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Registry of Toxic Effects of Chemical Substances (RTECS)

Cobalt(II) chloride

RTECS #

GF9800000

CAS #

7646-79-9

Updated

September 201

Molecular Weight

129.83

Molecular Formula

Cl2Co

Synonyms

Cobalt chloride
Cobalt dichloride
Cobalt muriate
Cobaltous chloride
Cobaltous dichloride
Dichlorocobalt
Kobalt chlorid (German)

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /human 1%/48HCODEDG 12,93,1985

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA Damage/Other microorganisms750 µmol/LSCIEAS 198,513,1977
DNA Damagelymphocyte/mammal (species unspecified)750 µmol/LSCIEAS 198,513,1977
DNA inhibitionHeLa cell/human1 mmol/LMUREAV 92,427,1982
DNA repair/Bacillus subtilis50 mmol/LMUREAV 77,109,1980
gene conversion and mitotic recombination/Saccharomyes cerevisiae3 gm/LMUREAV 155,117,1985
mutation in mammalian somatic cellslung/hamster200 µmol/LMUREAV 68,259,1979
mutation in microorganisms/Saccharomyes cerevisiae100 µmol/L (-enzymatic activation step)CPBTAL 33,1571,1985
mutation in microorganisms/Salmonella typhimurium1 mg/L (+enzymatic activation step)BECTA6 40,597,1988
other mutation test systemsleukocyte/human24 mg/L/24HTXAPA9 227,299,2008
specific locus testoral/Drosophila melanogaster2 mmol/LMUREAV 320,133,1994
Unscheduled DNA Synthesisembryo/hamster200 µmol/LMUREAV 131,173,1984

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat 30 gm/kg (15-16D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
TJADAB 29(3),23A,1984
intraperitoneal/mouse 25 mg/kg (10D pregnant)Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)JPMSAE 58,766,1969
oral/mouse 7280 mg/kg (13W male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)
TOXID9 6,31,1986
oral/mouse 3940 mg/kg (84D male)Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)TXAPA9 197,351,2004
oral/mouse 2155 mg/kg (84D male)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death
TXAPA9 197,351,2004
oral/mouse 3360 mg/kg (7D male)Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)HBTME* -,511,2007
oral/rat 336 mg/kg (14D preg-21D after birth)Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
HPV091 -,-,2006
oral/rat 1344 mg/kg (14D preg-21D after birth)Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
HPV091 -,-,2006
oral/rat 11 mg/kg (1-22D pregnant)Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)GISAAA 45(2),6,1980
subcutaneous/rat 77.9 mg/kg (1D preg-2D after birth)Reproductive: Effects on newborn: Biochemical and metabolicEKFAE9 58,41,1995

Tumorigenic Data and References

Route/OrganismDoseEffectReference
subcutaneous/rat lowest published toxic dose: 400 mg/kg/19D- intermittentTumorigenic: Carcinogenic by RTECS criteria

Tumorigenic: Tumors at site of application
LBANAX 11,43,1977

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/jkhInhibitor Concentration Low: 50 µmol/L/24HIn Vitro Toxicity Studies: Other assaysTXCYAC 274,27,2010
In Vitro/Rat, lung Inhibitor Concentration (50 percent kill): 0.78 mmol/L/24HIn Vitro Toxicity Studies: Cell countingTIVIEQ 18,79,2004
intraperitoneal/chicken lowest published toxic dose: 10 mg/kgBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)CBPAB5 46,427,1973
intraperitoneal/chicken lowest published toxic dose: 20 mg/kgEndocrine: Other changesCBPAB5 46,427,1973
intraperitoneal/chicken lowest published toxic dose: 40 mg/kgEndocrine: HyperglycemiaCBPAB5 46,427,1973
intraperitoneal/guinea pig lowest published lethal dose: 165 mg/kgAEHLAU 11,201,1965
intraperitoneal/mouse lethal dose (50 percent kill): 49 mg/kgAEPPAE 244,17,1962
intraperitoneal/rat lethal dose (50 percent kill): 17402 µg/kgJAPMA8 48,143,1959
intraperitoneal/rat lowest published toxic dose: 2.2 mg/kgEndocrine: Hyperglycemia

Blood: Other changes
TXAPA9 32,316,1975
intraperitoneal/rat lowest published lethal dose: 30 mg/kgCardiac: Cardiomyopathy including infarction

Cardiac: Arrythmias (indlucing changes in conduction)

