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Cobalt (II) sulfate (1:1) , heptahydrate

RTECS #: GG3200000

CAS #: 10026-24-1

UPDATE: February 2009 MW: 281.13 MF: CoO4S•7H2O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Cobalt monosulfate heptahydrate
  2. Cobalt sulfate heptahydrate
  3. Cobalt (II) sulphate heptahydrate
  1. Cobaltous sulfate heptahydrate
  2. Sulfuric acid, cobalt (2+) salt (1:1) , heptahydrate (8CI,9CI)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
micronucleus test hamster embryo 1 mg/L MUREAV 392,61,1997


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published toxic concentration: 30 mg/m3/6 hour (13 week male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct 		FAATDF 15,357,1990


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intramuscular
rat 		lethal dose (50 percent kill): 320 mg/kg N/R FATOBP 13,94,1978
intravenous
dog 		lowest published lethal dose: 16,200 µg/kg N/R EQSSDX 1,1,1975
oral
rat 		lethal dose (50 percent kill): 582 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Gastrointestinal: Hypermotility, diarrhea 		ATDAEI 1,688,1992


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published toxic concentration: 30 mg/m3/6 hour/13 week- intermittent Lung, Thorax, or Respiration: Changes in lung weight

Endocrine: Effect on menstrual cycle

Related to Chronic Data: Changes in testicular weight 		FAATDF 15,357,1990
inhalation
rat 		lowest published toxic concentration: 91 mg/m3/6 hour/16 day- intermittent Eye: Chromodacryorrhea

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Endocrine: Changes in thymus weight 		NTPTR* NIH-91-3124
inhalation
rat 		lowest published toxic concentration: 18 mg/m3/6 hour/13 week- intermittent Lung, Thorax, or Respiration: Changes in lung weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Blood: Pigmented or nucleated red blood cells 		NTPTR* NIH-91-3124


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.02 mg(Co)/m3 DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed animal carcinogen DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
MUREAV 584,1,2005
TOXICOLOGY REVIEW
MUREAV 566,49,2004


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - HUNGARY time-weighted average 0.1 mg(Co)/m3, short term exposure limit 0.4 mg(Co)/m3, SEP2000
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.05 mg(Co)/m3, 2B carcinogen, APR2007
Occupational Exposure Limit - SWEDEN time-weighted average 0.05 mg(Co)/m3, Sen, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 mg(Co)/m3, dust, aerosol, DEC2006


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X2377;
Number of Industries 5;
Total Number of Facilities 126;
Number of Occupations 5;
Total Number of Employees Exposed 3,264;
Total Number of Female Employees Exposed 1,853


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
NCI Carcinogenesis Studies (inhal);clear evidence:mouse,rat
NTP Toxicity studies, RPT# TOX-05, October 2000


REFERENCES:

CODEN
REFERENCE
ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EQSSDX Environmental Quality and Safety, Supplement. (Stuttgart, Fed. Rep. Ger.) V.1-5, 1975-76. Discontinued.
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FATOBP Farmakologiya i Toksikologiya (Kiev). Pharmacology and Toxicology. (Kievskii Nauchno- Issledovatel'skii Institut Farmakologii i Toksikologii, Kiev, USSR) No.1- 1964-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector

Click Here for Additional Information about RTECS

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