes

Immunological Including Allergic: Decrease in humoral immune response

Biochemical: Metabolism (intermediary): Lipids including transport
TOVEFN -,13,2009
multiple/non-mammalian species lowest published toxic dose: 0.02 gm/m3/45D- continuousLiver: Other changes

Liver: Changes in liver weight

Immunological Including Allergic: Decrease in humoral immune response
TOVEFN -,13,2009
multiple/non-mammalian species lowest published toxic dose: 0.002 gm/m3/60D- continuousLiver: Other changes

Liver: Changes in liver weight

Immunological Including Allergic: Decrease in humoral immune response
TOVEFN -,13,2009
oral/human lowest published toxic dose: 598.5 mg/kg/5W- intermittentGastrointestinal: Nausea or vomitingRTOPDW 34,137,2001
oral/mouse lowest published toxic dose: 3 gm/kg/8W- continuousBlood: Changes in spleen

Immunological Including Allergic: Decrease in cellular immune response

Immunological Including Allergic: Decrease in humoral immune response
FAATDF 16,249,1991
oral/mouse lowest published toxic dose: 2 gm/kg/3W- continuousBlood: Changes in spleen

Immunological Including Allergic: Decrease in cellular immune response

Immunological Including Allergic: Decrease in humoral immune response
FAATDF 16,249,1991
oral/mouse lowest published toxic dose: 240 mg/kg/3D- intermittentLiver: Other changes

Liver: Changes in liver weight
TXCYAC 249,176,2008
oral/rat lowest published toxic dose: 14 mg/kg/7D- intermittentNutritional and Gross Metabolic: Changes in: Ca

Musculoskeletal: Other changes
BPBLEO 28,2296,2005
oral/rat lowest published toxic dose: 675 mg/kg/45D- intermittentLiver: Hepatitis, fibrous (cirrhosis, post- necrotic scarring)

Liver: Jaundice, cholestatic

Liver: Liver function tests impaired
TXAPA9 250,54,2011
oral/rat lowest published toxic dose: 10.4 gm/kg/18W- continuousLiver: Hepatitis (hepatocellular necrosis), diffuse

Liver: Liver function tests impaired
JTCTDW 38,709,2000
oral/rat lowest published toxic dose: 50.4 gm/kg/16W- continuousLiver: Hepatitis (hepatocellular necrosis), diffuse

Liver: Liver function tests impaired
JTCTDW 38,709,2000
oral/rat lowest published toxic dose: 9.45 gm/kg/18W- intermittentLiver: Hepatitis (hepatocellular necrosis), diffuse

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
JTCTDW 38,709,2000
oral/rat lowest published toxic dose: 37.8 gm/kg/12W- intermittentLiver: Hepatitis (hepatocellular necrosis), diffuse

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
JTCTDW 38,709,2000
oral/rat lowest published toxic dose: 915 mg/kg/1Y- intermittentCardiac: Changes in coronary arteries

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
GISAAA 54(2),64,1989
oral/rat lowest published toxic dose: 157 mg/kg/6W- intermittentEndocrine: Changes in adrenal weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
TXAPA9 28,395,1974
oral/rat lowest published toxic dose: 7530 mg/kg/30D- intermittentBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Blood: Changes in erythrocyte (RBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TOLED5 38,275,1987
oral/rat lowest published toxic dose: 2 gm/kg/20D- intermittentLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
TOLED5 6,163,1980
oral/woman lowest published toxic dose: 0.7 mg/kg/7D- continuousGastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Nausea or vomiting

Gastrointestinal: Other changes
EVHPAZ 109,949,2001

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWADTEAS 5,51,1972
TOXICOLOGY REVIEWAJMEAZ 38,409,1965
TOXICOLOGY REVIEW85DHAX Cu,23,1977
TOXICOLOGY REVIEWTOLED5 128,45,2002
TOXICOLOGY REVIEWMUTAEX 21,93,2006
TOXICOLOGY REVIEWDIMON* 39,678,1993
TOXICOLOGY REVIEWENTOX* -,665,2005
TOXICOLOGY REVIEWENTOX* -,110,2005
TOXICOLOGY REVIEWHUTOX* -,561,1996
TOXICOLOGY REVIEWHTOPA* 1,595,2002
TOXICOLOGY REVIEWMUREAV 681,80,2009
TOXICOLOGY REVIEWNBREV* 5,1,1981
TOXICOLOGY REVIEWNBREV* 11,107,1987
TOXICOLOGY REVIEWMUTAEX 21,343,2006
TOXICOLOGY REVIEWMUREAV 721,27,2011

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESSupportedRBREV* -,105,1998
Occupational Exposure Limit-ARAB Republic of Egypttime-weighted average 0.1 mg(Cu)/m3 (fume), JAN1993
Occupational Exposure Limit-FINLANDtime-weighted average 1 mg(Cu)/m3, NOV2011
Occupational Exposure Limit-GERMANYMAK 0.1 mg(Cu)/m3, inhal, 2011
Occupational Exposure Limit-HUNGARYtime-weighted average 1 mg(Cu)/m3, short term exposure limit 4 mg(Cu)/m3, SEP2000
Occupational Exposure Limit-INDIAtime-weighted average 0.2 mg(Cu)/m3 (fume), JAN1993
Occupational Exposure Limit-RUSSIAtime-weighted average 0.5 mg/m3, short term exposure limit 1.5 mg/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 1 mg(Cu)/m3;time-weighted average 0.2 mg(Cu)/m3 (resp. dust), JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.1 mg(Cu)/m3, KZG-week 0.2 mg(Cu)/m3, inhal, JAN2011
Occupational Exposure Limit-THAILANDtime-weighted average 1 mg(Cu)/m3, JAN1993
Occupational Exposure Limit-THAILANDtime-weighted average 0.1 mg(Cu)/m3 (fume), JAN1993
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 1.0 mg(Cu)/m3 (fume), JAN1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 20900; Number of Industries 114; Total Number of Facilities 9321; Number of Occupations 94; Total Number of Employees Exposed 227496; Total Number of Female Employees Exposed 105906
National Occupational Hazard Survey 1974Hazard Code 20900; Number of Industries 76; Total Number of Facilities 4642; Number of Occupations 58; Total Number of Employees Exposed 57558

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-SA7/SHE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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