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Cobalt (II) sulfate (1:1)

RTECS #: GG3100000

CAS #: 10124-43-3


UPDATE: February 2009 MW: 154.99 MF: O4SCo


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Cobalt monosulfate
  2. Cobalt sulfate
  3. Cobalt sulfate (1:1)
  4. Cobalt (2+) sulfate
  1. Cobalt (II) sulfate
  2. Cobalt (II) sulphate
  3. Cobaltous sulfate
  4. Sulfuric acid, cobalt (2+) salt (1:1)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lethal dose (50 percent kill): 126 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold
INJPD2 23,153,1991
intraperitoneal
rat
lethal dose (50 percent kill): 31,600 g/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold
INJPD2 23,153,1991
intravenous
dog
lowest published lethal dose: 20 mg/kg N/R HBAMAK 4,1289,1935
intravenous
mouse
lethal dose (50 percent kill): 27,100 g/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold
INJPD2 23,153,1991
intravenous
rat
lethal dose (50 percent kill): 18,200 g/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold
INJPD2 23,153,1991
oral
mouse
lethal dose (50 percent kill): 584 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold
INJPD2 23,153,1991
oral
rat
lethal dose (50 percent kill): 424 mg/kg Behavioral: Tremor

Gastrointestinal: Hypermotility, diarrhea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FCTOD7 20,311,1982
oral
rat
lethal dose (50 percent kill): 424 mg/kg Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli

Blood: Hemorrhage
VCVN5* -,453,1989
oral
rabbit
lowest published lethal dose: 1,800 mg/kg N/R HBAMAK 4,1289,1935
unreported route
rabbit
lowest published toxic dose: 0.2 mg/kg Vascular: BP lowering not characterized in autonomic section VCVN5* -,456,1989


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic concentration: 3 mg/m3/13 week- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) HBTME* -,511,2007
oral
rat
lowest published toxic dose: 140 mg/kg/2 week- intermittent Cardiac: Other changes VCVN5* -,459,1989
oral
rabbit
lowest published toxic dose: 140 mg/kg/2 week- intermittent Cardiac: Other changes VCVN5* -,459,1989


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.02 mg(Co)/m3 DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed animal carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 52,363,1991
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMEMDT 52,363,1991
TOXICOLOGY REVIEW
HBTME* ,511,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - HUNGARY time-weighted average 0.1 mg(Co)/m3, short term exposure limit 0.4 mg(Co)/m3, SEP2000
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.05 mg(Co)/m3, 2B carcinogen, APR2007
Occupational Exposure Limit - SWEDEN time-weighted average 0.05 mg(Co)/m3, Sen, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 mg(Co)/m3, dust, aerosol, DEC2006


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M1023;
Number of Industries 12;
Total Number of Facilities 387;
Number of Occupations 22;
Total Number of Employees Exposed 8,273
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M1023;
Number of Industries 67;
Total Number of Facilities 5,293;
Number of Occupations 41;
Total Number of Employees Exposed 44,607;
Total Number of Female Employees Exposed 11,292


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Positive: B subtilis rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in pigments, glazes, plating, additive to soils and animal feed, water purification
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen


REFERENCES:

CODEN
REFERENCE

DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.)
HBTME*
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
INJPD2 Indian Journal of Pharmacology. (Dept. of Pharmacology, Baranas Hindu Univ., Varanasi 221 005, India) V.1- 1968(?)-
VCVN5* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov V-VII groopp" (Hazardous substances. Inornanic substances containing V-VII group elements), Bandman A.L. et al., Chimia, 1989.

Used in pigments, glazes, plating, additive to soils and animal feed, water purification

NIOSH PROFILE (COBALT and ITS COMPOUNDS), SRI, 10/77

RTECS Compound Description:
   Tumorigen
   Mutagen

Click Here for Additional Information about RTECS

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