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Copper (II) sulfate (1:1)

RTECS #: GL8800000

CAS #: 7758-98-7


UPDATE: May 2009 MW: 159.60 MF: O4SCu


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. BCS copper fungicide
  2. Blue Copper
  3. Blue stone
  4. Blue vitriol
  5. Copper sulfate
  6. Copper sulfate (1:1)
  7. Copper monosulfate
  8. Copper (II) sulfate
  9. Copper (2+) sulfate
  10. Copper (2+) sulfate (1:1)
  11. Cupric sulfate anhydrous
  12. Cupric sulphate
  1. Griffin super Cu
  2. Incracide 10A
  3. Incracide E 51
  4. Kilcop 53
  5. Kobasic
  6. Phyto - bordeaux
  7. Roman vitriol
  8. Sulfate de cuivre (French)
  9. Sulfuric acid, copper (2+) salt (1:1)
  10. TNCS 53
  11. Trinagle


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
DNA damage oral
mouse
1.25 mg/kg FCTOD7 42,1931,2004
DNA damage multiple
non-mammalian species
7.50 mg/L/2 hour MUREAV 605,78,2006
DNA damage rat Ascites tumor 500 mol/L JBCHA3 261,3370,1986
DNA damage rat liver 1 mmol/L SinJF# 26OCT1982
DNA inhibition intraperitoneal
mouse
20 gm/kg ARGEAR 51,605,1981
unscheduled DNA synthesis hamster embryo 200 mol/L MUREAV 131,173,1984
mutation in microorganisms Bacillus subtilis 400 mol/L (-enzymatic activation step) AMAHA5 21,297,1974
mutation in microorganisms Escherichia coli 7,500 ppt/3 hour (-enzymatic activation step) AMNTA4 85,119,1951
micronucleus test oral
mouse
8.5 mg/kg MUREAV 577S,1,2005
micronucleus test multiple
non-mammalian species
3.75 mg/L/24 hour MUREAV 605,78,2006
morphological transform hamster embryo 80 mol/L CNREA8 39,193,1979
other mutation test systems Bacillus subtilis 400 mol/L JOBAAY 85,1003,1963
sex chromosome loss and nondisjunction parenteral
Drosophila melanogaster
1,000 ppm PNASA6 24,546,1938
sex chromosome loss and nondisjunction unreported route
Drosophila melanogaster
7,100 ppm BMAOA3 7,635,1938


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
rat
lowest published toxic dose: 7,500 g/kg (3 day pregnant) Reproductive: Effects on fertility: Other measures of fertility BECTA6 25,702,1980
intratesticular
rat
lowest published toxic dose: 3,192 g/kg (1 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
JRPFA4 7,21,1964
intravenous
hamster
lowest published toxic dose: 2,130 g/kg (8 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Body wall
BIREBV 11,97,1974
intravenous
mouse
lowest published toxic dose: 3,200 g/kg (8 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system
WRABDT 186,297,1979
intravenous
mouse
lowest published toxic dose: 3,200 g/kg (7 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) WRABDT 186,297,1979
oral
pig
lowest published toxic dose: 140 mg/kg (1-15 week pregnant/4 week after birth) Reproductive: Effects on newborn: Biochemical and metabolic CNJNAT 71,227,1991
subcutaneous
mouse
lowest published toxic dose: 12,768 g/kg (30 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct JRPFA4 7,21,1964
subcutaneous
rat
lowest published toxic dose: 12,768 g/kg (1 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct JRPFA4 7,21,1964


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
parenteral
chicken
lowest published toxic dose: 10 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Endocrine: Tumors
BEXBAN 9,519,1940


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lethal dose (50 percent kill): 7,182 g/kg N/R COREAF 256,1043,1963
intraperitoneal
rat
lethal dose (50 percent kill): 20 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold
INJPD2 23,153,1991
intratracheal
rat
lowest published toxic dose: 100 g/kg Lung, Thorax, or Respiration: Sputum HBTME* -,529,2007
intravenous
frog
lowest published lethal dose: 25 mg/kg N/R HBTXAC 1,76,1955
intravenous
guinea pig
lowest published lethal dose: 2 mg/kg N/R EQSSDX 1,1,1975
intravenous
mouse
lethal dose (50 percent kill): 23,300 g/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold
INJPD2 23,153,1991
intravenous
rat
lethal dose (50 percent kill): 48,900 g/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold
INJPD2 23,153,1991
intravenous
rat
lowest published toxic dose: 12 mg/kg Endocrine: Change in LH ENEXAM 4,37,1970
intravenous
rabbit
lethal dose (50 percent kill): 10 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Food intake (animal)