Vascular: Thromobosis distant from injection site
VCVN5* -,455,1989
intravenous/Dog lowest published lethal dose: 36 mg/kgHBAMAK 4,1289,1935
intravenous/mouse lethal dose (50 percent kill): 23300 µg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold
INJPD2 23,153,1991
intravenous/rabbit lowest published toxic dose: 20 mg/kgGastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Changes in structure or function of exocrine pancreas

Endocrine: Hyperglycemia
PSEBAA 82,406,1953
intravenous/rabbit lowest published lethal dose: 40 mg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea
PSEBAA 82,406,1953
intravenous/rabbit lowest published lethal dose: 9 mg/kgBehavioral: Food intake (animal)

Behavioral: Muscle contraction or spasticity

Kidney, Ureter, and Bladder: Incontinence
VCVN5* -,453,1989
intravenous/rabbit lowest published toxic dose: 10 mg/kgVascular: BP lowering not characterized in autonomic section

Endocrine: Hyperglycemia
VCVN5* -,454,1989
intravenous/rabbit lowest published toxic dose: 0.01 mg/kgPeripheral Nerve and Sensation: Recording from peripheral motor nerveVCVN5* -,454,1989
intravenous/rat lethal dose (50 percent kill): 4300 µg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold
INJPD2 23,153,1991
oral/child lowest published toxic dose: 48 mg/kgBehavioral: Anorexia (human)

Endocrine: Thyroid weight (goiter)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JAMAAP 157,117,1955
oral/child lowest published lethal dose: 1500 mg/kg34ZIAG -,182,1969
oral/guinea pig lethal dose (50 percent kill): 55 mg/kgVCVN5* -,453,1989
oral/man lowest published toxic dose: 1042 mg/kg/13W- intermittentEye: Optic nerve neuropathy

Eye: Visual field changes
IJMDAI 8,61,1972
oral/mouse lethal dose (50 percent kill): 80 mg/kgVCVN5* -,453,1989
oral/rabbit lowest published lethal dose: 1272 mg/kgSMSJAR 26,131,1826
oral/rabbit lowest published toxic dose: 0.1 mg/kgBlood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other hydrolases
VCVN5* -,454,1989
oral/rat lethal dose (50 percent kill): 418 mg/kgKidney, Ureter, and Bladder: Changes in both tubules and glomeruli

Blood: Hemorrhage
VCVN5* -,453,1989
oral/rat lethal dose (50 percent kill): 80 mg/kgHYSAAV 36(1-3),277,1971
skin/guinea pig lowest published lethal dose: 165 mg/kgAEHLAU 11,201,1965
skin/rat lowest published lethal dose: 2 gm/kgNutritional and Gross Metabolic: Weight loss or decreased weight gainRCCRC* NOTOX1073/1335,1988
subcutaneous/mouse lowest published toxic dose: 60 mg/kgLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
TOLED5 138,235,2003
subcutaneous/rabbit lowest published lethal dose: 200 mg/kgHBAMAK 4,1289,1935
subcutaneous/rat lowest published toxic dose: 32.458 mg/kgLung, Thorax, or Respiration: Respiratory depression

Blood: Changes in erythrocyte (RBC) count
VCVN5* -,454,1989
subcutaneous/rat lowest published toxic dose: 15 mg/kgKidney, Ureter, and Bladder: Changes primarily in glomeruli

Kidney, Ureter, and Bladder: Other changes in urine composition

Blood: Methemoglobinemia- Carboxhemoglobinemia
TOLED5 151,459,2004
subcutaneous/rat lowest published lethal dose: 20 mg/kgKidney, Ureter, and Bladder: Changes primarily in glomeruli

Kidney, Ureter, and Bladder: Other changes in urine composition

Blood: Methemoglobinemia- Carboxhemoglobinemia
TOLED5 151,459,2004
unreported route/rabbit lowest published toxic dose: 0.2 mg/kgVascular: BP lowering not characterized in autonomic sectionVCVN5* -,456,1989
unreported route/rat lowest published toxic dose: 10 mg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: PhosphatasesVCVN5* -,455,1989

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/guinea pig lowest published toxic concentration: 2.4 mg/m3/2W- intermittentLung, Thorax, or Respiration: SputumHBTME* -,511,2007
inhalation/mouse lowest published toxic concentration: 649.15 mg/m3/2W- intermittentLung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TOXID9 -,325,2009
inhalation/rabbit lowest published toxic concentration: 0.5 mg/m3/6H/4W- intermittentLung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Emphysema

Immunological Including Allergic: Decreased immune response
VCVN5* -,457,1989
intraperitoneal/guinea pig lowest published toxic dose: 60 mg/kg/2D- intermittentKidney, Ureter, and Bladder: Proteinuria

