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Registry of Toxic Effects of Chemical Substances (RTECS)

Citric acid, triethyl ester

RTECS #

GE8050000

CAS #

77-93-0

Updated

January 1997

Molecular Weight

276.32

Molecular Formula

C12H20O7

Synonyms

1,2,3-Propanetricarboxylic acid, 2-hydroxy-, triethyl ester (9CI)
Citroflex 2
Ethyl citrate
NSC 8907
TEC
Triaethylcitrat (German)
Triethyl citrate
Triethylester kyseliny citronove (Czech)

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lethal concentration (50 percent kill): 1300 ppm/6HLung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Pleural effusion

Lung, Thorax, or Respiration: Dyspnea
14CYAT 2,1892,1963
intraperitoneal/mouse lethal dose (50 percent kill): 1750 mg/kgBehavioral: Somnolence (general depressed activity)

Vascular: Other changes
JPMSAE 53,774,1964
intraperitoneal/rat lethal dose (50 percent kill): 4 gm/kgBehavioral: Altered sleep time (including change in righting reflex)

Lung, Thorax, or Respiration: Respiratory depression

Nutritional and Gross Metabolic: Body temperature decrease
IYKEDH 16,214,1985
oral/cat lethal dose (50 percent kill): 3500 mg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Gastrointestinal: Nausea or vomiting
FCTXAV 17,389,1979
oral/guinea pig lethal dose (50 percent kill): >25 mL/kgGWXXBX #2703360
oral/rat lethal dose (50 percent kill): 5900 mg/kgBehavioral: Altered sleep time (including change in righting reflex)

Lung, Thorax, or Respiration: Respiratory depression

Nutritional and Gross Metabolic: Body temperature decrease
IYKEDH 16,214,1985
skin/rabbit lethal dose (50 percent kill): >5 gm/kgFCTXAV 17,389,1979
subcutaneous/rat lethal dose (50 percent kill): 6600 mg/kgBehavioral: Altered sleep time (including change in righting reflex)

Lung, Thorax, or Respiration: Respiratory depression

Nutritional and Gross Metabolic: Body temperature decrease
IYKEDH 16,214,1985

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lowest published toxic dose: 4900 mg/kg/14D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainJPMSAE 53,774,1964
oral/cat lowest published toxic dose: 15904 mg/kg/8W- continuousBehavioral: Somnolence (general depressed activity)

Behavioral: Muscle weakness

Behavioral: Ataxia
TXAPA9 1,283,1959

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X7556; Number of Industries 9; Total Number of Facilities 358; Number of Occupations 20; Total Number of Employees Exposed 11496; Total Number of Female Employees Exposed 3993

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
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