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Cobalt (II) nitrate (1:2)

RTECS #: GG1109000

CAS #: 10141-05-6


UPDATE: February 2009 MW: 182.95 MF: N2O6Co


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Cobalt bis (nitrate)
  2. Cobalt dinitrate
  3. Cobalt nitrate
  4. Cobalt (2+) nitrate
  1. Cobalt (II) nitrate
  2. Cobaltous nitrate
  3. Nitric acid, cobalt (2+) salt


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intratesticular
rat
lowest published toxic dose: 14,636 g/kg (1 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct JRPFA4 7,21,1964
subcutaneous
mouse
lowest published toxic dose: 14,636 g/kg (30 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct JRPFA4 7,21,1964


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
subcutaneous
rabbit
lowest published toxic dose: 4,530 g/kg/5 day- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application
COREAF 236,1387,1953


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intramuscular
pigeon
lowest published lethal dose: 50 mg/kg N/R HBAMAK 4,1289,1935
oral
rat
lethal dose (50 percent kill): 434 mg/kg Behavioral: Somnolence (general depressed activity)

Gastrointestinal: Hypermotility, diarrhea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FCTOD7 20,311,1982
oral
rat
lethal dose (50 percent kill): 434 mg/kg Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli

Blood: Hemorrhage
VCVN5* -,453,1989
oral
rabbit
lowest published lethal dose: 250 mg/kg N/R EQSSDX 1,1,1975
subcutaneous
frog
lowest published lethal dose: 150 mg/kg N/R HBAMAK 4,1289,1935
subcutaneous
rabbit
lowest published lethal dose: 75 mg/kg N/R EQSSDX 1,1,1975
unreported route
rabbit
lowest published toxic dose: 0.2 mg/kg Vascular: BP lowering not characterized in autonomic section VCVN5* -,456,1989
unreported route
rabbit
lowest published lethal dose: 60 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Muscle weakness

Behavioral: Tetany
VCVN5* -,456,1989


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
subcutaneous
rat
lowest published toxic dose: 140 mg/kg/4 week- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Renal function tests depressed

Kidney, Ureter, and Bladder: Other changes in urine composition
ETOPFR 17,159,2004


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.02 mg(Co)/m3 DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed animal carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 52,363,1991
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMEMDT 52,363,1991


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - HUNGARY time-weighted average 0.1 mg(Co)/m3, short term exposure limit 0.4 mg(Co)/m3, SEP2000
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.05 mg(Co)/m3, 2B carcinogen, APR2007
Occupational Exposure Limit - SWEDEN time-weighted average 0.05 mg(Co)/m3, Sen, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 mg(Co)/m3, dust, aerosol, DEC2006


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84330;
Number of Industries 18;
Total Number of Facilities 1,152;
Number of Occupations 15;
Total Number of Employees Exposed 6,182
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84330;
Number of Industries 18;
Total Number of Facilities 732;
Number of Occupations 24;
Total Number of Employees Exposed 16,243;
Total Number of Female Employees Exposed 4,029


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE

COREAF Comptes Rendus Hebdomadaires des Seances, Academie des Sciences. (Paris, France) V.1-261, 1835-1965. For publisher information, see CRASEV.
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EQSSDX Environmental Quality and Safety, Supplement. (Stuttgart, Fed. Rep. Ger.) V.1-5, 1975-76. Discontinued.
ETOPFR Environmental Toxicology and Pharmacology (Elsevier Science, P.O.Box 7247-7682,Philadelphia,PA 19170 -7682,USA OR Elsevier Science B.V.,P.O.Box 1270,1000 BG Amsterdam,The Netherlands) V.1- Feb.1996-
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.)
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960-
VCVN5* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov V-VII groopp" (Hazardous substances. Inornanic substances containing V-VII group elements), Bandman A.L. et al., Chimia, 1989.

Used in sympathetic inks, pigments preparation of catalysts, additive to soils, animal feed

NIOSH PROFILE (COBALT and ITS COMPOUNDS), SRI, 10/77

RTECS Compound Description:
   Tumorigen
   Reproductive Effector

Click Here for Additional Information about RTECS

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