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Registry of Toxic Effects of Chemical Substances (RTECS)

Chrysene

RTECS #

GC0700000

CAS #

218-01-9

Updated

September 201

Molecular Weight

228.30

Molecular Formula

C18H12

Synonyms

1,2,5,6-Dibenzonaphthalene
1,2-Benzophenanthrene
1,2-Benzphenanthrene
Benz(a)phenanthrene
Benzo(a)phenanthrene
Chrysene (ACGIH:OSHA)
Coal tar pitch volatiles: chrysene (OSHA)
RCRA waste number U050

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisoral/mouse450 mg/kgMUREAV 48,249,1977
DNA adductskin/mouse192 µmol/kgCRNGDP 5,231,1984
DNA adductembryo/hamster1 mg/LCRNGDP 3,1051,1982
DNA Damage/Escherichia coli135.8 µg/L/3H (+enzymatic activation step)MUREAV 515,85,2002
DNA Damagefibroblast/human1 µmol/L/24HMUREAV 547,109,2004
micronucleus testskin/mouse2 mg/kgEMMUEG 17,163,1991
micronucleus testliver/human50 µmol/L/24HTXCYAC 198,315,2004
morphological transformkidney/hamster25 µg/LTOLED5 7,143,1980
morphological transformembryo/hamster10 mg/LIJCNAW 19,642,1977
morphological transformembryo/mouse0.2 mg/L/2DMUREAV 588,7,2005
morphological transformembryo/mouse0.1 mg/L/12DMUREAV 588,7,2005
mutation in mammalian somatic cellslymphocyte/human6 µmol/LDTESD7 10,277,1982
mutation in mammalian somatic cellsother cell types/human12 µmol/LMUREAV 130,127,1984
mutation in microorganisms/Salmonella typhimurium5 µg/plate (-enzymatic activation step)MUREAV 156,61,1985
mutation in microorganismsovary/hamster2500 µg/L (+enzymatic activation step)MUREAV 279,153,1992
mutation in microorganisms/Salmonella typhimurium50 nmol/plate/20M (+enzymatic activation step)MUREAV 586,87,2005
mutation in microorganisms/Salmonella typhimurium0.5 nmol/plate/48H (-enzymatic activation step)MUREAV 557,99,2004
mutation in microorganisms/Salmonella typhimurium68 nmol/plate/48H (+enzymatic activation step)MUREAV 557,99,2004
mutation in microorganisms/Salmonella typhimurium2.4 µg/plate/20M (+enzymatic activation step)MUTAEX 20,217,2005
mutation in microorganisms/Salmonella typhimurium4328.4 pmol/L (+enzymatic activation step)MUREAV 626,88,2007
mutation in microorganisms/Salmonella typhimurium2.4 µg/plate/48H (+enzymatic activation step)MUTAEX 20,217,2005
other mutation test systemsintraperitoneal/mouse10 mg/kgEMMUEG 19,259,1992
other mutation test systems/Salmonella typhimurium15 mg/LMUREAV 192,239,1987
other mutation test systems/Escherichia coli50 mg/LMUREAV 131,101,1984
sister chromatid exchangeintraperitoneal/hamster900 mg/kg/24HMUREAV 66,65,1979
specific locus testintraperitoneal/mouse800 mg/kg/4W- intermittentMUREAV 586,1,2005

Tumorigenic Data and References

Route/OrganismDoseEffectReference
skin/mouse toxic dose: 99 mg/kg/31W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors
CNREA8 11,301,1951
skin/mouse toxic dose: 40 mg/kg/3W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors
CCSUDL 1,325,1976
skin/mouse toxic dose: 3600 mg/kg/30W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors
CANCAR 12,1079,1959
skin/mouse toxic dose: 23 mg/kgTumorigenic: Neoplastic by RTECS criteria

Skin and Appendages: Tumors
CNREA8 40,642,1980
skin/mouse lowest published toxic dose: 3600 µg/kgTumorigenic: Neoplastic by RTECS criteria

Skin and Appendages: Tumors
CNREA8 38,1831,1978
subcutaneous/mouse lowest published toxic dose: 200 mg/kgTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application
CNREA8 15,632,1955

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, liver tumor Inhibitor Concentration Low: 1 µmol/L/14HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TXCYAC 279,36,2011
intraperitoneal/mouse lethal dose (50 percent kill): 320 mg/kgENTOX* -,607,2005

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
multiple/rat lowest published toxic dose: 342.45 mg/kg/3D- intermittentLung, Thorax, or Respiration: Other changes

Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
ARTODN 81,169,2007
oral/mouse lowest published toxic dose: 47943 µg/kg/7D- intermittentLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TOXID9 78,397,2004
unreported route/mouse lowest published toxic dose: 180 mg/kg/12D- intermittentImmunological Including Allergic: Uncharacterized (multiple organ involvement)TOXID9 48,13,1999

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Control as low as possibleDTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Confirmed animal carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMEMDT 32,247,1983
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 32,247,1983
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMSUDL 7,56,1987
TOXICOLOGY REVIEWMUREAV 540,89,2003
TOXICOLOGY REVIEWMUREAV 558,155,2004
TOXICOLOGY REVIEWMUREAV 558,7,2004
TOXICOLOGY REVIEWMUREAV 544,397,2003
TOXICOLOGY REVIEWTOLED5 140-141,353,2003
TOXICOLOGY REVIEWMUREAV 567,401,2004
TOXICOLOGY REVIEWMUREAV 567,347,2004
TOXICOLOGY REVIEWENTOX* -,607,2005
TOXICOLOGY REVIEWMUREAV 543,17,2003
TOXICOLOGY REVIEWFCTOD7 46,813,2008
TOXICOLOGY REVIEWMUREAV 636,144,2007
TOXICOLOGY REVIEWMUREAV 636,4,2007
TOXICOLOGY REVIEWMUREAV 636,36,2007
TOXICOLOGY REVIEWMUREAV 727,1,2011
TOXICOLOGY REVIEWMUREAV 721,27,2011

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIACarcinogen, JUL2008
Occupational Exposure Limit-NORWAYtime-weighted average 0.04 mg/m3, JAN1999
Occupational Exposure Limit-SWITZERLANDcarc 2, JAN2011
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 0.2 mg/m3CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 0.2 mg/m3CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 0.2 mg/m3CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 0.2 mg/m3CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CHRYSENE-airCarcinogen lowest feasible conc.NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code T1320; Number of Industries 2; Total Number of Facilities 553; Number of Occupations 2; Total Number of Employees Exposed 9359
National Occupational Hazard Survey 1974Hazard Code T1320; Number of Industries 1; Total Number of Facilities 11; Number of Occupations 1; Total Number of Employees Exposed 32

Status in Federal Agencies

OrganizationReference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/95/264370)
EPA GENETOX PROGRAM 1988, Inconclusive: E coli polA without S9; In vivo SCE-nonhuman
EPA GENETOX PROGRAM 1988, Negative: Cell transform.-mouse prostate
EPA GENETOX PROGRAM 1988, Negative: Cytogenetics-male germ cell; Host-mediated assay
EPA GENETOX PROGRAM 1988, Negative: E coli polA with S9; S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Positive/limited: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Positive: SHE-clonal assay; Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Polynuclear aromatic hydrocarbons by HPLC, 5506; by GC, 5515
On EPA IRIS database
OSHA ANALYTICAL METHOD #ID-58
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