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Registry of Toxic Effects of Chemical Substances (RTECS)

Coal tar creosote

RTECS #

GF8615000

CAS #

8001-58-9

Updated

November 2009

Molecular Weight

N/R

Molecular Formula

N/R

Synonyms

AWPA #1
Brick oil
Coal tar oil
Creosote
Creosote oil
Creosote P1
Creosote, from coal tar
Creosotum
Cresylic creosote
Heavy oil
Liquid pitch oil
Naphthalene oil
Preserv-O-sote
RCRA waste number U051
Tar oil
Wash oil

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
body fluid assaySalmonella typhimurium/rat250 mg/kgIAPUDO 59,279,1984
micronucleus testintraperitoneal/mouse185 mg/kg/48H- intermittentMUREAV 389,3,1997
mutation in microorganisms/Salmonella typhimurium20 µg/plate (-enzymatic activation step)MUREAV 119,21,1983
other mutation test systems/Escherichia coli1 µg/tubeMUREAV 265,223,1992
sister chromatid exchangeovary/hamster10 mg/LMUREAV 265,223,1992

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/mouse 2 gm/kg (5-9D pregnant)Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
RCOCB8 82,371,1993

Tumorigenic Data and References

Route/OrganismDoseEffectReference
skin/mouse lowest published toxic dose: 99 gm/kg/33W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors
FAATDF 7,228,1986
skin/mouse lowest published toxic dose: 315000 mg/kg/105W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Increased incidence of tumors in susceptible strains
HPV183 -,-,2003

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
oral/rat lethal dose (50 percent kill): 725 mg/kgENTOX* -,677,2005

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 35,83,1985
International Agency for Research on Cancer (IARC)Cancer Review:Human Limited EvidenceIMEMDT 35,83,1985
International Agency for Research on Cancer (IARC)Cancer Review:Animal SUFFICIENT EVICENCEIMEMDT 3,22,1973
International Agency for Research on Cancer (IARC)Cancer Review:Group 2AIMSUDL 7,177,1987
TOXICOLOGY REVIEWMUREAV 543,201,2003
TOXICOLOGY REVIEWMUREAV 567,227,2004
TOXICOLOGY REVIEWMUREAV 567,109,2004
TOXICOLOGY REVIEWENTOX* -,677,2005

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESSupportedRBREV* -,102,1998
Occupational Exposure Limit-MEXICOtime-weighted average 0.002 mg/m3, 2004

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CREOSOTE-air10H Carcinogen time-weighted average 0.1 mg/m3NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code X2258; Number of Industries 1; Total Number of Facilities 3; Number of Occupations 1; Total Number of Employees Exposed 241; Total Number of Female Employees Exposed 17

Status in Federal Agencies

OrganizationReference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/97/121024/AS)
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP 9th Report on Carcinogens, 2000:Known to be human carcinogen
On EPA IRIS database
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