Gastrointestinal: Hypermotility, diarrhea
JIHTAB 31,301,1949
oral
child
lowest published toxic dose: 150 mg/kg Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Other hemolysis with or without anemia
AJDCAI 131,149,1977
oral
dog
lowest published toxic dose: 37.5 mg/kg Gastrointestinal: Nausea or vomiting FATOAO 47,55,1984
oral
human
lowest published lethal dose: 50 mg/kg Behavioral: Somnolence (general depressed activity)

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Hemorrhage
JAMAAP 235,801,1976
oral
human
lowest published toxic dose: 11 mg/kg Gastrointestinal: Gastritis

Gastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Nausea or vomiting
LANCAO 2,700,1960
oral
human
lethal dose (50 percent kill): 50 mg/kg N/R USXXAM #6770674
oral
human
lowest published toxic dose: 0.29 mg/kg Kidney, Ureter, and Bladder: Other changes in urine composition HBTME* -,529,2007
oral
man
lowest published lethal dose: 857 mg/kg Gastrointestinal: Nausea or vomiting ATXKA8 17,20,1958
oral
mouse
lethal dose (50 percent kill): 369 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold
INJPD2 23,153,1991
oral
mouse
lethal dose (50 percent kill): 87 mg/kg N/R HBPTO* 2,1361,2001
oral
rat
lethal dose (50 percent kill): 960 mg/kg Behavioral: Muscle contraction or spasticity

Vascular: Shock

Gastrointestinal: Nausea or vomiting
HBPTO* 2,1361,2001
oral
rat
lethal dose (50 percent kill): 300 mg/kg N/R USXXAM #6770674
oral
woman
lowest published toxic dose: 2,100 g/kg/5 week- intermittent Gastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Nausea or vomiting

Gastrointestinal: Other changes
TOXID9 54,73,2000
oral
woman
lowest published lethal dose: 47,320 L/kg Gastrointestinal: Hypermotility, diarrhea

Liver: Hepatitis (hepatocellular necrosis), diffuse

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
NPRNAY 15,74,1975
oral
woman
lowest published lethal dose: 50 mg/kg Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) CTOXAO 39,161,2001
oral
woman
lowest published toxic dose: 24 g/kg Gastrointestinal: Nausea or vomiting TOXID9 66,102,2002
oral
woman
lowest published toxic dose: 0.24 mg/kg Reproductive: Maternal effects: Ovaries, fallopian tubes

Reproductive: Maternal effects: Menstrual cycle changes or disorders
TOXID9 60,436,2001
subcutaneous
mouse
lowest published lethal dose: 500 g/kg N/R TJIZAF 48,313,1978
subcutaneous
rat
lethal dose (50 percent kill): 43 mg/kg N/R PESTD5 16,252,1975
unreported route
rat
lethal dose (50 percent kill): 520 mg/kg N/R GTPZAB 26(6),21,1982


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
rat
lowest published toxic dose: 791 mg/kg/18 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain TXAPA9 18,562,1971
oral
human
lowest published toxic dose: 598.5 mg/kg/5 week- intermittent Gastrointestinal: Nausea or vomiting RTOPDW 34,137,2001
oral
mouse
lowest published toxic dose: 3 gm/kg/8 week- continuous Blood: Changes in spleen

Immunological Including Allergic: Decrease in cellular immune response

Immunological Including Allergic: Decrease in humoral immune response
FAATDF 16,249,1991
oral
mouse
lowest published toxic dose: 2 gm/kg/3 week- continuous Blood: Changes in spleen

Immunological Including Allergic: Decrease in cellular immune response

Immunological Including Allergic: Decrease in humoral immune response
FAATDF 16,249,1991
oral
mouse
lowest published toxic dose: 240 mg/kg/3 day- intermittent Liver: Other changes

