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Registry of Toxic Effects of Chemical Substances (RTECS)

Cobalt(II) nitrate (1:2)

RTECS #

GG1109000

CAS #

10141-05-6

Updated

September 201

Molecular Weight

182.95

Molecular Formula

N2O6·Co

Synonyms

Cobalt bis(nitrate)
Cobalt dinitrate
Cobalt nitrate
Cobalt(2+) nitrate
Cobalt(II) nitrate
Cobaltous nitrate
Nitric acid, cobalt(2+) salt

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intratesticular/rat 14636 µg/kg (1D male)Reproductive: Paternal effects: Testes, epididymis, sperm ductJRPFA4 7,21,1964
subcutaneous/mouse 14636 µg/kg (30D male)Reproductive: Paternal effects: Testes, epididymis, sperm ductJRPFA4 7,21,1964

Tumorigenic Data and References

Route/OrganismDoseEffectReference
subcutaneous/rabbit lowest published toxic dose: 4530 µg/kg/5D- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application
COREAF 236,1387,1953

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intramuscular/pigeon lowest published lethal dose: 50 mg/kgHBAMAK 4,1289,1935
oral/rabbit lowest published lethal dose: 250 mg/kgEQSSDX 1,1,1975
oral/rat lethal dose (50 percent kill): 434 mg/kgKidney, Ureter, and Bladder: Changes in both tubules and glomeruli

Blood: Hemorrhage
VCVN5* -,453,1989
oral/rat lethal dose (50 percent kill): 434 mg/kgBehavioral: Somnolence (general depressed activity)

Gastrointestinal: Hypermotility, diarrhea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FCTOD7 20,311,1982
subcutaneous/frog lowest published lethal dose: 150 mg/kgHBAMAK 4,1289,1935
subcutaneous/rabbit lowest published lethal dose: 75 mg/kgEQSSDX 1,1,1975
unreported route/rabbit lowest published toxic dose: 0.2 mg/kgVascular: BP lowering not characterized in autonomic sectionVCVN5* -,456,1989
unreported route/rabbit lowest published lethal dose: 60 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Muscle weakness

Behavioral: Tetany
VCVN5* -,456,1989

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
subcutaneous/rat lowest published toxic dose: 140 mg/kg/4W- intermittentKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Renal function tests depressed

Kidney, Ureter, and Bladder: Other changes in urine composition
ETOPFR 17,159,2004

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.02 mg(Co)/m3DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Confirmed animal carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 52,363,1991
International Agency for Research on Cancer (IARC)Cancer Review:Group 2BIMEMDT 52,363,1991

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-HUNGARYtime-weighted average 0.1 mg(Co)/m3, short term exposure limit 0.4 mg(Co)/m3, SEP2000
Occupational Exposure Limit-JAPANOccupational Exposure Limit 0.05 mg(Co)/m3, 2B carc, a1 sen, s2 sen, MAY2012
Occupational Exposure Limit-SWEDENtime-weighted average 0.05 mg(Co)/m3, Sen, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.05 mg(Co)/m3, carc 2, inhal, skin, sen, JAN2011
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 0.1 mg(Co)/m3, sen, OCT2007

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 84330; Number of Industries 18; Total Number of Facilities 732; Number of Occupations 24; Total Number of Employees Exposed 16243; Total Number of Female Employees Exposed 4029
National Occupational Hazard Survey 1974Hazard Code 84330; Number of Industries 18; Total Number of Facilities 1152; Number of Occupations 15; Total Number of Employees Exposed 6182

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
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