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Citric acid, triethyl ester

RTECS #: GE8050000

CAS #: 77-93-0


UPDATE: January 1997 MW: 276.32 MF: C12H20O7


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. NIOSH DOCUMENTATION AND SURVEILLANCE:
  5. STATUS IN FEDERAL AGENCIES:
  6. REFERENCES:

SYNONYMS:

  1. 1,2,3 - Propanetricarboxylic acid, 2 - hydroxy - , triethyl ester (9CI)
  2. Citroflex 2
  3. Ethyl citrate
  4. NSC 8907
  1. TEC
  2. Triaethylcitrat (German)
  3. Triethyl citrate
  4. Triethylester kyseliny citronove (Czech)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lethal concentration (50 percent kill): 1,300 ppm/6 hour Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Pleural effusion

Lung, Thorax, or Respiration: Dyspnea
14CYAT 2,1892,1963
intraperitoneal
mouse
lethal dose (50 percent kill): 1,750 mg/kg Behavioral: Somnolence (general depressed activity)

Vascular: Other changes
JPMSAE 53,774,1964
intraperitoneal
rat
lethal dose (50 percent kill): 4 gm/kg Behavioral: Altered sleep time (including change in righting reflex)

Lung, Thorax, or Respiration: Respiratory depression

Nutritional and Gross Metabolic: Body temperature decrease
IYKEDH 16,214,1985
oral
cat
lethal dose (50 percent kill): 3,500 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Gastrointestinal: Nausea or vomiting
FCTXAV 17,389,1979
oral
guinea pig
lethal dose (50 percent kill): >25 mL/kg N/R GWXXBX #2703360
oral
rat
lethal dose (50 percent kill): 5,900 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Lung, Thorax, or Respiration: Respiratory depression

Nutritional and Gross Metabolic: Body temperature decrease
IYKEDH 16,214,1985
subcutaneous
rat
lethal dose (50 percent kill): 6,600 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Lung, Thorax, or Respiration: Respiratory depression

Nutritional and Gross Metabolic: Body temperature decrease
IYKEDH 16,214,1985
skin
rabbit
lethal dose (50 percent kill): >5 gm/kg N/R FCTXAV 17,389,1979


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lowest published toxic dose: 4,900 mg/kg/14 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain JPMSAE 53,774,1964
oral
cat
lowest published toxic dose: 15,904 mg/kg/8 week- continuous Behavioral: Somnolence (general depressed activity)

Behavioral: Muscle weakness

Behavioral: Ataxia
TXAPA9 1,283,1959


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X7556;
Number of Industries 9;
Total Number of Facilities 358;
Number of Occupations 20;
Total Number of Employees Exposed 11,496;
Total Number of Female Employees Exposed 3,993


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE

14CYAT "Industrial Hygiene and Toxicology," 2nd ed., Patty, F.A., ed., New York, John Wiley & Sons, Inc., 1958-63
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
GWXXBX German Offenlegungsschrift Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231)
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970-
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

RTECS Compound Description:
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