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Registry of Toxic Effects of Chemical Substances (RTECS)

Citric acid

RTECS #

GE7350000

CAS #

77-92-9

Updated

April 2012

Molecular Weight

192.14

Molecular Formula

C6H8O7

Synonyms

1,2,3-Propanetricarboxylic acid, 2-hydroxy-
2-Hydroxy-1,2,3-propanetricarboxylic acid
Aciletten
Anhydrous citric acid
beta-Hydroxytricarballylic acid
Citretten
Citric acid, anhydrous
Citro
Kyselina 2-hydroxy-1,2,3-propantrikarbonova (Czech)
Kyselina citronova (Czech)
NSC 30279

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 750 µg/24H severe85JCAE -,658,1986
skin /rabbit 0.5 mL moderateHPV093 -,-,2001
skin /rabbit 500 mg/24H mild85JCAE -,658,1986

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, liver tumor Inhibitor Concentration (50 percent kill): 20 mmol/L/24HIn Vitro Toxicity Studies: Cell protein synthesisTIVIEQ 3,189,1989
In Vitro/Non-mammalian species, fibroblast Inhibitor Concentration (50 percent kill): 3.4 mmol/L/24HIn Vitro Toxicity Studies: Cell countingTIVIEQ 7,537,1993
inhalation/guinea pig lowest published toxic concentration: 115284 gm/m3/2MLung, Thorax, or Respiration: Cough

Lung, Thorax, or Respiration: Other changes
JPHPH* 58,419,2007
inhalation/guinea pig lowest published toxic concentration: 19214 gm/m3/10MLung, Thorax, or Respiration: CoughEJPHAZ 528,158,2005
inhalation/guinea pig lowest published toxic concentration: 100000 gm/m3Lung, Thorax, or Respiration: CoughTOXID9 44,298,2005
inhalation/guinea pig lowest published toxic concentration: 300000 gm/m3Lung, Thorax, or Respiration: Bronchiolar constriction, including asthmaTOXID9 44,298,2005
inhalation/guinea pig lowest published toxic concentration: 11528 gm/m3/3MLung, Thorax, or Respiration: Cough

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TXAPA9 202,18,2005
inhalation/guinea pig lowest published toxic concentration: 20 pph/10MLung, Thorax, or Respiration: CoughBJPCBM 138,407,2003
inhalation/human lowest published toxic concentration: 87328 gm/m3/0.0083MLung, Thorax, or Respiration: CoughJPHPH* 58,531,2007
inhalation/monkey lowest published toxic concentration: 2.5 pph/5MLung, Thorax, or Respiration: CoughTOXID9 44,298,2005
inhalation/rat lowest published toxic concentration: 180 mg/m3Lung, Thorax, or Respiration: Other changes

Liver: Liver function tests impaired

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
TOVEFN (5),9,1994
intraperitoneal/mouse lethal dose (50 percent kill): 903 mg/kgTXCYAC 62,203,1990
intraperitoneal/rat lethal dose (50 percent kill): 290 mg/kgTOVEFN (5),9,1994
intraperitoneal/rat lethal dose (16 percent kill): 197 mg/kgTOVEFN (5),9,1994
intraperitoneal/rat lowest published lethal dose: 382 mg/kgTOVEFN (5),9,1994
intratracheal/guinea pig lowest published toxic dose: 3 mg/kgLung, Thorax, or Respiration: CoughJPHSC* 101,118,2006
intratracheal/guinea pig lowest published toxic dose: 118 gm/kgLung, Thorax, or Respiration: Bronchiolar constriction, including asthma

Lung, Thorax, or Respiration: Sputum

Biochemical: Metabolism (intermediary): Histamines (including liberation not immunochemical in origin)
TXAPA9 206,343,2005
intravenous/Dog lowest published toxic dose: 64 mg/kg/30MCardiac: Change in rate

