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Registry of Toxic Effects of Chemical Substances (RTECS)

Cobalt(III) oxide

RTECS #

GG2900000

CAS #

1308-04-9

Updated

September 201

Molecular Weight

165.86

Molecular Formula

Co2O3

Synonyms

C.I. 77323
Cobalt oxide (8CI,9CI)
Cobalt peroxide
Cobalt sesqioxide
Cobalt sesquioxide
Cobalt trioxide
Cobalt(3+) oxide
Cobaltic oxide
Dicobalt oxide
Dicobalt trioxide

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat lethal dose (50 percent kill): 5 gm/kgVascular: Regional or general arteriolar or venous dilation

Liver: Other changes

Blood: Other changes
INMEAF 15,482,1946
subcutaneous/mouse lethal dose (50 percent kill): 2064 mg/kgZVKOA6 19,186,1974

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 700 µg/m3/3H/13W- intermittentLung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Fibrosis (interstitial)

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
WDZAEK 4,27,1990

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.02 mg(Co)/m3DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Confirmed animal carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 52,363,1991
International Agency for Research on Cancer (IARC)Cancer Review:Group 2BIMEMDT 52,363,1991
TOXICOLOGY REVIEWHBTME* ,511,2007

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-FINLANDtime-weighted average 0.02 mg(Co)/m3, NOV2011
Occupational Exposure Limit-HUNGARYtime-weighted average 0.1 mg(Co)/m3, short term exposure limit 0.4 mg(Co)/m3, SEP2000
Occupational Exposure Limit-JAPANOccupational Exposure Limit 0.05 mg(Co)/m3, 2B carc, a1 sen, s2 sen, MAY2012
Occupational Exposure Limit-NORWAYtime-weighted average 0.05 mg(Co)/m3, JAN1999
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.5 mg/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 0.05 mg(Co)/m3, Sen, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.05 mg(Co)/m3, carc 2, inhal, skin, sen, JAN2011
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 0.1 mg(Co)/m3, sen, OCT2007

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
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