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Registry of Toxic Effects of Chemical Substances (RTECS)

Citric acid, monohydrate

RTECS #

GE7810000

CAS #

5949-29-1

Updated

August 2009

Molecular Weight

210.16

Molecular Formula

C6H8O7·H2O

Synonyms

1,2,3-Propanetricarboxylic acid, 2-hydroxy-, monohydrate
Citric acid hydrate

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 5 mg/30S rinse mildTXCYAC 23,281,1982

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/guinea pig lowest published toxic concentration: 84060000 mg/m3/1MLung, Thorax, or Respiration: CoughJPETAB 292,803,2000
intraperitoneal/rat lethal dose (50 percent kill): 375 mg/kgNTIS** AD-A121-876
oral/mouse lethal dose (50 percent kill): 5790 mg/kgBehavioral: Ataxia

Cardiac: Change in rate

Lung, Thorax, or Respiration: Respiratory depression
HPV093 -,-,2001
subcutaneous/mouse lethal dose (50 percent kill): 2700 mg/kgLung, Thorax, or Respiration: Respiratory depressionHPV093 -,-,2001
subcutaneous/rat lethal dose (50 percent kill): 5500 mg/kgLung, Thorax, or Respiration: Respiratory depressionHPV093 -,-,2001

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X3648; Number of Industries 11; Total Number of Facilities 715; Number of Occupations 15; Total Number of Employees Exposed 17300; Total Number of Female Employees Exposed 9926
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