Liver: Changes in liver weight
TXCYAC 249,176,2008
oral
rat
lowest published toxic dose: 915 mg/kg/1 year- intermittent Cardiac: Changes in coronary arteries

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
GISAAA 54(2),64,1989
oral
rat
lowest published toxic dose: 157 mg/kg/6 week- intermittent Endocrine: Changes in adrenal weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
TXAPA9 28,395,1974
oral
rat
lowest published toxic dose: 7,530 mg/kg/30 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Blood: Changes in erythrocyte (RBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TOLED5 38,275,1987
oral
rat
lowest published toxic dose: 2 gm/kg/20 day- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
TOLED5 6,163,1980
oral
rat
lowest published toxic dose: 10.4 gm/kg/18 week- continuous Liver: Hepatitis (hepatocellular necrosis), diffuse

Liver: Liver function tests impaired
JTCTDW 38,709,2000
oral
rat
lowest published toxic dose: 50.4 gm/kg/16 week- continuous Liver: Hepatitis (hepatocellular necrosis), diffuse

Liver: Liver function tests impaired
JTCTDW 38,709,2000
oral
rat
lowest published toxic dose: 9.45 gm/kg/18 week- intermittent Liver: Hepatitis (hepatocellular necrosis), diffuse

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
JTCTDW 38,709,2000
oral
rat
lowest published toxic dose: 37.8 gm/kg/12 week- intermittent Liver: Hepatitis (hepatocellular necrosis), diffuse

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
JTCTDW 38,709,2000
oral
rat
lowest published toxic dose: 14 mg/kg/7 day- intermittent Nutritional and Gross Metabolic: Changes in: Ca

Musculoskeletal: Other changes
BPBLEO 28,2296,2005
oral
woman
lowest published toxic dose: 0.7 mg/kg/7 day- continuous Gastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Nausea or vomiting

Gastrointestinal: Other changes
EVHPAZ 109,949,2001


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
ADTEAS 5,51,1972
TOXICOLOGY REVIEW
AJMEAZ 38,409,1965
TOXICOLOGY REVIEW
85DHAX Cu,23,1977
TOXICOLOGY REVIEW
TOLED5 128,45,2002
TOXICOLOGY REVIEW
MUTAEX 21,93,2006
TOXICOLOGY REVIEW
DIMON* 39,678,1993
TOXICOLOGY REVIEW
ENTOX* -,665,2005
TOXICOLOGY REVIEW
ENTOX* -,110,2005
TOXICOLOGY REVIEW
HUTOX* -,561,1996
TOXICOLOGY REVIEW
HTOPA* 1,595,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,105,1998
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 0.1 mg(Cu)/m3 (fume), JAN1993
Occupational Exposure Limit - FINLAND time-weighted average 1 mg(Cu)/m3 (dust), JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 0.2 mg(Cu)/m3 (fume), JAN1999
Occupational Exposure Limit - HUNGARY time-weighted average 1 mg(Cu)/m3, short term exposure limit 4 mg(Cu)/m3, SEP2000
Occupational Exposure Limit - INDIA time-weighted average 0.2 mg(Cu)/m3 (fume), JAN1993
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 1.0 mg(Cu)/m3 (fume), JAN1993
Occupational Exposure Limit - RUSSIA time-weighted average 0.5 mg/m3, short term exposure limit 1.5 mg/m3, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 1 mg(Cu)/m3;
time-weighted average 0.2 mg(Cu)/m3 (resp. dust), JUN2005
Occupational Exposure Limit - THAILAND time-weighted average 1 mg(Cu)/m3, JAN1993
Occupational Exposure Limit - THAILAND time-weighted average 0.1 mg(Cu)/m3 (fume), JAN1993


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 20900;
Number of Industries 76;
Total Number of Facilities 4,642;
Number of Occupations 58;
Total Number of Employees Exposed 57,558
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 20900;
Number of Industries 114;
Total Number of Facilities 9,321;
Number of Occupations 94;
Total Number of Employees Exposed 227,496;
Total Number of Female Employees Exposed 105,906


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Positive: Cell transform.-SA7/SHE
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as intermediate and wood preservative, also used in production of copper compounds
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

