Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to page options Skip directly to site content

Registry of Toxic Effects of Chemical Substances (RTECS)

Cobalt(II) sulfate (1:1)

RTECS #

GG3100000

CAS #

10124-43-3

Updated

September 201

Molecular Weight

154.99

Molecular Formula

O4S·Co

Synonyms

Cobalt (2+) sulfate
Cobalt monosulfate
Cobalt sulfate
Cobalt sulfate (1:1)
Cobalt(II) sulfate
Cobalt(II) sulphate
Cobaltous sulfate
Sulfuric acid, cobalt(2+) salt (1:1)

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): 126 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold
INJPD2 23,153,1991
intraperitoneal/rat lethal dose (50 percent kill): 31600 µg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold
INJPD2 23,153,1991
intravenous/Dog lowest published lethal dose: 20 mg/kgHBAMAK 4,1289,1935
intravenous/mouse lethal dose (50 percent kill): 27100 µg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold
INJPD2 23,153,1991
intravenous/rat lethal dose (50 percent kill): 18200 µg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold
INJPD2 23,153,1991
oral/mouse lethal dose (50 percent kill): 584 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold
INJPD2 23,153,1991
oral/rabbit lowest published lethal dose: 1800 mg/kgHBAMAK 4,1289,1935
oral/rat lethal dose (50 percent kill): 424 mg/kgKidney, Ureter, and Bladder: Changes in both tubules and glomeruli

Blood: Hemorrhage
VCVN5* -,453,1989
oral/rat lethal dose (50 percent kill): 424 mg/kgBehavioral: Tremor

Gastrointestinal: Hypermotility, diarrhea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FCTOD7 20,311,1982
unreported route/rabbit lowest published toxic dose: 0.2 mg/kgVascular: BP lowering not characterized in autonomic sectionVCVN5* -,456,1989

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 3 mg/m3/13W- intermittentReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)HBTME* -,511,2007
oral/rabbit lowest published toxic dose: 140 mg/kg/2W- intermittentCardiac: Other changesVCVN5* -,459,1989
oral/rat lowest published toxic dose: 140 mg/kg/2W- intermittentCardiac: Other changesVCVN5* -,459,1989

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.02 mg(Co)/m3DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Confirmed animal carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review: Group 2BIMEMDT 86,133,2006
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 52,363,1991
International Agency for Research on Cancer (IARC)Cancer Review:Group 2BIMEMDT 52,363,1991
TOXICOLOGY REVIEWHBTME* ,511,2007

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-FINLANDtime-weighted average 0.02 mg(Co)/m3, NOV2011
Occupational Exposure Limit-HUNGARYtime-weighted average 0.1 mg(Co)/m3, short term exposure limit 0.4 mg(Co)/m3, SEP2000
Occupational Exposure Limit-JAPANOccupational Exposure Limit 0.05 mg(Co)/m3, 2B carc, a1 sen, s2 sen, MAY2012
Occupational Exposure Limit-SWEDENtime-weighted average 0.05 mg(Co)/m3, Sen, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.05 mg(Co)/m3, carc 2, inhal, skin, sen, JAN2011
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 0.1 mg(Co)/m3, sen, carc, OCT2007

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code M1023; Number of Industries 67; Total Number of Facilities 5293; Number of Occupations 41; Total Number of Employees Exposed 44607; Total Number of Female Employees Exposed 11292
National Occupational Hazard Survey 1974Hazard Code M1023; Number of Industries 12; Total Number of Facilities 387; Number of Occupations 22; Total Number of Employees Exposed 8273

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Positive: B subtilis rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen
TOP