Nutritional and Gross Metabolic: Changes in: Ca

Nutritional and Gross Metabolic: Changes in: Other metals
CLNUT* 25,984,2006
intravenous/Dog lowest published toxic dose: 63 mg/kg/1HCardiac: EKG changes not diagnostic of above

Nutritional and Gross Metabolic: Changes in: Ca

Nutritional and Gross Metabolic: Changes in: Other metals
CLNUT* 25,984,2006
intravenous/Dog lowest published toxic dose: 256 mg/kg/2HCardiac: EKG changes not diagnostic of above

Gastrointestinal: Nausea or vomiting

Nutritional and Gross Metabolic: Changes in: Ca
CLNUT* 25,984,2006
intravenous/Dog lowest published toxic dose: 256 mg/kg/1HCardiac: Arrythmias (indlucing changes in conduction)

Gastrointestinal: Changes in structure or function of salivary glands

Gastrointestinal: Nausea or vomiting
CLNUT* 25,984,2006
intravenous/mouse lethal dose (50 percent kill): 42 mg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Cyanosis

Gastrointestinal: Changes in structure or function of salivary glands
JPETAB 94,65,1948
intravenous/rabbit lethal dose (50 percent kill): 330 mg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Cyanosis

Gastrointestinal: Changes in structure or function of salivary glands
JPETAB 94,65,1948
oral/mouse lethal dose (16 percent kill): 5440 mg/kgTOVEFN (5),9,1994
oral/mouse lethal dose (50 percent kill): 7280 mg/kgTOVEFN (5),9,1994
oral/mouse lowest published lethal dose: 9080 mg/kgTOVEFN (5),9,1994
oral/mouse lethal dose (50 percent kill): 5040 mg/kgLung, Thorax, or Respiration: Other changes

Musculoskeletal: Other changes
TAKHAA 30,25,1971
oral/rabbit lowest published lethal dose: 7 gm/kgBehavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Muscle contraction or spasticity
IECHAD 15,628,1923
oral/rat lethal dose (50 percent kill): 3 gm/kgOYYAA2 43,561,1992
oral/rat lethal dose (16 percent kill): 5000 mg/kgTOVEFN (5),9,1994
oral/rat lowest published lethal dose: 8300 mg/kgTOVEFN (5),9,1994
oral/rat lethal dose (50 percent kill): 11700 mg/kgBehavioral: Ataxia

Cardiac: Change in rate

Lung, Thorax, or Respiration: Respiratory depression
HPV093 -,-,2001
subcutaneous/mouse lethal dose (50 percent kill): 2700 mg/kgLung, Thorax, or Respiration: Other changes

Musculoskeletal: Other changes
TAKHAA 30,25,1971
subcutaneous/rat lethal dose (50 percent kill): 5500 mg/kgLung, Thorax, or Respiration: Other changes

Musculoskeletal: Other changes
TAKHAA 30,25,1971

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 9.3 gm/kg/15D- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
GISAAA -,65,1993
oral/rat lowest published toxic dose: 18.6 gm/kg/30D- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Peptidases

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
GISAAA -,65,1993
oral/rat lowest published toxic dose: 12.6 gm/kg/21D- intermittentImmunological Including Allergic: Decreased immune responseGISAAA -,65,1993

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESRED CompletedRBREV* -,302,1998
Occupational Exposure Limit-RUSSIAshort term exposure limit 1 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X1191; Number of Industries 1; Total Number of Facilities 22; Number of Occupations 2; Total Number of Employees Exposed 130; Total Number of Female Employees Exposed 108
National Occupational Exposure Survey 1983Hazard Code 19680; Number of Industries 244; Total Number of Facilities 49113; Number of Occupations 182; Total Number of Employees Exposed 1691218; Total Number of Female Employees Exposed 1083005
National Occupational Hazard Survey 1974Hazard Code 19680; Number of Industries 157; Total Number of Facilities 28313; Number of Occupations 112; Total Number of Employees Exposed 307205

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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