85DHAX "Medical and Biologic Effects of Environmental Pollutants Series," Washington, DC, National Academy of Sciences, 1972-77
ADTEAS Advances in Teratology. (New York, NY) V.1-5, 1966-72. Discontinued.
AJDCAI American Journal of Diseases of Children. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1-80(3), 1911-50; V.100- 1960-
AJMEAZ American Journal of Medicine. (Technical Pub., 875 Third Ave., New York, NY 10022) V.1- 1946-
AMAHA5 Acta Microbiologica Academiae Scientiarum Hungaricae. (Budapest, Hungary) V.1-29, 1954-82.
AMNTA4 American Naturalist. (Univ. of Chicago Press, Journals Div., POB 37005, Chicago, IL 60637) V.1- 1867-
ARGEAR Archiv fuer Geschwulstforschung. (VEB Verlag Volk und Gesundheit Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1949-
ATXKA8 Archiv fuer Toxikologie. (Berlin, Fed. Rep. Ger.) V.15-31, 1954-74. For publisher information, see ARTODN.
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
BEXBAN Bulletin of Experimental Biology and Medicine (English Translation). Translation of BEBMAE. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.41- 1956-
BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W. Clark St., Champaign, IL 61820) V.1- 1969-
BMAOA3 Biologicheskii Zhurnal. Biological Journal. (Moscow, USSR) V.1-7, 1932-38. For publisher information, see ZOBIAU.
BPBLEO Biological and Pharmaceutical Bulletin. (Pharmaceutical Society of Japan, 2-12-15-201 Shibuya Shibuya-ku, Tokyo 150, Japan) V.16- 1993-
CNJNAT Canadian Journal of Animal Science. (Agricultural Institute of Canada, 151 Slater St., Suite 907, Ottawa, ON K1P 5H4, Canada) V.37- 1957-
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
COREAF Comptes Rendus Hebdomadaires des Seances, Academie des Sciences. (Paris, France) V.1-261, 1835-1965. For publisher information, see CRASEV.
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW.
DIMON* Disease-a Month (Chicago : Year Book Publishers) V. 24- 1978-
ENEXAM Endocrinologia Experimentalis. (Karger-Libri, P.O. Box, CH-4009 Basel, Switzerland) V.1- 1964-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
EQSSDX Environmental Quality and Safety, Supplement. (Stuttgart, Fed. Rep. Ger.) V.1-5, 1975-76. Discontinued.
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939-
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
HBTME*
HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59
HTOPA*
HUTOX*
INJPD2 Indian Journal of Pharmacology. (Dept. of Pharmacology, Baranas Hindu Univ., Varanasi 221 005, India) V.1- 1968(?)-
JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883-
JBCHA3 Journal of Biological Chemistry. (428 E. Preston St., Baltimore, MD 21202) V.1- 1905-
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
JOBAAY Journal of Bacteriology. (American Soc. for Microbiology, 1913 I St., NW, Washington, DC 20006) V.1- 1916-
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960-
JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.19- 1982-
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NPRNAY Nephron. (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.1- 1964-
PESTD5 Proceedings of the European Society of Toxicology. (Amsterdam, Netherlands) V.16-18, 1975-77. Discontinued.
PNASA6 Proceedings of the National Academy of Sciences of the United States of America. (National Academy of Sciences, Printing & Pub. Office, 2101 Constitution Ave., Washington, DC 20418) V.1- 1915-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
RTOPDW Regulatory Toxicology and Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981-
SinJF# Personal Communication from J.F. Sina, Merck Institute for Therapeutic Research, West Point, PA 19486, Oct. 26, 1982
TJIZAF Tokyo Joshi Ika Daigaku Zasshi. Journal of Tokyo Women's Medical College. (Society of Tokyo Women's Medical College, c/o Tokyo Joshi Ika Daigaku Toshokan, 10, Kawada-cho, Shinjuku-ku, Tokyo 162, Japan.) V.1- 1931-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231)
WRABDT Wilhelm Roux's Archives of Developmental Biology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.177- 1975-

Used as intermediate and wood preservative, also used in production of copper compounds

NIOSH PROFILE (COPPER and COMPOUNDS), SRC, 3/82

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data

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