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Registry of Toxic Effects of Chemical Substances (RTECS)

Cobalt(II) sulfate (1:1), heptahydrate

RTECS #

GG3200000

CAS #

10026-24-1

Updated

September 201

Molecular Weight

281.13

Molecular Formula

CoO4S·7H2O

Synonyms

Cobalt monosulfate heptahydrate
Cobalt sulfate heptahydrate
Cobalt(II) sulphate heptahydrate
Cobaltous sulfate heptahydrate
Sulfuric acid, cobalt(2+) salt (1:1), heptahydrate (8CI,9CI)

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
micronucleus testembryo/hamster1 mg/LMUREAV 392,61,1997

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/mouse 30 mg/m3/6H (13W male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
FAATDF 15,357,1990

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intramuscular/rat lethal dose (50 percent kill): 320 mg/kgFATOBP 13,94,1978
intravenous/Dog lowest published lethal dose: 16200 µg/kgEQSSDX 1,1,1975
oral/rat lethal dose (50 percent kill): 582 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Gastrointestinal: Hypermotility, diarrhea
ATDAEI 1,688,1992

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 30 mg/m3/6H/13W- intermittentLung, Thorax, or Respiration: Changes in lung weight

Endocrine: Effect on menstrual cycle

Related to Chronic Data: Changes in testicular weight
FAATDF 15,357,1990
inhalation/rat lowest published toxic concentration: 91 mg/m3/6H/16D- intermittentEye: Chromodacryorrhea

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Endocrine: Changes in thymus weight
NTPTR* NIH-91-3124
inhalation/rat lowest published toxic concentration: 18 mg/m3/6H/13W- intermittentLung, Thorax, or Respiration: Changes in lung weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Blood: Pigmented or nucleated red blood cells
NTPTR* NIH-91-3124

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.02 mg(Co)/m3DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Confirmed animal carcinogenDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWMUREAV 566,49,2004

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-FINLANDtime-weighted average 0.02 mg(Co)/m3, NOV2011
Occupational Exposure Limit-HUNGARYtime-weighted average 0.1 mg(Co)/m3, short term exposure limit 0.4 mg(Co)/m3, SEP2000
Occupational Exposure Limit-JAPANOccupational Exposure Limit 0.05 mg(Co)/m3, 2B carc, a1 sen, s2 sen, MAY2012
Occupational Exposure Limit-SWEDENtime-weighted average 0.05 mg(Co)/m3, Sen, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.05 mg(Co)/m3, carc 2, inhal, skin, sen, JAN2011
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 0.1 mg(Co)/m3, sen, carc, OCT2007

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X2377; Number of Industries 5; Total Number of Facilities 126; Number of Occupations 5; Total Number of Employees Exposed 3264; Total Number of Female Employees Exposed 1853

Status in Federal Agencies

OrganizationReference
NCI Carcinogenesis Studies (inhal);clear evidence:mouse,rat
NTP Toxicity studies, RPT# TOX-05, October 2000
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