Endocrine: Hyperglycemia
VCVN5* -,459,1989
intraperitoneal/guinea pig lowest published toxic dose: 180 mg/kg/6D- intermittentKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Urine volume decreased or anuria
VCVN5* -,459,1989
intravenous/Dog lowest published toxic dose: 1150 mg/kg/10W- intermittentBehavioral: Somnolence (general depressed activity)

Cardiac: Other changes

Lung, Thorax, or Respiration: Dyspnea
TXAPA9 61,89,1981
oral/man lowest published toxic dose: 220 µg/kg/22D- intermittentBlood: Changes in erythrocyte (RBC) countTOXID9 72,246,2003
oral/mouse lowest published toxic dose: 3940.44 mg/kg/12W- continuousReproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands

Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)
TXAPA9 197,351,2004
oral/mouse lowest published toxic dose: 2155.44 mg/kg/12W- continuousReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)TXAPA9 197,351,2004
oral/rabbit lowest published toxic dose: 140 mg/kg/2W- intermittentCardiac: Other changesVCVN5* -,459,1989
oral/rat lowest published toxic dose: 140 mg/kg/2W- intermittentCardiac: Other changesVCVN5* -,459,1989
oral/rat lowest published toxic dose: 87.5 mg(Co)/kg/7D- intermittentBiochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammationTXAPA9 231,354,2008
oral/rat lowest published toxic dose: 1071 mg(Co)/kg/150D- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Blood: Changes in other cell count (unspecified)
HPV091 -,-,2006
oral/rat lowest published toxic dose: 1003 mg/kg/30W- intermittentBehavioral: Alteration of classical conditioningGISAAA 36(2),95,1971
oral/rat lowest published toxic dose: 90 mg/kg/30W- intermittentBehavioral: Alteration of classical conditioning

Blood: Changes in erythrocyte (RBC) count

Immunological Including Allergic: Decrease in cellular immune response
VCVN5* -,462,1989
subcutaneous/rat lowest published toxic dose: 60 mg/kg/3D- intermittentBehavioral: Food intake (animal)

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JJPAAZ 43,335,1987
subcutaneous/rat lowest published toxic dose: 77.9 mg/kg/24D- intermittentBrain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
EKFAE9 58,41,1995
subcutaneous/rat lowest published toxic dose: 46 mg/kg/2D- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)FCTOD7 41,431,2003
unreported route/Dog lowest published toxic dose: 2 mg/kg/10D- intermittentGastrointestinal: Alteration in gastric secretionVCVN5* -,462,1989

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.02 mg(Co)/m3DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Confirmed animal carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMEMDT 52,363,1991
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 52,363,1991
International Agency for Research on Cancer (IARC)Cancer Review:Group 2BIMEMDT 52,363,1991
TOXICOLOGY REVIEWMUREAV 567,227,2004
TOXICOLOGY REVIEWMUREAV 567,109,2004
TOXICOLOGY REVIEWMUREAV 567,151,2004
TOXICOLOGY REVIEWMUTAEX 15,431,2000
TOXICOLOGY REVIEWMUREAV 533,227,2003
TOXICOLOGY REVIEWHBTME* ,511,2007
TOXICOLOGY REVIEWMUREAV 543,191,2003
TOXICOLOGY REVIEWNBREV* 5,1,1981

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-FINLANDtime-weighted average 0.02 mg(Co)/m3, NOV2011
Occupational Exposure Limit-HUNGARYtime-weighted average 0.1 mg(Co)/m3, short term exposure limit 0.4 mg(Co)/m3, SEP2000
Occupational Exposure Limit-JAPANOccupational Exposure Limit 0.05 mg(Co)/m3, 2B carc, a1 sen, s2 sen, MAY2012
Occupational Exposure Limit-SWEDENtime-weighted average 0.05 mg(Co)/m3, Sen, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.05 mg(Co)/m3, carc 2, inhal, skin, sen, JAN2011
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 0.1 mg(Co)/m3, sen, carc, OCT2007

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 84329; Number of Industries 9; Total Number of Facilities 185; Number of Occupations 13; Total Number of Employees Exposed 9392; Total Number of Female Employees Exposed 4192
National Occupational Hazard Survey 1974Hazard Code 84329; Number of Industries 13; Total Number of Facilities 267; Number of Occupations 12; Total Number of Employees Exposed 2790

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Negative: N crassa-aneuploidy
EPA GENETOX PROGRAM 1988, Positive: B subtilis rec assay; S cerevisiae-homozygosis
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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